3D-Printed KVPOF/rGO Aerogel Electrodes as High-Performance 5V-Class Cathode for Advanced Potassium-Ion Battery.

A porous KVPOF/reduced graphene oxide (KVPF/rGO) microgrid aerogel electrode is designed and fabricated using direct ink writing 3D printing for high-performance potassium-ion battery cathodes. This 3D-printed KVPF/rGO aerogel electrode, which integrates well-dispersed KVPOF microspheres in the reduced graphene oxide matrix, shows enhanced structural integrity and electrical conductivity, thereby facilitating efficient ion and electron transport. The KVPF/rGO electrode achieves a reversible discharge capacity of 99.

A Comparative CT Study on Anatomical Characteristics of Pediatric Habitual Patellar Dislocation in Extension and Flexion.

Objective: Habitual patellar dislocation (HDP) in children and adolescents is divided into dislocation in flexion and dislocation in extension, but their pathogenesis remains unclear. Our purpose is to focus on investigating the anatomical difference between the extended dislocation and the flexed dislocation of HDP.

Methods: We retrospectively observed all patients diagnosed as HDP who underwent surgery at our institution from May 2016 to August 2023.

Therapeutic exploration of biased ligands at class A G protein-coupled receptors over the past 20 years.

Recent decades have witnessed significant advances in the development of biased ligands for G protein-coupled receptors (GPCRs) as potential therapeutic agents with enhanced efficacy and reduced on-target side effects. This is largely attributed to the unique capability of biased ligands to activate pathway-selective signaling, which can effectively modulate in vivo pharmacology. This review presents a comprehensive analysis of biased ligands targeting class A GPCRs over the past 20 years, encompassing discovery strategies, assays, biological effects and therapeutic applications.

Multi-target renal protection in AKI: Exercise-mediated coordination of AMPK energy homeostasis, mTOR autophagy regulation, and NF-κB inflammatory control.

Background: Aerobic exercise (AE) confers protection against acute kidney injury (AKI), but mechanisms remain incompletely elucidated. We investigated how AE preconditioning protects against sepsis-induced AKI through transcriptomic reprogramming, inflammatory regulation, autophagy modulation, and metabolic adaptation.

Methods: Mice were subjected to 4-week AE before AKI induction.

Generative Artificial Intelligence in the Metaverse Era: A Review on Models and Applications.

The Metaverse is a decentralized, immersive 3-dimensional virtual environment that merges the physical and virtual worlds, fundamentally transforming digital interaction and garnering widespread attention. However, its primary platforms face challenges such as low-quality content and underdeveloped virtual environments, leading to a subpar user experience. Artificial intelligence-generated content (AIGC) has emerged as a key driver in Metaverse development, enabling the efficient and cost-effective creation of digital content.

Discovery of dopamine D1 receptor antagonists from Stephania epigaea using label-free cell phenotypic assays.

The traditional Chinese medicine Stephania epigaea (S. epigaea) has been used for medicinal purposes, including the treatment of abdominal pain and malaria. Increasing evidence suggests a relationship between pain relief, gut regulation, and the dopaminergic system, particularly the dopamine D1 receptor (D1R).

Proteomics analysis of damage mechanism of RAW264.7 cells under Th(IV) stress.

Thorium (Th) is widely distributed in the earth's crust and poses a risk to human health. In this study, the viability of murine macrophages RAW264.7 cells was evaluated, and changes in reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) were assessed under various Th(IV) stress.

Current status and influencing factors of medication behavior among children and adolescents: a cross-sectional study in China.

Background: Children face higher medication risks than adults, making safe and rational drug use a societal concern. For children aged 8 and older, early intervention is key to fostering responsible medication habits. This study, grounded in Temporal Self-Regulation Theory (TST), suggests that temporal valuations, behavioral prepotency, and self-regulatory capacity influence medication behaviors, with weaker self-regulation potentially linked to stronger behavioral prepotency.

Computational spectral imaging reconstruction via a spatial-spectral cross-attention-driven network.

