Association between insomnia and its symptoms and cognitive impairment in community-dwelling older adults in China: A multicenter study.

BackgroundLimited evidence exists on insomnia symptoms' association with mild cognitive impairment (MCI) and dementia in older Chinese adults across rural and urban areas.ObjectiveTo examine associations between insomnia symptoms, sleep duration, and cognitive impairment.MethodsThis cross-sectional study utilized data from China's Multicenter Dementia Survey (2019-2020), examining the association between insomnia symptoms, sleep duration, and cognitive impairment, using logistic and linear regression models.

Combined Functional and Structural Imaging of White Matter Reveals Brain Connectivity Alterations in Fibromyalgia Patients.

Background: Fibromyalgia syndrome (FMS) is a prevalent central chronic pain condition of unknown pathophysiology. White matter (WM) plays a crucial role in brain signal transmission, and WM structural abnormalities have been reported in FMS. However, functional WM changes in FMS patients have not been investigated.

Hyperspectral imaging to characterize the vegetative tissue biochemical changes in response to water deficit conditions in sorghum ().

Hyperspectral imaging has been used to determine plant stress status. However, the biological interpretation of the spectral changes remain less explored. This can be addressed by building associations between stress-induced biochemical changes and variations in spectral reflectance.

Social isolation in relation to the incidence and dynamic progression of frailty in the oldest old: a trajectory analysis of a nationwide cohort.

Background: There is still a lack of evidence examining the association of behavioral and social factors with frailty transitions and mortality. We investigated whether social isolation is associated with different progressions and outcomes of frailty among community-dwelling older adults.

Methods: This community-based cohort study assessed the frailty index and objective social isolation of 31,168 participants (58.

Marital Status-Specific Associations Between Multidomain Leisure Activities and Cognitive Reserve in Clinically Unimpaired Older Adults: Based on a National Chinese Cohort.

It is unclear how marital status moderates the association between multidomain leisure activities and the progression of cognitive decline in community-dwelling older adults. Data from the Chinese Longitudinal Healthy Longevity Survey with up to 10 years of follow-up were used. The study included participants aged ≥65 years without cognitive impairment at baseline.

Impaired LTB4-induced neutrophil chemotactic directionality in myelodysplastic neoplasms patients.

Objectives: Myelodysplastic neoplasm (MDS) patients are at a high risk of infections, contributing significantly to morbidity and mortality. While neutrophil dysfunction is considered a primary factor, specific functional defects remain elusive.

Methods: We conducted a comprehensive study involving 90 participants, including controls and de novo MDS patients.

Association between home dwelling situations, neighborhood social interactions, and subjective cognitive decline plus among older adults: A cross-sectional study.

BackgroundHome-dwelling situations (HDS) and neighborhood social interactions (NSI) significantly impact older adults' post-retirement lives. However, their relationship with subjective cognitive decline plus (SCD-plus), a potential biomarker of preclinical Alzheimer's disease (AD), remains uncertain.ObjectiveTo explore the association between NSI, HDS and SCD-plus among older adults.

Relationship between sleep quality and dietary nutrients in rural elderly individuals: a latent class analysis.

Background: This study sought to identify sleep patterns in older adults residing in rural regions, as well as investigate the potential influence of dietary nutrient intake on these patterns.

Methods: Data were collected from a cross-sectional sample of Qingdao Town, Shandong Province, China. The study investigated 1,167 elderly participants using a general questionnaire, the Pittsburgh Sleep Quality Index, the simplified Food Frequency Questionnaire, and 24-h dietary recall methods.

Association between depressive symptom trajectories and unhealthy lifestyle factors among adolescents based on the China family panel studies.

Background: The prevalence of depressive symptom in adolescents has sharply increased over the past decade. Depressive symptom during adolescence could hinder the development of social, cognitive, and psychological competencies, potentially influencing young adults' lifestyle factors. This study aimed to identify trajectories of depressive symptom from adolescence to early adulthood and evaluated their association with lifestyle factors in early adulthood.

