Advances in the prevention and management of postoperative bleeding complications in pancreaticoduodenectomy: Current strategies and future directions precise.

Postoperative bleeding (POB) is a major complication following pancreaticoduodenectomy (PD), leading to significant morbidity and potential mortality. This minireview focuses on the prevention and management strategies for POB, synthesizing current evidence on surgical techniques, perioperative management, and postoperative interventions. Effective prevention strategies include the use of regional vessel wrapping, optimal pancreatic anastomosis, and meticulous intraoperative hemostasis.

Monitoring the effect of alcohol intake via facial temperature variations using thermography synchronized with heartbeat.

Accurate assessment of alcohol-induced physiological effects is critical for preventing overconsumption and ensuring safe activities such as driving. While breath alcohol concentration (BrAC) measurement is widely used due to its simplicity, it can be confounded by mouth alcohol effects and provides only momentary data. Building on our previously developed Synchro-thermography technique, which synchronizes infrared thermal imaging with heart rate variability to detect vascular-related skin temperature fluctuations, we applied it to monitor physiological changes induced by alcohol.

Association between indoor musty odors and cognitive impairment among older adults.

Indoor pollution has been a growing concern, especially about its potential effects on human health. Musty odors are a good indicator of indoor mold contamination and have been shown to be associated with numerous diseases, but their association with cognitive function in older adults is unclear. The study's data came from the Chinese Longitudinal Healthy Longevity Survey.

Lead-Free Halide Perovskite CsZrX Doped with Cr for Multifunctional X-ray and NIR Imaging.

Traditional X-ray imaging based on scintillators primarily provides structural insights but falls short of the capacity to resolve intricate biological features. In this work, we propose a multifunctional imaging strategy enabled by CsZrX:Cr halide perovskite that uniquely exhibits both efficient near-infrared (NIR) photoluminescence under UV excitation and intense radioluminescence under X-ray irradiation. The material presents a high light yield of 56,250 photons MeV and a NIR photoluminescence quantum yield (PLQY) of 62.

Networks of HIV Service Organisations: Changes Over Time and Implications for HIV Elimination.

Comprehensive Human Immunodeficiency Virus (HIV) services are seldom found within a single organisation. This motivates organisations to form partnerships to achieve optimal outcomes. However, the complexity of inter-organisational relationships can hinder the process of achieving an effective and coordinated response to the HIV epidemic.

Associations Between Alcohol Delivery Policy and Pandemic Alcohol Use Among Sexual and Gender Minority Youth and Young Adults.

Introduction: In an effort to promote social distancing as a response to the COVID-19 pandemic, many jurisdictions altered policies surrounding alcohol delivery, newly allowing both on-premises (i.e., from restaurants) and off-premises (i.

High-order dynamics in an ultra-adaptive neuromorphic vision device.

Neuromorphic hardware for artificial general vision intelligence holds the potential to match and surpass biological visual systems by processing complex visual dynamics with high adaptability and efficiency. However, current implementations rely on multiple complementary metal-oxide-semiconductor or neuromorphic elements, leading to significant area and power inefficiencies and system complexity. This is owing to a key challenge that no single electronic device, to our knowledge, has yet been demonstrated that can integrate retina-like and cortex-like spiking and graded neuronal dynamics operable across both optical and electrical domains.

Lysine β-hydroxybutyrylation in metabolic plasticity and disease pathogenesis.

Lysine β-hydroxybutyrylation (Kbhb) represents a novel post-translational modification (PTM) mediated by ketone body metabolites, particularly β-hydroxybutyric acid (BHB). This modification exhibits dynamic elevation under ketogenic conditions including diabetic ketoacidosis, neonatal metabolic disorders, fasting, and sustained physical exertion, where circulating BHB concentrations exceed physiological thresholds. Emerging evidence positions Kbhb as a critical epigenetic-metabolic interface, with demonstrated regulatory roles spanning oncology, immunomodulation, cardiovascular homeostasis, neuropsychiatric disorders, circadian biology, and developmental processes.

