Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer.

Introduction: Platinum-based drugs, the most widely used chemotherapeutic drugs in clinical oncology, have long faced the problem of drug resistance, which is urgently in need of resolution. Identifying biomarkers of drug resistance may help reduce platinum resistance and improve therapeutic efficacy.

Objectives: This study aims to identify potential biomarkers associated with the development of cisplatin resistance in non-small cell lung cancer (NSCLC) and explore mechanisms to overcome chemoresistance.

Bronchopulmonary foregut malformation with severe hemoptysis in advanced age: a case report and literature review.

Bronchopulmonary foregut malformation (BPFM) is a rare developmental malformation disease due to embryonic defects, with an even rarer occurrence in adults. We report a diagnosed case in an adult patient, and notably, this is the first reported case of such advanced age. Additionally, she experienced coughing up approximately 1 liter of blood and partial lung tissue, accompanied by respiratory failure and shock.

Mallory-Weiss syndrome in four hemodialysis patients: a case study.

Background: Hemodialysis patients are prone to gastrointestinal bleeding, and Mallory-Weiss syndrome (MWS) is one of the causes. Mallory-Weiss syndrome is often induced by severe vomiting, manifests as upper gastrointestinal bleeding, and is self-limited with a good prognosis. However, mild vomiting in hemodialysis patients can lead to the occurrence of MWS, and the mild early symptoms are easy to misdiagnose, leading to the aggravation of the disease.

[Chemerin mediated neutrophil infiltration in oral squamous cell carcinoma and predicted poor prognosis].

Purpose: To explore the effect of Chemerin in oral squamous cell carcinoma (OSCC) tissue on neutrophils infiltration and its possible molecular mechanism.

Methods: The relationship between Chemerin expression and neutrophils density was assessed via double immunohistochemistry staining.The chemotactic effect of Chemerin on neutrophils in OSCC was detected by transwell assay, real-time quantitative PCR(qRT-PCR), Western blot, enzyme-linked immunosorbent assay(ELISA) and flow cytometry.

Identification and validation of an immune-related lncRNAs signature to predict the overall survival of ovarian cancer.

Ovarian cancer (OC) is the most lethal gynecological cancer in women. Studies had reported that immune-related lncRNAs signatures were valuable in predicting the survival and prognosis of patients with various cancers. In our study, the prognostic value of immune-related lncRNAs was investigated in OC patients from TCGA-RNA-seq cohort (n=378) and HG-U133_Plus_2 cohort (n=590), respectively.

Evaluating the influence of 6MV and 10MV photon beams on cervical cancer volumetric-modulated arc therapy plans.

Background: Cervical cancer is a common gynecological cancer among women worldwide.

Objective: To determine the effects of 6 MV and 10 MV volumetric-modulated arc therapy (VMAT) photon beams on the target volume (TV) planning and critical organs in cases of cervical cancer.

Methods: Fifty patients with carcinoma of the cervix who underwent radiotherapy were selected.

Dosimetric analysis of postoperative radiotherapy for thymoma.

Purpose: To compare the dosimetric differences between intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in the treatment of male and female thymoma.

Material And Methods: This single-institutional analysis included 20 patients with thymoma treated with RT between January 2017 and December 2020. Twenty patients were retrospectively planned for IMRT (IMRT1 with an average field angle of 216°, 288°, 0°, 72°,and 144°; IMRT2 with fan-shaped field angles of 280°, 320°, 0°, 40°, and 80°) and VMAT (VMAT1 with two arcs ranging form 280° to 80°,clockwise and then counterclockwise; VMAT2 with two 360° arcs).

Horseshoe kidney with PLA2R-positive membranous nephropathy.

Background: Horseshoe kidney (HSK) is a common congenital defect of the urinary system. The most common complications are urinary tract infection, urinary stones, and hydronephrosis. HSK can be combined with glomerular diseases, but the diagnosis rate of renal biopsy is low due to structural abnormalities.

[Sources and Characteristics of Regional Background PM in North China During the Autumn and Winter Polluted Period].

The campaign of investigating the chemical compositions and particle size distributions of NR-PM(non-refractory PM) was conducted by using a High Resolution Time of Flight Aerosol Mass Spectrometer(HR-ToF-AMS) at the Shangdianzi(SDZ) regional atmospheric background site(117.07°E, 40.39°N), northeast of Beijing, from October 17 2015 to January 27 2016.

Intervention of transforming pulmonary fibrosis with NF-κB p65 antisense oligonucleotide.

Objective: NF-κB, especially p65 subunit, plays important role in the process of pulmonary fibrosis. In this study, we transformed fibroblast into myofibroblast induced by bleomycin, and then studied the effects of NF-κB p65 antisense oligonucleotide on pulmonary fibrosis in mouse model.

