MicroRNA participates in embryo implantation by modulating endometrial tolerance in sows during peri-implantation period.

MicroRNAs (miRNAs) are a class of non-coding RNA. MiRNAs affect physiological processes by regulating messenger RNA (mRNA) translation of target genes. The peri-implantation period is the period with the most loss of pig embryos, during which the endometrium provides support for embryo selectivity.

Elevated Squamous Cell Carcinoma Associated Antigen and Pulmonary Nodule Caused by Airway Foreign Bodies Mimic Lung Cancer.

Background: Airway foreign bodies can occur at any age and often expose the patients to the risk of pulmonary infections, pulmonary atelectasis, and even asphyxia. It is more commonly observed in children and less likely in adults. We report a case of an elderly man with elevated squamous cell carcinoma-associated antigen combined with multiple nodules in both lungs, initially diagnosed as lung cancer and eventually diagnosed as multiple foreign bodies in both lungs by bronchoscopy.

Dietary inulin supplementation in early gestation regulates uterine fluid exosomes and angiogenesis to improve embryo implantation in sows.

Background: Embryo implantation in early gestation is crucial for reproductive success, while dietary fiber plays a key role in regulating sow fertility. However, the underlying mechanisms remain unclear. This study explores the influence of dietary inulin on embryonic implantation using a sow model.

The morphology, genetic structure, and haplotype distribution of the invasive freshwater snails Biomphalaria straminea and Physa acuta in Guangdong, China.

Background: Biomphalaria and Physa (order Gastropoda) serve as vectors and reservoirs for infectious agents that affect both humans and animals. This study provides updated insights into the epidemiology, morphology, phylogeny, and haplotype diversity of Biomphalaria and Physa snails in Guangdong Province, southern China.

Methods: Field surveys were conducted across Guangdong Province from 2016 to 2023.

Correction: Life-safety disparity index: a comprehensive, valid, and reliable tool to assess Chinese people's life-safety performance.

[This corrects the article DOI: 10.3389/fpubh.2025.

Impact of clinicopathological features of meibomian gland adenocarcinoma on the outcomes of surgical resection combined with eyelid reconstruction.

This study aims to investigate the clinical and pathological characteristics of meibomian gland carcinoma (MGC) and their impact on the outcomes of surgical resection combined with eyelid defect reconstruction. A retrospective study was conducted on 128 patients diagnosed with MGC between December 2020 and January 2022. Demographic, clinical, pathological, surgical, and postoperative follow-up data were collected from the medical records.

Effects of 25-hydroxycholecalciferol supplementation during gestation on sow performance, offspring development, and intestinal microbiota in sows and piglets.

The 25-hydroxycholecalciferol (25OHD3) is a metabolite of vitamin D (VD) and status biomarker of VD in blood. We investigate the effect of dietary 25OHD3 supplementation on gestation sow litter performance, milk composition, nutrient metabolism, the growth performance of offspring, and intestinal microbiota. A total of 60 sows were randomly allocated to receive VD3 diet (CON, 50 µg·kg-1, n = 30) or 25OHD3 diet (50 µg·kg-1, n = 30).

Liver ERα mediates sex differences in metabolic pattern changes in response to time-restricted feeding.

Time-restricted feeding (TRF) is a dietary strategy used to prevent and treat obesity in both sexes. However, TRF affects liver metabolism differently in males and females, and the mechanisms behind these differences remain unclear. Our study reveals that during TRF, female livers are more likely to break down amino acids (AAs) to synthesize fats, while male livers significantly reduce fatty acid synthesis.

NAD Repletion Enhances Mammary Lactogenesis and Improves Offspring Development in a Sow Model.

Background: Breastfeeding provides bidirectional biosocial benefits for maternal-neonatal dyads, yet lactation insufficiency remains a major clinical challenge due to incomplete understanding of lactogenesis mechanisms. Emerging evidence has identified nicotinamide adenine dinucleotide (NAD+) as a critical modulator of reproductive physiology.

Objectives: We characterized mammary gland (MG) NAD+ metabolism and evaluated maternal nicotinamide riboside (NR), an NAD+ precursor, supplementation in orchestrating mammary lactogenesis.

Maternal obesity impairs fetal brown adipogenesis by attenuating fetal FGF21 signaling.

In mammals, maternal obesity typically impairs brown adipose tissue (BAT) formation in fetuses, increasing their risk of metabolic disorders in adulthood. However, the mechanisms behind this phenomenon are not well understood. Our single-nucleus transcriptomic analysis revealed dynamic changes in cell heterogeneity within the fetal interscapular BAT (iBAT) from obese dams, leading to compromised thermogenesis in their offspring.

Intermittent Fasting in Female Reproduction: A Double-Edged Sword.

