SLAMF7 regulates goblet cell mucus production and negatively impacts gut homeostasis and commensalism.

Crosstalk between the intestinal mucosal barrier and the gut microbiota contributes to maintaining intestinal homeostasis. Accumulating evidence suggests that diverse mechanisms are involved in maintaining intestinal homeostasis. Any disturbance in these pathways can compromise gut homeostasis and trigger chronic inflammatory diseases such as inflammatory bowel disease (IBD).

[Dahuang Zhechong Pills delay heart aging by reducing cardiomyocyte apoptosis via PI3K/AKT/HIF-1α signaling pathway].

This study aimed to investigate the effect of Dahuang Zhechong Pills(DHZCP) in delaying heart aging(HA) and explore the potential mechanism. Network pharmacology and molecular docking were employed to explore the targets and potential mechanisms of DHZCP in delaying HA. Furthermore, in vitro experiments were conducted with the DHZCP-containing serum to verify key targets and pathways in D-galactose(D-gal)-induced aging of cardiomyocytes.

[Network pharmacology and animal experiments reveal molecular mechanisms of Cordyceps sinensis in ameliorating heart aging and injury in mice by regulating Nrf2/HO-1/NF-κB pathway].

This study aims to explore the effects and mechanisms of the traditional Chinese medicine Cordyceps sinensis(CS) in ameliorating heart aging and injury in mice based on animal experiments and network pharmacology. A mouse model of heart aging was established by continuously subcutaneous injection of D-galactose(D-gal). Thirty mice were randomly assigned into a normal group, a model group, a low-dose CS(CS-L) group, a high-dose CS(CS-H) group, and a vitamin E(VE) group.

[Non-targeted renal metabolomics reveals multi-target effects of Dahuang Zhechong Pills on renal aging in rats].

This study aims to observe the effects of the traditional Chinese medicine prescription Dahuang Zhechong Pills(DHZCP on renal aging and explore its potential multi-target effects. Rats were assigned into the normal, model, DHZCP, and vitamin E(VE)groups. Firstly, the rat model of D-galactose(D-gal)-induced renal aging was established.

Inhibition of microbially mediated total organic carbon decomposition in different types of cadmium contaminated soils with wheat straw addition.

Wheat straw returning is a common agronomic measure in the farmland. Understanding organic carbon transformation is of great significance for carbon budget under the premise of widespread distribution of cadmium (Cd) contaminated soils. An incubation experiment was conducted to assess the influence of Cd contamination on the decomposition and accumulation of total organic carbon (TOC) as well as the composition and abundance of bacterial communities in eight soil types with wheat straw addition.

Neurologic music therapy for non-fluent aphasia: a systematic review and meta-analysis of randomized controlled trials.

Introduction: The efficacy of neurologic music therapy (NMT) techniques for the treatment of non-fluent aphasia has been widely accepted by the rehabilitation medical community. However, consensus on which dimensions of speech function can be improved by NMT techniques and standardized intervention dosage remains elusive. This study aimed to provide evidence regarding the efficacy of NMT in improving speech function and explore the optimal intervention dose.

Role of N-acetylkynurenine in mediating the effect of gut microbiota on urinary tract infection: a Mendelian randomization study.

Introduction: This study explored the causal connections between gut microbiota (GM), urinary tract infection (UTI), and potential metabolite mediators using Mendelian randomization (MR).

Methods: We utilized summary statistics from the most comprehensive and extensive genome-wide association studies (GWAS) available to date, including 196 bacterial traits for GM, 1,091 blood metabolites, 309 metabolite ratios, alongside UTI data from ukb-b-8814 and ebi-a-GCST90013890. Bidirectional MR analyses were conducted to investigate the causal links between GM and UTI.

Identification of the soil physicochemical and bacterial indicators for soil organic carbon and nitrogen transformation under the wheat straw returning.

Wheat straw returning is widely practiced in agriculture; therefore, it is critical to determine the physicochemical and bacterial indicators in soil for the organic carbon storage, accumulative C mineralization, total nitrogen improvement, and nitrogen mineralization in various soil types after wheat straw returning. This study evaluated the influenced indicators of wheat straw addition on soil organic carbon and nitrogen transformation in diverse soil types. For this purpose, an incubation experiment was conducted to analyze the carbon and nitrogen transformation in soil from eight Chinese provinces treated with the same dry weight of wheat straw.

