Regulation of R-loops by nucleic acid and protein modifications.

R-loop, a three-stranded nucleic acid structure consisting of the RNA:DNA hybrid and the displaced singlestranded DNA, is crucial for many cellular processes but could be a threat to genome integrity if dysregulated. The homeostasis of R-loops is governed by various factors including helicases, nucleases, and chromatin remodelers. Since there are many excellent reviews about R-loops, we focus on discussing how R-loop homeostasis is regulated via nucleic acid and protein modifications.

Dynamic frailty risk prediction in elderly hip replacement: a deep learning approach to personalized rehabilitation.

Background: Osteoarthritis and related degenerative conditions in the elderly often necessitate hip replacement surgery. Frailty is common in this population and significantly increases the risk of postoperative complications and delayed recovery. Accurate prediction of postoperative frailty risk and its temporal progression is essential for guiding personalized rehabilitation strategies.

Incidence and risk factors of active carbapenem-resistant enterobacteriaceae surveillance in hematology patients: a propensity score matching study.

Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) infections pose a significant threat to hematological patients, contributing to high mortality rates. This retrospective study evaluated the incidence, risk factors, and patient outcomes associated with active CRE surveillance in the hematology department.

Methods: The study identified 23,832 hematological patients between 2019 and 2021.

A novel framework integrating GeoAI and human perceptions to estimate walkability in Wuhan, China.

Evidence shows enhanced walking environment promotes overall physical activities and further alleviates the risk of chronic diseases and mental disorders. Current walkability research is limited by traditional GIS methods that fail to capture micro-level details and human perceptions. Additionally, existing image segmentation techniques return low accuracy when extracting complex street environment features.

Development and validation of a novel modified cancer cachexia index in patients with locally advanced gastric cancer undergoing neoadjuvant chemotherapy: a multicenter cohort study.

Background: Although the cachexia index(CXI) is a well established prognostic predictor in gastric cancer(GC) patients, its effectiveness in patients with locally advanced gastric cancer(LAGC) who have undergone neoadjuvant chemotherapy(NACT) remains unclear.

Methods: This multicenter study included 600 LAGC patients treated with NACT from January 2010 to June 2022. A modified CXI was constructed based on Random Forest model, calculated as (post-NACT subcutaneous adipose tissue area at L3) ×(post-NACT serum albumin)/(post-NACT platelet count).

Construction of stable and multifunctional tellurium nanoparticles using chitosan and carbon quantum dots as functional templates.

Herein, chitosan (CS) and carbon quantum dots (CQDs) were chosen to be functional templates to synthesize tellurium nanoparticles (TeNPs) with high stability, antioxidant, and photoluminescence properties. The synergistic interaction between CS and CQDs not only ensured the stable dispersion of TeNPs, achieving a monodisperse state with precisely controlled particle sizes of 2.7 ± 0.

Extranodal diffuse large B-cell lymphoma: Clinical and molecular insights with survival outcomes from the multicenter EXPECT study.

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of aggressive non-Hodgkin's lymphoma with distinct clinical and molecular heterogeneity. DLBCL that arises in extranodal organs is particularly linked to poor prognosis. This study aimed to determine the clinical and molecular characteristics of extranodal involvement (ENI) in DLBCL and assess the actual survival status of the patients.

Dynamic change in Epstein-Barr virus DNA predicts prognosis in early stage natural killer/T-cell lymphoma with pegaspargase-based treatment: long-term follow-up and biomarker analysis from the NHL-004 multicenter randomized study.

The multi-center randomized phase 3 NHL-004 study compared etoposide, dexamethasone and pegaspargase (ESA) versus methotrexate, etoposide, dexamethasone and pegaspargase (MESA) regimen, combined with sandwiched radiotherapy, in newly diagnosed early-stage nasal natural killer/T-cell lymphoma (NKTCL). Here we report the long-term outcomes (median follow-up, 64 months) and biomarker analysis. 256 eligible patients aged 14-70 years were randomly assigned (1:1) to ESA or MESA arm.

Corrigendum: Classification of autism spectrum disorder using electroencephalography in Chinese children: a cross- sectional retrospective study.

[This corrects the article DOI: 10.3389/fnins.2024.

The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation.

RNF214 is an understudied ubiquitin ligase with little knowledge of its biological functions or protein substrates. Here we show that the TEAD transcription factors in the Hippo pathway are substrates of RNF214. RNF214 induces non-proteolytic ubiquitylation at a conserved lysine residue of TEADs, enhances interactions between TEADs and YAP, and promotes transactivation of the downstream genes of the Hippo signaling.

Association between Dietary Inflammatory Index (DII) and sarcopenia in ischemic heart disease: an 1999-2004 NHANES study of 1088 US individuals.

Background: The aim of this study was to investigate the relationship between DII and sarcopenia in individuals with ischemic heart disease (IHD).

Methods: This was a retrospective study utilizing data of the National Health and Nutrition Examination Survey (NHANES) from 1999-2004. Adults aged ≥50 years diagnosed with IHD, having complete 24-hour dietary recall data, and dual energy X-ray absorptiometry (DEXA)-measured muscle mass were eligible for inclusion.

Surface-SOS: Self-Supervised Object Segmentation via Neural Surface Representation.

