Global patterns and trends in cancer-related premature death and their impact on life expectancy across 185 countries: a population-based analysis.

Background: The level of premature deaths (deaths among those aged 30-69 years) caused by cancer is an important indicator of evaluating the level of cancer prevention and control. However, the current burden and temporal trends in cancer-related premature deaths, and their impact on life expectancy at the global, regional, and national levels are not clear.

Methods: Cancer mortality data for 185 countries were obtained from the GLOBOCAN 2022 database.

Succinylation - encoded metabolic codes: cracking the molecular logic of cellular adaptation.

Lysine succinylation is the covalent modification of succinyl groups (-CO-CH ₂ -CH ₂ -COOH) to lysine residues of target proteins, which causes conformational changes and regulates their functional states. In this figure, mitochondria are used as the metabolic hub to summarize the production and consumption of succinyl-CoA in the TCA cycle and mediate the succinylation of key enzymes and transcription factors such as PDH, SDH, GLUD1, HMGCS2, and FEN1. The central region showed the negative regulation of SIRT5/SIRT7 and the positive regulation of KAT2A, alpha-KGDH, CPT1A, HAT1, and other acyltransferases.

Histone ZmH2B regulates resistance to the Southern corn leaf blight pathogen Bipolaris maydis in maize.

Background: H2B histones play crucial roles in plant responses to biotic stress. However, to date, most research on H2B histones has focused on their roles in post-translational modification, and studies specifically investigating the intrinsic properties of these histones remain relatively limited. Here we identified the ZmH2B in maize () and investigated its role in the response of maize to infection by the Southern corn leaf blight pathogen .

Substrate stoichiometry and microbial metabolic preference drive the divergent accumulation of plant and microbial necromass carbon in cropland soils: evidence from a short-term experiment.

Substrate input and subsequent modification and turnover mediated by microbial systems determine the formation of soil organic carbon (C). However, the effects and mechanisms by which substrate stoichiometry (SS) adapts to microbial metabolic preferences and influences the dynamics of plant and microbial necromass C (PNC, MNC) remain unclear. Therefore, the variations and controlling factors of PNC and MNC in top- (0-20 cm) and subsoil (20-40 cm) across different SS conditions were investigated during the whole maize season.

IL-33 Has a Protective Effect Against Perinatal Listeriosis by Regulating Mitophagy of CD8 T Lymphocytes.

Listeriosis is a foodborne disease caused by (Lm) that usually leads to serious adverse outcomes in pregnant women. Interleukin (IL)-33/serum stimulation (ST)2 axis has an important impact on infectious diseases, but its role in listeriosis is rarely studied. Here, the immunomodulatory effects of IL-33/ST2 axis during perinatal Lm infection were investigated.

Global landscape and trends in lifetime risks of haematologic malignancies in 185 countries: population-based estimates from GLOBOCAN 2022.

Background: Haematologic malignancies accounted for 6.6% of total cancer cases and 7.2% of total cancer-related deaths worldwide in 2022.

The Exserohilum turcicum effector EtEC81 reprograms alternative splicing in maize and activates immunity.

Some pathogen-derived effectors reprogram mRNA splicing in host plants to regulate plant immune responses. Whether effectors from Exserohilum turcicum, which causes northern corn leaf blight (NLB), interfere with RNA splicing remains unknown. We identify that the secreted protein EtEC81 (Exserohilum turcicum effector 81) modulates the alternative splicing (AS) of maize (Zea mays) pre-mRNAs and negatively regulates the pathogenicity of E.

Daidzein alleviates skin fibrosis by suppressing TGF-β1 signaling pathway via targeting PKM2.

Skin fibrosis including keloids, which are characterized including excessive deposition, abnormal proliferation, aggressiveness, and migration of the extracellular matrix of dermal fibroblasts. TGF-β signaling is a classical pro-fibrotic pathway, and it plays a crucial part in the occurrence and progression of skin fibrosis. Daidzein (Dai), an isoflavone compound, has been proved to possess anti-fibrosis effect by TGF-β signaling in various inflammatory and fibrotic diseases.

Miglustat ameliorates isoproterenol-induced cardiac fibrosis via targeting UGCG.

Background: Cardiac fibrosis is significant global health problem, which is associated with numerous cardiovascular diseases, and ultimately leads to the progression to heart failure. β-adrenergic receptor (β-AR) overactivation play a role in the development of cardiac fibrosis. Miglustat (Mig) has shown anti-fibrosis effects in multiple fibrotic diseases.

Synthesis of CF-Indazoles via Rh(III)-Catalyzed C-H [4+1] Annulation of Azobenzenes with CF-Imidoyl Sulfoxonium Ylides.

An efficient Rh(III)-catalyzed C-H activation of azobenzenes and subsequent [4+1] cascade annulation with CF-imidoyl sulfoxonium ylides was developed, yielding diverse CF-indazoles. This protocol featured easily available starting materials, excellent functional group tolerance and high efficiency. Moreover, the antitumor activities of selected CF-indazoles against human cancer cell lines were also studied, and the results indicated that several compounds displayed considerable antiproliferative activities.

Efficacy and Safety of Jiedu Tongluo Therapy for Diabetic Kidney Disease Treatment: A Systematic Review and Meta-Analysis.

No comprehensive meta-analysis has evaluated the efficacy and safety of the protective effect of Jiedu Tongluo Therapy on the kidney of DKD until now. This meta-analysis covers this gap in knowledge. We have conducted an extensive search of databases, including CNKI, Wanfang, PubMed, and Web of Science.

Global, regional, and national burden of early-onset gastric cancer.

