Beyond Regional Boundaries: Insights From ICU Nursing Practices in Western China to Advance Global Strategies Patient Experience Strategies.

Background: As front-line caregivers in high-risk settings, intensive care unit (ICU) nurses worldwide play a pivotal role in redefining patient-centered critical care. Their daily practices not only influence individual patient outcomes and experiences but also provide transferable insights that can inform evidence-based and humanistic models of care. By examining how ICU nurses improve patient experiences-through structured communication frameworks, family engagement protocols, and innovative approaches to pain management-we can integrate these strategies into clinical workflows, professional education, and policy development.

Microbial diversity and function in bamboo ecosystems.

Bamboo is widely distributed or cultivated globally, offering significant economic and ecological values. Soil microorganisms are crucial for plant environmental adaptation, playing essential roles in regulating plant growth and development, nutrient absorption, and resistance to environmental stresses. In recent years, substantial progress has been made in the study of bamboo soil microorganisms.

Different prefrontal cortex activity patterns in bipolar and unipolar depression during verbal fluency tasks based on functional near infrared spectroscopy study.

This study aimed to investigate the functionality of the prefrontal cortex in patients with unipolar depression (UD) and bipolar depression (BD) using functional near-infrared spectroscopy (fNIRS) during a verbal fluency task (VFT). Additionally, it evaluated the reliability of fNIRS as a diagnostic tool for cognitive assessments through a deep learning approach using one-dimensional convolutional networks. The study included 73 patients with UD, 59 patients with BD, and 40 healthy controls (HC).

Big team science reveals promises and limitations of machine learning efforts to model physiological markers of affective experience.

Researchers are increasingly using machine learning to study physiological markers of emotion. We evaluated the promises and limitations of this approach via a big team science competition. Twelve teams competed to predict self-reported affective experiences using a multi-modal set of peripheral nervous system measures.

Generalized anxiety disorder patients' cognitive control in affective contexts.

Background: Growing evidence suggests a relationship between deficits in cognitive control and anxiety. However, studies examining cognitive control within affective contexts (affective control) are limited, and the specific characteristics of affective control in patients with Generalized Anxiety Disorder (GAD) remain unclear. This study investigated whether differences exist in cognitive control under affective contexts.

[Lycopene ameliorates D-galactose-induced hepatic senescence in CD-1 female mice through fibroblast growth factor 21/mitochondrial dynamics mediation].

Objective: Evaluation of whether lycopene(LYC)ameliorates D-galactose-induced liver senescence and its associated molecular mechanisms.

Methods: Forty-five 2-month-old female CD-1 mice were acclimatized and fed for 1 week and randomly divided into 3 groups(15 mice/group): Control group receiving 0.9% physiological saline(intraperitoneally injected, i.

Effectiveness of ultrasound-guided versus anatomical landmark-guided percutaneous dilatational tracheostomy: a systematic review and meta-analysis.

Background: Percutaneous dilatational tracheostomy (PDT) is increasingly used in intensive care units owing to its advantages of reduced surgical trauma and fewer complications. Recently, ultrasonography has become a potentially useful tool for assisting PDT.

Objective: To compare ultrasound- and landmark-guided PDT for major bleeding, first-puncture success rates, periprocedural complications, and tracheotomy procedure times.

Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation.

Impaired differentiation is a hallmark of myeloid malignancies. Therapies that enable cells to circumvent the differentiation block, such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), are by and large curative in acute promyelocytic leukaemia, but whether 'differentiation therapy' is a generalizable therapeutic approach for acute myeloid leukaemia (AML) and beyond remains incompletely understood. Here we demonstrate that simultaneous inhibition of the histone demethylase LSD1 (LSD1i) and the WNT pathway antagonist GSK3 kinase (GSK3i) robustly promotes therapeutic differentiation of established AML cell lines and primary human AML cells, as well as reducing tumour burden and significantly extending survival in a patient-derived xenograft mouse model.

Prognosis of non-albuminuric patients with the cardiovascular-kidney-metabolic syndrome.

Background: Cardiovascular-kidney-metabolic (CKM) syndrome affects a significant portion of the general population. Urinary albumin-to-creatinine ratio (UACR) is an important indicator of kidney injury. While some studies have indicated associations between UACR within the normal range and mortality outcomes, it remains uncertain whether traditionally normal UACR could help to distinguish the prognosis of CKM patients.

Diffusion Models in Low-Level Vision: A Survey.

Deep generative models have gained considerable attention in low-level vision tasks due to their powerful generative capabilities. Among these, diffusion model-based approaches, which employ a forward diffusion process to degrade an image and a reverse denoising process for image generation, have become particularly prominent for producing high-quality, diverse samples with intricate texture details. Despite their widespread success in low-level vision, there remains a lack of a comprehensive, insightful survey that synthesizes and organizes the advances in diffusion model-based techniques.

Summary of the best evidence for the management of kinesiophobia in patients after cardiac surgery.

Background: This study aimed to systematically search for relevant evidence on the management of kinesiophobia in patients after cardiac surgery both home and abroad. The evidence was evaluated and integrated to provide reference for clinical practice.

Methods: According to the '6S' evidence pyramid model, evidence related to managing kinesiophobia in patients after cardiac surgery were systematically searched from relevant domestic and foreign guideline websites and professional association websites and databases from the date of their establishment to December 31, 2024.

