Optimizing Muscle Quality in Common Carp ( L.): Impacts of Body Size on Nutrient Composition, Texture, and Volatile Profile.

To investigate the effect of body size on muscle quality of common carp ( L.), we systematically tracked the dynamic changes in nutrient content, texture, and volatile organic compounds (VOCs) among small-sized (~100 g), medium-sized (~250 g), and large-sized (~600 g) fish (SYRC, MYRC, and HYRC, respectively) over a 30-week feeding trial. The results indicated that the HYRC showed significantly reduced moisture and lipid content, along with increased protein content, hydroxyproline, hardness, and chewiness compared to the SYRC ( < 0.

Effects of Dietary GABA Levels on Growth, Muscle Quality, and Liver Lipid Profile: Insights from Lipidomics in Juvenile Yellowfin Seabream .

Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, is used as a feed additive in aquaculture. However, its effects on muscle quality and lipid metabolism in fish remain understudied. Therefore, three diets supplemented with 0%, 0.

Comparison of LC-PUFAs Biosynthetic Characteristics in Male and Female Tilapia at Different Ontogenetic Stages.

Tilapia possess the ability to biosynthesize long-chain polyunsaturated fatty acids (LC-PUFA); however, variations in this capacity across different growth stages and between sexes remain poorly understood. This study evaluated the LC-PUFA biosynthetic capacity in male and female tilapia fed two distinct diets-perilla oil (rich in α-linolenic acid, ALA) and peanut oil (rich in linoleic acid, LA)-over 24 weeks, spanning four growth stages (I-IV, from fry to adult). The results revealed that during stages I to III, both diets produced similar final body weights.

Transcriptomic Analysis Reveals Regulatory Responses of Fatty Acid Positional Distribution in Triacylglycerols and Lipid Composition to Dietary n-3 HUFA in the Muscle of .

The nutritional value of lipids depends not only on their fatty acid composition but also on their stereospecific positioning on the glycerol backbone. This study investigated the fatty acid composition and -2 positional distribution of triacylglycerols (TAG), as well as the composition of major phospholipids in golden pompano () juveniles (initial weight: 10 g) fed five diets including graded levels of dietary n-3 highly unsaturated fatty acids (HUFA; 0.64-2.

Effects of dietary long-chain polyunsaturated fatty acids on osmoregulation and salinity adaptation in red tilapia (Oreochromis mossambicus♀ × O. niloticus♂) under salinity stress.

The roles of long-chain polyunsaturated fatty acids (LC-PUFA) in osmoregulation and salinity adaptation in teleost fish were investigated in red tilapia (Oreochromis mossambicus♀ × O. niloticus♂). Groups of juvenile fish were reared initially in freshwater (FW, 0 ppt) or seawater (SW, 32 ppt) and fed diets containing either LC-PUFA-rich fish oil (FO) or rapeseed oil (VO) that lacks LC-PUFA, but is rich in C18 PUFA.

Diagnostic performance of choroid plexus and cerebrospinal fluid space volumes in idiopathic normal pressure hydrocephalus.

Background: Choroid plexus (CP) enlargement is found in Alzheimer's disease (AD), multiple sclerosis, and Parkinson's disease. As a source of cerebrospinal fluid (CSF), the diagnostic value of CP enlargement in idiopathic normal pressure hydrocephalus (iNPH) is unknown.

Purpose: This study aimed to evaluate the diagnostic performance of CP and CSF space volumes in iNPH.

Internalized polystyrene nanoplastics trigger testicular damage and promote ferroptosis via CISD1 downregulation in mouse spermatocyte.

Background: There is a growing body of research regarding the potential reproductive toxicity of microplastics and nanoplastics. However, the underlying mechanisms by which nanoplastics exposure adversely affects the testes remain poorly understood. Our study aims to clarify the relationship between ferritinophagy and mitochondrial dysfunction based on polystyrene nanoplastics (PS-NPs)-caused testicular damage in mice.

