Successful perinatal management in pregnant women with R9 limb-girdle muscular dystrophy and left ventricular ejection fraction of 27%: a case report.

A 29-year-old woman with muscle weakness at 26 + 5 weeks of pregnancy was hospitalized for heart failure, and genetic testing revealed that she had R9 limb-girdle muscular dystrophy (LGMDR9). Since LGMDR9 is associated with cardiac and respiratory dysfunction, we promoted fetal lung maturation and performed an emergency cesarean section at 29 + 2 weeks to prevent further deterioration of cardiac function and muscle weakness. This case highlights the importance of choosing the right mode of delivery, timing of delivery, and early genetic testing for LGMDR9 patients.

ZmPP2C45 and ZmBELL4 suppress maize biochemical defense against insect herbivores.

Benzoxazinoids (BZX) are the most abundant defensive metabolites of maize (Zea mays). Genetic fine-tuning of BZX metabolism holds the potential to enhance maize resistance against insect herbivory. Natural variation in BZX abundance has been associated with genetic polymorphism in ZmPP2C45.

Safety of budesonide/glycopyrronium/formoterol fumarate dihydrate delivered by HFO-1234ze versus HFA-134a in chronic obstructive pulmonary disease: a phase 3, multi-site, randomised, double-blind, parallel-group, active-comparator study.

Background: Pressurised metered dose inhalers (pMDIs) contain a hydrofluorocarbon propellant, such as hydrofluoroalkane-134a (HFA-134a), which is known to have global warming potential (GWP). Transitioning pMDIs to propellants with lower GWP will reduce the environmental impact of pMDIs. This study assessed the safety of a near-zero GWP propellant, hydrofluoroolefin-1234ze (HFO-1234ze), compared with HFA-134a when used in the delivery of budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF) in participants with chronic obstructive pulmonary disease (COPD).

Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in hepatocellular carcinoma after FOLFOX-HAIC therapy.

Tertiary lymphoid structures (TLSs) emerge as crucial determinants of anti-tumor immune responses and clinical outcomes. However, their clinical significance and formation mechanisms in hepatocellular carcinoma (HCC) remain unclear. Here, we demonstrate that hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin, leucovorin, and fluorouracil (FOLFOX) significantly enhances TLS formation in HCC tissues, correlating with improved therapeutic efficacy and prolonged progression-free survival in patients with HCC.

Empowering hypoxia to convert cold tumors into hot tumors for breast cancer immunotherapy.

Breast cancer remains the most common cancer among women globally and a leading cause of cancer-related death. Despite the promise of immunotherapy for triple-negative breast cancer (TNBC), its overall effectiveness is hindered by the cold tumor microenvironment (TME), characterized by sparse immune cell infiltration. This review explores the pivotal role of hypoxia in shaping the breast cancer TME and its influence on immunotherapy efficacy.

The role of formin-like protein 1 in pancreatic cancer and its specific effects on immunity.

ObjectiveTo investigate the functions and immunological implication of formin-like protein 1 in pancreatic cancer.MethodsA multitude of public datasets and an in-house cohort were used to assess the clinical relevance and the immunological relevance of formin-like protein 1 in pancreatic cancer. Subsequently, in vitro assays were conducted to evaluate the biological roles of formin-like protein 1 in pancreatic cancer and its effects on immunity.

Timing Matters: Dual-Track Recovery of Critical Habitats in Dam-Regulated Rivers.

Sandbars function as critical habitats for rare and endangered species within riverine ecosystems, exhibiting ecological significance disproportionate to their spatial extent. Sandbar restoration, including active restoration (AR) and passive recovery (PR), is essential for maintaining riverine ecology integrity, especially in dam-regulated rivers where sandbars are susceptible to hydrological alterations. However, when and how to integrate AR and PR, considering both effectiveness and efficiency, remains a question.

Polycystin-1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1-Dependent Microfilament Remodeling.

Extracellular matrix (ECM) stiffness-mediated mechanotransduction is a common signaling scheme in both physiological and pathological contexts; however, its molecular mechanisms remain incompletely understood. Polycystin-1 is a transmembrane protein that is known to participate in mechano-transduction. Here, it is demonstrated that, in response to extracellular collagen and increased ECM stiffness, polycystin-1 interacts with disheveled-associated activator of morphogenesis 1 (Daam1), a cytoskeletal regulator, thereby promoting microfilament remodeling, cellular protrusion formation, and enhanced motility of tumor cells through activating the RhoA signaling axis.

Prediction of Early Recurrence After Bronchial Arterial Chemoembolization in Non-small Cell Lung Cancer Patients Using Dual-energy CT: An Interpretable Model Based on SHAP Methodology.

Rationale And Objectives: Bronchial artery chemoembolization (BACE) is a new treatment method for lung cancer. This study aimed to investigate the ability of dual-energy computed tomography (DECT) to predict early recurrence (ER) after BACE among patients with non-small cell lung cancer (NSCLC) who failed first-line therapy.

