Model Prediction of Infection Risk After Glucocorticoid Treatment for Severe Drug-Induced Liver Injury: Globulin is a Core Predictive Factor.

Purpose: Glucocorticoids are frequently administered in cases of severe drug-induced liver injury (DILI) to promote patient recovery and shorten hospitalization duration. However, their use is associated with an increased risk of infection. This study developed a predictive model for infection after glucocorticoid therapy in patients with DILI.

Impact Factors for Trajectories of Medication and Healthy Lifestyle Adherence in Young Adults With Hypertension: A Mixed Methods Study.

Treatment adherence is a cornerstone of effective hypertension management. However, the dynamic patterns of adherence and their influencing factors among young Chinese adults with hypertension remain insufficiently understood. This study aimed to explore the trajectories of medication adherence and healthy lifestyle behaviors, as well as the associated influencing factors, in this population.

Five/six carbon monosaccharides-glycated coconut protein-stabilized emulsions: Impact on stability and digestion.

This study examined the impact of different monosaccharide-glycated coconut protein isolates (CPI) as emulsion stabilizers on the stability, rheological, and digestion properties of CPI-based emulsions. The results showed that the interfacial tension (13.6-27.

Regulating Reversible Zn Deposition via a 2D Metal-Organic Framework-Laden Hydrogel Electrolyte.

The practical deployment of aqueous Zn-ion batteries (AZIBs) is impeded by dendritic growth and parasitic side reactions of Zn anodes, which severely compromise reversibility and cycle stability. Herein, a hydrogel electrolyte (HE) is reported integrated with a 2D porphyrin-based metal-organic framework (MOF) as a multifunctional filler to address these issues. The incorporation of the 2D MOF not only reinforces the mechanical integrity and enhances the ionic conductivity (14.

A gallic acid coordination self-assembled multifunctional interphase enabling highly reversible Zn anodes.

Zinc metal batteries have emerged as compelling contenders for next-generation energy storage systems, yet their practical viability remains severely hampered by intrinsic challenges associated with Zn metal anodes, such as uncontrolled dendritic growth, vigorous hydrogen evolution, and sluggish interfacial kinetics. Addressing these issues, we rationally engineer a coordination self-assembled multifunctional interphase (GSI) derived from gallic acid, which spontaneously constructs on the Zn surface via strong coordination interactions. The GSI interphase, enriched with densely packed phenolic hydroxyl and carboxyl moieties, acts as a multifunctional regulator: it offers abundant zincophilic sites to guide homogeneous Zn flux and significantly lowers the nucleation energy barrier, thereby enabling smooth and reversible Zn plating/stripping.

From malaria fighter to diabetes guardian: the emerging role of artesunate in treating diabetes and diabetic complications.

Diabetes mellitus (DM) is a metabolic disease influenced by both genetic and environmental factors. The global incidence of DM is rising, and its multiple complications seriously affect patients' quality of life and create a huge economic burden. At present, the prevention and treatment of DM mainly rely on oral or subcutaneous drugs, although oral drugs are more acceptable, they may produce more side effects and have limited effect on the treatment of diabetic complications.

Rational design of an Ag@MOF functional separator for controlled lithium deposition and enhanced interfacial stability in lithium metal batteries.

The increasing demand for high-energy-density batteries has driven intensive research into lithium metal batteries (LMBs) as promising alternatives to conventional lithium-ion batteries. Despite their ultrahigh theoretical capacity, lithium metal anodes (LMAs) suffer from uncontrolled dendrite growth, leading to safety hazards and irreversible capacity loss. Herein, we develop a functional separator based on a composite of Ag nanoparticles (NPs) and metal-organic frameworks (MOFs) to enhance LMA stability.

Cerium partial fluoridation efficiently promotes Pd nanoparticle catalysis of formic acid oxidation.

