Harnessing the FXII-Fibrin-Fibroblast Cascade to Overcome the "Inert Hard Implant-Active Soft Tissue Integration Conflict".

Inert hard implant materials, known for their minimal interaction with host tissues, are widely applied in biomedical areas. However, these "rigid, inert" devices usually require integration with surrounding "soft, active" tissues. Divergent clinical outcomes of soft tissue integration yielded by congeneric inert materials call for a reinterpretation of the "inertness", and warrant a fresh look at the mechanisms of inert implant-mediated host responses.

Neutrophil Extracellular Traps Induce Pyroptosis of Gingival Fibroblasts in Peri-Implantitis.

Objectives: This study aimed to verify the release of neutrophil extracellular traps (NETs) in peri-implantitis and explore whether NETs induce pyroptosis and inflammatory responses in human gingival fibroblasts (HGFs).

Materials And Methods: Peri-implant soft tissue samples were collected from healthy individuals and patients with peri-implantitis. NETs and the expression of pyroptosis-related factors including NLRP3, Caspase1, GSDMD, and IL-1β were detected.

Glossary of Computer-Assisted Implant Surgery and Related Terms. First Edition.

The rapid development of computer-assisted implant surgery (CAIS) and the respective research and clinical applications have necessitated a standardization of the terminology related not only to different devices, but also the different steps involved, surgical and presurgical procedures. The present glossary was introduced at the 1st International Team for Implantology Symposium on Computer-assisted Implant Surgery, based on the collective work of clinicians and researchers with deep understanding and experience in these technologies. The glossary was further refined and revised through the structured input of a large group of global experts within clinical application, research, and education of CAIS.

Expert consensus on peri-implant keratinized mucosa augmentation at second-stage surgery.

Peri-implant keratinized mucosa (PIKM) augmentation refers to surgical procedures aimed at increasing the width of PIKM. Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-term peri-implant health. Currently, several surgical techniques have been validated for their effectiveness in increasing PIKM.

Comparison of photogrammetric imaging, intraoral scanning and conventional impression accuracy of full-arch dental implant rehabilitation: an in vitro study.

Background: To compare the accuracy of photogrammetric imaging, intraoral scanning and conventional impression technique in full-arch dental implant rehabilitation.

Methods: A resin edentulous mandibular model with six parallel implants was fabricated as master model. And three impression groups were performed: conventional splinted open tray impression technique (CON, n = 10); intraoral scanning technique with 3 Shape scanner (IOS, n = 10; TRIOS3, 3 Shape); digital photogrammetry impression technique with two different photogrammetric system namely PG-1 (Icam4D) and PG-2 (PIC) groups (n = 10).

Beyond Accuracy: Clinical Outcomes of Computer Assisted Implant Surgery.

Objectives: Computer Assisted Implant Surgery (CAIS) with different technologies and modalities is becoming increasingly utilized in clinical practice. The aim of this White Paper was to synthesize evidence, reported experience, and best practices with regard to clinically relevant outcomes of static, dynamic, and robotic CAIS.

Materials And Methods: A review of the literature compiled existing evidence from clinical studies up to November 2024, which was later discussed and synthesized into clinically relevant questions with a panel of international experts.

Fluorine-Incorporated Biogenic Hydroxyapatite Enhances Socket Bone Healing via Addressing Macrophage-Mediated Inflammatory Response.

Biological hydroxyapatite (BHA) has been extensively employed in alveolar socket preservation, yet its clinical application is often compromised by delayed bone healing triggered by macrophage-mediated pro-inflammatory responses. Building upon our previous work, in which we successfully incorporated fluorine into BHA to develop fluorinated biogenic hydroxyapatite (FBHA) with superior physicochemical and biological properties, this study systematically investigated the effects of fluorine doping on macrophage-mediated osteoimmunomodulation and socket bone healing. The synthesized FBHA was characterized using SEM, EDS, and fluoride ion release assays to confirm fluorine incorporation.

