Case report: Duplicate renal ureteral malformation with renal tumor, ureteral tumor, renal rupture, calculi and infection.

Introduction: The Multiple primary malignant tumors (MPMT) refers to the occurrence of two primary malignant tumors in the same organ or organs in the same patient at the same time. However, MPMT is rare in the urinary system. Congenital urinary tract anomalies (e.

Athletic pseudonephritis in male cross-country ultra-marathoners: a comparative observational study.

Background/objective: Athletes have commonly reported hematuria, cylindruria, and proteinuria, which are consistent with "athletic pseudonephritis." To date, little is known about the overall consequences of 100 km (62.5-mile) cross-country ultra-marathons on Asian male runners.

Thirty-Day And One-Year Outcomes Of Navitor Transcatheter Aortic Valve In Low- or Intermediate-Risk Patients.

Background: The Navitor transcatheter aortic valve is a self-expanding, intra-annular valve indicated for patients with severe aortic stenosis (AS) at high or extreme surgical risk.

Objectives: To assess the safety and effectiveness of the Navitor valve in severe AS patients at low or intermediate surgical risk.

Methods: VANTAGE is a prospective, single-arm, multicenter study.

Propensity score weighting with survey weighted data when outcomes are binary: a simulation study.

Propensity score methods have been widely adopted in observational studies, however research on propensity score-based weighting (PSW) methods in complex survey data settings is lacking, particularly for binary outcomes. We conducted a simulation study to compare eight propensity score weighting approaches for estimating treatment effects using survey weighted data. Each of the eight methods is applied to estimation of two measures of the population-level treatment effect: the population average treatment effect (PATE), and the population average treatment effect on the treated (PATT).

Network pharmacology and experimental validation reveal that betulin alleviates 5-fluorouracil-induced intestinal injury by inhibiting intestinal senescence and enhances antitumor efficacy.

5-Fluorouracil (5-FU) remains the first-line chemotherapeutic agent for colorectal cancer. Although 5-FU significantly improves patient survival, its severe gastrointestinal toxicity-particularly intestinal injury and diarrhea-impairs treatment adherence and patient quality of life, often leading to therapeutic failure. Thus, effective interventions to prevent or mitigate these adverse effects are urgently needed.

Network pharmacology and experimental validation reveal clotrimazole alleviates dextran sulfate sodium-induced ulcerative colitis by inhibiting intestinal senescence.

Ulcerative colitis (UC) is one of the spontaneous inflammatory bowel disease, which is characterized by chronic and relapsing intestinal mucosal inflammation that principally affects the colon. Chronic inflammation is a hallmark of senescent tissues, and intestinal tissue gradually appears injured with the occurrence of senescence. Therefore, senescence may aggravate the severity of UC.

Examining Potential Implicit Bias in Oncologist-Patient Communication (CONNECT): Protocol for an Observational 2-Site Study.

Background: Compared with White patients, minoritized patients (Black and Hispanic patients) have a higher incidence of advanced solid cancers and have a higher mortality. These patients also report poor patient-centered communication and worse pain assessment and management. Although many factors contribute to these disparities, physician implicit bias may be a contributing factor.

UPSST: Unsupervised Pathology Domain Identification by Integrating Tissue Morphology, Imputing and Clustering of Spatial Transcriptomics With GAT.

Spatial transcriptomics is an emerging technology that allows for analysis of cellular and molecular heterogeneity at spatial resolution. The accurate identification of pathological regions in spatial transcriptomics data is essential for understanding tissue heterogeneity and disease progression. We introduce UPSST, a comprehensive framework that integrates tissue morphology, imputes gene expression, and clusters spatial regions using a graph attention neural network (GAT).

S.T.O.P kit for Myopia Control: Stage 1 results from a randomized controlled clinical trial in Chinese children.

Purpose: The S.T.O.

Decoding periodate-driven phototransformation of dissolved organic matter in sunlit waters: Multidimensional property shifts and molecular network reconfiguration.

