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Digestive endoscopy has been widely used in the diagnosis and treatment of digestive diseases. However, the anatomical complexity of specific lesions increases the difficulty of these operations, resulting in complications or treatment failure. Although various strategies, such as floss traction and the application of transparent caps, have been explored, their effectiveness remains limited due to individual differences in patients' anatomical characteristics. The multibending (MB) endoscope represents a significant innovation as it is a conventional endoscope with an additional bending section and dual channels. Currently, this technology has been applied in gastroscopy, duodenoscopy and peroral cholangioscopy. The bending part of the endoscope facilitates its passage into difficult-to-reach anatomical regions and improves operating angles, thereby enhancing surgical precision and efficiency while reducing complication rates. Furthermore, the dual-channel design accelerates procedural workflows and increases operational versatility. This innovation is poised to transform endoscopic diagnosis and treatment of digestive system diseases. Since the MB endoscope is relatively new, further research is needed to comprehensively explore its benefits for and potential in endoscopic diagnosis and treatment. The aim of this review is to summarize the current research, indications, and future directions of MB endoscope.
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http://dx.doi.org/10.4253/wjge.v17.i8.106087 | DOI Listing |
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September 2025
Institute of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address:
To maintain genomic stability, cells have evolved complex mechanisms collectively known as the DNA damage response (DDR), which includes DNA repair, cell cycle checkpoints, apoptosis, and gene expression regulation. Recent studies have revealed that long non-coding RNAs (lncRNAs) are pivotal regulators of the DDR. Beyond their established roles in recruiting repair proteins and modulating gene expression, emerging evidence highlights two particularly intriguing functions.
View Article and Find Full Text PDFJMIR Cancer
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iCARE Secure Data Environment & Digital Collaboration Space, NIHR Imperial Biomedical Research Centre, London, United Kingdom.
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View Article and Find Full Text PDFJMIR Res Protoc
September 2025
Department of Urology, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Background: Circumcision is a widely practiced procedure with cultural and medical significance. However, certain penile abnormalities-such as hypospadias or webbed penis-may contraindicate the procedure and require specialized care. In low-resource settings, limited access to pediatric urologists often leads to missed or delayed diagnoses.
View Article and Find Full Text PDFNeuro Endocrinol Lett
September 2025
Faculty of Science, Jan Evangelista Purkyně University, Ústí nad Labem, Czech Republic.
Objective: In addition to hypogonadism, other endocrine disorders-particularly hyperprolactinemia-can significantly influence erectile dysfunction (ED) in men. The aim of our study was to evaluate the effect of normalizing prolactin (PRL) levels on erectile function in men diagnosed with ED and hyperprolactinemia. The primary outcome was improvement in IIEF-5.
View Article and Find Full Text PDFNeuro Endocrinol Lett
September 2025
Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, China.
Background: Pheochromocytomas and paragangliomas (PPGLs) are rare catecholamine-secreting neuroendocrine tumors originating from the embryonic neural crest. Approximately 30% of PPGLs are hereditary and are frequently associated with genetic syndromes, including neurofibromatosis type 1 (NF1). Composite PPGLs, which include components of both PPGLs and related tumors such as ganglioneuromas, are extremely rare in NF1 patients.
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