Materials And Methods: Clinical and imaging data from NSCLC patients undergoing BACE at Wenzhou Medical University Affiliated Fifth *** Hospital (10/2023-06/2024) were retrospectively analyzed.

MASLD: insights on the role of folate in hepatic lipid metabolism.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is also known as fatty liver disease associated with non-alcoholic fatty liver disease (NAFLD), which is a spectrum of chronic liver diseases characterized by steatosis, inflammation, fibrosis and liver injury. The incidence and prevalence of MASLD is increasing rapidly worldwide. It is a multifactorial disease and there is no single drug approved for its treatment.

Targeting collagen to optimize cancer immunotherapy.

Collagen in the tumor microenvironment plays diverse biological roles, from serving as the structural framework of tumors to influencing immune responses, angiogenesis, and tumor progression. Consequently, developing strategies to optimize the suppression of collagen's promotive effects on tumor growth while maintaining its inhibitory functions on tumor initiation has become a key focus of cancer research and therapy. A significant challenge remains in identifying a biomarker with both high sensitivity and specificity for cancer diagnosis.

Macrophages form dendrite-like pseudopods to enhance bacterial ingestion.

Macrophages are critical innate immune cells that exhibit remarkable adaptability during pathogen infections. However, the relationship between their morphological plasticity and physiological functions remains largely elusive. Here, we discovered an unprecedented paradigm of macrophage adaptation within a few hours upon severe Gram-negative bacterial infections, characterized by the formation of dendrite-like pseudopods (DLPs).

Impact of Elevated Oestrogen Levels on hCG Trigger Day on Clinical Pregnancy Outcome and OHSS Incidence in Long-Acting GnRHa Down-Regulated IVF/ICSI-ET Cycles.

Background: The relevance of oestrogen (E) levels on human chorionic gonadotropin (hCG) trigger day and clinical pregnancy outcomes was unclear. This study aimed to investigate whether E levels on the hCG trigger day affect pregnancy outcome in long-acting gonadotropin releasing hormone agonist (GnRHa) down-regulated in-vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) cycles.

Methods: This is a retrospective study including 6967 patients undergoing their first long-acting GnRHa down-regulated IVF/ICSI-ET cycles at the Reproductive Medicine Centre of Nanjing Drum Tower Hospital from January 2016 to December 2021.

Multiband Electromagnetic Interference Shielding Composite with Dynamic Thermal Management and Passive Infrared Stealth Performance.

With the rapid advancement of modern communication and infrared detection technologies, there is an urgent demand in military protection for multiband electromagnetic interference (EMI) shielding materials integrated with infrared stealth capabilities. Traditional passive infrared stealth strategies relying on thermal resistance materials and low infrared emissivity coatings often fail to achieve stable temperature regulation in complex environments, leading to target exposure due to thermal contrasts. To address this, we developed an innovative PF@Ag-MF@Ag-x composite via an electroless plating process.

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Immune Checkpoint Blockade in Triple-Negative Breast Cancer.

In the previous study, patients with tumors based on collagen deposition and immunoreactivity are classified and identified the armored & cold subtype as the most treatment-refractory tumor type. Triple-negative breast cancer (TNBC) is the most lethal tumor type globally, making it critical to overcome the armored and cold tumor microenvironment (TME) for effective treatment of these patients. In this study, the transcriptomic collagen activity and immune profiles of cancer patients treated with immune checkpoint blockade (ICB) are analyzed, and found that intratumoral collagen is associated with an unfavorable immunotherapeutic response and T cell exhaustion.

Serum GDF15 level as predictive biomarker of clinical outcome in patients with unresectable hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy.

Background: Hepatic arterial infusion chemotherapy (HAIC) using the FOLFOX regimen has been explored for unresectable hepatocellular carcinoma (HCC) patients, yet predictive biomarkers are lacking. This study aimed to evaluate the potential of serum growth differentiation factor 15 (GDF15) as a biomarker for predicting therapeutic response and survival outcomes in HCC patients undergoing FOLFOX-HAIC.

Methods: Pretreatment serum samples were collected from patients with unresectable HCC who received FOLFOX-HAIC between October 2016 and January 2019.

Systemic inflammation partially mediates the association between lipid accumulation and osteoarthritis in normal BMI adults.

This study aims to investigate the association between lipid accumulation product (LAP) levels and osteoarthritis (OA) in participants with normal BMI, and the potential role of the systemic inflammation response index (SIRI) in this association. Participants with normal BMI from the national health and nutrition examination survey (NHANES) database (2009-2018) were included. A weighted multivariable logistic regression was used to analyze the association between LAP levels and OA, and mediation analysis was applied to explore the role of SIRI in this relationship.

