Common network related to hyperkinetic seizures revealed by functional lesion network mapping.

Objective: This study aims to determine whether the anatomically heterogeneous lesions that cause hyperkinetic seizures (HKS) are connected to a common functional network.

Methods: We identified patients from the Beijing Tiantan-Fengtai Epilepsy Center with HKs as the primary ictal semiology. These included patients had focal seizure-onset zone, here referred to as a "lesion.

Progressive structural alterations in the cerebral small vessel disease with cognitive impairment and vascular dementia.

BackgroundThe progression of cerebral small vessel disease (CSVD) leads to cognitive decline, which can be categorized into subcortical vascular mild cognitive impairment (svMCI) and vascular dementia (VaD).ObjectiveThis research aimed to examine the structural changes in gray (GM) and white matter (WM) in the brain across the disease spectrum.MethodsA total of 30 healthy controls (HC), 26 individuals with svMCI, and 29 individuals with VaD were included in study.

Selective Plasticity of Hippocampal Sub-Regions in the Amnestic Mild Cognitive Impairment After Acupuncture.

Background: Acupuncture has been demonstrated to be effective in reducing cognitive decline in patients with amnestic mild cognitive impairment (aMCI). Hippocampal atrophy has been typically reported as a core neuromechanism in the aMCI. However, whether and how hippocampal subregions plasticity exists in aMCI after acupuncture remains largely unknown.

Shared and distinct brain activation patterns of acupoints HT7, ST36, and KI4: a task-based fMRI study.

Objective: We aimed to investigate the shared and distinct of brain responses to manual acupuncture at HT7, ST36, and KI4.

Methods: Sixteen healthy participants receiving acupuncture at HT7, 19 at ST36, and 16 at KI4. All subjects experienced deqi sensation without severe pain during the acupuncture sessions.

Factors associated with switching from active surveillance to treatment in men with low-risk prostate cancer: A population-based study.

Background: The authors sought to identify modifiable and nonmodifiable factors associated with switching from active surveillance to treatment among men with low-risk prostate cancer (LRPC).

Methods: Eligible men with low-risk prostate cancer (prostate-specific antigen <10 ng/mL, Gleason score ≤6, clinical stage ≤T2a) were identified from two population-based cancer registries (in Metropolitan Detroit and the State of Georgia). All participants received a baseline survey and men who adopted active surveillance (AS) were mailed a second survey at 2 years after diagnosis, rating factors regarding their decision to remain on AS or switch to treatment.

Progressive gray matter alterations in the Meige's syndrome and across sub-types.

Meige Syndrome (MS) is a form of segmental dystonia, categorized into four subtypes. The common and specific neuro-mechanisms among these subtypes remain to be elucidated. Herein, 3D T1-weighted MRI images were obtained from 159 patients with primary MS (31 with MS-I, 92 with MS-II, and 36 with MS-IV).

Sleep disturbances are related to glymphatic dysfunction in blepharospasm.

Research has shown a close relationship between sleep and glymphatic function, with impaired glymphatic function potentially contributing to sleep problems in a bidirectional way. However, its role in sleep disturbances associated with dystonia remains unknown. This cross-sectional study aimed to investigate whether glymphatic function is impaired in dystonia and to explore its relationship with sleep disturbances.

Quality of Life 2 Years After Diagnosis of Low-Risk Prostate Cancer in the Treatment Options for Prostate Cancer Study Cohort.

Introduction: Current evidence-based best practices recommend an active surveillance (AS) protocol for men with low-risk prostate cancer (LRPC).

Methods: We evaluated quality of life (QOL) at baseline and at 2 years after diagnosis among men with LRPC in a prospective, population-based cohort of 1049 Black and White men from 2 cancer registries (metropolitan Detroit and Georgia). General and prostate cancer-specific QOL domains were assessed using the Short Form-12 and Expanded Prostate Cancer Index Composite-26 scales at baseline and 2-year follow-up.

Putaminal-cortical circuits predict response of bilateral deep brain stimulation of the subthalamic nucleus in the primary Meige syndrome after 5 years.