Methods: Pulmonary fibrosis was induced by bleomycin in C57BL/6 mouse (modeling group).

Radiation enhancing effects with the combination of sanazole and irinotecan in hypoxic HeLa human cervical cancer cell line.

Purpose: This study was conducted to determine the synergistic radiation sensitizing effects of the combination of sanazole and irinotecan in hypoxic cervical cancer HeLa human tumor cell line.

Methods: The 3-(4,5 dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay was used to evaluate the number of surviving cells. Cell cycle was determined by flow cytometry.

[Estimation of PM2.5 over eastern China from MODIS aerosol optical depth using the back propagation neural network].

With the fast economic development in China in recent years, air pollutions are becoming increasingly serious. It is, therefore, imperative to develop new technology to solve this issue. Due to the wide spatial coverage of satellite remote sensing, along with the relatively lower cost compared to ground-based in situ aerosol measurements, satellite retrieved aerosol optical depth (AOD) is widely recognized as a good surrogate of surface PM2.

[Application of simplified intensity modulated radiation therapy in gastric cancer after operation].

Objective: To elucidate the application and the dosimetry characteristic of the simplified intensity modulated radiation therapy (sIMRT) for gastric cancer after operation, and to compare the dose distribution with intensity modulated radiation therapy (IMRT) and three-dimension conformal radiation therapy (3D-CRT).

Methods: Twelve patients with gastric cancer after operation were enrolled in this study. 3D-CRT plan, 5-field IMRT plans (20 degree, 80 degree, 180 degree, 280 degree, 340 degree) and 5-field sIMRT plans (20 degree, 80 degree, 180 degree, 280 degree, 340 degree) were performed for each patient.

C-reactive protein level predicts prognosis in patients with locoregionally advanced laryngeal carcinoma treated with chemoradiotherapy.

The aim of this study was to investigate the effect of C-reactive protein (CRP) level on the prognosis of patients with locoregionally advanced laryngeal carcinoma treated with chemoradiotherapy. Fifty-seven patients with locoregionally advanced laryngeal carcinoma (cT3-4, N0-3, M0) treated with chemoradiotherapy were reviewed retrospectively. Chemoradiotherapy comprised external beam radiotherapy to the larynx (70 Gy) with three cycles of cisplatin at 3-week intervals.

[Research progress of selective mGluR1 antagonists].

As an important member of metabotropic glutamate receptors (mGluR), metabotropic glutamate receptor 1 (mGluR1) plays an important role in the signal transduction of central nervous system. Selective mGluR1 antagonists can block the signaling pathway activated by mGluR1 and exert a series of physiological actions including analgesia, antianxiety, antidepression, etc. Currently, the discovery and modification of selective mGluR1 antagonists have become a hot research focus.

Aerosol background at two remote CAWNET sites in western China.

The frequency distributions and some statistical features of background aerosol concentrations were investigated at two remote China Atmosphere Watch Network (CAWNET) stations. The estimated elemental carbon (EC) background at Akdala (AKD) in the mid-latitudes of northwestern China (approximately 0.15 microg m(-3)) was only half of that at Zhuzhang (ZUZ) in low-latitude southwestern China (approximately 0.

Chemical characteristics of aerosol particles (PM2.5) at a site of Horqin Sand-land in northeast China.

The objective of this study was to characterize the mass concentration and chemical composition of aerosol particles (PM2.5) collected at Tongliao (Inner Mongolia Autonomous Region, China), a site in Horqin Sand-land in northeast China. During spring 2005, the mass concentration for PM2.

[Clay ratio as a tracer to assess the origin of soil-derived dust].

The objectives of this research are to characterise the mineralogy of soil-derived dust in Northern China and to set up the mineralogical signature to trace their origin. Mineral composition of aerosol particles is investigated at five sites (Aksu, Dunhuang, Yulin, Tongliao and Changwu) during the intensive field campaign period of ACE-Asia. The results show that the Kaolinite (K) to Chlorite (C) ratio is sensitive to the regional origin of Asian dust.

Effect of antisense oligonucleotides to nuclear factor-kappaB on the survival of LPS-induced ARDS in mouse.

Because nuclear factor (NF)-kappaB-regulated cytokines, including tumor necrosis factor-alpha (TNF-alpha), from monocytes and macrophages have been implicated in the pathogenesis and development of septic shock and acute respiratory distress syndrome (ARDS), the effect of the antisense oligonucleotide to the p65 subunit of NF-kappaB on the survival of lipopolysaccharide (LPS)-induced ARDS in BALB/c mice was examined. None and 70% of the animals died of diffuse hemorrhagic lung edema 1 to 2.5 days after intraperitoneal administration of 10 and 20 mg/kg LPS alone, respectively.