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http://dx.doi.org/10.1161/CIRCRESAHA.125.326823 | DOI Listing |
Circ Res
September 2025
MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Birmingham, United Kingdom. (Y.S., A.O.K.).
J Hazard Mater
August 2025
Department of Biomedical Sciences, University of Lausanne, Rue du Bugnon 7, Lausanne 1005, Switzerland; Swiss Centre for Applied Human Toxicology (SCAHT), Basel, Switzerland. Electronic address:
The global rise of environmental contaminants (ECs), including microplastics, heavy metals, pesticides, and drugs, poses an urgent threat to human health. Traditional toxicological models often fail to replicate human-specific responses, delaying effective risk assessment and regulation. Conversely, human organoid models represent a breakthrough in environmental health research by offering unprecedented physiological relevance.
View Article and Find Full Text PDFInt J Biol Macromol
July 2025
Department of Medical Laboratories, College of Applied Medical Sciences, Shaqra University, Shaqra 11961, Saudi Arabia.
Despite significant advances in cancer immunotherapy, current approaches face critical limitations, including systemic toxicity, inadequate tumor penetration, and insufficient therapeutic efficacy against immunosuppressive tumor microenvironments. A significant research gap exists in developing platforms that can simultaneously address these challenges while providing real-time monitoring capabilities. We critically analyze recent innovations in scaffold-based delivery systems that enable the controlled release of immunomodulatory agents directly within tumor microenvironments, thereby minimizing systemic exposure and associated toxicities.
View Article and Find Full Text PDFAgeing Res Rev
December 2024
Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China; Hunan Provincial Key Laboratory of Complex Effects Analysis for Chinese Patent Medic
Front Endocrinol (Lausanne)
May 2023
Botnar Institute for Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
Introduction: For decades, functional primary human osteocyte cultures have been crucially needed for understanding their role in bone anabolic processes and in endocrine phosphate regulation via the bone-kidney axis. Mature osteocyte proteins (sclerostin, DMP1, Phex and FGF23) play a key role in various systemic diseases and are targeted by successful bone anabolic drugs (anti-sclerostin antibody and teriparatide (PTH1-34)). However, cell lines available to study osteocytes produce very little sclerostin and low levels of mature osteocyte markers.
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