Immunochromatographic assay for rapid detection of SIGLEC15 to evaluate its therapeutic potential in cervical cancer.

SIGLEC15 is a novel immunosuppressive transmembrane protein promotes cancer development. However, the role of SIGLEC15 in cervical cancer remains poorly understood until now. In this study, we identified that the expression of SIGLEC15 was significantly increased in cervical cancer cells and tissues, and it was closely related to the metastasis of cervical cancer (70.

Rational construction of a simplified hemicyanine-based fluorescent probe CCX-1 with dual pH and viscosity response for lysosome-specific tumour imaging.

A simplified D-π-A hemicyanine probe CCX-1 was rationally designed and synthesised a one-step condensation reaction. CCX-1 exhibits dual-responsive fluorescence behavior towards pH and viscosity changes, along with specific lysosomal targeting capability. Notably, CCX-1 enables discrimination between tumor and normal cells, and tumor visualization in living mice, showing significant potential for precise cancer imaging and diagnosis.

Clinical significance of post-chemoradiotherapy 2-[F]FDG PET/CT response in locally advanced nasopharyngeal carcinoma: A real-world study.

Purpose: To investigate the prognostic value of post-chemoradiotherapy 2-[F]FDG PET/CT in locally advanced nasopharyngeal carcinoma (LANPC) and develop an accurate prognostic model based on the 2-[F]FDG PET/CT results.

Methods: 900 LANPC patients who underwent pretreatment and post-chemoradiotherapy 2-[F]FDG PET/CT from May 2014 to August 2022 were included in the study. We divided the patients into two distinct cohorts for the purpose of our study: a training cohort comprising 506 individuals, included from May 2008 to April 2020, and a validation cohort consisting of 394 individuals, included from May 2020 to August 2022.

Recent advances in the treatment of gout with NLRP3 inflammasome inhibitors.

Gout is an autoinflammatory disorder characterized by the accumulation of monosodium urate crystals in joints and other tissues, representing the predominant type of inflammatory arthritis with a notable prevalence and propensity for severe outcomes. The NLRP3 inflammasome, a member of the pyrin domain-containing NOD-like receptor family, exerts a substantial impact on both innate and adaptive immune responses and serves as a pivotal factor in the pathogenesis of gout. In recent years, there has been significant academic and industrial interest in the development of NLRP3-targeted small molecule inhibitors as a promising therapeutic approach for gout.

Targeting Hippo/YAP in intrahepatic cholangiocarcinoma: Promising molecules in cancer therapy.

The tumorigenesis of intrahepatic cholangiocarcinoma (ICC) has been identified to be exceptionally involved in dysregulated Hippo/Yes-associated protein (YAP) signaling pathway (Hippo/YAP). Hippo/YAP functions as a master regulator engaged in a plethora of physiological and oncogenic processes as well. Therefore, the aberrant Hippo/YAP could serve as an Achilles' heel regarding the molecular therapeutic avenues for ICC patients.

EDB-FN targeted probes for the surgical navigation, radionuclide imaging, and therapy of thyroid cancer.

Purpose: Extradomain B of fibronectin (EDB-FN) is a promising diagnostic and therapeutic biomarker for thyroid cancer (TC). Here, we identified a high-affinity EDB-FN targeted peptide named EDBp (AVRTSAD) and developed three EDBp-based probes, Cy5-PEG4-EDBp(Cy5-EDBp), [F]-NOTA-PEG4-EDBp([F]-EDBp), and [Lu]-DOTA-PEG4-EDBp ([Lu]-EDBp), for the surgical navigation, radionuclide imaging, and therapy of TC.

Methods: Based on the previously identified EDB-FN targeted peptide ZD2, the optimized EDB-FN targeted peptide EDBp was identified by using the alanine scan strategy.

Noninvasive Imaging of Tumor PD-L1 Expression Using [Tc]Tc-Labeled KN035 with SPECT/CT.

Programmed cell death protein-1/ligand-1 (PD-1/PD-L1) checkpoint blockade is a major breakthrough in cancer therapy, but identifying patients likely to benefit from this therapy remains challenging. Immunohistochemistry is not informative about PD-L1 expression heterogeneity because of the limitations of invasive tissue collection. Noninvasive SPECT imaging is an approach to patient selection and therapeutic monitoring by assessing the PD-L1 status throughout the whole body.

A sensitive double antibodies sandwich ELISA for the diagnosis and therapeutic evaluation of cervical cancer.

Background: Vascular endothelial growth factor (VEGF) is a highly specific factor for tumors growth. However, the study on the mechanism of VEGF in cervical cancer, and the correlation between the expression level of VEGF and the therapeutic evaluation, prognosis of cervical cancer is not clear till now.

Methods: In this study, RT-qPCR and IHC were used to evaluate the abnormal expression of VEGF in cervical cancer.

Value of baseline and end of chemotherapy F-FDG PET/CT in pediatric patients with Burkitt lymphoma.

The aim of this study was to analyze whether the baseline metabolic parameters of F-FDG PET/CT in pediatric patients with Burkitt lymphoma (BL) can predict treatment response and prognosis. We retrospectively analyzed 68 pediatric patients with BL who underwent PET/CT before treatment. PET images were analyzed semi-quantitatively by measuring the maximum standardized uptake (SUVmax), total metabolic tumor volume (tMTV), and total lesion glycolysis (TLG).

Strong Hollow Spherical LaNiO Photocatalytic Microreactor for Round-the-Clock Environmental Remediation.

This work reports a moderate round-the-clock route to treating organic pollutants by utilizing a LaNiO hollow-sphere microreactor. A glycerol-assisted solvothermal route followed by an annealing process was applied for fabricating the catalyst. Both the physicochemical properties and the catalytic performance of the as-obtained microreactor for treating pollutants were discussed.

Efficient Photocatalytic Fuel Cell via Simultaneous Visible-Photoelectrocatalytic Degradation and Electricity Generation on a Porous Coral-like WO/W Photoelectrode.

Photocatalytic fuel cells (PFCs) have proven to be effective for generating electricity and degrading pollutants with a goal to resolve environmental and energy problems. However, the degradation of persistent organic pollutants (POPs), such as perfluorooctanoic acid (PFOA), remains challenging. In the present work, a porous coral-like WO/W (PCW) photoelectrode with a well-designed energy band structure was used for the photoelectrocatalytic degradation of POPs and the simultaneous generation of electricity.

Role of programmed death ligands in effective T-cell interactions in extranodal natural killer/T-cell lymphoma.

Extranodal natural killer/T-cell lymphoma (ENKL) is marked by a profound cellular immune deficiency that may influence the capacity of T cells to extract an efficient antitumor immune response. It has been confirmed that the B7-CD28 pathway may promote tumor immune evasion by providing a negative regulatory signal. The current study analyzed the expression of programmed death 1 (PD-1)/programmed death ligand (PD-L) in ENKL cell lines and tissues.

Asparagine synthetase expression and its potential prognostic value in patients with NK/T cell lymphoma.

Natural killer (NK)/T cell lymphoma usually shows a highly aggressive clinical course and the overall prognosis is poor. At present, there are no standard therapeutic regimens for this disease. Although chemotherapeutic protocols containing L-asparaginase (L-Asp) or pegaspargase (PEG‑Asp) have improved the efficacy of treatment, some patients are resistant to L-Asp or PEG-Asp.