Self-supervised Object Segmentation (SOS) aims to segment objects without any annotations. Under conditions of multi-camera inputs, the structural, textural and geometrical consistency among each view can be leveraged to achieve fine-grained object segmentation. To make better use of the above information, we propose Surface representation based Self-supervised Object Segmentation (Surface-SOS), a new framework to segment objects for each view by 3D surface representation from multi-view images of a scene.

Classification of autism spectrum disorder using electroencephalography in Chinese children: a cross-sectional retrospective study.

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by diverse clinical features. EEG biomarkers such as spectral power and functional connectivity have emerged as potential tools for enhancing early diagnosis and understanding of the neural processes underlying ASD. However, existing studies yield conflicting results, necessitating a comprehensive, data-driven analysis.

Spatiotemporal characteristic analysis of PM in central China and modeling of driving factors based on MGWR: a case study of Henan Province.

Since the start of the twenty-first century, China's economy has grown at a high or moderate rate, and air pollution has become increasingly severe. The study was conducted using data from remote sensing observations between 1998 and 2019, employing the standard deviation ellipse model and spatial autocorrelation analysis, to explore the spatiotemporal distribution characteristics of PM in Henan Province. Additionally, a multiscale geographically weighted regression model (MGWR) was applied to explore the impact of 12 driving factors (e.

Targeting nucleolin improves sensitivity to chemotherapy in acute lymphoblastic leukemia.

Purpose: Most patients with acute lymphoblastic leukemia (ALL) are treated with chemotherapy as primary care. Although the treatment response is usually positive, resistance and relapse often occur via unknown mechanisms. The purpose of this study was to identify factors associated with chemotherapy resistance in ALL.

[A Retrospective Study on the Efficacy and Safety of Idarubicin Combined with High-Dose Cytarabine Consolidation in Patients with Acute Myeloid Leukemia over 60 Years of Age in First Remission].

Objective: To evaluate the efficacy and safety of idarubicin combined with high-dose cytarabine as a post-remission therapy for elderly patients with acute myeloid leukemia (AML).

Methods: From November 2017 to June 2021, 24 AML patients aged ≥60 years who were in complete remission for the first time were enrolled in consolidation chemotherapy with idarubicin (10 mg/m intravenously once for day 1) combined with high-dose cytarabine (1.5 g/m intravenously over 3 hours every 12 hours for day 1-3), and the efficacy and safety were observed.

Etoposide, dexamethasone, and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma: A randomized phase III study.

Methotrexate, etoposide, dexamethasone, and pegaspargase (MESA) with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma, nasal type (NKTCL). We explored the efficacy and safety of reduced-intensity, non-intravenous etoposide, dexamethasone, and pegaspargase (ESA) with sandwiched radiotherapy. This multicenter, randomized, phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.

Association between diet quality scores and risk of overweight and obesity in children and adolescents.

Background: This study examined the associations of diet quality assessed by Healthy Eating Index 2015 (HEI-2015), Alternative Healthy Eating Index 2010 (AHEI-2010), Mediterranean Diet (MedDiet) and overweight/obesity in children and adolescents.

Methods: This cross-sectional study used data of participants aged 2-19 years from National Health and Nutrition Examination Survey (NHANES) 2005-2018. The weighted logistic regression model was adopted to explore the association between diet quality scores and overweight, obesity in children and adolescents.

Histone H2A monoubiquitination marks are targeted to specific sites by cohesin subunits in Arabidopsis.

Histone H2A monoubiquitination (H2Aub1) functions as a conserved posttranslational modification in eukaryotes to maintain gene expression and guarantee cellular identity. Arabidopsis H2Aub1 is catalyzed by the core components AtRING1s and AtBMI1s of polycomb repressive complex 1 (PRC1). Because PRC1 components lack known DNA binding domains, it is unclear how H2Aub1 is established at specific genomic locations.

Association of iKIR-mismatch model and donor aKIRs with better outcome in haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia.

Objectives: Killer cell immunoglobulin like receptor (KIR) can trigger the alloreactivity of NK cells. However, there is no clear consensus as to their function. Here, we investigated the potential influence of KIR mismatch and KIR alleles on the outcome of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in acute myeloid leukemia (AML) patients.

Impact of resistance exercise rehabilitation and whey protein supplementation in elderly patients with heart failure with preserved ejection fraction with sarcopenia: a study protocol for a randomised controlled trial.

Introduction: Heart failure with preserved ejection fraction (HFpEF) affects more than half of the patients with heart failure. HFpEF and sarcopenia can interact with each other and contribute to reduced physiological function and increased mortality in elderly patients. Resistance training (RT) or resistance exercise rehabilitation (RER) may have benefits for elderly HFpEF patients with sarcopenia.

Triterpenoids from the genus Ilex attenuate free fatty acid-induced lipid accumulation in HepG2 cells by regulating lipid metabolism disorder and the AMPK signalling pathway.

Ethnopharmacological Relevance: Various traditional Chinese medicines from the genus Ilex (Aquifoliaceae) have been reported to have excellent hypolipidaemic effects. Although triterpenoids have been found to be the main active components, the underlying mechanisms have not been clarified.

Aim Of The Study: This study aimed to investigate the lipid-lowering effect, structure-activity relationship and action mechanism of triterpenoids from the genus Ilex.