USF1-induced RPS6KB2 activation influences aggressive phenotype in B-cell non-Hodgkin lymphoma.

B-cell non-Hodgkin lymphoma (B-NHL) is a diverse group of aggressive lymphoid malignancies characterized by its molecular complexity. This study investigated the role of the upstream stimulatory factor 1 (USF1)-ribosomal protein S6 kinase B2 (RPS6KB2) axis in B-NHL progression through the AKT/HDM2 (also known as MDM2)/p53 signaling pathway. Using data from the GEO database, RPS6KB2 was identified to be overexpressed in B-NHL, which was confirmed by RT-qPCR, immunohistochemistry, and western blotting in both B-NHL tissues and cell lines.

Advances in multibending endoscope: A paradigm shift in minimally invasive diagnostics and therapeutics.

Digestive endoscopy has been widely used in the diagnosis and treatment of digestive diseases. However, the anatomical complexity of specific lesions increases the difficulty of these operations, resulting in complications or treatment failure. Although various strategies, such as floss traction and the application of transparent caps, have been explored, their effectiveness remains limited due to individual differences in patients' anatomical characteristics.

Ethanolic Extract of Cyperus rotundus Augments Chemosensitivity to Docetaxel and Suppresses Autophagic Flux in HER2-Positive Breast Cancer Cells.

Introduction: Breast cancer (BC) represents a malignancy affecting populations globally. Its incidence is on the rise. The ethanolic extract of Cyperus rotundus (EECR) has demonstrated potent anticancer activities against multiple human cancer types, inducing apoptosis in BC cells.

Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage.

Influenza A virus (IAV) poses a significant threat to human health. The outcome of IAV results from the viral-host interaction, with the underlying molecular mechanisms largely unknown. By integrating the plasma proteomics data of the IAV-infected patients into the viral-inflammation protein-protein interaction (VI-PPI) network created in this study, purine nucleoside phosphorylase (PNP), the critical enzyme in purine salvage, was identified as a potential hub gene that connected the different stages of IAV infection.

Natural polysaccharide mediated hybrid intumescent flame retardant enables epoxy resin with high fire safety and mechanical performance.

Effectively integrating synergistic flame retardancy and mechanical preservation for high-performance epoxy resins (EP) remains a great challenge. Herein, we demonstrate a natural polysaccharide-assisted assembly strategy to fabricate custard apple-like hybrid intumescent flame retardant (ZTA) that combines the synergistic advantages of ammonium polyphosphate (APP), tannic acid (TA), and zinc borate (ZB) endows EP with high flame retardancy, smoke/toxicity suppression, and mechanical preservation. Leveraging biomass TA as interface binder to provide multiple noncovalent and coordination anchor sites, ZB microparticles are rapidly assembled on the APP surface to form ZTA with protuberant microparticles.

Recombinant Chitinase 3-like 1 Alleviates Liver Transplantation-induced Cold Ischemia/Reperfusion Injury by Promoting M2 Polarization of Kupffer Cells.

Background: Hepatic cold ischemia/reperfusion injury (IRI) significantly restricts graft utilization and adversely affects the prognosis of liver transplantation recipients. The overactivation of Kupffer cells (KCs) is recognized as a significant cellular response in hepatic IRI. This study aimed to investigate the potential of recombinant chitinase 3-like 1 (rCHI3L1) to regulate M2 polarization of KCs and alleviate hepatic cold IRI.

A case report of rare pancreatic lymphoma: wide range of diffuse large B-cell lymphoma located in the body and tail of pancreas.

Background: Pancreatic lymphoma is a rare pancreatic malignancy that is challenging to differentiate from diseases such as pancreatic cancer (PC). Although pathological examination of specimens obtained through surgery or endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) can aid in diagnosis, factors such as the occasional need for surgery and the variability in specimen quality from EUS-FNA complicate the diagnostic process. Misdiagnosis of pancreatic lymphoma as PC often leads to unnecessary surgery.

Predicting 10-year risk of type 2 diabetes in Chinese people with overweight or obesity treated with Tirzepatide: Post hoc analysis of SURMOUNT-CN trial.

Aim: To assess the association of tirzepatide use with a 10-year predicted risk of type 2 diabetes (T2D) among Chinese participants with obesity or overweight from the SURMOUNT-CN trial.

Materials And Methods: In this post hoc analysis, the QDiabetes-2018 risk engine was used to calculate the 10-year predicted T2D risk at baseline, week 24 and week 52 among SURMOUNT-CN participants randomized to receive tirzepatide 10 mg, 15 mg or placebo. A mixed model for repeated measures was used to compare mean predicted risk changes from baseline to weeks 24 and 52 between tirzepatide and placebo.

Cyperotundone promotes chemosensitivity of breast cancer via SRSF1.

Breast cancer is among the most common malignancies and the leading cause of cancer-related deaths in women. SRSF1 proteins belong to an important splicing factor (SF) family and bind to different splicing regulatory elements (SREs) to promote or inhibit splicing, such as oncogenic splice-switching of PTpMT1, which promoting the progression of cancer. Cyperotundone (CYT) is the major bioactive component of sedge and reported to exhibit multiple biological functions, including its potent cytotoxic effect on breast cancer cells.

MAFF alleviates hepatic ischemia-reperfusion injury by regulating the CLCF1/STAT3 signaling pathway.