More than 30% of reproductive-age women are obese or overweight. Intermittent fasting (IF), including alternate-day fasting (ADF), time-restricted eating (TRE), and 5:2 fasting, has been shown to reduce obesity-related metabolic diseases and is gaining popularity among women. However, the impact of ADF and TRE on female reproductive health remains controversial, given that women's reproductive physiology is particularly sensitive to environmental factors.

Nicotinamide Riboside Supplementation Alleviates Heat Stress-Induced Testicular Damage and Improves Semen Quality in Boars.

Rising global temperatures and increasing extreme weather events have profound and widespread health impacts, particularly on vulnerable populations and sensitive organs. This study aimed to investigate the impact of HS on testicular NAD metabolism and assess the potential of NAD precursor supplementation in alleviating heat stress (HS)-induced reductions in semen quality. This study aimed to investigate the impact of HS on testicular NAD metabolism and assess the potential of NAD precursor supplementation in alleviating HS-induced reductions in semen quality.

Effects of maternal and post-weaning supplementation with microbe-derived antioxidants on sow and piglet performance, oxidative status, and gut microbiota.

The antioxidants were found to improve inflammatory responses and redox status. This study investigated the effects of maternal and post-weaning supplementation with microbe-derived antioxidants (MA) on sow performance, redox status, and fecal microorganisms, as well as the growth performance, inflammatory responses and intestinal microbiota of weaned piglets. Sixty multiparous sows were randomly allocated to the control group (CON, basal diet) and the MA group (basal diet supplemented with 2.

Clinical and functional characterization of the GABRB3 p.Met80Val variant in early-onset epilepsy with long-term follow-up.

Background: GABRB3 encodes the β3 subunit of the GABA receptor, which is a crucial component in inhibitory neurotransmission within the central nervous system. GABRB3 variants are associated with developmental and epileptic encephalopathy 43. Noteworthy, GABRB3 variants can result in both gain-of-function and loss-of-function effects.

Life-safety disparity index: a comprehensive, valid, and reliable tool to assess Chinese people's life-safety performance.

Aims: In order to accurately and quantitatively grasp the current situation and trend of Chinese people's life-safety performance and to provide scientific basis and suggestions for the government, scientific research institutions, enterprises and the public to do a good job in life-safety protection.

Methods: The establishment process of life-safety disparity index (LDI) included six steps, including (i) concept building (ii) framework formulation; (iii) indicator selection; (iv) database building; (v) weight determination; and (vi) LDI scores calculation. The indicator scheme for LDI based on this framework was constructed after multiple rounds of panel discussions with our expert advisory committee.

Use of cornstarch or fermented soybean meal in lactation diet improved sows' nutrient utilization and litter performance during lactation.

Objective: This study investigated the effects of cornstarch (CS) and fermented soybean meal (FSM) substitutions for conventional corn and soybean meal, respectively, on sow's performance, nutrient digestibility, milk composition, and oxidative status during lactation.

Methods: Twenty-four lactating sows (8 sows/treatment) were assigned to either a standard lactation diet (CON), a CS diet in which pure CS substituted 60% of starch provided by conventional corn, or FSM diet in which FSM substituted 60% of crude protein provided by soybean meal. The experiment lasted from day 2 to 28 of lactation.

B7-H3 and c-MET in advanced prostate cancer: exploring possibilities of novel bi-specific drug development.

Purpose: Prostate cancer (PCa) is a serious malignancy worldwide with the fifth highest mortality rate among tumors in males, and there are unmet clinical needs for PCa treatment. In this work, we aim to explore the expression and overlap between B7 Homolog 3 protein (B7-H3) and cell-surface receptor c-mesenchymal-epithelial transition factor (c-MET), to provide insight on B7-H3 and c-MET bi-specific ADC drugs development for advanced PCa.

Patients And Methods: In this retrospective cross-sectional study, formalin-fixed paraffin-embedded (FFPE) samples were analyzed from 135 male patients with advanced PCa at Hubei Cancer Hospital between 2019 and 2023.

Cinnamaldehyde supplementation in sows and their offspring: effects on colostrum and milk composition, performance, redox status and intestinal health.

Background: Maternal nutrition significantly influences offspring development. This study investigated the effects of maternal or post-weaning cinnamaldehyde (CA) supplementation in sows and their offspring on reproductive performance and health. Sixty sows, selected based on body condition score and parity, were randomly allocated to control or CA (500 mg/kg) diets from d 107 of gestation to d 24 of lactation.

Effects of dietary cinnamaldehyde supplementation in the perinatal period on reproductive performance, milk composition, redox status and gut microbiota of sows.

Improving sow health during the perinatal period is crucial for reproductive performance. Cinnamaldehyde (CA), a naturally occurring compound, is known for its anti-inflammatory, antioxidant, and gut microbiota-modulating properties. This study evaluated the effects of dietary CA supplementation during the perinatal period on reproductive performance, milk composition, redox status, and gut microbiota of sows.