New insights into the adaptation mechanism of Cardisoma armatum hepatopancreas in the terrestrial environment by transcriptome analysis.

As a typical species of Gecarcinidae, Cardisoma armatum has adapted to the terrestrial environment. Meanwhile, C. armatum with unique living habits provides an excellent model for exploring the terrestrial adaptation mechanism of crabs.

Precise multi-factor immediate implant placement decision models based on machine learning.

This study aims to explore the effect of implant apex design, osteotomy preparation, intraosseous depth and bone quality on immediate implant placement insertion torque and establish a more sophisticated decision model with multi-factor analysis based on machine learning for improving the success rate of immediate implant placement. Six implant replicas of each of the three implant systems with different implant apex design were placed in polyurethane foam block with different densities(soft, medium and hard) via two osteotomy preparation protocols (normal preparation and undersized preparation) at different implant intraosseous depths (3 mm, 5 mm and 7 mm). The insertion torque for each implant was recorded and subsequently analyzed using one-way and four-way ANOVA.

Dipyridamole Attenuates Experimental Periodontitis by Regulating M1 Macrophage Polarization via PKA/PKG Pathways.

Aim: Periodontitis is a chronic inflammatory disease initiated by dysbiosis of the local microbial community. As a non-specific phosphodiesterase inhibitor, dipyridamole features anti-oxidant and anti-inflammatory properties. This study aimed to investigate the effects of dipyridamole in an experimental rat model of periodontitis.

Fluorinated Porcine Bone-Derived Hydroxyapatite Promotes Vascularized Osteogenesis by Coordinating Human Bone Marrow Mesenchymal Stem Cell/Human Umbilical Vein Endothelial Cell Complexes.

Biogenic hydroxyapatite is known for its osteoinductive potential due to its similarity to human bone and biocompatibility, but insufficient vascularization compared to autogenous bone during early implantation limits bone integration and osteogenesis. Fluorine has been shown to improve hydroxyapatite's mechanical properties and the coupling of osteogenic and angiogenic cells. In this study, fluorine-modified biogenic hydroxyapatite (FPHA) with varying fluorine concentrations was prepared and tested for its ability to promote vascularized osteogenesis.

Quantitative analysis of basal bone width as an index for immediate implant placement in the aesthetic zone: A retrospective study.

Purpose: The basal bone of the anterior maxilla plays a crucial role in maintaining primary stability of immediate implants. However, no consensus exists on the relationship between basal bone width and immediate implant success, unlike for basal bone length. This study presents a clinical scheme to predict the primary stability of immediate implants using the basal bone width.

miR-181a/MSC-Loaded Nano-Hydroxyapatite/Collagen Accelerated Bone Defect Repair in Rats by Targeting Ferroptosis Pathway.

: The reparative regeneration of jawbone defects poses a significant challenge within the field of dentistry. Despite being the gold standard, autogenous bone materials are not without drawbacks, including a heightened risk of postoperative infections. Consequently, the development of innovative materials that can surpass the osteogenic capabilities of autologous bone has emerged as a pivotal area of research.

Characteristics of heavy metal migration in the gasification-combustion process of rural solid waste: Influencing factors and mechanisms.

The miniaturized gasification-combustion model has potential advantages in treatment of rural solid waste (RSW) in China. In this study, the gasification-combustion technology concerning air-staged technology was employed in the treatment of seven combustible components in RSW, focusing on the analysis of heavy metal migration characteristics. Firstly, a comparison was made between combustion and gasification-combustion regarding the migration characteristics of heavy metals, demonstrating that gasification-combustion effectively reduces the volatilization rate of heavy metals.

Calcium enrichment activity initiates extracellular calcium influx-dependent inflammatory response of biologically-derived hydroxyapatite.

