Epigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency.

The EZH2 histone methyltransferase inhibitors tazemetostat and valemetostat have recently received approval for clinical use in follicular lymphoma and adult T-cell leukemia/lymphoma, respectively. In follicular lymphoma, the expression of AID is responsible for increased mutational signatures and genomic instability. Because EZH2 inhibitors induce epigenetic and transcriptional changes in normal and lymphoma B cells, we studied whether these inhibitors could alter the pattern of AID-mediated chromosomal translocations.

Long non-coding RNA NORAD serves as a promoter of oncogenesis and inhibits ferroptosis via miR-144-3p-mTOR-ferritinophagy axis in cancer.

Non-coding RNA activated by DNA damage (NORAD) has been found to enhance proliferation and metastasis of cancer cells. Ferroptosis is characterized by excess lipid peroxidation and has been confirmed to eliminate cancer cells. However, the specific role of NORAD in cancer and ferroptosis is not clear.

Transcription factor FTD1 mediates brassinosteroid signaling and maintains MONOCULM 1 stability to regulate rice tillering.

Brassinosteroids (BRs) are polyhydroxylated steroid phytohormones that regulate important agronomic traits, including tiller number in rice (Oryza sativa L.), although the underlying molecular mechanisms remain unclear. Here, we isolated the rice mutant fewer tillers and dwarf 1 (ftd1).

Dietary Cottonseed Protein Substituting Fish Meal Induces Hepatic Ferroptosis Through SIRT1-YAP-TRFC Axis in : Implications for Inflammatory Regulation and Liver Health.

Fish meal (FM) is a crucial high-quality protein source in aquafeeds, prized for its excellent palatability, high digestibility, and rich protein content [...

Integrating multi-dimensional data to reveal the mechanisms and molecular targets of baikening granules for treatment of pediatric influenza.

Background: Children are the main group affected by the influenza virus, posing challenges to their health. The high risk of viral variability, drug resistance, and drug development leads to a scarcity of therapeutic drugs. Baikening (BKN) granules are a marketed traditional Chinese medicine used to treat children's lung heat, asthma, whooping cough, etc.

Controlled deintercalation of graphene/organic superlattices with dense atomic-scale steric Schottky heterojunctions for extreme microwave absorption.

Integrating 2D (semi)metals and semiconductors into atomic-scale Schottky heterojunctions offers a promising pathway for achieving robust charge separation, crucial for microwave absorbers, electromagnetic interference shielding materials, electrocatalysts, photocatalysts, etc. However, conventional bottom-up assembly approaches often encounter challenges of severe agglomeration of 2D components and non-basal contacts due to lattice mismatch, resulting in a suboptimal interfacial density and insufficient charge separation. This study introduces a top-down approach involving the thermal deintercalation of graphene/alkylamine superlattices, leading to the in-situ formation of Schottky heterojunctions between the thermally reduced p-type rGO-alkylamine superlattice phase and entirely deintercalated semimetallic rGO phase (rGO denotes reduced graphene oxide), which can be flexibly tuned by the length of the alkylamines.

Manipulating d-orbital of Cu single atom site by coordination engineering for selective oxidation of benzene.

Single-atom catalysts (SACs) enable atomic-level control over active sites, but orbital-level manipulation to steer catalytic behavior remains challenging. Here, we address this issue through d-orbital engineering of Cu SACs, achieving simultaneous control over coordination geometry (Cu-N) and high metal loading (33.2 wt%) for direct benzene-to-phenol oxidation with HO.

A Phase II Clinical Trial of Neoadjuvant Concurrent Chemoradiotherapy for Locally Advanced High-Grade Thymic Tumors.

Introduction: Optimal management of locally advanced thymic tumors remains controversial. We conducted a clinical trial (ChiCTR-TNC-10001204) to investigate the safety and efficacy of neoadjuvant concurrent chemoradiotherapy in patients with locally advanced thymic tumors.

Methods: The trial was conducted at the Shanghai Chest Hospital in patients with potentially unresectable high-grade thymic tumors.

Super-resolution imaging informed scRNA sequencing analysis reveals the critical role of GDF15 in rejuvenating aged hematopoietic stem cells.