A Longitudinal Study Reveals Metabolomic Markers for Individuals at Risk, Disease Severity, and Treatment Response in Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is a systemic inflammatory joint disease characterized by heterogeneous clinical manifestations, which requires deeper exploration in identifying reliable biomarkers for early diagnosis, monitoring, and treatment assessment. The aim is to discover plasma metabolomic markers to predict RA onset, assess disease activity, and forecast treatment efficacy. The study includes 209 established RA patients who are disease-modifying antirheumatic drugs-free for six months prior to enrollment, with 197 of them followed for 3-6 months to assess treatment response.

Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma.

Background: Randomised controlled studies evaluating vitamin D supplementation in pregnancy or early childhood for preventing childhood asthma have yielded inconclusive results. Previous systematic reviews of vitamin D for asthma prevention focused on studies comparing vitamin D to placebo or studies intervening in pregnancy, limiting the body of evidence.

Objectives: Primary: to evaluate the efficacy of any vitamin D supplementation and high-dose vitamin D supplementation in early life, including the prenatal period, for preventing asthma in children.

Highly efficient amino-functionalized ionic liquid membrane contactor coupled system for low-concentration carbon dioxide absorption and desorption.

Carbon dioxide (CO) capture and storage (CCS) technology is crucial for rapid decarbonization within the fossil energy system, yet capturing low-concentration CO poses technical challenges due to high energy demands and limited durability. To address these obstacles, we developed four amino-functionalized ionic liquids (AFILs) targeting low CO concentrations (7 %, 11 % and 15 % by volume in the gas mixture, respectively). This study evaluated these AFILs in combination with a polytetrafluoroethylene (PTFE) hollow fiber membrane contactor for CO absorption.

The role of tumor necrosis factor receptor superfamily in cancer: insights into oncogenesis, progression, and therapeutic strategies.

The TNF receptor superfamily (TNFRSF) with extracellular cysteine-rich domains, transmembrane segments, and intracellular signaling motifs, plays crucial roles in cell death, inflammation, growth, and development. These cysteine-rich domains, which are located in the external portion of the TNFRSF, can contain varying numbers of domains, from as few as 1 (as seen in BCMA) to more than 3 (as observed in CD30, DR3), and function as the primary interaction sites for their corresponding ligands from TNFSF. In cancer research, TNFRSF members show abnormal expression across various cancer types, making them potential therapeutic targets.

New species of (Nematoda: Pharyngodonidae) parasite of (Lacertilia: Agamidae) from Turpan-Hami Basin, China.

A new nematode species, sp. nov. (Nematoda: Pharyngodonidae), is described from the cecum of (Agamidae) in China's Turpan-Hami Basin, marking the first documentation of intestinal helminths in this host.

Burst Nucleation in Area-Selective Atomic Layer Deposition.

Nucleation behavior governs the selectivity of area-selective atomic layer deposition (AS-ALD). Ideally, nontargeted regions should exhibit delayed nucleation or sparse nucleation that can be easily removed by post-treatment. Here, we report a burst nucleation phenomenon during AS-ALD on perfluoroalkyl self-assembled monolayer (SAM)-treated surfaces.

Water Management and Green Transition in China's Textile Industry: A Policy-Driven Comparative Analysis.

As one of the world's largest water-intensive industries, the textile industry may cause water shortages and environmental pollution, making the improvement of water use efficiency and sewage treatment imperative. Government-led environmental regulations, a key exogenous force, have catalyzed the industry's green transition. Therefore, exploring their impact and role on water extraction and discharge throughout the textile and apparel supply chain is of great significance for promoting the sustainable development of the textile industry.

A miR156-SPL module controls shade-induced inhibition of vascular cambium activity through cytokinin pathway in poplar.

