Correction: tRF-1:28-Val-CAC-2 promotes the development of nasopharyngeal cancer by targeting EPHB2.

[This corrects the article DOI: 10.3389/fonc.2025.

Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity.

Cells contain numerous types of membraneless organelles or biological condensates formed via phase separation. Cellular biological condensates have broad material properties ranging from Newtonian fluids to elastic solids. How the material property of a biological condensate is regulated for cellular functions is poorly understood.

Current practices in the study of biomolecular condensates: a community comment.

The realization that the cell is abundantly compartmentalized into biomolecular condensates has opened new opportunities for understanding the physics and chemistry underlying many cellular processes, fundamentally changing the study of biology. The term biomolecular condensate refers to non-stoichiometric assemblies that are composed of multiple types of macromolecules in cells, occur through phase transitions, and can be investigated by using concepts from soft matter physics. As such, they are intimately related to aqueous two-phase systems and water-in-water emulsions.

Modulating synaptic glutamate receptors by targeting network nodes of the postsynaptic density condensate.

Biological condensates are assembled through phase separation and play critical roles in diverse cellular processes. Condensates in cells form percolated molecular networks via multi-valent interactions among biomolecules. How the network properties of a condensate are connected to its biological function is poorly understood.

Berberine for preventing colorectal adenoma recurrence and neoplasm occurrence: 6-Year follow-up of a randomized clinical trial.

Berberine has been reported as a safe and effective pharmacological agent to reduce colorectal adenoma recurrence after polypectomy. This retrospective cohort study is an extended follow-up of a previous clinical trial (NCT02226185) during the post-treatment observational phase. We aim to evaluate the long-term protective effects of berberine on adenoma recurrence.

Association of prenatal exposure to phthalates with risks of asthma, wheeze, and allergic diseases during childhood: a systematic review and meta-analysis.

Background: Phthalates are one of the most common environmental contaminants and endocrine disruptors. Environmental exposure to phthalates may increase the risk for allergic diseases. However, the existing literature presents conflicting findings regarding the long-term impact of early-life exposure to these substances.

Long noncoding RNA FGD5-AS1-encoded micropeptides improve right heart functions of pulmonary arterial hypertension through restricting the synthesis of hyaluronic acid.

Pulmonary arterial hypertension (PAH) is marked by elevated vascular resistance, right ventricular (RV) failure, and poor clinical outcomes. Current therapies primarily target pulmonary vascular hemodynamics, necessitating novel strategies to address RV remodeling. In this study, we investigated the role of lncRNA FGD5-AS1 and its micropeptides in PAH and RV remodeling, focusing on their effects on hyaluronic acid (HA) synthesis and extracellular matrix organization.

Fha initiates the inside-out assembly of the type VI secretion system.

How cells orchestrate the quantity and location while building complex intracellular machinery remains a fundamental biological question. The type VI secretion system (T6SS) is a powerful bacterial apparatus that delivers toxins into a variety of target cells, yet its assembly process is not fully understood. Contrary to the prevailing "outside-in" model, our study reveals a novel "inside-out" assembly mechanism in Acidovorax citrulli, an important plant pathogen.

Depression impact on PTSD in Cancer patients through serial mediation of hope and perceived social support.

Previous studies have only established a strong association between depression and post-traumatic stress disorder in cancer patients, without clarifying the potential mechanisms underlying this relationship. This study examines the relationship between depression and PTSD(Post-Traumatic Stress Disorder) in cancer patients, focusing on the sequential mediation of hope and perceived social support. A cross-sectional study was conducted at oncology wards in an Anhui tertiary hospital between February-August 2024.

Yellow serofluid-inclusion enhanced anaerobic preservation of whole plant maize for subsequently reducing potential methane emission during in vitro ruminal fermentation.

