Publications by authors named "Nemo Ikonen"
Impaired differentiation is a hallmark of myeloid malignancies. Therapies that enable cells to circumvent the differentiation block, such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), are by and large curative in acute promyelocytic leukaemia, but whether 'differentiation therapy' is a generalizable therapeutic approach for acute myeloid leukaemia (AML) and beyond remains incompletely understood. Here we demonstrate that simultaneous inhibition of the histone demethylase LSD1 (LSD1i) and the WNT pathway antagonist GSK3 kinase (GSK3i) robustly promotes therapeutic differentiation of established AML cell lines and primary human AML cells, as well as reducing tumour burden and significantly extending survival in a patient-derived xenograft mouse model.
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- The study addresses the challenge of treating advanced cancers, where cellular diversity requires therapies targeting multiple cancer cell populations.* -
- A machine learning tool called scTherapy uses single-cell transcriptomic data to identify personalized multi-targeting treatment options for patients with various cancers, like acute myeloid leukemia and ovarian carcinoma.* -
- Results show that 96% of the proposed treatments are effective and selective for cancer cells, with 83% having low toxicity to healthy cells, suggesting a promising avenue for safer and more effective cancer therapies.*
Monosomy 7 and del(7q) (-7/-7q) are frequent chromosomal abnormalities detected in up to 10% of patients with acute myeloid leukemia (AML). Despite unfavorable treatment outcomes, no approved targeted therapies exist for patients with -7/-7q. Therefore, we aimed to identify novel vulnerabilities.
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