Bundle recommendation methods considering rating data differences for online retailers.

Bundling has emerged as a pivotal marketing strategy for online retailers, offering mutual benefits to both merchants and consumers in the rapidly expanding e-commerce landscape. Among various types of user behavior data, user-generated product ratings serve as a critical indicator of individual preferences and satisfaction levels. This research proposes a novel bundle recommendation framework that leverages rating disparities to capture nuanced user preferences and unmet demands.

Vitamin D₃ inhibits proliferation and the early stage of adipogenic differentiation but promotes gene expression and lipid accumulation during the late stage of adipogenic differentiation in intramuscular adipose cells of Korean native cattle.

This study investigated the role of 1,25-dihydroxyvitamin D₃ (vitamin D₃) in regulating adipogenesis in stromal vascular (SV) cells derived from Korean native cattle (Hanwoo), focusing on its dose- (0, 1, 10, and 100 nM) and time-dependent effects across the growth phase and the early(day 3), mid (day 7), and late (day 14) stages of the differentiation phase. SV cells were isolated from the intramuscular fat of the Longissimus thoracis muscle of four female Hanwoo cattle (29 to 32 mo old) raised on the same farm. Vitamin D₃ treatment during the growth phase significantly suppressed preadipocyte proliferation in a dose-dependent manner.

Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection.

Unlabelled: Extrachromosomal DNA (ecDNA), a major focal oncogene amplification mode found across cancer, has recently regained attention as an emerging cancer hallmark, with a pervasive presence across cancers. With technical advancements such as high-coverage sequencing and live-cell genome imaging, we can now investigate the behaviors and functions of ecDNA. However, we still lack an understanding of how to eliminate ecDNA.

Tethered to survive: Mitotic transcription secures faithful inheritance of extrachromosomal DNA.

In this issue of Molecular Cell, Nichols et al. uncover a transcription-dependent tethering mechanism that enables mitotic inheritance of extrachromosomal DNA (ecDNA) in cancer cells, revealing how transcriptionally active ecDNA escapes degradation and drives oncogene persistence through cell division.

Regulation of working memory switches from striatal dopamine D2-receptor to D1-receptor neurons under high cognitive load.

Working memory (WM) is a fundamental cognitive function crucial adaptive behavior. The intricate interplay between the frontal cortex and striatum in governing WM maintenance and updating remains a central question. In this study, we employed optogenetics to demonstrate that inhibiting both dorsomedial striatum (DMS) D1R- and D2R-neurons enhances WM, while their activation impairs it across T-maze and operant-based delayed-non-match-to-place (DNMTP) paradigms in mice.

Chiral Dominance in Supramolecular Co-assemblies via Cation-π Driven Stereochemical Locking.

Controlling supramolecular chirality in multicomponent systems remains a significant challenge due to competing stereochemical interactions. In this study, we report a case of competitive chiral dominance in binary co-assemblies composed of enantiomeric tartaric acid derivatives (a1 and a2) and enantiomeric pyridine derivatives (R/S-py). The dibenzoyl-substituted tartaric acid (a1) is capable of overriding the chirality of the co-assemblies by protonating the chiral pyridines to form pyridinium-carboxylate pairs.

Wave 2 of the Multilingual Eye-Movement Corpus (MECO): New text reading data across languages.

This paper reports the Wave 2 expansion of the Multilingual Eye-Movement Corpus (MECO), a collaborative multi-lab project collecting eye-tracking data on text reading in a variety of languages. The present expansion comes with new eye-tracking data of N = 654 from 13 languages, collected in 16 labs over 15 countries, including in several languages that have little to no representation in current eye-tracking studies on reading. MECO also contains demographic, language use, and other individual differences data.

Clinical characteristics of atrophic macular hole in pathologic myopia: A multicenter study.

Purpose: This study aims to describe and analyze the clinical characteristics of atrophic macular hole (AMH), a severe complication in patients with pathologic myopia (PM).

