High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy.

Introduction: Women with advanced maternal age (AMA) face a higher risk of pregnancy complications including preeclampsia, fetal growth restriction, and preterm birth. While placental dysfunction is implicated, the underlying mechanisms remain unclear. This study employs high-throughput sequencing-based transcriptomics to investigate AMA-associated dysregulation in placental angiogenesis, exploring links to redox imbalance.

Fish Diversity and Environmental Relationships in the Jinsha River During the Initial Phases of the 10-Year Fishing Ban: A Metabarcoding Approach.

Fish diversity is essential for maintaining the balance of aquatic ecosystems, particularly in rivers impacted by overfishing and hydropower projects, such as the Jinsha river, the upstream segment of the Yangtze river. During initial phases (August and November, 2023) of the 10-year fishing ban in the Yangtze river basin, we investigated fish diversity, seasonal variations, and their correlation with environmental factors in the Jinsha river using environmental DNA (eDNA) metabarcoding. Utilizing two pairs of 12S rRNA primers, MiFish-U and AcMDB07, we identified 61 fish species across 5 orders, 17 families, and 52 genera, including 4 national protected and 7 invasive alien fish.

Chitinase 3-Like 1 Promotes Endothelial-to-Mesenchymal Transition in Systemic Sclerosis via mTORC1 Signaling Pathway.

Objective: Systemic sclerosis (SSc) is a complicated autoimmune connective tissue disorder. Endothelial-to-mesenchymal transition (EndoMT) contributes to vasculopathy and fibrosis in SSc, yet its underlying mechanism remains to be elucidated. Here, we determined the role and mechanism of chitinase 3-Like 1 (CHI3L1) in SSc EndoMT.

Related differences in fecal bacteria of Chinese northern pregnant women of different ages: associations with maternal clinical indicators and neonatal outcomes.

The gut microbiota, a vital "microbial organ," influences digestion, immunity, and metabolism. Aging alters gut microbiota of pregnant women through metabolic and hormonal pathways, thereby impacting neonatal health. In this study conducted in northern China, we compared two groups: advanced maternal age (AMA, ≥35 years) and younger maternal age (YMA, 20-34 years), analyzing fecal bacteria and maternal metabolism via biomarker measurements and microbial sequencing.

Association between insomnia and its symptoms and cognitive impairment in community-dwelling older adults in China: A multicenter study.

BackgroundLimited evidence exists on insomnia symptoms' association with mild cognitive impairment (MCI) and dementia in older Chinese adults across rural and urban areas.ObjectiveTo examine associations between insomnia symptoms, sleep duration, and cognitive impairment.MethodsThis cross-sectional study utilized data from China's Multicenter Dementia Survey (2019-2020), examining the association between insomnia symptoms, sleep duration, and cognitive impairment, using logistic and linear regression models.

Meta-analysis of compression therapy for prevention of chemotherapy-induced peripheral neuropathy.

Objective: To investigate the prophylactic effect of compression therapy against chemotherapy-induced peripheral neuropathy (CIPN) through meta-analytic evaluation.

Methods: Systematically searched PubMed, Embase, Web of Science, Cochrane Library, Scopus, and Chinese databases (CBM, CNKI, Wan fang, VIP) until December 2024. Included studies were RCTs and quasi-experimental designs.

Association of Ambient Temperature and Relative Humidity With Respiratory Syncytial Virus Infections Among Hospitalized Children in Suzhou, Eastern China: A Time-Series Analysis.

Respiratory syncytial virus (RSV) is the leading cause of clinical pneumonia in children. We aimed to investigate the associations between ambient temperature, relative humidity, and pediatric RSV infections, and to assess the disease burden attributable to cold or humid conditions. Daily data on RSV hospitalizations among children aged ≤5 years, mean temperature, and relative humidity in Suzhou, China, from January 2016 to December 2019 were collected.

Social isolation in relation to the incidence and dynamic progression of frailty in the oldest old: a trajectory analysis of a nationwide cohort.

Background: There is still a lack of evidence examining the association of behavioral and social factors with frailty transitions and mortality. We investigated whether social isolation is associated with different progressions and outcomes of frailty among community-dwelling older adults.

Methods: This community-based cohort study assessed the frailty index and objective social isolation of 31,168 participants (58.

l-Arginine-Functionalized Pd-Ni Catalyst Enhances Direct HO Synthesis in Microreactors.

Using an l-arginine (LA)-functionalized Pd-Ni catalyst, hydrogen peroxide (HO) was directly synthesized via a self-designed microreactor at ambient temperature and pressure. The yield of HO achieved 574.31g kg h, with the concentration of HO in the solution reaching 4.

Effects of self-managed lifestyle behavioral changes on cognitive impairment control in Chinese older adults: a population-based prospective study.

Few studies have examined the effects of self-managed lifestyle behavioral adjustment on cognitive status. This study aimed to explore the association between self-managed behavioral changes and transitions in cognitive status. The Hubei Memory and Aging Cohort Study was a prospective cohort study conducted from 2018-2023 in rural and urban areas.

Marital Status-Specific Associations Between Multidomain Leisure Activities and Cognitive Reserve in Clinically Unimpaired Older Adults: Based on a National Chinese Cohort.

It is unclear how marital status moderates the association between multidomain leisure activities and the progression of cognitive decline in community-dwelling older adults. Data from the Chinese Longitudinal Healthy Longevity Survey with up to 10 years of follow-up were used. The study included participants aged ≥65 years without cognitive impairment at baseline.

Length-Weight Relationship, Age, and Growth of Invasive in Lugu Lake, China.

