Targeted degradation of hexokinase 2 by a novel engineered bispecific chimeric liposome-based Nano-PROTACs for enhancing tumor chemotherapy.

Aerobic glycolysis is critical for tumor development and metastasis. Regulating the activity of vital metabolic enzymes in the tumor glycolysis process, such as hexokinase 2 (HK-2), is expected for tumor treatment. However, conventional small molecule inhibitors only block the activity of proteases with consistently high doses via occupation-driven pattern, leading to off-target effects which limit their clinical application.

Interfacial Li Diffusion Booster Accelerated by Enhanced Metal-Organic Framework Sieving and Wettability for High-Voltage Solid-State Lithium Metal Batteries.

Solid-state lithium metal batteries (SSLMBs) are promising for realizing higher energy density. However, the poor interfacial Li transport kinetics and Li dendrite growth inhibit SSLMBs, leading to sluggish interfacial ion diffusion and depressive lifespan, which is attributed to high barriers blocked by anions or interface space in solid-state electrolytes. Herein, a flexible solid-state polymer skeleton employed with ionic liquid and metal-organic frameworks (PIM) electrolyte is proposed to strengthen interfacial Li ion exchange by improving the Li sieving effect and interfacial wettability.

Predictive Value of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve for Survival in Patients with Esophageal Cancer Following Esophagectomy.

Objective: This study aimed to assess the predictive value of CT-FFR on survival in patients with esophageal carcinoma (EC) after esophagectomy.

Methods: Five hundred and eighty patients with EC who had coronary computed tomography angiography (CCTA) and esophagectomy from January 2012 to September 2023 were included in this study. The lesion-specific fractional flow reserve (FFR) was derived from CCTA.

Barriers to early rehabilitation and support needs among elderly hip fracture patients with kinesiophobia: a qualitative study.

Purpose: To explore the early rehabilitation experiences of elderly patients with postoperative kinesiophobia following hip fractures.

Methods: This qualitative inquiry adopted a phenomenological approach. 15 elderly patients with postoperative kinesiophobia were recruited 2-7 days after surgery to repair a hip fracture.

Reducing the oil absorption and improving the quality of fried potato chips by ultrasound combined with acid soaking.

Background: The present study aimed to delve into a method combining ultrasonic technology with acetic acid (AA) soaking, as well as explore the possible mechanisms influencing the oil absorption performance and quality of potato chips based on microstructural characteristics.

Results: The results indicated that the method combining ultrasonic technology with AA pretreatment can enhance the rigidity of potato cells and promote the gelation of pectin with the cells according to the microstructure analysis, effectively blocking the oil penetration. Furthermore, when potato chips were pretreated by ultrasound at a power of 400 W combined with 1.

Dapagliflozin ameliorates high glucose-induced epithelial-mesenchymal transition via up-regulating ACE2 mediated by EZH2 in diabetic nephropathy.

Purpose: To investigate the protective function and underlying mechanism of dapagliflozin on tubulointerstitial fibrosis (TIF) in diabetic nephropathy (DN).

Methods: In this study, we constructed the high-fat and high-glucose diet combined with streptozocin (STZ)-induced DN rat model and 0.2 mg/kg/d of dapagliflozin pretreatment model.

Climate change influences on algal bloom intensity in lakes in the Yangtze River Basin, China from 1985 to 2022.

This study investigates the long-term influence of climate change on the spatiotemporal dynamics of harmful algal blooms in lakes larger than 10 km² across the Yangtze River Basin from 1985 to 2022. Using Landsat satellite imagery, we quantified bloom activity using three indices: annual average bloom area, maximum annual bloom area, and annual bloom frequency percentage, and assessed their relationships with climate drivers using a boosted regression tree model. Among the 90 lakes analysed, 40.

Protein acylations in cancer immunity: effects and therapeutic opportunities.

