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Rapid urbanization alters land use patterns and, in turn, regional carbon metabolism. Focusing on Hunan Province, China (2000-2020), we combined high-resolution land-use inventories with ecological network analysis to quantify carbon emissions, carbon sequestration, and the interactions among major land categories. Emissions rose markedly over two decades, driven mainly by expanding transportation and industrial zones. Forests and open woodlands remained the chief sinks, yet showed a declining sequestration capacity. Spatial mapping revealed persistent emission hotspots on urban fringes and within industrial parks, whereas high-sequestration areas clustered in protected forests. Network analysis identified competition, exploitation-control, and mutualistic linkages among land types, highlighting the ecological interdependencies that shape regional carbon flows. These findings clarify how specific land transitions amplify or mitigate carbon imbalance and provide actionable guidance for land-use planning aimed at strengthening ecosystem service capacity and supporting long-term carbon-neutral development.
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http://dx.doi.org/10.1016/j.isci.2025.113209 | DOI Listing |
J Phys Chem B
September 2025
School of Science, RMIT University, Melbourne 3000, Australia.
Pentameric ligand-gated ion channels control synaptic neurotransmission via an allosteric mechanism, whereby agonist binding induces global protein conformational changes that open an ion-conducting pore. For the proton-activated bacterial () ligand-gated ion channel (GLIC), high-resolution structures are available in multiple conformational states. We used a library of atomistic molecular dynamics (MD) simulations to study conformational changes and to perform dynamic network analysis to elucidate the communication pathways underlying the gating process.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Importance: The cost-effectiveness of adding early in-bed cycling to usual physiotherapy among adults receiving mechanical ventilation in the intensive care unit (ICU) compared with usual physiotherapy alone is unknown.
Objective: To evaluate the cost-effectiveness of in-bed cycling plus usual physiotherapy compared with usual therapy alone in the Critical Care Cycling to Improve Lower Extremity Strength (CYCLE) randomized clinical trial.
Design, Setting, And Participants: This trial-based economic evaluation with a 90-day time horizon compared early cycling plus usual physiotherapy vs usual physiotherapy alone from a societal perspective.
JAMA Pediatr
September 2025
Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada.
Importance: Youth living with type 1 diabetes (T1D) are increasingly choosing automated insulin delivery (AID) systems to manage their blood glucose. Few systematic reviews meta-analyzing results from randomized clinical trials (RCTs) are available to guide decision-making.
Objective: To study the association of prolonged AID system use in an outpatient setting with measures of glucose management and quality of life in youth with T1D.
Bioinformatics
September 2025
Centre National de Recherche en Génomique Humaine, Institut François Jacob CEA Université Paris-Saclay.
Motivation: Graph Neural Network (GNN) models have emerged in many fields and notably for biological networks constituted by genes or proteins and their interactions. The majority of enrichment study methods apply over-representation analysis and gene/protein set scores according to the existing overlap between pathways. Such methods neglect knowledges coming from the interactions between the gene/protein sets.
View Article and Find Full Text PDFVet Med Sci
September 2025
Department of Pharmacology and Toxicology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, Bangladesh.
The emergence of antimicrobial resistance (AMR) Escherichia coli in poultry farming is a growing global public health concern, particularly in Bangladesh, where the use of antibiotics remains largely unregulated. This study aimed to determine the prevalence and AMR patterns of E. coli isolated from broiler chickens in Sylhet district of Bangladesh and to investigate the network of coexisting resistance traits among the isolates.
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