Preliminary study on ameliorative effects of P-Hydroxycinnamic acid on high-fat diet-induced injury in zebrafish.

P-Hydroxycinnamic acid (PCA), a natural phenolic compound, exhibits multifaceted biological activities, including antioxidant and metabolic regulatory properties in mammals, whereas its role in fish is rarely reported. To investigate whether PCA can alleviate the negative effects caused by high-fat diets on fish liver health and disease resistance, here we used zebrafish as experimental animals. In this study, six zebrafish diets, including basal diet, high-fat diet (HFD), and HFD supplemented with PCA at 500, 1000, 1500, or 2500 mg/kg and assigned as CK, HFD, PCA0.

In vitro gastrin-releasing peptide response in chicken ovarian follicles.

The gastrin-releasing peptide (GRP) is reported to be mainly produced by the pituitary in chickens, with its receptor (GRPR) highly expressed in the ovaries, indicating its regulatory role in ovarian function. Present study aims to verify the role of GRP and GRPR in regulating the growth of ovarian follicles in chickens in vitro. GRPR was found to be highly expressed in granulosa cells of early follicles (1-6 mm), but shows barely detectable expression in theca cells.

Inhibition of histone deacetylase 6 activity mitigates neurological impairment and post-hemorrhagic hydrocephalus after intraventricular hemorrhage by modulating pyroptosis and autophagy pathways.

Background: Posthemorrhagic hydrocephalus (PHH) is a frequent and significant complication that impacts the prognosis of patients suffering from intraventricular hemorrhage (IVH). However, the underlying mechanism is uncertain. Neuronal pyroptosis is characterized by neuronal lysis and destruction, along with the release of inflammatory factors.

Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus.

JOURNAL/nrgr/04.03/01300535-202602000-00045/figure1/v/2025-05-05T160104Z/r/image-tiff Neural stem cells (NSCs) have the potential for self-renewal and multidirectional differentiation, and their transplantation has achieved good efficacy in a variety of diseases. However, only 1%-10% of transplanted NSCs survive in the ischemic and hypoxic microenvironment of posthemorrhagic hydrocephalus.

ZnO NPs protect boar sperm in liquid storage through increasing the phosphorylation of PKAs.

It remains a problem to efficiently improve the boar sperm quality of liquid storage due to reactive oxygen species (ROS) accumulation. To reduce the effects of ROS on boar sperm, in this study, 1 μg/mL zinc oxide nanoparticles (ZnO NPs) was added into the extender of boar semen during liquid storage at 4°C and 17°C for 7 days. The finding revealed that sperm motility, viability, plasma membrane integrity (PMI) and acrosome integrity significantly increased when compared with the control group ( ˂ 0.

Clinical value of inflammatory indices in predicting poor prognosis and post-hemorrhagic hydrocephalus in patients with intraventricular hemorrhage.

Background: Hemorrhagic stroke has a high mortality and disability rate. Among them, intraventricular hemorrhage (IVH) is an important factor leading to adverse outcomes. IVH can induce acute obstructive hydrocephalus and chronic communicating hydrocephalus.

The Role of Choroid Plexus in Hydrocephalus from the Perspective of Structure and Function: a Therapeutic Target.

Hydrocephalus is one of the most common neurological diseases, characterized by abnormal excessive accumulation of cerebrospinal fluid (CSF) in the ventricular system. Its pathophysiological mechanism is believed to be related to the imbalance of CSF circulation and homeostasis. As the main source of CSF secretion, the choroid plexus is closely related to hydrocephalus.

Rapeseed and Palm Oils Can Improve the Growth, Muscle Texture, Fatty Acids and Volatiles of Marine Teleost Golden Pompano Fed Low Fish Oil Diets.