Acylations are conserved and dynamic modifications that control various biological processes, including gene transcription and protein biology, and have been tied to diseases, such as cancers. Due to their reversible characteristic, acylations exhibit great therapeutic potential through targeting of their regulatory enzymes and proteins. Recent studies have improved our understanding of the close interplay between acylations and the tumor immune microenvironment (TIME), showing the potential to improve antitumor immune responses via acylation manipulation.

Complete Mitochondrial Genome of (Odonata: Anisoptera: Chlorogomphidae) and Phylogenetic Analyses.

This study aimed to elucidate the mitochondrial genome organization of and the phylogenetic relationships of Chlorogomphidae. We used the Illumina MiSeq sequencing platform to sequence the mitochondrial genome of , which was subsequently assembled, annotated, and analyzed. Bayesian inference, maximum likelihood, and maximum parsimony methods were employed to construct the mitochondrial phylogenetic tree of 25 species of Chlorogomphidae based on and genes.

Non-steroidal mineralocorticoid receptor antagonist finerenone inhibits peritoneal fibrosis induced by high-glucose dialysate via regulating enhancer of zeste homolog 2 (EZH2) expression.

Finerenone, a novel high-selective aldosterone receptor antagonist, exhibits powerful anti-inflammatory and antifibrotic effects in previous researches. The aim of our study was to investigate of it on peritoneal fibrosis. In our current research, we found that high glucose could induce epithelial mesothelial transformation (EMT) of peritoneal mesothelial cells (HPMCs).

Experiences and Perceptions of Chinese Elderly Dry Eye Patients Seeking Health Behavior Management: A Qualitative Study Based on a Health Belief Model.

Aim: This study aims to explore the life experiences and health behavior management experiences of elderly patients with dry eye disease, and to provide a reference for improving the health status of patients with dry eye disease.

Methods: A qualitative phenomenological design was employed to collect data from 16 dry eye patients who visited the eye clinic of a tertiary hospital in Shanghai, China, from October to December 2024, by conducting face-to-face semi-structured interviews, and analyzing the data using the Colaizzi 7-step analysis method. Interviews were transcribed verbatim, and themes were coded and extracted using NVivo 14.

Continuous-Flow Microreactor System for Enhanced Selectivity and Safety in Nitrobenzene Nitration.

Dinitrobenzene, a crucial intermediate in pesticide and dye production, is typically synthesized through the exothermic nitration of nitrobenzene. This study presents a continuous-flow microreactor system integrated with micromixers to enhance selectivity and safety in the nitration process. An open-source Python program was developed to precisely control the mass flow rate ratio of nitrobenzene to the mixed acid.

Medicaid Enrollment After Hospital Presumptive Eligibility in the Emergency Department.

Importance: Hospital presumptive eligibility (HPE) is an emergency Medicaid program enabling eligible uninsured patients to temporarily access Medicaid benefits during hospital encounters. It provides a pathway to long-term Medicaid coverage, but this feature may be underutilized among patients who received HPE in the emergency department (ED) and were discharged immediately thereafter.

Objective: To characterize if 6-month Medicaid enrollment rates varied by patient demographics and ED encounter characteristics and identify factors that potentially impact enrollment.

The Predictive Value of Preoperative Coronary Artery Calcium Score for Long-term Survival in Elderly Patients with Lung Cancer After Surgery.

Background: A large proportion of elderly lung cancer patients have coronary atherosclerosis. However, it remains unclear which coronary artery indicators provide optimal prognostic value for elderly patients with lung cancer after surgery.

Methods: This study retrospectively analyzed the clinical data of elderly patients with lung cancer who underwent surgery between September 2013 and September 2021.

Comprehensive insights into oil absorption in fried foods: The role of surface characteristics.

The mechanisms of oil absorption in fried foods remain unclear due to the complex interactions between food surface properties, oil characteristics, and frying conditions. This review systematically examines oil absorption behavior by analyzing food surface characteristics, oil properties, and their interactions. Key factors influencing oil uptake, including food pretreatment, material composition, and frying parameters, are critically evaluated.

Ultrasound-guided percutaneous cryoneurolysis of intercostal nerves in traumatic rib fractures.