Structure-based molecular screening and dynamic simulation of phytocompounds targeting VEGFR-2: a novel therapeutic approach for papillary thyroid carcinoma.

Papillary thyroid carcinoma (PTC) is the most prevalent type of thyroid cancer, with aggressive variants presenting major therapeutic challenges. Vascular endothelial growth factor receptor-2 (VEGFR-2) is a key regulator of tumor angiogenesis and is highly expressed in PTC, making it a promising target for therapeutic intervention. This highlights the potential of VEGFR-2 inhibition as an effective strategy for managing PTC.

Extracellular matrix dynamics in tumor immunoregulation: from tumor microenvironment to immunotherapy.

The extracellular matrix (ECM), closely linked to the dynamic changes in the tumor microenvironment (TME), plays a critical role in modulating tumor immunity. The dual role of the ECM in tumor progression, encompassing both promotion and inhibition, is attributed to its components influencing immune cell activation, migration, and infiltration. This mechanism is intricately connected with the efficacy of immunotherapies.

Causal role of the plasma lipidome in the occurrence and progression of chronic kidney disease: a two-sample Mendelian randomization study.

Objective: This study aimed to utilize Mendelian randomization (MR) techniques to determine causal relationships between the plasma lipidome and the occurrence and progression of chronic kidney disease (CKD).

Methods: Summary statistics for 179 lipid species and six CKD-related phenotypes were retrieved from published large-scale genome-wide association studies. A bidirectional two-sample MR analysis was performed using the inverse-variance weighting (IVW) as the primary MR method.

A threefold interpenetrated three-dimensional cobalt(II) coordination polymer with highly sensitive sensing for nitrofurazone in aqueous medium.

A novel Co-based coordination polymer, poly[[μ-4,4'-bis(2-methyl-1H-imidazol-1-yl)-1,1'-biphenyl-κN:N](μ-5-nitrobenzene-1,3-dicarboxylato-κO:O)cobalt(II)], [Co(CHNO)(CHN)] or [Co(NO-BDC)(4,4'-BMIBP)], (I), was synthesized successfully via a hydrothermal reaction. The synthesis employed 5-nitrobenzene-1,3-dicarboxylic acid (NO-HBDC) as the organic linker, 4,4'-bis(2-methyl-1H-imidazol-1-yl)-1,1'-biphenyl (4,4'-BMIBP) as the N-donor auxiliary ligand and cobalt(II) nitrate hexahydrate as the metal source. Structural characterization revealed that (I) crystallizes in a unique three-dimensional framework featuring a threefold parallel interwoven dmp network topology.

Multi-omics analysis and experiments uncover the link between cancer intrinsic drivers, stemness, and immunotherapy in ovarian cancer with validation in a pan-cancer census.

Background: Although immune checkpoint inhibitors (ICIs) represent a substantial breakthrough in cancer treatment, it is crucial to acknowledge that their efficacy is limited to a subset of patients. The heterogeneity and stemness of cancer render its response to immunotherapy variable, warranting the identification of robust biomarkers for evaluation.

Methods: Publicly available Ovarian Cancer (OV) single-cell RNA (scRNA) sequence dataset was collected and analyzed to elucidate the intrinsic driver gene of OV cancer cells.

Right Ventricular Strain as a Key Feature in Interpretable Machine Learning for Identification of Takotsubo Syndrome: A Multicenter CMR-based Study.

Rationale And Objectives: To develop an interpretable machine learning (ML) model based on cardiac magnetic resonance (CMR) multimodal parameters and clinical data to discriminate Takotsubo syndrome (TTS), acute myocardial infarction (AMI), and acute myocarditis (AM), and to further assess the diagnostic value of right ventricular (RV) strain in TTS.

Materials And Methods: This study analyzed CMR and clinical data of 130 patients from three centers. Key features were selected using least absolute shrinkage and selection operator regression and random forest.

Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer.

Introduction: Platinum-based drugs, the most widely used chemotherapeutic drugs in clinical oncology, have long faced the problem of drug resistance, which is urgently in need of resolution. Identifying biomarkers of drug resistance may help reduce platinum resistance and improve therapeutic efficacy.

Objectives: This study aims to identify potential biomarkers associated with the development of cisplatin resistance in non-small cell lung cancer (NSCLC) and explore mechanisms to overcome chemoresistance.

Deep learning-based prediction of individualized Real-time FSH doses in GnRH agonist long protocols.

Background: Individualizing follicle-stimulating hormone (FSH) dosing during controlled ovarian stimulation (COS) is critical for optimizing outcomes in assisted reproduction but remains difficult due to patient heterogeneity. Most existing models are limited to static predictions of initial doses and do not support real-time adjustments throughout stimulation.

Methods: We developed a deep learning model that integrates cross-temporal and cross-feature encoding (CTFE) to predict personalized daily FSH doses in patients undergoing COS using the GnRH agonist long protocol.