Methods: A multicenter, retrospective analysis was conducted involving 17 patients (17 eyes) diagnosed with AMH and 52 patients (52 eyes) diagnosed with simple macular hole (SMH) in PM from January 2023 to December 2023. Clinical data and multimodal images were collected.

Global, regional, and national burden of lower respiratory infections and chronic obstructive pulmonary disease, 1990-2021: a systematic analysis from the global burden of disease study 2021.

Purpose: This study evaluates the global burden of lower respiratory infections (LRIs) and chronic obstructive pulmonary disease (COPD), focusing on their combined impact across age groups and regions.

Methods: Data from 204 countries were analyzed using spatiotemporal Gaussian process regression to estimate LRI and COPD incidence, prevalence, and disability-adjusted life years (DALYs). Age-standardized ratios (ASR) and the Socio-Demographic Index (SDI) were used to compare disease burdens, with trends assessed via linear regression and restricted cubic spline models.

Chiral dual-annihilator model for controllable photon upconversion and multi-dimensional optical modulation.

Triplet-triplet annihilation photon upconversion seeks efficient conversion of low-energy photons to high-energy emission. However, the triplet-triplet annihilation photon upconversion system faces limitations in emission gamut because efficient triplet-triplet energy transfer between sensitizer and annihilator relies on triplet energy matching, making it challenging to realize multi-channel luminescence and multi-dimensional optical control. Here, to overcome this barrier, we propose a chiral dual-annihilator model, which mitigates the restriction of energy matching and achieves facile manipulation of circularly polarized luminescence through a dual-channel triplet-triplet energy transfer process.

No wrap-up effect in Chinese reading: Evidence from eye movements.

Research conducted on alphabetic languages has yielded findings suggesting that readers tend to allocate more time toward processing the final words of a sentence or clause, commonly referred to as the wrap-up effect. Several theoretical accounts of the wrap-up effect advocate causal mechanisms that are supposed to generalize over readers of all languages, yet they are based on a small selection of written languages and writing systems. Whether the wrap-up effect occurs in naturally unspaced, logographic languages such as Chinese remains unclear.

Reproducible extracellular matrices for tumor organoid culture: challenges and opportunities.

Tumor organoid models have emerged as valuable 3D in vitro systems to study cancer behavior in a physiologically relevant environment. The composition and architecture of the extracellular matrix (ECM) play critical roles in tumor organoid culture by influencing the tumor microenvironment and tumor behavior. Traditional matrices such as Matrigel and collagen, have been widely used, but their batch-to-batch variability and limited tunability hinder their reproducibility and broader applications.

Reduced expression of the PER2 protein contributes to β -AA-induced cardiac autophagy rhythm disorders.

Heart failure may be linked to fluctuations in the rhythm of autophagy in cardiomyocytes throughout the day. Circadian rhythms depend on the regulation of core biological clock proteins, with PER2 playing a crucial role. Our previous research confirmed that the presence of β -adrenergic receptor autoantibodies (β -AAs) could inhibit myocardial autophagy, leading to cell death and heart failure.

Mechanisms by which SNX-BAR subfamily controls the fate of SNXs' cargo.

The SNX-BAR subfamily is a component of the sorting nexins (SNXs) superfamily. Distinct from other SNXs, which feature a PX domain for phosphoinositide binding, the SNX-BAR subfamily includes a BAR domain that induces membrane curvature. Members of the SNX-BAR subfamily work together to recognize and select specific cargo, regulate receptor signaling, and manage cargo sorting both with and without the involvement of sorting complexes.

Wearable Hydrogels for Personal Protection Applications.

As the Internet of Things and artificial intelligence technologies have advanced, wearable technology has attracted significant attention from academia and industry. Hydrogel has already received much attention as an emerging candidate material for wearable devices due to its unique 3D network structure, excellent biocompatibility, and soft stretchability. It is aimed here to provide a comprehensive overview of the development of hydrogels for wearable applications.

Modulating CCTG repeat expansion toxicity in DM2 Drosophila model through TDP1 inhibition.