Background: Multimodal pain control is the cornerstone of managing acute traumatic rib fractures. We employed surgeon-administered, ultrasound-guided percutaneous cryoneurolysis of intercostal nerves (USPCNIN) as an adjunct opioid-sparing analgesic modality at the bedside.

Methods: This was a single-institution case series.

Finerenone Ameliorates High Glucose-Induced Podocytes Epithelial-Mesenchymal Transition Through the Regulation of Krüppel-Like Factor 5 in Diabetic Nephropathy.

Introduction: Diabetic nephropathy (DN) could impair the function of the glomerular filtration barrier by damaging the podocytes. Extant research has demonstrated that aldosterone plays a crucial role in this progression. Finerenone is a novel, high-selective mineralocorticoid receptor antagonist that has been demonstrated to be efficacious in renal protection in DN patients, albeit with an unclear underlying mechanism.

Genome-wide CRISPR screening identifies PHF8 as an effective therapeutic target for KRAS- or BRAF-mutant colorectal cancers.

Background: Mutations in KRAS and BRAF genes are prevalent in colorectal cancer (CRC), which strikingly promote tumorigenesis and lead to poor response to a variety of treatments including immunotherapy by activating the MAPK/ERK pathway. Thus, there is an urgent need to discover effective therapeutic targets and strategies.

Methods: CRISPR-Cas9 lentiviral knockout library was used to screen the suppressors of anti-PD1 immunotherapy.

Development and Evaluation of Non-Antibiotic Growth Promoters for Food Animals.

The widespread utilization of antibiotic growth promoters (AGPs) boosts the growth rate of food animals and enhances human living standards. Nevertheless, it is accompanied by escalating antibiotic resistance. Consequently, there is an urgent demand to develop novel alternatives to growth promoters.

Impact of baicalin and components of Scutellaria baicalensis on renal fibrosis of diabetic kidney disease.

Background: Fibrosis is key in the development and progression of diabetic kidney disease (DKD). Baicalin (BA), wogonin (WGN), and wogonoside (WGS) have renoprotective effects. The mechanism of alleviation of DKD progression, by improving renal fibrosis, is unclear.

Necroptosis in obesity: a complex cell death event.

Obesity is an exceedingly prevalent and frequent health issue in today's society. Fat deposition is accompanied by low-grade inflammation in fat tissue and throughout the body, leading to metabolic disorders that ultimately promote the onset of obesity-related diseases. The development of obesity is accompanied by cell death events such as apoptosis as well as pyroptosis, however, the role of necroptosis in obesity has been widely reported in recent years.

Responses of magnetic properties to heavy metals pollution recorded by sediments of Nanchang City reach of Ganjiang River, East China.

In this paper, sediment samples from the HT and QS profiles of the Ganjiang River are selected to represent the river reach that does not enter and entered the Nanchang City urban area, respectively. Environmental magnetism, granulometry, and heavy metal of these samples were analyzed to assess the relationship between magnetic properties and heavy metal. The results showed that the mean χ value of QS profile is 20.

Promotion of angiogenesis and suppression of inflammatory response in skin wound healing using exosome-loaded collagen sponge.

Effectively promoting skin wound healing remains a significant challenge in the medical field. Although stem cell-derived exosomes show potential in tissue regeneration, their local delivery and sustained release face challenges. To address these issues, we developed a collagen sponge based on type I and recombinant humanized type III collagen.

Loss of AXIN1 regulates response to lenvatinib through a WNT/KDM5B/p15 signalling axis in hepatocellular carcinoma.

Background And Purpose: As a highly heterogeneous cancer, hepatocellular carcinoma (HCC) shows different response rates to the multi-kinase inhibitor lenvatinib. Thus, it is important to explore genetic biomarkers for precision lenvatinib therapy in HCC.

Experimental Approach: The effect and mechanism of AXIN1 mutation on HCC were revealed by cell proliferation assay, long-term clone formation assay, sphere formation assay and small molecule inhibitor library screening.