Effects of energy and amino acid intake during gestation on reproductive performance, milk composition, antioxidant status and placental nutrient transport in high-parity sows.

Appropriate nutritional strategies show promise for enhancing productive performance and longevity of sows. This study aimed to determine the effects of increased energy and amino acids (AA) intake during gestation on reproductive performance, milk composition, blood parameters, placental nutrient transport and antioxidant capacity of high-parity sows. A total of 72 Landrace × Yorkshire sows (seventh to ninth parity) were randomly assigned to dietary treatments consisting of combinations of 2 energy levels and 2 AA levels in a 2 × 2 factorial design.

Impact of replacing sow milk with milk replacer on growth performance, intestinal development, bacterial profile and muscular maturation in neonatal and nursery piglets.

Along with the increasing litter sizes in pig industry, using milk replacer (MR) as a nutrient supplement has been widely practiced, yet the effects of replacing sow milk (SM) with MR on growth and development of piglets remain unclear. This study evaluated the differential effects of MR versus SM on growth performance, body composition, muscle fiber types, and intestinal health of piglets during the neonatal and nursery periods. Forty 2-day-old piglets, selected from 10 healthy sows, were randomly divided into two groups receiving either SM or MR ad libitum until postnatal day 23 (PND 23), then transitioned to be fed with nursery diet until PND 37.

Dynamic changes in peripheral blood CD4+ T cell subsets are associated with litter performance in primiparous gestating sows.

This study aimed to investigate the dynamic changes in peripheral blood CD4+ T cells and their association with litter performance in primiparous gestating sows. Blood samples were collected from 72 Large White × Landrace crossbred primiparous sows on the day of mating (G0), and on days 30 (G30), G60, G90, and G110 of gestation, and were analyzed for levels of CD4+ T cell subsets include T helper 1 cells (Th1), T helper 17 cells (Th17), regulatory T cells (Tregs), and related cytokines, such as interferon-gamma (IFN-γ), interleukin-12 (IL-12), IL-4, IL-5, IL-17A, IL-22, and IL-10, Transforming growth factor-beta (TGF-β) and reproductive hormones pregn-4-ene-3,20-dione (P4) and Estra-1,3,5 (10)-triene-3,17β-diol (E2). Results showed that Th1 and Th17 levels increased during early gestation (G0 ~ G30) and late gestation (G90 ~ G110) but decreased in middle gestation (G60), with their typical cytokines (IFN-γ, IL-12, and IL-17A) following a broadly similar pattern.

Feasibility study on the application of HD-sEMG-based force estimation technology in the assessment of hand dysfunction in cerebral palsy.

Introduction: In response to the demand for a quantifiable means for assessing hand dysfunction in cerebral palsy (CP), this paper proposed and conducted a novel high-density (HD)-surface electromyography (sEMG)-based muscle force estimation framework.

Methods And Results: A highly generalized source network was developed firstly based on long short-term memory (LSTM) networks and three different healthy adult HD-sEMG-force datasets, achieving a root mean square error (RMSE) of 6.31% in force estimation across various force modes; Then, transfer learning techniques were applied to fine tune the well-trained source network using data from healthy children, establishing five gesture-specific target networks that achieved RMSE below 10% in force estimation tasks independent of the subjects; Finally, a muscle force estimation experiment was conducted on 16 children with CP using the gesture-specific target networks.

Impact of Iron Supplementation on Growth Performance, Iron Homeostasis and Redox Balance of Suckling Piglets.

This study evaluates the effects of intramuscular injection or oral supplementation of iron on the growth performance, iron homeostasis, and redox status of suckling piglets. A total of 94 newborn piglets, selected from 8 healthy sows, were randomly allocated into 4 treatment groups during the lactation period, receiving injections of normal saline without iron (CON, n = 23), intramuscular dextran injection of bound iron at 2 mL (200 mg Fe) on postnatal day 3 (PND 3) (FeDex, n = 24), oral supplementation from PND 2 to 13 with 10 g of FerkoFer containing 2.2 g Fe per day (FeOra, n = 23), or both FeDex and FeOra (FeDPO, n = 24).

Effects of unconventional diets and unconventional low-protein diets on reproductive performance, placental nutrient transport, and fecal microorganisms of multiparous sows during gestation.

The objective of this experiment was to investigate the effects of unconventional ingredients (wheat, broken rice, rapeseed meal, rice bran meal, and fermented distiller grains) in sow diets on sow reproductive performance, placental nutrient transport function, and fecal microbiota. Thirty multiparous sows with similar parity and backfat thickness were randomly assigned to 3 groups: corn-soybean meal diet (CG), unconventional diet (DY), and unconventional low-protein diet (DYL). The DYL group had 2% lower crude protein than CG and DY.