Although changes in mitochondrial morphology consistently associated with the aging of hematopoietic stem cells (HSCs), the specific molecular and cellular mechanisms involved are partially unclear. Live-cell super-resolution (SR) microscopy has been used to identify distinct HSC subsets that characterized by mitochondria unique morphologies and spatial distributions. The integration of SR microscopy with single-cell RNA sequencing enabled the classification of approximately 200 HSCs from young and aged mice into 5 discrete clusters.

Decorating tungsten single atoms on MnO nanorods for enhanced selective catalytic reduction of NO with NH.

Manganese dioxide (MnO) shows significant potential for selective catalytic reduction with NH (NH-SCR). However, the selectivity and water vapor tolerance of MnO are generally unsatisfactory. This study tackles these issues by decorating tungsten single atoms (W SAs) onto MnO nanorods.

Clinical Characteristics, Risk Factors and Prognosis of Carbapenem-Resistant Bloodstream Infections in Cancer Patients: An 8-year Retrospective Study in a Tertiary Cancer Hospital.

Purpose: To ascertain clinical characteristics, risk factors and prognosis of bloodstream infection (BSI) caused by carbapenem-resistant (CRPA) among cancer patients with solid tumors (ST) and hematological malignancies (HM).

Methods: A retrospective study (January 2015 to December 2023) was performed on the health records of cancer patients with (PA) BSI at a tertiary cancer hospital in China. Ninety-two CRPA BSI cases were randomly paired with contemporaneous carbapenem-sensitive (CSPA) BSI cases at a ratio of 1:1.

Association between anemia and mortality in patients with rheumatoid arthritis: A retrospective cohort study of the National Health and nutrition examination survey (NHANES) database.

Objectives: This study aimed to investigate the impact of anemia on all-cause and cardiovascular disease (CVD) mortality in patients with rheumatoid arthritis.

Methods: Data on patients with rheumatoid arthritis were extracted from the National Health and Nutrition Examination Survey (NHANES) dataset from 1999 to 2006 and 2017-2018. The associations of total anemia, ferritin, iron deficiency anemia, non‑iron deficiency anemia, and transferrin saturation with all-cause and CVD mortality were evaluated using a weighted multivariable Cox regression model, with hazard ratios (HRs) and 95 % confidence intervals (CIs) calculated.

Green synthetic PPy/MXene-based cotton fabric hydrovolt generators for self-powered wearables.

Harvesting energy from naturally abundant water resources is expected to alleviate the need for the current energy shortage. However, existing studies rarely consider the effect of capacitors on the output of hydropower generation. Here, inspired by capacitors, we prepared a flexible and efficient hydrovoltaic generator by loading polypyrrole (PPy) and TiCTx MXene onto cotton fabrics by a simple green one-step synthesis method with self-assembly.

Ratiometric responses of AIE/ACQ co-guests functionalized ZIF-8 nano-vehicles: Color-oriented ATP detection and intracellular imaging.

In this work, two guests with opposite emission characteristics in aggregated states were rationally selected and delicately incorporated into zeolitic imidazolate framework-8 (ZIF-8) host. The simultaneous presentation aggregation-induced emission (AIE) of 1,1,2,2-Tetra (4-carboxyphenyl) ethylene (HTCPE) and aggregation-caused quenching (ACQ) of 5-carboxytetramethylrhodamine (5-TAMRA) endowed the as-formed HTCPE/5-TAMRA@ZIF-8 with dual responsive properties. Upon stimulation with ATP, the coordination environment of HTCPE/5-TAMRA@ZIF-8 was interrupted, leading to the collapse of ZIF-8 host and the release of guests into their free states.

CtBP2 Regulates Wnt Signal Through EGR1 to Influence the Proliferation and Apoptosis of DLBCL Cells.

Diffuse large B-cell lymphoma (DLBCL) is the most prevalent form of lymphoma. The overexpression of CtBP2 in tissues may contribute to tumor occurrence and progression. The expression of EGR1 in DLBCL is elevated, suggesting its potential role as an oncogene that promotes the proliferation of DLBCL cells.

Spontaneous Nanocrystals/Amorphous MoS Film Induced by Fe Irradiation with Superior Irradiation Tolerance and Tribology Properties.