Myotonic dystrophy type 2 (DM2), caused by CCTG repeat expansion, is a common adult-onset disorder characterized by myotonia and progressive muscle degeneration with no effective treatment. Here, we identified Tyrosyl-DNA phosphodiesterase 1 (TDP1) as a novel modifier for DM2 therapeutic intervention through a high-throughput chemical screening of 2160 compounds. Moreover, we detailed how both genetic and pharmacological inhibition of TDP1 translates to a cascade of beneficial effects, including improved motor functions, amelioration of progressive muscle degeneration, repair of muscle fiber damage, and normalization of aberrant molecular pathology.

Selective depletion of cancer cells with extrachromosomal DNA via lentiviral infection.

Dear Editor Extrachromosomal DNA (ecDNA), a major focal oncogene amplification mode found across cancer, has recently regained attention as an emerging cancer hallmark , with a pervasive presence across cancers . With technical advancements such as high-coverage sequencing and live-cell genome imaging, we can now investigate ecDNA's behaviors and functions . However, we still lack an understanding of how to eliminate ecDNA.

Endowing Polycyclic Aromatic Hydrocarbons with Induced Supramolecular Chirality by Engineering Cation-π Interaction.

The cation-π interaction is a crucial noncovalent binding force prevalent in many biological and chemical systems, however, are rarely reported in chiral supramolecular systems. Here, a supramolecular chiral system is reported, wherein cation-π interaction play significant roles. The interaction involves a chiral cationic palladium complex (R-Pd) co-assembling with 12 different polycyclic aromatic hydrocarbons (PAHs), resulting in the formation of supramolecular gels in mixed solvents.

Gut microbiota and derived metabolites mediate obstructive sleep apnea induced atherosclerosis.

Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia/hypercapnia (IHC), affects predominantly obese individuals, and increases atherosclerosis risk. Since we and others have implicated gut microbiota and metabolites in atherogenesis, we dissected their contributions to OSA-induced atherosclerosis. Atherosclerotic lesions were compared between conventionally-reared specific pathogen free (SPF) and germ-free (GF) Apoe mice following a high fat high cholesterol diet (HFHC), with and without IHC conditions.

Network analysis and experimental validation to investigate against functional dyspepsia through TLR4/MyD88 by regulating the gut microbial structure.

Functional dyspepsia (FD) is a prevalent functional gastrointestinal disorder characterized by the absence of organic lesions; it affects nearly one-fifth of the global population. There is currently no specific drug for treating it. Citri reticulatae Pericarpium (CRP) has been utilized in China for millennia as a therapeutic agent for alleviating bloating and spleen-stomach disharmony.

Global trends of purinergic receptors and depression: A bibliometric analysis from 2003 to 2023.

Background: Depression significantly threatens human health. Purinergic receptors are reported to be associated with depression. However, there is no bibliometric research in this field have been published.

Efficacy of narrative intervention on Chinese-speaking school-age children with and without developmental language disorder.

Purposes: The effect of intervening on narrative skills in Chinese-speaking school-age children with developmental language disorder (DLD) is underexplored.

Methods: The aim of the present study was to investigate the effectiveness of narrative intervention on written narratives of Chinese children with and without DLD and to explore the potential differences in response to the intervention between the two groups of children. Children with DLD (N = 22; M age = 9.

Insulin resistance and β-cell dysfunction in individuals with normal glucose tolerance but elevated 1-h post-load plasma glucose.

Objective: Diabetes and its complications impose a significant burden on public health, necessitating early identification and intervention, yet current prediabetes diagnostic criteria may not fully capture all high-risk individuals. Evaluate and compare insulin resistance (IR) and β-cell dysfunction in individuals with normal glucose tolerance (NGT) and 1-hour post-load plasma glucose (1-h PG) ≥ 8.6 mmol/L versus < 8.

Potential effects of indoor microbiome characteristics on health: A systematic review.

Objectives: This systematic review aims to assess the potential effects of exposure to microbial agents in the indoor environment on health outcomes.

Study Design: Systematic review.

Methods: A systematic literature search was conducted on Embase, PubMed, and Web of Science through January 2024, and reference lists of relevant articles were reviewed.