Partial fluoridation of cerium provides more oxygen vacancies and surface-adsorbed active OH species, effectively promoting Pd nanoparticle for the formic acid electrooxidation reaction. As a result, Pd-CeF/CeO showed high activity for formic acid oxidation due to the strong interaction arising from its Pd-O-Ce linkage and its high anti-poisoning ability.

Nomogram for predicting survival after transjugular intrahepatic portosystemic shunt in portal hypertension patients with bleeding.

Background: Portal hypertension (PHT) is a life-threatening complication of cirrhosis, often resulting in gastrointestinal bleeding that requires transjugular intrahepatic portosystemic shunt (TIPS). While TIPS effectively reduces portal pressure, predicting long-term survival remains challenging due to the multifactorial nature of patient outcomes. Accurate survival prediction tools are lacking, and existing models often omit critical factors such as portal vein diameter.

Effect of portal pressure gradient reduction on outcomes after transjugular intrahepatic portosystemic shunt in portal hypertension patients.

Background: Portal hypertension (PHT), a complication of liver cirrhosis, is sometimes managed with transjugular intrahepatic portosystemic shunt (TIPS) to reduce portal pressure. Although effective, TIPS poses risks, including hepatic encephalopathy (HE). This study investigates whether a significant reduction in the portal pressure gradient (PPG) after TIPS improves outcomes in PHT patients.

Effect of chronic intermittent hypoxia on hippocampal lipid metabolism in mice: A targeted lipidomics study.

Evidence suggests that cognitive impairments due to obstructive sleep apnea (OSA) are related to abnormal lipid metabolism. Abnormal lipid metabolism in the brain might be a potential cause of neurodegeneration. Nonetheless, there is limited clarity regarding the comprehensive lipid metabolism changes in the hippocampus induced by chronic intermittent hypoxia (CIH).

In situ engineering of a glutathione-derived hydrophobic layer for durable and dendrite-free Zn anodes.

Aqueous Zn-ion batteries (AZIBs) are gaining increasing attention for large-scale energy storage due to their cost-effectiveness, safety, and high volumetric energy density. However, their practical application is still hindered by challenges such as uncontrolled growth of Zn dendrites and unwanted side reactions. In this study, we introduce an interfacial engineering strategy by applying a glutathione (GSH) functional layer on the surface of the Zn anode (GSH@Zn).

Pickering emulsions stabilized by soybean protein-based nanoparticles: A review of formulation, characterization, and food-grade applications.

Pickering emulsions (PEs) have attracted considerable interest as platforms for encapsulating and controlling the release of bioactive compounds. Recent studies emphasize the potential of soybean protein nanoparticles to improve PE-based carriers, enhancing the stability and bioavailability of these compounds through unique self-assembly behaviors. This review analyzes recent advancements in the use of soybean protein nanoparticle-stabilized PEs as carriers for bioactive compounds.

Association between the triglyceride-glucose index and silent myocardial infarction in the general population.

This study aimed to explore the relationship between the triglyceride-glucose (TyG) index and silent myocardial infarction (SMI) in the general population, with a focus on elucidating potential links and contributing to the understanding of risk factors for undetected cardiac events. This prospective cohort study was carried out within a community-based population, using data from the Atherosclerosis Risk in Communities study in the United States. The dataset included information on demographics, cardiovascular risk factors, blood lipids, liver and kidney function, and other variables.

The association of chronic pain, painkiller use, and potential mediators with liver fat content.

Excessive accumulation of liver fat content (LFC) is a pathological manifestation of steatotic liver diseases. This study aims to investigate the relationship between chronic pain and LFC development. In the UK Biobank, chronic pain sites were collected via questionnaire, while LFC was measured by magnetic resonance imaging and quantified by Proton Density Fat Fraction (PDFF).

A Gradient Solid-like Electrolyte Stabilizing Zn Anodes by In Situ Formation of a ZnSe Interphase.