Functional near-infrared spectroscopy (fNIRS) in patients with major depressive disorder, generalized anxiety disorder and their comorbidity: Comparison with healthy controls.

Background: This study aimed to investigate prefrontal function in patients with generalized anxiety disorder (GAD), major depressive disorder (MDD), and the comorbidity of MDD and GAD (CMG), using the fNIRS-VFT task. And to assess the reliability of functional near-infrared spectroscopy (fNIRS) devices as a clinical aid for diagnostic tools when performing cognitive tasks by building a deep neural network.

Methods: Including 75 patients with GAD, 75 patients with MDD, 71 patients with CMG, and 75 healthy controls (HC).

Performance evaluation of a machine learning-based methodology using dynamical features to detect nonwear intervals in actigraphy data in a free-living setting.

Goal And Aims: One challenge using wearable sensors is nonwear time. Without a nonwear (e.g.

Application of Gamification Teaching in Disaster Education: Scoping Review.

Background: With climate change, the number of natural disasters is increasing globally, and the resulting weather-related events lead to increased loss of life and property. Meanwhile, the significance of disaster education is becoming increasingly important. Despite natural disasters being hard to predict, people's responses to such events can be improved by education and training.

Enabling personalized smart tourism with location-based social networks.

With the rapid advance of mobile internet, communication technology and the Internet of Things (IoT), the tourism industry is undergoing unprecedented transformation. Smart tourism offers users personalized and customized services for travel planning and recommendations. Location-based social networks (LBSNs) play a crucial role in smart tourism industry by providing abundant data sources through their social networking attributes.

Hyaluronic Acid-Nanocoated Bacteria Generate an Anti-Inflammatory Tissue-Repair Effect in Impaired Gut and Extraintestinal Organs.

Diverse extraintestinal diseases are characterized by localized inflammatory responses and tissue damage, accompanied with intestinal inflammation and injury. Here, a dual-functionality and dual-location intervention strategy is reported, which is the use of hyaluronic acid-nanocoated Clostridium butyricum to generate an anti-inflammatory tissue-repair effect in the impaired gut and extraintestinal organs. Nanocoated bacteria attenuate intestinal mucosal inflammation and recover gut barrier integrity by leveraging the immunosuppressive nature of hyaluronic acid and the butyrate-producing ability of Clostridium butyricum.

Association between insulin resistance indices and kidney stones: results from the 2015-2018 National Health and Nutrition Examination Survey.

Objective: To explore the association between representative insulin resistance (IR) indices and the risk of kidney stone disease in an American adult population. The representative IR indices referred to metabolic score for IR (METS-IR), triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, triglyceride glucose-body mass index (TyG-BMI), visceral adiposity index (VAI), and homeostatic model assessment of IR (HOMA-IR).

Methods: We investigated adult participants who joined the 2015-2018 National Health and Nutrition Examination Survey (NHANES) and reported kidney stone histories.

Copper aggravated synaptic damage after traumatic brain injury by downregulating BNIP3-mediated mitophagy.

Synaptic damage is a crucial pathological process in traumatic brain injury. However, the mechanisms driving this process remain poorly understood. In this report, we demonstrate that the accumulation of damaged mitochondria, resulting from impaired mitphagy, plays a significant role in causing synaptic damage.

Lycopene attenuates D-galactose-induced memory and behavioral deficits by mediating microbiota-SCFAs-gut-brain axis balance in female CD-1 mice.

Aging impairs cognitive function, whereas nutritional intervention can delay aging and age-related diseases. Lycopene (LYC), a naturally occurring carotenoid, posses multiple health-promoting properties, including neuroprotective function. Here, the effects of LYC on memory and behavioral deficits induced by D-galactose (D-gal) treatment and the relative contribution of LYC-derived gut microbiota in these process were investigated.

Lycopene alleviates age-related cognitive deficit via activating liver-brain fibroblast growth factor-21 signalling.

Brain function is linked with many peripheral tissues, including the liver, where hepatic fibroblast growth factor 21 (FGF21) mediates communication between the liver and brain. Lycopene (LYC), a naturally occurring carotenoid, posses multiple health-promoting properties, including neuroprotective function. Here, we investigated the effects of LYC on age-related memory impairment and the relative contribution of liver-brain FGF21 signaling in these process.

Kinesiophobia in patients after cardiac surgery: a scoping review.

Background: This paper reviews the scope of research on kinesiophobia in patients after cardiac surgery. Further, it reviews the current situation, evaluation tools, risk factors, adverse effects, and intervention methods of kinesiophobia to provide a reference for promoting early rehabilitation of patients after cardiac surgery.

Methods: Guided by the scoping methodology, the Web of Science, PubMed, CINAHL, Cochrane Library, China Biomedical Literature Database, VIP Database, Wanfang Database, CNKI, and other databases were searched from database inception until July 31, 2024.

Gene therapy in Aβ-induced cell and mouse models of Alzheimer's disease through compensating defective mitochondrial complex I function.

Background: Alzheimer's disease (AD) is the most common neurogenerative disorder without effective treatments. Defects in mitochondrial complex I are thought to contribute to AD pathogenesis. The aim of this study is to explore whether a novel gene therapy transducing yeast complex I gene NDI1 can be used to treat AD with severely reduced complex I function in cell and animal models.