In natural forests and plantations, trees often encounter neighbor proximity that hinders wood production. However, the mechanisms by which shade regulates cambial activity during secondary growth remain elusive. Here, we show that high stand density and simulated shade (low R/FR ratios) inhibit cambial division and differentiation in Populus trees.

Detection of IgG antibody against the porcine norovirus GII.11 in human, domestic and wild animals.

Zoonotic diseases pose a critical threat to global public health, with noroviruses (NoVs) increasingly recognized for their potential to cross species barriers. Traditionally, NoVs were considered host-specific; however, recent evidence suggests the possibility of interspecies transmission. This study investigates the zoonotic potential of porcine NoV (PorNoV) genotype GII.

Psychiatric disorders: teasing apart genetic similarities and differences.

Given the high comorbidity between psychiatric disorders, previous studies have focused on genetic factors shared across the disorders. In a recent preprint, Grotzinger et al. comprehensively investigated shared and disorder-specific genetic factors across 14 neuropsychiatric disorders.

Synergistic plant-fungal interactions under Phragmites australis - mangrove mixed growth regimes boost particulate organic carbon sequestration in estuarine wetlands.

Estuarine wetlands, as globally critical carbon sink systems, rely heavily on the dynamics of soil particulate organic carbon (POC) to regulate carbon cycling. However, the mechanisms underlying how plant-fungal synergies under mixed plant communities drive POC accumulation remain unclear. This study focuses on the Min River Estuary wetlands, comparing the effects of mangrove wetland, Phragmites australis wetland, and mixed P.

Association between residential proximity to major roadways and nonfatal cardiovascular disease in Chinese older adults: a nationwide study.

The established association between residential proximity to major roadways and some negative health outcomes has been unequivocally substantiated. However, there is limited evidence regarding the association between residential proximity to major roadways and nonfatal cardiovascular disease (CVD). The research utilized an array of data sourced from the 2018 Chinese longitudinal healthy longevity survey.

Rest intolerance and associated factors among Chinese nursing students: a cross-sectional network analysis.

Background: In today's fast paced society, the phenomenon of rest intolerance has emerged as a prevalent psychological concern, which has been shown to pose potential risks to the mental and physical health of many people. However, rest intolerance remains underexplored, particularly among nursing students who face high academic pressure.

Objective: This study aims to investigate rest intolerance and its associated factors among nursing students using the social ecological model, and to identify central indicators for intervention targets that alleviate this issue through network analysis.

Factors associated with nursing students' support for the implementation of environmental measures in healthcare services to reduce carbon footprint: a multisite cross-sectional correlation study.

Background: Reducing the carbon footprint in healthcare services is essential for combating climate change and promoting sustainable health systems. Nursing students play a key role in supporting environmentally friendly practices. This study aimed to assess the level of support among Chinese nursing students and to explore the factors associated with their support.

Crotonylation driving Streptococcus pneumoniae adaption and virulence.

Introduction: To cope with the host's stressful environment and immune clearance, some drug-resistant bacteria have reduced their virulence. Protein post-translational modifications (PTMs) are known to regulate numerous critical biological processes; however, their specific role in modulating bacterial virulence remains poorly understood.

Objective: This study seeks to elucidate the mechanistic role of lysine crotonylation (Kcr) in modulating Streptococcus pneumoniae virulence and adaptive survival.

Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation.

Disulfidptosis, an emerging regulated cell death modality characterized by pathological disulfide bond aggregation and subsequent actin cytoskeletal disintegration, presents promising therapeutic potential for apoptosis- and ferroptosis-resistant malignancies. However, the molecular initiators of disulfidptosis and their connection with mitochondrial dysregulation remain elusive. Herein, we identified alexidine dihydrochloride (AD) as a selective disulfidptosis enhancer in hepatocellular carcinoma (HCC), and the comprehensive multi-omics analysis and other functional validation indicated that ATF4-DDIT3 signaling could be significantly activated by AD.