Objective: The burden of gastric cancer (GC) across different age groups needs updating. We determined the GC global, regional, and national burden profiles and changes in incidence for 3 sequential 5-year intervals from 2003 to 2017.

Methods: The latest incidence and mortality estimates of GC from 185 countries and regions were extracted from the GLOBOCAN 2022 database.

Strategic Implementation of Fragile X Carrier Screening in China: A Focused Pilot Study.

Fragile X syndrome is the leading genetic cause of intellectual disability and autism spectrum disorders. Female premutation carriers exhibit no obvious symptoms during reproductive age, but the premutation allele can expand to full mutation when transmitted to the fetus. Given the relatively low prevalence but large population, the distinct health care system, the middle-income economic status, and low awareness among public and medical professionals, the optimal genetic screening strategy remains unknown.

Numerical Simulation Study on the Influence of Fracture on Borehole Wave Modes: Insights from Fracture Width, Filling Condition, and Acoustic Frequency.

Unconventional reservoirs, such as shale and tight formations, have become increasingly vital contributors to oil and gas production. In these reservoirs, fractures serve as crucial spaces for fluid migration and storage, making their precise assessment essential. Array acoustic logging stands out as a pivotal method for evaluating fractures.

The characteristics and prognosis of different disease patterns of multiple primary lung cancers categorized according to the 8th edition lung cancer staging system.

Introduction: The 8th edition lung cancer staging system was the first to describe the detailed diagnosis and staging of multiple primary lung cancers (MPLC). However, the characteristics and prognosis of MPLC categorized according to the new system have not been evaluated.

Method: We retrospectively analyzed data from surgically treated MPLC patients in a single center from 2011 to 2013 and explored the characteristics and outcomes of different MPLC disease patterns.

Gypenoside induces apoptosis by inhibiting the PI3K/AKT/mTOR pathway and enhances T-cell antitumor immunity by inhibiting PD-L1 in gastric cancer.

Gypenoside is a natural extract of (Thunb.) Makino, a plant in the Cucurbitaceae family. It has been reported to have antitumor effects on the proliferation, migration and apoptosis of various types of cancer cells.

Hemorheology and Inflammatory Marker Changes in Patients with Acute Ischemic Stroke after Intravenous Thrombolysis with Mechanical Thrombectomy.

Objective: To investigate hemorheology and inflammatory marker changes after treatment for acute ischemic stroke (AIS) using intravenous thrombolysis (IVT) with mechanical thrombectomy (MT).

Methods: We retrospectively reviewed clinical records of patients with AIS (=83) treated in The First Affiliated Hospital of Bengbu Medical College between January 2021 and December 2022 (=83). The control group consisted of 38 patients who underwent IVT alone and the observation group consisted of 45 patients who underwent IVT with MT.

Study on the association between pregnancy-associated plasma protein-A and acute cerebral infarction.

Objective: We aimed to study the correlation between pregnancy-associated plasma protein-A (PAPP-A) and acute cerebral infarction (ACI).

Methods: Patients who had the symptoms of paralysis, aphasia, or sudden neurological impairment from June 2020 to October 2021 were chosen. There were 159 patients diagnosed with ACI as the experimental group and 102 patients without ACI as the control group.

Dictamnine suppresses the development of pear ring rot induced by Botryosphaeria dothidea infection by disrupting the chitin biosynthesis.

Ring rot induced by Botryosphaeria dothidea is a major cause of growth and postharvest losses in various fruits. There is an urgent need to develop green fungicides due to pesticide resistance and environmental pressure. Here, we demonstrated the efficacy of dictamnine (DIC, 4-methoxyfuro [2,3-β] quinoline, purity 98%), a compound isolated from the stems and leaves of Clausena lansium, in effectively suppressing pear ring rot by inhibiting the mycelial growth of B.

Cholesterol metabolism in T-cell aging: Accomplices or victims.

Aging has a significant impact on the function and metabolism of T cells. Cholesterol, the most important sterol in mammals, is known as the "gold of the body" because it maintains membrane fluidity, rigidity, and signal transduction while also serving as a precursor of oxysterols, bile acids, and steroid hormones. Cholesterol homeostasis is primarily controlled by uptake, biosynthesis, efflux, and regulatory mechanisms.

Ecological footprint model of heavy metal pollution in water environment based on the potential ecological risk index.

Social heavy metal pollution poses a significant threat to aquatic ecosystems. Heavy metals are easily adsorbed by sediments and have cumulative effects on aquatic organisms, which is different with the hypothesis of the conventional ecological footprint model that the pollutants are independently degraded by water bodies. To solve this problem, an ecological footprint for heavy metal pollution (EFHM) is constructed based on the potential ecological risk index (PERI).

LncRNA HOXA11-AS modulates the miR-148b-3p/MLPH axis to promote prostate cancer cell proliferation.

Prostate cancer refers to the epithelial malignant tumor of the prostate. It has a high incidence and mortality rate, seriously endangering the lives of men. In recent years, lncRNAs have become a hot topic for lots of scholars for their regulation functions on assorted cancers.

Guillain-Barre syndrome after myocardial infarction: a case report and literature review.

Background: Guillain-Barre syndrome after myocardial infarction occurs infrequently, and its occurrence following percutaneous coronary intervention is extremely rare. Due to the high mortality rate of myocardial infarction and the disability of Guillain-Barre syndrome, early identification of Guillain-Barre syndrome after myocardial infarction and early intervention can decrease the mortality rate, lead to early recovery, and provide a better outcome.

Case Presentation: Herein, we reported a rare case of Guillain-Barre syndrome after myocardial infarction treated with percutaneous coronary intervention.