The deep brain stimulation (DBS) in the subthalamic nucleus (STN) has attracted more attention for primary Meige syndrome due to easier target location and lower power consumption. However, potential and reliable preoperative predictors of longitudinal outcomes of STN-DBS to guide therapeutic decisions remain largely unexplored. Herein, we used preoperative structural MRI and Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) from 55 patients with primary Meige syndrome who finished STN-DBS after 5 years.

Niche-inspired collagen infused melt electrowritten scaffolds for craniofacial bone regeneration.

Advances in tissue engineering are focused on devising improved therapeutics to reconstruct craniofacial bones. In cell-based strategies, biomaterials with specific physicochemical properties can mimic natural environments, supporting stem cell renewal, survivability, and cell fate. This study highlights the engineering of a 3D-printed (Melt Electrowritten, MEW) fluorinated‑calcium phosphate (F/CaP)-coated polymeric scaffold infused with collagen (COL) that boosts the performance of transplanted alveolar bone-derived mesenchymal stem cells (aBMSCs).

Association between functional alterations and specific transcriptional expression patterns in craniocervical dystonia.

Purpose: Craniocervical dystonia (CCD) is a large-scale network disorder that involves functional changes in multiple brain regions. However, the association between these functional changes and the underlying molecular mechanisms has not been explored.

Objective: We aimed to characterize the molecular changes associated with the imaging-defined functional architecture of the brain in CCD.

Multidimensional structural analyses revealed a correlation between thalamic atrophy and white matter degeneration in idiopathic dystonia.

Although aberrant changes in grey and white matter are core features of idiopathic dystonia, few studies have explored the correlation between grey and white matter changes in this disease. This study aimed to investigate the coupling correlation between morphological and microstructural alterations in patients with idiopathic dystonia. Structural T1 imaging and diffusion tensor imaging were performed on a relatively large cohort of patients.

Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study.

Background: Subcortical vascular mild cognitive impairment (svMCI) frequently occurs alongside depression symptoms, significantly affecting patients' quality of life. While cognitive decline and depression symptoms are linked to cerebellar changes, the specific relationship between these changes and cognitive status in svMCI patients with depression symptoms remains unclear.

Objective: This study aimed to investigates the gray matter volume and functional alterations in the cerebellum of svMCI patients, with and without depression symptoms, and their correlation with cognitive and depressive symptoms.

Synthetic Periodontal Guided Tissue Regeneration Membrane with Self-Assembling Biphasic Structure and Temperature-Sensitive Shape Maintenance.

Periodontal disease poses significant challenges to the long-term stability of oral health by destroying the supporting structures of teeth. Guided tissue regeneration techniques, particularly barrier membranes, enable local regeneration by providing an isolated, protected compartment for osseous wound healing while excluding epithelial tissue. Here, this study reports on a thermosensitive periodontal membrane (TSPM) technology designed to overcome the mechanical limitations of current membranes through a semi-interpenetrating network of high molecular weight poly(L-lactic acid) (PLLA) and in situ-polymerized mesh of poly(ε-caprolactone)diacrylate (PCL-DA), and poly lactide-co-glycolide diacrylate (PLGA-DA).

Disruptive and complementary effects of depression symptoms on spontaneous brain activity in the subcortical vascular mild cognitive impairment.

Background: Although depression symptoms are commonly reported in patients with subcortical vascular mild cognitive impairment (svMCI), their impact on brain functions remains largely unknown, with diagnoses mainly dependent on behavioral assessments.

Methods: In this study, we analyzed resting-state fMRI data from a cohort of 34 svMCI patients, comprising 18 patients with depression symptoms (svMCI+D) and 16 patients without (svMCI-D), along with 34 normal controls (NC). The study used the fraction of the amplitude of low-frequency fluctuations (fALFF), resting-state functional connectivity, correlation analyses, and support vector machine (SVM) techniques.

Atrophy patterns in hippocampal subregions and their relationship with cognitive function in fibromyalgia patients with mild cognitive impairment.

Objectives: Fibromyalgia (FM) has been associated with decreased hippocampal volume; however, the atrophy patterns of hippocampal subregions have not yet been identified. We therefore aimed to evaluate the volumes of hippocampal subregions in FM patients with mild cognitive impairment (MCI), and to explore the relationship between different subregional alterations and cognitive function.

Methods: The study included 35 FM patients (21 with MCI and 14 without MCI) and 35 healthy subjects.