This study evaluated the effects of different lipid sources-fish oil (FO), soybean oil, rapeseed oil, and palm oil-on the growth and muscle quality of golden pompano () cultured in offshore cages for 10 weeks. Three diets (D1-D3) were formulated: D1 used only fish oil, D2 blended fish, rapeseed oil, and palm oil, and D3 combined fish and soybean oils. Fish in the D1 group showed the highest weight gain, specific growth rate, and muscle protein content, significantly outperforming D3.

Exploring the relationship between air pollution, non-alcoholic fatty liver disease, and liver function indicators: a two-sample Mendelian randomization analysis study.

Background And Aims: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder worldwide, with an increasing incidence in recent years. While previous studies have suggested an association between the air pollutant PM2.5 and NAFLD, there is still considerable debate regarding the existence of a clear causal relationship between air pollution and NAFLD.

Efficiently Substituting Dietary Fish Meal with Terrestrial Compound Protein Enhances Growth, Health, and Protein Synthesis in Largemouth Bass.

Inappropriate substitution of dietary fishmeal (FM) can adversely affect the growth, health, and metabolism of carnivorous fish species. To effectively reduce the amount of dietary FM in carnivorous largemouth bass (), a terrestrial compound protein (Cpro) with chicken meal, bone meal, and black soldier fly protein was used to formulate four isoproteic (52%) and isolipidic (12%) diets, namely T1 (36% FM), T2 (30% FM), T3 (24% FM), and T4 (18% FM), for feeding juveniles (initial weight: ~12 g) for 81 days. Results indicated that the growth performance, feed efficiency, and morphological indicators, as well as muscle texture and edible quality of fish, did not differ significantly among the four groups.

The Improvement Effects of a Nutritional Fortifier on the Reproductive Performance, Sex Steroid Hormone Production, and Health of the Striped Bamboo Shark .

To explore a method of improving the reproductive performance of the striped bamboo shark, three groups (D0, D1, and D2) of mature individuals were fed squid with (D1 and D2) or without (D0) a nutritional fortifier during the breeding seasons of 2022 and 2023. Compared with the D0 group, the D1 and D2 groups had an increase of 20.90% and 31.

ZnO NPs induce miR-342-5p mediated ferroptosis of spermatocytes through the NF-κB pathway in mice.

Background: Zinc oxide nanoparticle (ZnO NP) is one of the metal nanomaterials with extensive use in many fields such as feed additive and textile, which is an emerging threat to human health due to widely distributed in the environment. Thus, there is an urgent need to understand the toxic effects associated with ZnO NPs. Although previous studies have found accumulation of ZnO NPs in testis, the molecular mechanism of ZnO NPs dominated a decline in male fertility have not been elucidated.

Evaluation of imaging indicators in differentiating idiopathic normal pressure hydrocephalus from Alzheimer's disease.

Background: There are currently many imaging indicators for idiopathic normal pressure hydrocephalus (iNPH). However, their diagnostic performance has not been well compared, especially in differentiating iNPH from Alzheimer's disease (AD). This study aimed to evaluate the diagnostic performance of these imaging indicators in differentiating iNPH from AD.

Shenling Baizhu powder alleviates non-alcoholic fatty liver disease by modulating autophagy and energy metabolism in high-fat diet-induced rats.

Background: Non-alcoholic fatty liver disease (NAFLD) has emerged as a burgeoning health problem worldwide, but no specific drug has been approved for its treatment. Shenling Baizhu powder (SL) is extensively used to treat NAFLD in Chinese clinical practice. However, the therapeutic components and pharmacological mechanisms of SL against NAFLD have not been thoroughly investigated.

Molecular characterization of vascular endothelial growth factor b from spotted sea bass (Lateolabrax maculatus) and its potential roles in decreasing lipid deposition.

Vascular endothelial growth factor B (VEGFB), a member of the VEGF family, exhibits limited angiogenic activity in mammals but plays an unexpected role in targeting lipids to peripheral tissues. However, its role in lipid metabolism in fish is unknown. In this study, the vegfb gene was cloned and characterized from spotted sea bass (Lateolabrax maculatus).