A Case Report of Eosinophilic Enteritis Complicated with Infection in a Chinese Male.

Eosinophilic gastrointestinal diseases (EGIDs) are chronic, progressive, immune-mediated inflammatory conditions. Its delayed diagnosis and treatment are often due to the lack of specific clinical manifestations. is usually considered normal flora of the gut and rarely causes intestinal infections.

A multidimensional epidemiological perspective on frailty dynamics and prevention.

Frailty, characterized by reduced resilience and increased vulnerability, is a growing public health concern in aging populations. It is increasingly recognized as a dynamic and potentially reversible condition, with transitions between non-frail, pre-frail, and frail states. Recent research has advanced our understanding of frailty through improved multidimensional assessment instruments, trajectories and transitions, and recognition of key risk factors.

Air Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights.

Frailty is an underappreciated but modifiable clinical syndrome, but little about how air quality improvements could influence frailty progression is known. Here, we utilized two Chinese cohorts with repeated follow-up visits to address this knowledge gap and explored the underlying DNA methylation mechanisms. We first conducted a multistate modeling analysis in the Chinese Longitudinal Healthy Longevity Study (CLHLS), a nationwide cohort with 21,654 older adults who had participated in at least two survey waves.

IS26 carrying bla mediates carbapenem resistance heterogeneity in extensively drug-resistant Klebsiella pneumoniae isolated from clinical sites.

Background: Due to the widespread and irrational use of antibiotics, the emergence and prevalence of carbapenem-resistant Klebsiella pneumoniae (K. pneumoniae) have become a major challenge in controlling bacterial infections in hospitals. The bla gene located on mobile genetic elements has further complicated the control of resistant bacteria transmission.

The emergence of highly resistant and hypervirulent ST405 clone in a tertiary hospital over 8 years.

The emergence of carbapenem-resistant (CREC) poses crucial challenges in clinical management, requiring continuous monitoring to inform control and treatment strategies. This study aimed to investigate the genomic and epidemiological characteristics of CREC isolates obtained from a tertiary hospital in China between 2015 and 2022. Next-generation sequencing was used for genomic profiling, and clinical data from patients were integrated into the analysis.

easyEWAS: a flexible and user-friendly R package for epigenome-wide association study.

Motivation: Rapid advancements in high-throughput sequencing technologies especially the Illumina DNA methylation Beadchip greatly fuelled the surge in epigenome-wide association study (EWAS), providing crucial insights into intrinsic DNA methylation modifications associated with environmental exposure, diseases, and health traits. However, current tools are complex and less user-friendly to accommodate appropriate EWAS designs and make downstream analyses and result interpretations complicated, especially for clinicians and public health professionals with limited bioinformatic skills.

Results: We integrated the current state-of-the-art EWAS analysis methods and tools to develop a flexible and user-friendly R package easyEWAS for conducting DNA methylation-based research using Illumina DNA methylation Beadchips.

Impact of air pollution on the progress-free survival of non-small cell lung cancer patients with anti-PD-1/PD-L1 immunotherapy: A cohort study.

Air pollution is a well-established risk factor for lung cancer, but limited evidence exists on its impact on the treatment of lung cancer. The objective of this study was to investigate the impact of key pollutants on the efficacy of PD-1/PD-L1 inhibitor immunotherapy in non-small cell lung cancer (NSCLC) patients, thereby providing clinicians with evidence to potentially enhance the efficacy of PD-1 therapy and inform policy decisions for cancer care. To this end, we conducted a study involving 361 NSCLC patients who received PD-1/PD-L1 inhibitor immunotherapy, examining the correlation between air pollution exposure and progression-free survival (PFS) following immunotherapy treatment.

A rare intestinal mucormycosis caused by in a patient with diabetes: a case report.

Mucormycosis is an aggressive fungal disease. Gastrointestinal mucormycosis is rare, but its clinical symptoms lack specificity and mortality is high. Here, we report a case of intestinal mucormycosis caused by in a 65-year-old woman with diabetes mellitus.

A novel chicken-origin colistin-resistant Klebsiella pneumoniae ST5982 Co-harboring mcr-3.11 and CTX-M-27.

Klebsiella pneumoniae (K. pneumoniae) is an important zoonotic opportunistic pathogen of Enterobacteriaceae that has become one of the most common infectious diseases causing Enterobacteriaceae after Escherichia coli. In this study, we identified a colistin-resistant, multidrug-resistant ST5982 K.

Accelerated biological aging elevates the risk of cardiometabolic multimorbidity and mortality.

Associations of biological aging with the development and mortality of cardiometabolic multimorbidity (CMM) remain unclear. Here we conducted a multistate analysis in 341,159 adults of the UK Biobank. CMM was defined as the coexistence of two or three cardiometabolic diseases (CMDs), including type 2 diabetes, ischemic heart disease and stroke.

Clean air policy reduces the atherogenic lipid profile levels: Results from China Health Evaluation And risk Reduction through nationwide Teamwork (ChinaHEART) Study.

Evidence of the associations between long-term exposure to PM and O and human blood lipid concentrations is abundant yet inconclusive. Whether clean air policies could improve lipid profiles remains unclear. In total, 2979312 participants from a Chinese nationwide prospective study were included.

Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis.

Cirrhosis impairs macrophage function and disrupts bile acid homeostasis. Although bile acids affect macrophage function in patients with sepsis, whether and how the bile acid profile is changed by infection in patients with cirrhosis to modulate macrophage function remains unclear. The present study aimed to investigate the changes in the bile acid profile of patients with cirrhosis and infection and their effects on macrophage function.

Short-Term PM Exposure and DNA Methylation Changes of Circadian Rhythm Genes: Evidence from Two Experimental Studies.

The circadian rhythm regulates many crucial physiological processes, impacting human aging and aging-related outcomes. Observational evidence links circadian rhythm disturbance to PM exposure, yet the underlying DNA methylation mechanisms remain unclear due to limited PM-dominated experimental settings. Therefore, we investigated the associations between short-term PM exposure and DNA methylation changes of 1188 CpG candidates across circadian genes among 32 young adults in the FDU study, with the validation in 26 individuals from the PKU study.

Cardiovascular effects of wearing respirators against particulate matter: A randomized crossover trial.

Fine particles (PM) are implicated as an important risk to cardiovascular health. N95 respirators had been widely used to provide protection by filtering particles. Yet the practical effects of wearing respirators have not been fully understood.

Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants.

Theory predicts that biological processes of aging may contribute to poor mental health in late life. To test this hypothesis, we evaluated prospective associations between biological age and incident depression and anxiety in 424,299 UK Biobank participants. We measured biological age from clinical traits using the KDM-BA and PhenoAge algorithms.

Genomic Characteristics and Phylogenetic Analyses of a Multiple Drug-Resistant Harboring Plasmid-Mediated Isolated from Tai'an City, China.

is a clinically common opportunistic pathogen that causes pneumonia and upper respiratory tract infection in humans as well as community-and hospital-acquired infections, posing significant threats to public health. Moreover, the insertion of a plasmid carrying the mobile colistin resistance (MCR) genes brings obstacles to the clinical treatment of infection. In this study, a strain of colistin-resistant (CRKP) was isolated from sputum samples of a patient who was admitted to a tertiary hospital in Tai'an city, China, and tested for drug sensitivity.

Long-term fine particular exposure and incidence of frailty in older adults: findings from the Chinese Longitudinal Healthy Longevity Survey.

Background: The association between fine particular matter (PM2.5) and frailty is less studied, and the national burden of PM2.5-related frailty in China is unknown.

Long-Term Air Pollution, Genetic Susceptibility, and the Risk of Depression and Anxiety: A Prospective Study in the UK Biobank Cohort.

Background: Depression and anxiety are two mental disorders that are often comorbid. However, the associations of long-term air pollution exposure with depression and anxiety remain inconclusive.

Objective: We conducted a cross-sectional and prospective study to examine the associations of ambient exposure to particulate matter (PM) with a diameter of (), (), and (), nitrogen oxides (), and nitrogen dioxide () with the risk of depression and anxiety in the UK Biobank.

Sini San ameliorates CCl4-induced liver fibrosis in mice by inhibiting AKT-mediated hepatocyte apoptosis.

Ethnopharmacological Relevance: Sini San (SNS) is recorded in Zhang Zhongjing's "Treatise on Typhoids" and is used in the treatment of non-alcoholic fatty liver disease, hepatitis, and other liver diseases, with good efficacy in liver fibrosis. However, its anti-liver fibrosis mechanism remains unclear.

Aim Of The Study: This study aimed to evaluate the ameliorative effect of SNS on carbon tetrachloride (CCl4)-induced liver fibrosis in mice and the underlying mechanisms.

Mortality and morbidity risk prediction for older former smokers based on a score of smoking history: evidence from UK Biobank and ESTHER cohorts.

Background: Rapid population ageing has raised the proportion of older former smokers considerably, but a comprehensive assessment tool of former smoking-related health risks is absent.

Objective: We utilised the large-scale data of UK Biobank and ESTHER study to build a former smoking score (FSS) for older former smokers using three major former smoking traits: pack-years, smoking duration and time since smoking cessation.

Design: UK Biobank and ESTHER study are two cohorts of older adults with 502,528 and 9,940 participants from the UK and Germany, respectively.

Phenotypic and Molecular Characterization of K54-ST29 Hypervirulent Causing Multi-System Infection in a Patient With Diabetes.

Worldwide, hypervirulent (hvKp) is one of the leading causes of multisystem infection. Serotype K54 has also been considered as one of the hvKp-associated capsular types that are rarely reported. In this study, we reported a K54-ST29 hvKp isolated from a 58-year-old male patient with diabetes in a teaching hospital in China.

Association of DNA methylation in circulating CD4T cells with short-term PM pollution waves: A quasi-experimental study of healthy young adults.

Background: Fine particulate matter (PM) is a modifiable environmental risk factor with established adverse effects on human health. However, associations between acute PM fluctuation and DNA methylation remain unknown.

Methods: A quasi-experimental study utilizing naturally occurring PM pollution waves (PPWs) was conducted on 32 healthy young adults.