Compared with traditional hyperspectral imaging, computational spectral imaging (CSI) has the advantage of snapshot imaging with high spatial and temporal resolution, which has attracted considerable attention. The core challenge of CSI is to achieve computational imaging reconstruction from a single 2D measurement image to the corresponding 3D spatial-hyperspectral image (HSI). Existing reconstruction methods still face problems in exploring spatial-spectral cross correlation, leading to significant spatial-spectral distortion.

A method for ECG denoising based on generative adversarial networks.

Objectives: To tackle the challenge of noise in grayscale electrocardiograms (ECGs) transcribed from paper records, this study proposes a Generative Adversarial Networks (GANs)-based framework that includes both a denoising dataset construction method and an end-to-end denoising model for accurate waveform recovery.

Methods: We propose a GANs-based ECG waveform denoising approach, referred to Generative Adversarial Network Electrocardiogram Denoising. This method simultaneously trains a generator and a discriminator, enabling the generator to extract clean ECG waveforms in an end-to-end manner.

Machine learning design of spectral-selective infrared metasurfaces based on Conway patterns.

Metasurfaces offer precise control over infrared radiation, holding great potential for thermal management, stealth technology, and sensing applications. However, existing computational approaches, especially machine learning-based methods, typically rely on simplistic geometries and limited material selections, constraining design complexity and performance. To overcome these challenges, we introduce a machine learning-driven platform employing Conway-inspired patterns to achieve band-selective infrared metasurfaces.

Physiological and Transcriptome Analysis Revealed the Effect of ABA on Promoting Persimmon Fruit Postharvest Deastringency.

Persimmon ( Thunb.) fruit can accumulate proanthocyanidins (tannins) during development, which causes astringency and affects consumption. The hormone abscisic acid (ABA) has been reported to play a key role in fruit ripening and softening.

Specific binding of human P[28] rotavirus VP8* protein to blood group ABH antigens on type 1 chains.

Group A rotavirus (RV) has been the major cause of acute gastroenteritis in infants and young children. Among the five P genogroups almost all P genotype RVs in P[II], P[III] and P[IV] genogroups that infect humans can bind glycan histo-blood group antigens (HBGAs) as the receptors on the host cell surface to infect host through the viral spike protein VP8*. Although P[I] is the largest genogroup, P[28] and P[10] are the only two genotype RVs infecting humans in the group.

Emerging epidemic of the predominant clusters of FC428-like Neisseria gonorrhoeae in Guangdong, China.

Objectives: This study aimed to investigate the molecular characteristics of predominant epidemic clusters of FC428-like N. gonorrhoeae in Guangdong, China in 2022.

Methods: Minimum inhibitory concentrations (MICs) were determined for N.

Radiative Cooling Materials for Extreme Environmental Applications.

Radiative cooling is a passive thermal management strategy that leverages the natural ability of materials to dissipate heat through infrared radiation. It has significant implications for energy efficiency, climate adaptation, and sustainable technology development, with applications in personal thermal management, building temperature regulation, and aerospace engineering. However, radiative cooling performance is susceptible to environmental aging and special environmental conditions, limiting its applicability in extreme environments.

Ultrabroadband and band-selective thermal meta-emitters by machine learning.

Thermal nanophotonics enables fundamental breakthroughs across technological applications from energy technology to information processing. From thermal emitters to thermophotovoltaics and thermal camouflage, precise spectral engineering has been bottlenecked by trial-and-error approaches. Concurrently, machine learning has demonstrated its powerful capabilities in the design of nanophotonic and meta-materials.

3.0 T multi-parametric MRI combined with clinical features improve malignancy prediction of BI-RADS 4 lesions and preoperative prediction of Nottingham Prognostic Index.

Purpose: To establish an optimal model to improve the malignancy prediction of BI-RADS 4 lesions and the preoperative prediction of tumor prognosis.

Materials And Methods: Ninety-six patients with 126 histopathology-confirmed breast lesions were included in the study. Conventional imaging features, radiomic features based on 3.

A High-Fidelity RNA-Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma.