Background: Although hepatic ischemia-reperfusion injury (IRI) frequently occurs during liver resection and transplantation, the underlying mechanisms remain incompletely understood. Through high-throughput sequencing, we found that v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (MAFF) expression was significantly increased after hepatic IRI. The specific role of MAFF, a basic leucine zipper (bZIP) transcription factor, in hepatic IRI is unknown.

N-Acetyltransferase 10 Promotes Gastric Cancer Progression by Mediating the N4-Acetylcytidine Modification of Lactate Dehydrogenase A.

The N4-acetylcytidine (ac4C) modification, which is catalyzed by NAT10, represents a significant posttranscriptional modification of mRNA in multiple cancers. However, the significance of this modification in gastric cancer (GC) progression remains unclear. To evaluate the potential of differential NAT10 expression in GC, RT-qPCR and western blot were employed.

Cross-Domain Invariant Feature Absorption and Domain-Specific Feature Retention for Domain Incremental Chest X-Ray Classification.

Chest X-ray (CXR) images have been widely adopted in clinical care and pathological diagnosis in recent years. Some advanced methods on CXR classification task achieve impressive performance by training the model statically. However, in the real clinical environment, the model needs to learn continually and this can be viewed as a domain incremental learning (DIL) problem.

NF-κB-mediated EAAT3 upregulation in antioxidant defense and ferroptosis sensitivity in lung cancer.

Cellular glutathione (GSH) in lung cancer cells represents the most abundant antioxidant. GSH production is regulated not only by upregulated cystine/glutamate exchanger (xCT) but also by the involvement of glutamate transporters, specifically excitatory amino acid transporter 3 (EAAT3). Our prior research established that the uptake of glutamate via EAAT3 plays a pivotal role in driving cystine uptake through xCT, contributing to GSH biosynthesis during lung tumorigenesis.

Rad5 and Ubc4 directly ubiquitinate PCNA at Lys164 in vitro.

Ubiquitination of the proliferating cell nuclear antigen (PCNA) by the budding yeast protein Rad5 have important functions in replication stress responses. Rad5 together with the Ubc13-Mms2 complex attaches Lys63-linked ubiquitin chain to a highly conserved Lys164 residue in PCNA. The reaction requires prior PCNA monoubiquitination by the Rad6-Rad18 complex and signals for error-free DNA damage tolerance responses.

Diagnostic value and immune infiltration characterization of WTAP as a critical m6A regulator in liver transplantation.

Background: RNA N6-methyladenosine (m6A) regulators are essential for numerous biological processes and are implicated in various diseases. However, the comprehensive role of m6A regulators in the context of liver transplantation (LT) remains poorly understood. This study aimed to illustrate the relationship between m6A regulators and ischemia-reperfusion injury (IRI) following LT.

Sustainable lignin-based high-efficiency flame-retardant epoxy resins with excellent mechanical properties.

As an abundant natural aromatic polymer, how to realize the high-value utilization of lignin (LA) is still a difficult problem. Herein, a sustainable flame retardant (LA@APP) was synthesized through hydrogen bonding interactions between LA and ammonium polyphosphate (APP), then flame retarded alone epoxy resin (EP/LA@APP). With loading of 6 wt% LA@APP, the LOI of EP/LA@APP6 rose to 27.

Migration and natural attenuation of leachate pollutants in bedrock fissure aquifer at a valley landfill site.

Groundwater pollution from valley type landfills is concerning, and natural attenuation by contaminants is increasingly relied upon. However, the reliability of natural attenuation in such complex sites has been called into question due to incomplete understanding of their attenuation mechanisms. Therefore, we conducted field investigations, monitoring analyses, mathematical statistics, and machine learning techniques to elucidate the natural attenuation mechanisms of pollutants within bedrock fissures at a prototypical valley type landfill located in the east Yanshan Mountains, China.

The m6A writer KIAA1429 regulates photoaging progression via MFAP4-dependent collagen synthesis.

Background: N6-Methyladenosine (mA) methylation, a common form of RNA modification, play an important role in the pathogenesis of various diseases and in the ontogeny of organisms. Nevertheless, the precise function of mA methylation in photoaging remains unknown.

Objectives: This study aims to investigate the biological role and underlying mechanism of mA methylation in photoaging.

Targeting the Labile Iron Pool with Engineered DFO Nanosheets to Inhibit Ferroptosis for Parkinson's Disease Therapy.

Ferroptosis in neurons is considered one of the key factors that induces Parkinson's disease (PD), which is caused by excessive iron accumulation in the intracellular labile iron pool (LIP). The iron ions released from the LIP lead to the aberrant generation of reactive oxygen species (ROS) to trigger ferroptosis and exacerbate PD progression. Herein, a pioneering design of multifunctional nanoregulator deferoxamine (DFO)-integrated nanosheets (BDPR NSs) is presented that target the LIP to restrict ferroptosis and protect against PD.

Stevioside protects against acute kidney injury by inhibiting gasdermin D pathway.

Recent studies indicate a significant upregulation of gasdermin D (GSDMD) in acute kidney injury (AKI), a severe medical condition characterized by high morbidity and mortality globally. In this study, we identified and validated the therapeutic effects of small molecule inhibitors targeting the GSDMD pathway for AKI treatment. Using a drug screening assay, we evaluated thousands of small molecules from DrugBank against Lipopolysaccharide (LPS) and Nigericin-stimulated immortalized bone marrow-derived macrophages (iBMDMs) to discern GSDMD pathway activators.