Residual periodate (PI) from advanced oxidation processes poses emerging threats to aquatic carbon cycling, yet its role in reprogramming the phototransformation of dissolved organic matter (DOM) remains poorly understood. Here, we reveal the multidimensional effects of PI residues (20.0-300.

Tilapia IFP35 is differently induced by three subgroups of type I IFNs via the JAK-STAT signaling.

Interferons (IFNs) trigger effective antiviral responses by activating the expression of a series of interferon-stimulated genes (ISGs), and interferon-induced protein 35 (IFP35) has been identified as a typical ISG in mammals and fish. Nevertheless, it is required to compare distinct responses of IFP35 to different subgroups of type I IFNs in fish. Here, we cloned IFP35 gene (named as On-IFP35) from tilapia, and syntenic analysis showed that On-IFP35 gene was found in a locus conserved in cartilaginous and bony fishes.

Preparation of a Golgi-targetable and photo-triggered NO donor and its application in living cells and zebrafish imaging.

Enhancing the concentration of nitric oxide (NO) in tumor tissues via exogenous NO donors represents an efficient approach to augment the anti-tumor therapeutic effect of NO. Herein, a Golgi-targetable and photo-triggered NO donor, DYG-NO has been designed for the quantitative and localized NO release using an aminoquinoline derivative as the fluorescence reporter and Golgi-targetable group. The solution of DYG-NO was colorless and non-fluorescent due to the inhibition of intramolecular charge transfer state of the 7-aminoquolines between the imine group and trifluoromethyl group.

Network pharmacology and experimental validation reveal Thiamphenicol ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of intestinal senescence and modulation of the NF-κB/AMPK signaling pathway.

Background: Ulcerative colitis (UC), as a prevalent subtype of inflammatory bowel disease (IBD), is a chronic, non-specific inflammatory bowel disease characterized by persistent inflammation of the colonic mucosa, impaired intestinal barrier function, and recurrent clinical manifestations such as diarrhea and hematochezia. Recent studies have revealed that cellular senescence plays a pivotal role in UC pathogenesis, wherein senescent cells exacerbate intestinal inflammation through the secretion of the senescence-associated secretory phenotype (SASP), which primarily consists of pro-inflammatory factors. Thiamphenicol (TP), a broad-spectrum antibiotic, has exhibited promising anti-inflammatory and senescence-modulating properties beyond its conventional antimicrobial effects.

Miconazole alleviates colitis by suppressing colonic senescence, NF-κB Signaling and gut microbiota modulation.

Ulcerative colitis (UC) is a chronic relapsing non-transmural inflammatory bowel disease characterized by bloody diarrhea, closely associated with intestinal epithelial cell senescence and chronic inflammation. This study reveals novel mechanisms of the imidazole antifungal drug Miconazole (MCZ) in UC treatment. Through compound library screening, we found that MCZ effectively inhibits dextran sulfate sodium (DSS)-induced senescence in colonic epithelial NCM460 cells.

Elevated Ocular and Visual Disorder Risk in Developmental Disabilities: Insights from Cross-Sectional Study and Mendelian Randomization Analysis.

The visual health of children diagnosed with developmental disabilities has received limited attention, partly due to the intricate nature of their conditions. This study aims to clarify the associations between developmental disabilities and ocular disorders, exploring both correlations and potential causal relationships, to emphasize the importance of providing focused ocular attention for these children. This 3-year cross-sectional study included 13,889 students (309 with developmental disorders).

Relieving oxidative stress microenvironment and promoting vascularized bone formation to treat femoral head necrosis using 3D-printed scaffold with ultralong-term multienzyme-like activity.

Background: Characterized by microcirculatory disorder and oxidative stress microenvironment, the repair of bone defect after hip preservation therapy (such as core decompression) for osteonecrosis of the femoral head (ONFH) remains a clinical challenge. Thus, an ideal bone scaffold for treating ONFH should not only promote bone and vessel formation but also alleviate hypoxia and oxidative stress.

Method: We integrated manganese oxides (MnO) nanoparticles (NPs) with a 3D-printed poly(lactic-co-glycolic acid) (PLGA) scaffold to achieve this goal.