High-throughput mutagenesis and screening approach for the identification of drug-resistant mutations in the rifampicin resistance-determining region of mycobacteria.

Rifampicin is the most powerful first-line antibiotic for tuberculosis, which is caused by Mycobacterium tuberculosis. Although accumulating evidence from sequencing data of clinical M. tuberculosis isolates suggested that mutations in the rifampicin-resistance-determining region (RRDR) are strongly associated with rifampicin resistance, the comprehensive characterisation of RRDR polymorphisms that confer this resistance remains challenging.

Experience of rehabilitation specialist nurses in providing bowel care for stroke patients: A qualitative study.

Aims: This study aims to explore the experiences of rehabilitation specialist nurses in providing bowel care to stroke patients and to identify the factors that either facilitate or hinder their practice.

Design: This was a descriptive qualitative design study.

Methods: Between May 2022 and October 2022, we conducted in-depth and semi-structured interviews with 12 rehabilitation specialist nurses from two tertiary hospitals in Changsha, China.

Effectiveness and safety of digital rectal stimulation and abdominal massage for neurogenic bowel dysfunction in stroke patients: a randomized controlled trial protocol.

Background: Neurogenic bowel dysfunction (NBD) is a prevalent complication among stroke patients, significantly affecting their quality of life, duration of hospitalization, medical expenses, and even mortality. Although current guidelines suggest a conservative strategy for addressing bowel dysfunction, which includes techniques such as digital rectal stimulation (DRS) and abdominal massage, the availability of interventions remains limited in healthcare facilities.

Methods: This study follows a prospective randomized controlled parallel-group clinical trial design.

Effects of a Modified Six-Sigma-Methodology-Based Training Program on Core Competencies in Rehabilitation Nurse Specialists.

Purpose: Nurses play an important role in ensuring patient rehabilitation and are involved in all aspects of multidimensional rehabilitation. Therefore, strengthening rehabilitation nursing education is vital to ascertain high-quality rehabilitation and optimum outcomes. This study examined the effectiveness of a new teaching reform-a modified Six-Sigma-based training program-against a conventional educational program on rehabilitation specialist nurses' core competencies, post-training performance, and satisfaction.

Synthesis and in vitro cytotoxicity study of three di-organotin(IV) Schiff base di-acylhydrazone complexes.

Three di-organotin(IV) complexes have been synthesized by the reaction of Schiff base di-acylhydrazone ligands bis(5-chlorosalicylaldehyde) adipoylhydrazone and RSnCl [R = Me (1), Ph (2), n-Bu (3)]. Structures of all complexes were characterized by H, C, Sn NMR, elemental analysis, IR and mass spectrometry. Experimental results showed that the symmetric diacylhydrazone ligands coordinate the tin atom in a hexadentate form, where the tin atom shows a penta-coordination, in a distorted triangular bipyramid geometry.

Influence of Psychological Nursing Procedure on Negative Emotion, Stress State, Quality of Life and Nursing Satisfaction in Patients with Lung Cancer Radical Operation.

Objective: To discuss the influence of psychological nursing procedure on negative emotion, stress state, quality of life and nursing satisfaction in patients with lung cancer radical operation.

Methods: 106 patients with lung cancer who underwent radical resection in our hospital from September 2019 to September 2021 were selected. According to the intervention time, patients were divided into Group A and Group B, with 53 cases in each group.

A Cyclin D1-Specific Single-Chain Variable Fragment Antibody that Inhibits HepG2 Cell Growth and Proliferation.

Cyclin D1 is a key regulatory factor of the G1 to S transition during cell cycle progression. Aberrant cyclin D gene amplification and abnormal protein expression have been linked to hepatocellular carcinoma (HCC) tumorigenesis. Intrabodies, effective anticancer therapies that specifically inhibit target protein function within all intracellular compartments, may block cyclin D1 function.

Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis.