Biologically-derived hydroxyapatite is a widely used biomaterial in various clinical applications including bone augmentation. However, the osteogenic application of biological hydroxyapatite is limited by inflammatory responses, and the underlying mechanism remains unknown. The current study aimed to elucidate the molecular mechanisms underlying the inflammatory response to biological hydroxyapatite.

Unveiling the governing role of 'remodeling triangle area' in soft-hard tissue interface equilibrium for metal implants advancement.

Metal implants holds significant promise for diverse fixed prostheses. However, their long-term reliability and broader application are hindered by challenges related to the disequilibrium at the soft-hard tissue interface. By using anti-inflammatory (PDA/IL4) and pro-inflammatory (PDA/LPS/IFNγ) coatings to modulate distinct immune characteristics, we discovered a dynamic bioactive structure at the soft-hard tissue interface around metal implant, which we have named the 'Remodeling Triangle Area' (RTA).

Multi-Quantifying Maxillofacial Traits via a Demographic Parity-Based AI Model.

The multi-quantification of the distinct individualized maxillofacial traits, that is, quantifying multiple indices, is vital for diagnosis, decision-making, and prognosis of the maxillofacial surgery. While the discrete and demographically disproportionate distributions of the multiple indices restrict the generalization ability of artificial intelligence (AI)-based automatic analysis, this study presents a demographic-parity strategy for AI-based multi-quantification. In the aesthetic-concerning maxillary alveolar basal bone, which requires quantifying a total of 9 indices from length and width dimensional, this study collected a total of 4,000 cone-beam computed tomography (CBCT) sagittal images, and developed a deep learning model composed of a backbone and multiple regression heads with fully shared parameters to intelligently predict these quantitative metrics.

Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation.

Background: Biological-derived hydroxyapatite is widely used as a bone substitute for addressing bone defects, but its limited osteoconductive properties necessitate further improvement. The osteo-immunomodulatory properties hold crucial promise in maintaining bone homeostasis, and precise modulation of macrophage polarization is essential in this process. Metabolism serves as a guiding force for immunity, and fluoride modification represents a promising strategy for modulating the osteoimmunological environment by regulating immunometabolism.

Unraveling the multi-pollutant removal using M-MoWTi (M = Fe, Mn, Cr) catalyst: experiment and mechanistic study of competition for active sites.

Multi-pollutant removal (MPR) of NO and VOCs simultaneously is efficient of flue gas treatment in coal-fired power plants. But reducing the competition for active sites between NH, NO, CH, and CH remains challenging. Herein, Cr, Mn, and Fe were respectively doped to MoWTi catalyst via wet impregnation.

Copper/Nickel/Cobalt modified molybdenum-tungsten-titanium dioxide-based catalysts for multi-pollution control of nitrogen oxide, benzene, and toluene: Enhanced redox capacity and mechanism study.

Previous studies have indicated the potential of monometallic-modified TiO catalysts in controlling nitrogen oxide (NO) and volatile organic compounds (VOCs) in coal-fired flue gas. Unfortunately, increasing selective catalytic reduction (SCR) activity under complicated coal-fired flue gas status is tricky. In this study, modified Co-MoWTiO catalysts with multiple active sites were synthesized using the wet impregnation method, which exhibited excellent multi-pollution control ability of NO, benzene and toluene under low oxygen and high SO concentrations.

The influence of guide stabilizers and their application sequences on trueness and precision of surgical guides in free end situations: An in vitro analysis.

Objectives: To evaluate the impact of guide stabilizers and their application sequences on implant placement accuracy of guided implant surgery in multiple teeth loss at free end.

Materials And Methods: In this study, 96 implants were placed in the regions of #34, #36, and #37 of 32 identical mandibular models. The influence of using guide stabilizers or not (group A and group B) and various guide stabilizers application sequences (group B: #34 → #36 → #37; group C: #36 → #34 → #37; group D: #37 → #34 → #36) on implant placement trueness and precision was investigated.