Adherence to GLP-1 receptor agonists and SGLT2 inhibitors by out-of-pocket spending among Medicare beneficiaries with diabetes.

Aims: To assess associations between out-of-pocket (OOP) expenditures and adherence to glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) among low-income Medicare beneficiaries with diabetes.

Materials And Methods: We analysed Medicare Current Beneficiary Survey two-year longitudinal data (2016-2021) on beneficiaries with diabetes using GLP-1RAs (N = 168; weighted = 2 187 500) or SGLT2i (N = 139; weighted = 1 741 910) in year one (baseline). Among these, N = 97 (weighted = 1 117 637) GLP-1RA and N = 73 (weighted = 785 301) SGLT2i users had an income below 200% of the Federal Poverty Level (low-income).

Medical semantic knowledge-integrated multitask learning network for report generation and neoadjuvant chemotherapy response prediction.

Background: Automatically generated reports and predictions of neoadjuvant chemotherapy (NAC) responses can support physicians in clinical decision-making. However, previous research has not thoroughly considered the connection between the detailed descriptions within these reports and their impact on predicting NAC responses.

Objectives: This study aims to develop an effective medical semantic knowledge-integrated multitask learning (MSKMTL) network to enhance the accuracy of NAC response predictions and improve the quality of automatically generated medical reports.

Axial Growth and Meridian Modulation of Cornea Power in Children Wearing Orthokeratology Lenses of Different Back Optic Zone Diameters.

Purpose: To evaluate the effect of orthokeratology lenses with different back optical zone diameters (BOZD) on relative corneal refraction power shift (RCRPS) and explore its association with axial length growth (ALG).

Design: A randomized, double-blinded, controlled clinical trial.

Methods: Subjects aged between 8 and 15 years, with the refraction of -1.

Combined model-driven and dual-cycle interactive strategy few-shot learning scheme for predicting breast cancer molecular subtypes based on DCE-MRI.

Background And Objective: Deep learning has achieved significant success in solving classification problems in the medical field, which has, in turn, facilitated the development of continuous and real-time health monitoring systems. Yet medical images have extremely low data regimes, unlike natural images with a large amount of data. Hence, to classify medical images with a few per-class data samples is a challenging problem.

UMPlex™: a targeted next-generation sequencing primer design workflow.

We have developed a tailored next-generation sequencing (tNGS) panel, employing our innovative UMPlex™ primer design workflow, to enhance pathogen identification in clinical diagnostics. Through iterative experimentation and rigorous validation, we refined the primer design by excluding those with insufficient specificity or efficiency. To mitigate amplification challenges arising from pathogenic mutations, we implemented a strategy of using a minimum of two primer pairs per pathogen, ensuring redundancy and robust detection.

Recent advances in biomarker detection of oral squamous cell carcinoma.

Oral squamous cell carcinoma is among the most prevalent tumours of the oral and maxillofacial region. The initial symptoms are typically minor and may remain misdiagnosed until the disease advances, resulting in a significantly reduced five-year survival rate for patients. Early detection is critical, as it can improve five-year survival rates from below 50% to 70-90%.

Cancer patient preferences for traditional Chinese medicine treatment: a discrete choice experiment study.

Background: Patient preferences have gradually been incorporated into decisions about cancer treatment regimens over recent years. Meanwhile, the efficacy of traditional Chinese medicine (TCM) in cancer-related treatments has been recognized. This study aimed to estimate the specific preferences of cancer patients for TCM treatment regimens to inform the clinical decision-making process for health promotion.

Inductive-Associative Meta-learning Pipeline with Human Cognitive Patterns for Unseen Drug-Target Interaction Prediction.

Significant differences in protein structures hinder the generalization of existing drug-target interaction (DTI) models, which often rely heavily on pre-learned binding principles or detailed annotations. In contrast, BioBridge designs an Inductive-Associative pipeline inspired by the workflow of scientists who base their accumulated expertise on drawing insights into novel drug-target pairs from weakly related references. BioBridge predicts novel drug-target interactions using limited sequence data, incorporating multi-level encoders with adversarial training to accumulate transferable binding principles.