Acetaminophen (APAP) overdose has become the most common cause of drug-induced acute liver failure. Angiogenesis and redox homeostasis play an important role in liver protection and repair of APAP-induced acute liver injury (AILI). Hypoxia inducible factor-1 (HIF-1) is a transcription factor that plays a crucial role in regulating the expression of genes associated with angiogenesis, redox homeostasis and energy balance.

POZ/BTB and AT-Hook-Containing Zinc Finger Protein 1 (PATZ1) Suppresses Progression of Ovarian Cancer and Serves as an Independent Prognosis Factor.

BACKGROUND The POZ/BTB and AT-hook-containing Zinc finger protein 1 (PATZ1) is a ubiquitously expressed transcription factor belonging to the POZ domain Krüppel-like zinc finger (POK) family. It is involved in the pathogenesis of a growing list of human diseases, including cancer. The effect of PATZ1 on serous ovarian carcinoma (SOC) remains unclear.

A linear tetranuclear single-molelcule magnet of Mn(II)(2)Mn(III)(2) with the anion of 2-(Hydroxymethyl)pyridine.

A tetranuclear manganese complex, [Mn(4)(hmp)(6)(N(CN)(2))(4)(H(2)O)(2)] [1; Hhmp = 2-(hydroxymethyl)pyridine; N(CN)(2)(-) = dicyanamide anion], was synthesized and characterized by single-crystal X-ray diffraction, bond valence sum calculations, IR spectra, elemental analysis, and magnetic measurements. The structure of 1 consists of a linear [Mn(II)(2)Mn(III)(2)] core formed by six hmp(-) groups linking Mn(II/III) ions. Magnetic studies show that 1 behaves as a single-molecule magnet with ferromagnetic coupling between the metal centers.

Bis[aqua-(2,3-naphtho-15-crown-5)sodium] tetra-kis(thio-cyanato-κN)cobaltate(II).

The title complex, [Na(C(18)H(22)O(5))(H(2)O)](2)[Co(NCS)(4)], consists of two aqua-(2,3-naphtho-15-crown-5)sodium complex cations and one [Co(NCS)(4)](2-) complex anion, which has crystallographic symmetry. In the anion, the Co(II) centre is coordinated by the N atoms of four NCS(-) ligands in a distorted tetra-hedral geometry. In the complex cations, the Na(I) centre is coordinated by five O atoms of the 2,3-naphtho-15-crown-5 ligand and one water O atom.

(Pyridino-15-crown-5-κN,O,O',O'',O''')bis-(thio-cyanato-κN)manganese(II).

The title complex, [Mn(NCS)(2)(C(13)H(19)NO(4))] {systematic name: [3,6,9,12-tetra-oxa-18-aza-bicyclo-[12.3.1]octa-cosa-14(18),15,17-triene-κ(5)N,O,O',O'',O''']bis-(thio-cyanato-κN)manganese(I-I)}, was obtained by the reaction of MnCl(2)·4H(2)O and NaSCN with pyridino-15-crown-5.

catena-Poly[[nickel(II)-μ(3)-1,1-dicyano-ethene-2,2-dithiol-ato-κS,S':N:N'-bis-[(15-crown-5)magnesium(II)]-μ(3)-1,1-dicyano-ethene-2,2-dithiol-ato-κN:N':S,S'] dichloride].

The reaction of MgCl(2), NiCl(2), and Na(2)(i-mnt) (i-mnt is 1,1-dicyano-thene-2,2-dithiol-ate) with 15-crown-5 (15-C-5) leads to an infinite chain polymer, {[NiMg(2)(C(4)N(2)S(2))(2)(C(10)H(20)O(5))(2)]Cl(2)}(n) or {[Mg(15-C-5)](2)[Ni(i-mnt)(2)]Cl(2)}(n), which consists of two [Mg(15-C-5)](2+) complex cations, one [Ni(i-mnt)(2)](2-) complex anion and two Cl(-) ions per formula unit. In the [Ni(i-mnt)(2)](2-) complex anion, Ni(2+) is located on a crystallographic mirror plane with a slightly distorted square-planar coordination by four S atoms. In the [Mg(15-C-5)](2+) complex cations, the Mg and one O atom of the crown lie on mirror planes and the Mg atoms are in sevenfold coordination environments of five O atoms from the crown and two N atoms from two i-mnt anions.