Rechargeable aqueous Zn-ion batteries are renowned for their safety, cost-effectiveness, environmental friendliness, and high capacity. However, critical issues, such as restricted electrode kinetics and uncontrolled dendrite growth of Zn anodes, have hindered their practical applications. Here, we propose a gradient solid-like electrolyte (GSLE) to enhance the overall performance of Zn anodes and Zn-ion batteries.

The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications.

Diabetic cardiomyopathy (DbCM), a significant chronic complication of diabetes, manifests as myocardial hypertrophy, fibrosis, and other pathological alterations that substantially impact cardiac function and elevate the risk of cardiovascular diseases and patient mortality. Myocardial energy metabolism disturbances in DbCM, encompassing glucose, fatty acid, ketone body and lactate metabolism, are crucial factors that contribute to the progression of DbCM. In recent years, novel protein post-translational modifications (PTMs) such as lactylation, β-hydroxybutyrylation, and succinylation have been demonstrated to be intimately associated with the myocardial energy metabolism process, and in conjunction with acetylation, they participate in the regulation of protein activity and gene expression activity in cardiomyocytes.

Prognostic Implications of Cardiac Geometry in Cirrhosis: Findings From a Large Cohort.

Background And Aims: Cirrhosis is characterised by hyperdynamic circulation, which contributes to cirrhotic cardiomyopathy (CCM). However, the expert consensus on CCM did not initially include cardiac structure because of scant evidence. Therefore, this study investigated the associations of cardiac chamber geometry with mortality and CCM.

Association Between Average Daily Activity Counts and Knee Osteoarthritis Progression.

Objective: The aim of the study was to explore the relationship between daily activity counts and knee osteoarthritis progression.

Design: A cohort study using Osteoarthritis Initiative data included 610 participants aged 45-79 yrs with knee osteoarthritis or at risk. Daily activity counts were measured using ActiGraph GT1M accelerometers.

Structural characteristics, techno-functionalities, innovation applications and future prospects of soybean β-conglycinin/glycinin: a comprehensive review.

The structural molecules and conformational variations of soybean β-conglycinin/glycinin are crucial in defining the characteristics of protein-based foods. Recently, significant attention has been focused on the characteristics of soybean β-conglycinin/glycinin across various fields, particularly their structure and application. The research contributes to expanding the application fields of soybean protein-related component in food industry.

A triflate porous layer stabilizing Zn anodes for high-performance Zn-ion batteries.

We meticulously designed a triflate porous layer on Zn anodes to enhance the overall performance of Zn-ion batteries. During battery operation, it stabilizes the surface pH of Zn anodes and facilitates the formation of a ZnF-containing interphase. Therefore, both the reversibility and reaction kinetics of Zn anodes are effectively promoted.

Stratified analysis of the correlation between wedged hepatic venous pressure and portal venous pressure in patients with portal hypertension.

To evaluate the differences in the agreement between wedged hepatic venous pressure (WHVP) and portal venous pressure (PVP) at different hepatic venous pressure gradient (HVPG) levels to identify specific HVPG thresholds where WHVP can reliably estimate PVP, thus enhancing the accuracy of risk stratification and treatment decision-making for portal hypertension (PHT) patients. A multicenter study of 616 patients with PHT from three centers was stratified into five groups by their HVPG: HVPG < 12 (group A), 12 ≤ HVPG < 16 mmHg (group B), 16 ≤ HVPG < 20 mmHg (group C), 20 ≤ HVPG < 24 mmHg (group D), HVPG ≥ 24 mmHg (group E). Concordance was analyzed using Pearson's correlation coefficient (R), the intraclass correlation coefficient (ICC), and Bland‒Altman analysis in each HVPG stratum.

The Critical Role of Phenylpropanoid Biosynthesis Pathway in Lily Resistance Against Gray Mold.

Gray mold caused by is one of the most determinative factors of lily growth and has become a major threat to lily productivity. However, the nature of the lily interaction remains largely unknown. Here, comparative transcriptomic and metabolomic were used to investigate the defense responses of resistant ('Sorbonne') and susceptible ('Tresor') lily cultivars to infection at 24 hpi.