Yellow serofluid, a wine industry by-product, may alter microbial communities, enhance fermentation, and reduce methane emissions from ruminal fermentation. However, the effect of yellow serofluids on silage fermentation and subsequent methane emissions from maize has not been studied. Therefore, this study aims to investigate the effects of yellow serofluid (Y) and Lentilactobacillus buchneri (L) on the silage preservation, bacterial community, and in vitro fermentation of maize.

Styrene-Maleic Acid Copolymer-Based Nanoprobes for Enhanced Boron Neutron Capture Therapy.

: Boron neutron capture therapy (BNCT) is a promising, less-invasive anticancer treatment. However, the development of effective boron-based agents (BNCT probes) remains a critical and challenging issue. Previously, we developed a styrene-maleic acid (SMA) copolymer conjugated with glucosamine, encapsulating boronic acid, which exhibited tumor-targeted distribution via the enhanced permeability and retention (EPR) effect.

Nanoarchitectonics of cobalt/nitrogen-doped carbon with an unbalanced double primitive bicontinuous motif for efficient electrocatalysis.

In virtue of the smooth mass transfer and unique physical properties enabled by the special three-dimensional (3D) interconnected network, bicontinuous porous functional materials have received extensive attention in catalysis, energy conversion, and cargo delivery. However, endowing materials with meticulous inner bicontinuous geometries and achieving precise control over the pore structures remain a huge challenge. Herein, we report a facile heterogeneous interface-induced topological phase transition method to obtain unbalanced double primitive architectural cobalt/nitrogen-doped (Co/N-doped) carbon particles.

Erratum: Three-Dimensional Reconfigurable Optical Singularities in Bilayer Photonic Crystals [Phys. Rev. Lett. 132, 073804 (2024)].

This corrects the article DOI: 10.1103/PhysRevLett.132.

Phase separation instead of binding strength determines target specificities of MAGUKs.

Homologous proteins often have distinct functions, even if they share overlapping binding targets. PSD-95 and MAGI-2, two membrane-associated guanylate kinase (MAGUK)-family scaffolds in neuronal synapses, exemplify this. With unknown mechanisms, the two MAGUKs are localized at distinct subsynaptic compartments with PSD-95 inside the postsynaptic density (PSD) and MAGI-2 outside.

tRF-1:28-Val-CAC-2 promotes the development of nasopharyngeal cancer by targeting EPHB2.

Introduction: Nasopharyngeal carcinoma (NPC) is highly aggressive, with a particularly high incidence in South China. is an aggressive cancer that affects particularly high numbers of patients in southern China and Southeast Asia. The cure rate of previous treatments is decreasing year by year, underscoring the need to devise new approaches to treating affected patients.

Emergent mechanics of a networked multivalent protein condensate.

Multivalent proteins can form membraneless condensates in cells by liquid-liquid phase separation, and significant efforts have been made to study their biochemical properties. Here, we demonstrate the emergent mechanics of a functional multivalent condensate reconstituted with six postsynaptic density proteins, using atomic-force-microscopy-based mesoscale rheology and quantitative fluorescence measurements. The measured relaxation modulus and protein mobility reveal that the majority (80%) of the proteins in the condensate are mobile and diffuse through a dynamically cross-linked network made of the remaining (20%) non-mobile scaffold proteins.

Preoperative Identification of Papillary Thyroid Carcinoma Subtypes and Lymph Node Metastasis via Deep Learning-Assisted Surface-Enhanced Raman Spectroscopy.

Accurate preoperative diagnosis of papillary thyroid carcinoma (PTC) histological subtypes and lymph node metastasis is essential for formulating personalized treatment strategies. However, their preoperative diagnosis is challenged by the limited reliability of cytological identification of histological subtypes and the low accuracy of lymph node detection using ultrasound imaging. Herein, a deep learning-assisted surface-enhanced Raman scattering (SERS) chip is developed for the preoperative diagnosis of PTC histological subtypes and evaluation of lymph node metastasis, using fine-needle aspiration (FNA) samples.

Induction of more severe central sensitization in a medication overuse headache model mice through active ingestion of rizatriptan.