Developmental dyslexia genes are selectively targeted by diverse environmental pollutants.

Background: Developmental dyslexia, a complex neurodevelopmental disorder, not only affects children's academic performance but is also associated with increased healthcare costs, lower employment rates, and reduced productivity. The pathogenesis of dyslexia remains unclear and it is generally considered to be caused by the overlap of genetic and environmental factors. Systematically exploring the close relationship between exposure to environmental compounds and susceptibility genes in the development of dyslexia is currently lacking but high necessary.

Atrophy patterns in hippocampal subregions and their relationship with cognitive function in fibromyalgia patients with mild cognitive impairment.

Objectives: Fibromyalgia (FM) has been associated with decreased hippocampal volume; however, the atrophy patterns of hippocampal subregions have not yet been identified. We therefore aimed to evaluate the volumes of hippocampal subregions in FM patients with mild cognitive impairment (MCI), and to explore the relationship between different subregional alterations and cognitive function.

Methods: The study included 35 FM patients (21 with MCI and 14 without MCI) and 35 healthy subjects.

RmdnCache: Dual-Space Prefetching Neural Network for Large-Scale Volume Visualization.

Volume visualization plays a significant role in revealing important intrinsic patterns of 3D scientific datasets. However, these datasets are often large, making it challenging for interactive visualization systems to deliver a seamless user experience because of high input latency that arises from I/O bottlenecks and limited fast memory resources with high miss rates. To address this issue, we have proposed a deep learning-based prefetching method called RmdnCache, which optimizes the data flow across the memory hierarchy to reduce the input latency of large-scale volume visualization.

Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development.

Osteoporosis has gradually become a major public health problem. Further elucidation of the pathophysiological mechanisms that induce osteoporosis and identification of more effective therapeutic targets will have important clinical significance. Experiments on bone marrow stem cells (BMSCs) subjected to osteogenic and adipogenic differentiation and on surgical bilateral ovariectomy (OVX) mouse models revealed that exosomes of vascular endothelial cells (EC-EXOs) can promote osteogenic differentiation of BMSCs and inhibit BMSC adipogenic differentiation through miR-3p-975_4191.

The association between closed-eye unipedal standing and the risk of cognitive impairment in the elderly: a 7-year community-based cohort study in Wuhan, China.

Objectives: The prevention of cognitive impairment in the elderly is one of the public health priority areas. However, the relationship between closed-eye unipedal standing and cognitive impairment remains unclear.

Methods: This study was conducted on a group of elderly individuals from a community, using a prospective cohort study design.

Exosome-derived miR-5p-72106_14 in vascular endothelial cells regulates fate determination of BMSCs.

Vascular endothelial cells have recently been shown to be associated with osteogenic activity. However, the mechanism of vascular endothelial cells promoting osteogenesis is unclear. Here, we found that exosomes secreted from human microvascular endothelial cells (HMEC-1) promoted osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and inhibited adipogenic differentiation.

The promoting effect of exercise motivation on physical fitness in college students: a mediation effect model.

Background: In recent years, the physical fitness situation of college students is worrying in China. Exercise motivation is of great importance for the physical activity and physical fitness. However, existing studies have paid limited attention to the specific effect between exercise motivation, physical activity and physical fitness, and even less to the different genders and exercise motivation dimensions.

Association between urinary 2-hydroxyethyl mercapturic acid and dyslexia among school-aged children.

Ethylene oxide is commonly used in industrial synthesis and medical disinfection. It is a known human carcinogen and has neurotoxicity. However, the association between ethylene oxide exposure and neurodevelopmental disorders remains unclear.

A network analysis of subjective well-being in Chinese high school students.

Background: The psychological situation of high school students during adolescence is not promising, and the most obvious manifestation is the lack of subjective well-being (SWB). This network analysis presents a model of the interaction and correlation between different items of SWB, identifying the most central items for high school students.

Methods: Through offline and online surveys, 4,378 questionnaires were sent out and finally 4,282 Chinese high school students were available.