Zinc ions coordinated carboxymethyl chitosan hydrogel doped with ellagic acid for accelerative diabetic wound healing.

Diabetic wound healing remains a critical clinical challenge due to persistent inflammation derived from long-term hyperglycemia. To address this challenge, we reported a zinc ion coordinated CMCS hydrogel for pH responsive delivery of ellagic acid to fulfill diabetic wound management. The incorporation of zinc ions and EA reinforce the hydrogel network via coordination and hydrogen bonding, and confer a pH-responsive release of EA under simulative wound microenvironment.

High-Reynolds-Number Turbulence Database: AeroFlowData.

Turbulence widely appears in natural and industrial environments, with its multi-scale structures posing significant challenges for accurate simulation and prediction. Nowadays, turbulence databases play a crucial role in advancing scientific research. However, existing turbulence databases primarily focus on fundamental turbulence problems and are predominantly limited to turbulent flows at low-to-moderate Reynolds number, making them insufficient to address high-Reynolds-number turbulence challenges in complex engineering applications.

Development of a rapid targeted and non-targeted analysis method for etomidate and its structural analogues by ambient flame ionization mass spectrometry.

Purpose: Etomidate, which is a psychoactive drug with an anesthetic effect, is used as a substitute for expensive mainstream drugs. There has been a trend toward abuse of etomidate and its emerging structural analogues now. Faced with a large number of samples, a rapid and effective detection method is needed.

Integrated low-temperature PVC and polyolefin upgrading.

Polyolefins and their chlorinated derivatives (e.g., PVC) are among the most prevalent plastics in global production and waste streams.

Negative mixing enthalpy and mixing enthalpy alloying leads to interface and size effects towards superb creep resistance of nickel-based single crystalline superalloys.

Nickel (Ni)-based single crystalline superalloys are the most important high-temperature service metallic materials for aircraft engine blades. These alloys' microstructures and mechanical properties must remain stable under high temperature and stress conditions for long periods of time. Rhenium (Re) has been the most effective alloying element, which serves as a guide to distinguish the third-generation Ni-based single crystalline superalloys.

High Resolution Mass Spectrometry Fragmentation Rules of Etomidate and Its Structural Analogues.

Objectives: To explore the characteristic fragment ions, ion abundance ratios and mass spectrometry fragmentation rules of etomidate and its structural analogues by using gas chromatography-quadrupole/orbitrap mass spectrometry (GC-Q/Orbitrap MS) and liquid chromatography-linear ion trap quadrupole-orbitrap mass spectrometry (LC-LTQ-Orbitrap MS) techniques, providing important data support for the identification and prediction of etomidate structural analogues.

Methods: GC-Q/Orbitrap MS and LC-LTQ-Orbitrap MS were used to analyze metomidate, etomidate, isopropoxate and propoxate, to obtain their GC high resolution mass spectra and LC high resolution mass spectra.

Results: Under the electron impact (EI) ion source mode, etomidate, metomidate and the other two analogues all produced their molecular ions and seven identical fragment ions ( 77.

Metabolism study of two phenethylamine - derived new psychoactive substances using in silico, in vivo, and in vitro approaches.

New psychoactive substances (NPS) are substances that are not controlled by international drug control conventions but are abused and pose a threat to public health. Proscaline and methallylescaline are two phenylethylamines with psychoactive and stimulant effects and are also derivatives of the classic hallucinogen mescaline. However, limited toxicity information on proscaline and methallylescaline has hindered the identification of these two NPS.

Metabolic Profile of Etomidate and Its Three Analogs in Zebrafish, Human Liver Microsomes, Human Urine and Hair Samples Using UHPLC-Q Exactive Orbitrap-HRMS.

Etomidate is a short-acting non-barbiturate imidazole used as an intravenous anesthetic agent in humans, while metomidate and propoxate are common anesthetic drug for fishes. Today, etomidate, and its analogs, including isopropoxate, are increasingly abused, leading to many public malignant events. The goal of this work was to use liquid chromatography-high resolution mass spectrometry (LC-HRMS) to study the in vivo and in vitro metabolism of etomidate and its analogs in zebrafish, human liver microsomes (HLMs), human urine and hair samples.

Rapid determination of etomidate and its structural analogues in e-liquid by probe electrospray ionization quadrupole time-of-flight mass spectrometry.

Etomidate and its structural analogues, which have anesthetic effects, are classified as controlled psychotropic drugs. Electronic cigarettes (e-cigarettes) have become more and more popular. With the increase of adding etomidate and its analogues to electronic liquids (e-liquids), there is a trend of abuse, which is a tough problem urgently need to be solved.

Detection of "smoke powder" etomidate and its metabolite etomidate acid in blood and urine by UHPLC-MS-MS: application in authentic cases.

Recently, etomidate has been widely used as an alternative in illicit drug market. It is usually added to regular cigarette tobacco (commonly known as "cigarette powder") or mixed in e-cigarette oil sold through the Internet, retail stores, or entertainment outlets and other channels. An ultra-high performance liquid chromatography tandem mass spectrometry method was developed to quantify etomidate and etomidate acid in human blood and urine.

Synthesis of fused-pyran derivatives a base-mediated annulation of bis-allenoates followed by auto-oxidation in air.

We introduce, for the first time, an inorganic base-mediated cyclization and auto-oxidation of bisallenones/bisalkynones. This reaction is realized under mild conditions through precise control of the base and atmosphere, providing a wide range of structurally diverse fused-pyran derivatives with moderate to excellent yields. Utilizing KOH as the initiator under a nitrogen atmosphere, a series of novel cyclohexane-fused pyran derivatives was obtained as the primary product.