Background: Medication overuse headache (MOH) is a secondary headache disorder arising from excessive use of acute analgesics in patients with primary headache. Current animal models that predominantly employ passive drug administration fail to recapitulate the hallmark feature of voluntary medication-seeking behaviour observed clinically. Therefore, we established a novel MOH mouse model with the active ingestion of rizatriptan (RIZ) to better simulate the clinical characteristics of MOH and explore changes in brain activation patterns.

Extract and Nardosinone Exert Neuroprotective Effects by Suppressing Glucose Metabolic Reprogramming and Modulating T Cell Infiltration.

Background: DC. (Gansong), a widely utilized herb in traditional Chinese medicine, has been historically employed in the management of various neuropsychiatric disorders. Nardosinone (Nar), a sesquiterpenoid compound, has been identified as one of the principal bioactive constituents of .

New chapter in precision medicine: strategies for endoscopic resection of 10-20 mm non-pedunculated colorectal polyps.

The preferred resection methods for 10-20 mm non-pedunculated lesions remain unclear. This review summarizes the current methods and novel technologies for resecting 10-20 mm non-pedunculated colorectal polyps, mainly focusing on hot snare polypectomy, cold snare polypectomy (CSP), endoscopic mucosal resection (EMR), and endoscopic submucosal dissection (ESD). The application of novel techniques involving bipolar snares and low-power pure-cut is expected to reduce adverse events (AEs) related to thermal damage, but prospective studies are needed to confirm their reliability.

Analysis of Bacterial and Metabolic Diversity of Pickles in Different Karst Regions of Guizhou, China.

The unique geographical environment of karst regions provides pickles with a favorable flavor and taste; however, the contribution of the microbial community to pickle fermentation has not been fully explored. In this study, high-throughput sequencing and untargeted metabolomics were used to characterize 60 naturally fermented pickle samples from 12 different karst regions. The bacterial communities and metabolites of naturally fermented pickles changed significantly between different karst regions.

Humoral and Cellular Immune Response to SARS-CoV-2 in Children Undergoing Cardiac Surgery.

Evaluating the impact of cardiac surgery on humoral and cellular immunity in pediatric congenital heart disease patients with prior Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection or vaccination is crucial for postoperative care planning. This study enrolled 61 pediatric patients undergoing cardiac surgery with cardiopulmonary bypass at a single institution. Measurements were taken before the operation, immediately postoperation, and during the first follow-up examination at least 1 month later.

Human gut microbiota adaptation to high-altitude exposure: longitudinal analysis over acute and prolonged periods.

Unlabelled: This study investigated the longitudinal effects of acute (7-day) and prolonged (3-month) high-altitude exposure on gut microbiota in healthy adult males, addressing the limited data available in human populations. A cohort of 406 healthy adult males was followed, and fecal samples were collected at three time points: baseline at 800 m (406 samples), 7 days after ascending to 4,500 m (406 samples), and 2 weeks post-return to 800 m following 3 months at high altitude (186 samples). High-throughput 16S ribosomal DNA sequencing was employed to analyze microbiota composition and diversity.

Discovery of benzethonium chloride as a potent STAT3 inhibitor for the treatment of HNSCC.

Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy with high mortality, and effective treatment strategies remain limited. This study investigated the effects of benzethonium chloride (BZN), an FDA-approved anti-infective agent, on HNSCC cell lines and its underlying mechanisms. BZN significantly inhibited the proliferation of HNSCC cell lines CAL27 and FaDu and induced apoptosis in both cell lines .

The quality of plant-based diets and liver cancer incidence and liver disease mortality in the UK Biobank.

Background & Aims: Plant-based diets have been associated with a lower risk of various chronic diseases. However, their role in preventing liver cancer and liver-related death is currently unclear. We aimed to investigate the association between plant-based diets and the risk of liver cancer incidence and liver disease mortality in the UK Biobank.