, a key invasive species in the high-altitude Lugu Lake (2690 m) in China, was studied to assess its length-weight relationship, age structure, and growth patterns using scale-based age determination. A total of 670 specimens were collected via systematic gillnet surveys conducted in May and October 2023. The population comprised five age groups (0+ to 4+), with 0+ and 1+ individuals dominating (69.

Spatiotemporal Dynamics of Fish Density in a Deep-Water Reservoir: Hydroacoustic Assessment of Aggregation Patterns and Key Drivers.

Understanding spatiotemporal patterns of fish density and their environmental drivers is critical for managing river-lake ecosystems, yet dynamic interactions in heterogeneous habitats remain poorly quantified. This study combined hydroacoustic surveys, spatial autocorrelation analysis (Moran's I), and generalized additive models (GAMs) to investigate seasonal and spatial fish distribution, aggregation characteristics, and regulatory mechanisms in China's Zhelin Reservoir. The results reveal pronounced seasonal fluctuations, with summer fish density peaking at 13.

RBAD: the first database dedicated alterations of blood RNA in individuals with Alzheimer's disease and their clinical relevance.

Alzheimer's disease-associated transcriptomic landscapes have been defined in brain tissue. However, changes in blood RNA and their clinical relevance remain poorly understood. In this study, we developed an RNA profile based on 1468 blood samples from both human and mouse studies, which include bulk RNA sequencing (RNA-seq), microRNA-seq, and single-cell RNA-seq data.

Association between home dwelling situations, neighborhood social interactions, and subjective cognitive decline plus among older adults: A cross-sectional study.

BackgroundHome-dwelling situations (HDS) and neighborhood social interactions (NSI) significantly impact older adults' post-retirement lives. However, their relationship with subjective cognitive decline plus (SCD-plus), a potential biomarker of preclinical Alzheimer's disease (AD), remains uncertain.ObjectiveTo explore the association between NSI, HDS and SCD-plus among older adults.

Effect of non-pharmacological interventions on chemotherapy induced delayed nausea and vomiting for tumors: A systematic review and Bayesian network meta-analysis.

Objective: To evaluate the efficacy of non-pharmacological interventions in improving chemotherapy induced delayed nausea and vomiting symptoms using a network meta-analysis.

Methods: Four Chinese databases (CNKI, Wanfang Data Knowledge Service Platform, VIP, Sinomed) and five English databases (PubMed, Cochrane Library, Embase, Web of Science, CINAHL) were searched from the establishment of the database to April 2024. A Bayesian network meta-analysis was performed on the response rate to the improvement of chemotherapy induced delayed nausea and vomiting, as well as improvement in KPS score, under different non-pharmacological interventions by using R 4.

Aberrant Chitinase 3-Like 1 Expression in Basal Cells Contributes to Systemic Sclerosis Fibrosis.

Systemic sclerosis (SSc) is an autoimmune disease characterized by extensive skin and internal organ fibrosis. However, the mechanism underlying fibrosis remains unclear, and effective treatments for halting or reversing fibrosis are lacking. In this study, single-cell RNA sequencing is used to obtain a comprehensive overview of skin cells from patients with SSc and healthy controls.

Xanthohumol Protects Against Neuronal Excitotoxicity and Mitochondrial Dysfunction in APP/PS1 Mice: An Omics-Based Study.

: Neuronal excitotoxicity and metabolic decline, which begin in the early stages of Alzheimer's disease (AD), pose challenges for effective amelioration. Our previous work suggested that the natural compound xanthohumol, the most abundant prenylated flavonoid in hops, prevents memory deficits in APP/PS1 mice; however, the underlying mechanisms remain unclear. : This study utilized APP/PS1 mice and cutting-edge omics techniques to investigate the effects of xanthohumol on hippocampal proteome, serum metabolome, and microbiome.

Initial Alterations of Fish Community Structure and Diversity Following Fishing Cessation in Qilu Lake, China.

The Qilu Lake is an eutrophic shallow lake located in Yunnan Province, China. An ecological fishery project was initiated in the lake from 2011 to 2021 to introduce filter-feeding fish species that feed on algae, with the aim of improving water quality. In January 2022, when the ecological fishery project expired, all fisheries-related activities (including fish stocking and fishing activities) ceased in the lake.

Linear morphea distributed along radial nerve with high incidence of neuromusculoskeletal disorders: A single-center case series.

Linear morphea is the most disabling subtype of morphea, which may cause a series of excutaneous manifestations and sequelae. To futher explore the clinical characteristics of linear morphea, we conducted a retrospective study of 22 patients diagnosed with linear morphea in our department during the past 2 years. Their baseline clinical information, skin manifestations, complications and therapeutic effect were analyzed.

Structural characteristics and in vitro starch digestibility of oil-modified cooked rice with varied addition manipulations.

Lipid has crucial applications in improving the quality of starchy products during heat processing. Herein, the influence of lipid modification and thermal treatment on the physicochemical properties and starch digestibility of cooked rice prepared with varied addition manipulations was investigated. Rice bran oil (RO) and medium chain triglyceride oil (MO) manipulations were performed either before (BC) or after cooking (AC).

BCR::ABL1 kinase N-lobe mutants confer moderate to high degrees of resistance to asciminib.

Secondary kinase domain mutations in BCR::ABL1 represent the most common cause of resistance to tyrosine kinase inhibitor (TKI) therapy in patients with chronic myeloid leukemia. The first 5 approved BCR::ABL1 TKIs target the adenosine triphosphate (ATP)-binding pocket. Mutations confer resistance to these ATP-competitive TKIs and those approved for other malignancies by decreasing TKI affinity and/or increasing ATP affinity.