Carbon fiber-sampling combined flame ionization mass spectrometry for direct analysis of drugs in oral fluid.

Drug-impaired driving poses a significant risk of collisions and other hazardous accidents, emphasizing the urgent need for simple and rapid roadside detection methods. Oral fluid, as an easily collectible and non-invasive test material, has gained widespread use in detecting drug-impaired driving. In this study, we have devised a method for direct sampling using a carbon fiber bundle combined with flame ionization mass spectrometry.

Metabolic characterization of 25X-NBOH and 25X-NBOMe phenethylamines based on UHPLC-Q-Exactive Orbitrap MS in human liver microsomes.

The types and quantities of new psychoactive substances synthesized based on structural modifications have increased rapidly in recent years and pose a great challenge to clinical and forensic laboratories. N-benzyl derivatives of phenethylamines, 25B-NBOH, 25E-NBOH, 25H-NBOH, and 25iP-NBOMe have begun to flow into the black market and have caused several poisoning cases and even fatal cases. The aim of this study was to avoid false negative results by detecting the parent drug and its metabolites to extend the detection window in biological matrices and provide basic data for the simultaneous determination of illegal drugs and metabolites in forensic and emergency cases.

Pancreatic Paragonimiasis in Children: A Case Report.

A few pediatric cases of abdominal paragonimiasis have been described. Here we describe a case of pulmonary and abdominal paragonimiasis with involvement of the pancreas in a 9-year-old boy. The aim of this study was to analyze the clinical and radiological features of pancreatic paragonimiasis in children and raise the awareness of this disease.

Negative mixing enthalpy solid solutions deliver high strength and ductility.

Body-centred cubic refractory multi-principal element alloys (MPEAs), with several refractory metal elements as constituents and featuring a yield strength greater than one gigapascal, are promising materials to meet the demands of aggressive structural applications. Their low-to-no tensile ductility at room temperature, however, limits their processability and scaled-up application. Here we present a HfNbTiVAl alloy that shows remarkable tensile ductility (roughly 20%) and ultrahigh yield strength (roughly 1,390 megapascals).

PiCO+: Contrastive Label Disambiguation for Robust Partial Label Learning.

Partial label learning (PLL) is an important problem that allows each training example to be labeled with a coarse candidate set with the ground-truth label included. However, in a more practical but challenging scenario, the annotator may miss the ground-truth and provide a wrong candidate set, which is known as the noisy PLL problem. To remedy this problem, we propose the PiCO+ framework that simultaneously disambiguates the candidate sets and mitigates label noise.

Global research trends in sexual health care: A bibliometric and visualized study.

Unlabelled: No Patient or Public Contribution, because the relevant data of this article comes from the literature database.

Purpose: The present study aimed to investigate the trends and research status of sexual healthcare.

Methods: We searched the Web of Science database for relevant articles concerning sexual healthcare, published between 2009 and 31 December 2022.

Fuse feeds as one: cross-modal framework for general identification of AMPs.

Antimicrobial peptides (AMPs) are promising candidates for the development of new antibiotics due to their broad-spectrum activity against a range of pathogens. However, identifying AMPs through a huge bunch of candidates is challenging due to their complex structures and diverse sequences. In this study, we propose SenseXAMP, a cross-modal framework that leverages semantic embeddings of and protein descriptors (PDs) of input sequences to improve the identification performance of AMPs.

Metabolism of dipentylone in zebrafish and human liver microsomes determined by liquid chromatography-high resolution mass spectrometry.

The consumption of novel psychoactive substances (NPS) is exceedingly prevalent in society, as these substances are sold and distributed as "legal highs." One novel synthetic cathinone emerging in the market is 1-(1,3-benzodioxol-5-yl)-2-(dimethylamino) pentan-1-one (dipentylone). The goal of this work was to study the in vivo and in vitro metabolism of dipentylone in zebrafish and human liver microsomes (HLMs) by liquid chromatography-high resolution mass spectrometry (LC-HRMS).

Quantitative Analysis of Three Synthetic Cannabinoids MDMB-4en-PINACA, ADB-BUTINACA, and ADB-4en-PINACA by Thermal-Assisted Carbon Fiber Ionization Mass Spectrometry.

Recently, synthetic cannabinoids (SCs) have emerged as new psychoactive substances (NPS) and have been frequently added to e-liquids, leading to their abuse. In order to detect SCs in e-liquids quickly and accurately, a thermal-assisted carbon fiber ionization mass spectrometry technique has been developed. The introduction of a heat source helps to reduce the matrix effects.

Analysis of 15 anti-obesity drugs in urine using thermal-assisted paper spray mass spectrometry.

Anti-obesity drugs, used to suppress appetite and reduce fat absorption, have been circulated and traded illegally worldwide. The traditional methods of liquid chromatography tandem mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry (GC-MS) for analyzing these drugs in samples require complex sample pretreatment and time-consuming procedures. To address this issue, a thermal-assisted paper spray mass spectrometry (PS-MS) method was developed in this study to analyze anti-obesity drugs in raw urine.

Physics Embedded Graph Convolution Neural Network for Power Flow Calculation Considering Uncertain Injections and Topology.

Probabilistic analysis tool is important to quantify the impacts of the uncertainties on power system operations. However, the repetitive calculations of power flow are time-consuming. To address this issue, data-driven approaches are proposed but they are not robust to the uncertain injections and varying topology.

Genetic and neural mechanisms of sleep disorders in children with autism spectrum disorder: a review.

Background: The incidence of sleep disorders in children with autism spectrum disorder (ASD) is very high. Sleep disorders can exacerbate the development of ASD and impose a heavy burden on families and society. The pathological mechanism of sleep disorders in autism is complex, but gene mutations and neural abnormalities may be involved.