High-performance radiation-resistant lubricating materials (RRLMs) with nanostructures hold great promise for enhancing the irradiation tolerance because of their sinking effect of boundaries on defects. Despite recent advances, challenges remain in finding a nanostructure that exhibits both superior irradiation tolerance and excellent lubricant properties. Unlike traditional nanostructured composite materials that required complex predesign, herein, a MoS nanocrystals (NCs)/amorphous dual phase in subirradiation saturation (SIS) state was spontaneously formed during irradiation, exhibiting high irradiation resistance under the synergistic effect of "defect traps" by interfaces and edge dislocation.

HTT1, a Stearoyl-Acyl Carrier Protein Desaturase Involved Unsaturated Fatty Acid Biosynthesis, Affects Rice Heat Tolerance.

Elucidating the mechanisms underlying heat tolerance in rice (Oryza Sativa. L) is vital for adapting this crop to rising global temperature while increasing yields. Here, we identified a rice mutant, high temperature tolerance 1 (htt1), with high survival rates under heat stress.

Investigating the landscape of immune-related genes and immunophenotypes in atherosclerosis: A bioinformatics Mendelian randomization study.

Background: Atherosclerosis, a leading cause of cardiovascular disease, is characterized by intricate interactions among lipid metabolism, inflammation, and immune response. Investigating immune-related genetic factors and immune cell infiltration in atherosclerotic tissues may provide insights into potential therapeutic targets.

Methods: We analyzed transcriptomic data from atherosclerotic and normal tissues to identify differentially expressed genes (DEGs).

Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies.

Introduction: Alopecia is a systemic disease with multiple contributing factors. Effective treatment is challenging when only hair growth mechanisms are targeted while ignoring the role of maintaining hair follicle microenvironment homeostasis, which is crucial for cell growth and angiogenesis. Oxidative stress and inflammation are major disruptors of this microenvironment, leading to inhibited cell proliferation and compromised hair follicle circulation.

Efficacy of comprehensive nursing intervention on nursing outcomes and prognostic quality of life in elderly patients with chronic heart failure.

Objective: To explore the effect of comprehensive nursing intervention on nursing outcomes, self-efficacy, and quality of life in elderly patients with chronic heart failure (CHF).

Method: A retrospective analysis was conducted on the clinical data from 120 elderly patients with CHF admitted to Baoding No.1 Central Hospital from June 2019 to June 2022.

Assessment of bidirectional relationships between frailty and acute respiratory distress syndrome: a bidirectional Mendelian Randomization study.

Background: While previous observational studies have suggested a link between frailty and acute respiratory distress syndrome (ARDS), the causality of this connection remains unclear. The objective of this study was to explore the potential bidirectional causal links between frailty and ARDS.

Methods: A two-sample univariable Mendelian randomization (MR) was performed to assess the causal relationship between frailty, as defined by frailty index (FI, n = 175,226) and fried frailty score (FFS, n = 386,565), and ARDS.

Downregulating miR-432-5p exacerbates adriamycin-induced cardiotoxicity via activating the RTN3 signaling pathway.

Background: Adriamycin (ADR) is a widely used chemotherapy drug in clinical practice and it causes toxicity in the myocardium affecting its clinical use. miR-432-5p is a miRNA primarily expressed in myocardial cells and has a protective effect in the myocardium. We aim to explore the protective effect of miR-432-5p on ADR-caused impaired mitochondrial ATP metabolism and endoplasmic reticulum stress (ERs).

The association between serum 25-hydroxyvitamin D levels and retinopathy of prematurity in preterm infants.

Objective: This study aimed to investigate the correlation between serum 25-hydroxyvitamin D (25(OH)D) levels and retinopathy of prematurity (ROP) in premature infants one month after birth.

Methods: Preterm infants (gestational age <32 weeks) admitted to the Affiliated Hospital of Qingdao University from 2017 to 2022 were divided into ROP and non-ROP groups based on ROP occurrence any stage. Serum 25(OH)D levels and clinical data were compared between the two groups at 1 month after birth, and the relationship between vitamin D levels and ROP was analyzed.