Glaucoma is a neurodegenerative disease characterized by the progressive degeneration of retinal ganglion cells (RGCs) and their axons, ultimately leading to irreversible vision loss. Elevated intraocular pressure (IOP) is one of the significant risk factors in glaucoma; however, neurodegeneration continues even after effective IOP management, underscoring the need for neuroprotective therapies. This study investigates the role of connexin43 (Cx43), which is extensively expressed in retinal macroglia, in regulating microglial activation and optic nerve degeneration in glaucoma.

Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening.

Proteolysis-targeting chimeras (PROTACs) enable the selective and sub-stoichiometric elimination of pathological proteins, yet only two E3 ligases are routinely used for this purpose. Here, we expand the repertoire of PROTAC-compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high-throughput screen. We highlight the utility of this ligand with the synthesis of PROTACs capable of potently degrading BRD4 in cells.

Securing diagonal integration of multimodal single-cell data against ambiguous mapping.

Motivation: Recent advances in single-cell multimodal omics technologies enable the exploration of cellular systems at unprecedented resolution, leading to the rapid generation of multimodal datasets that require sophisticated integration methods. Diagonal integration has emerged as a flexible solution for integrating heterogeneous single-cell data without relying on shared cells or features. However, the absence of anchoring elements introduces the risk of artificial integrations, where cells across modalities are incorrectly aligned due to ambiguous mapping.

Advances in Drug Treatments for Male Patients with Prolactinomas.

Background: Pituitary adenomas (PAs), the most common intracranial neuroendocrine tumors, are typically benign. Among them, prolactinomas - tumors that secrete prolactin - account for approximately 60% of all PAs and are characterized by hyperprolactinemia and potential mass effects. Significant epidemiological and clinical differences exist between male and female prolactinoma patients.

Responsive Metasurface for Directional Control of Laser and Thermal Emission Dynamic Regulation.

Responsive metasurfaces can efficiently control the propagation and spectral properties of electromagnetic (EM) waves, emerging as an attractive technology in energy and information fields. However, achieving non-interference manipulation of near-infrared (NIR) laser wavelength and mid-infrared (MIR) region with spatial and spectral responsive capabilities is a challenging and long-sought task for applications, such as multispectral adaptive camouflage and anti-counterfeiting. Here, a multispectral responsive metasurface is demonstrated that enables independent modulation of MIR thermal emission while maintaining robust, spatially directional control of NIR laser reflections.

Flexible Electro-Driven Nanophotonic Device for Dynamic Radiative Thermoregulation and Energy Storage.

Dynamic thermal management is useful for maintaining personal thermal comfort. However, integrating multifunctionalities into flexible thermal management device remains challenging. Inspired by color modulation mechanisms of cephalopod skin, we demonstrate a flexible electro-driven nanophotonic (FEN) device with dual-functionalities of dynamic radiative thermoregulation and all-time energy supply.

In Vitro and In Vivo Study of Novel PSMA-Targeted Radioligands: Enhancing Tumor Uptake and Therapeutic Efficacy through Zwitterionization and Albumin-Binding Strategies.

Prostate-specific membrane antigen (PSMA) targeted radioligand therapy (TRT) for metastatic castration-resistant prostate cancer has demonstrated significant potential. This study aimed to develop an optimal radiotherapeutic agent suitable for high-level PSMA expression by optimizing the ligand structure with albumin-binding zwitterionic strategies to increase tumor uptake and retention time and to explore the effects of these strategies on the in vitro and in vivo properties of PSMA inhibitors. All precursors were synthesized based on PSMA-targeting agent Flu-1.

Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease.

The role of cell-specific ANGPTL4 is not well known in the context of ECs, specifically in pathological angiogenesis and its relation to diabetic kidney disease. Here, we demonstrate that endothelial ANGPTL4 is required to induce a metabolic phenotype that favors mesenchymal activation in ECs and tubules in diabetic conditions. Diabetes accelerates mesenchymal activation and fibrogenesis in control mice however, the same effects were not observed in endothelial-cell specific knock out mice.