A predictive model for prognosis in infants with surgical necrotizing enterocolitis.

Background: Surgical intervention could improve the prognosis of infants with necrotizing enterocolitis (NEC), but it's also an independent risk factor for severe complications and death. This study aimed to establish a nomogram to predict the prognosis of infants with surgical NEC.

Methods: A total of 189 infants with surgical NEC were enrolled from January 2013 to May 2024.

Nutritional management adherence via an ePRO platform in patients with cancer: a machine learning model study.

Background: Electronic patient-reported outcome (ePRO) systems have significant potential for providing individualized and continuous nutritional management for patients with cancer. However, adherence to ePRO-guided nutritional interventions varies significantly, and the key factors associated with adherence remain poorly understood. This study aimed to assess adherence to nutritional targets via ePRO platforms and identify predictors influencing adherence to optimize management strategies.

Characteristics and clinical implication of mitral annular disjunction in apparently normal hearts: a cardiac magnetic resonance study.

Background: While mitral annular disjunction (MAD) is associated with mitral valve prolapse (MVP) and ventricular arrhythmia (VA), its prevalence and clinical implication in subjects with normal heart remain unclear. Therefore, this study aimed to assess the incidence and characteristics of MAD in apparently normal hearts (ANH) confirmed by comprehensive cardiac magnetic resonance (CMR), and to explore its impact on myocardial contraction and potential association with VA.

Methods: This retrospective cohort study was conducted on 444 patients who underwent CMR at a tertiary care center between January 2017 and March 2023.

[Characteristics of Gut Microbiota Changes and Their Relationship with Infectious Complications During Induction Chemotherapy in AML Patients].

Objective: To investigate the characteristics of gut microbiota changes in patients with acute myeloid leukemia (AML) undergoing induction chemotherapy and to explore the relationship between infectious complications and gut microbiota.

Methods: Fecal samples were collected from 37 newly diagnosed AML patients at four time points: before induction chemotherapy, during chemotherapy, during the neutropenic phase, and during the recovery phase. Metagenomic sequencing was used to analyze the dynamic changes in gut microbiota.

Discovery of novel flavonoid derivatives targeting VEGFR2 and tubulin with potent anticancer efficacy.

The clinical efficacy of VEGFR inhibitors and tubulin inhibitors as monotherapies is restricted by adverse reactions and resistance. We reported a classic pharmacophore hybridization strategy to develop dual VEGFR2/tubulin inhibitors that simultaneously inhibited tumor angiogenesis and tubulin assembly. A series of novel flavonoid derivatives containing N, N'-diethylurea group and trimethoxyphenyl were designed and synthesized.

Mesenchymal stem cells-derived exosomes alleviate radiation induced pulmonary fibrosis by inhibiting the protein kinase B/nuclear factor kappa B pathway.

Background: Radiation induced pulmonary fibrosis (RIPF) is a long-term lung condition with a bleak outlook and few treatment possibilities. Mesenchymal stem cells (MSCs)-derived exosomes (MSCs-exosomes) possess tissue repair and regenerative properties, but their exact mechanisms in RIPF remain unclear. This study explores whether MSCs-exosomes can alleviate RIPF by modulating inflammation, extracellular matrix (ECM) accumulation, and epithelial-mesenchymal transition (EMT) the protein kinase B (Akt)/nuclear factor kappa B (NF-κB) pathway.

Association of the single-nucleotide polymorphism in the MFG-E8 gene with coronary heart disease in Chinese Han population.

Coronary atherosclerosis narrows or occludes blood vessels, resulting in myocardial ischemia and hypoxia, which ultimately leads to coronary heart disease (CHD). The pathogenesis of CHD remains insufficiently elucidated. A widely accepted hypothesis is that various stimuli induce arterial intima injury, and atherosclerosis (AS)formation reflects the inflammatory-fibroproliferative response of the intima to such injury.

Smartphone-assisted colorimetric sensing platform based on Fe-LCDs nanozymes for detection of creatine in meat.

Creatine (CR) is an active compound closely associated with meat quality. However, current techniques for measuring CR in meat face challenges in achieving rapid and low-cost detection. In this study, nanozyme based on iron-doped carbon dots (Fe-LCDs) was synthesized by employing sodium lignosulfonate and iron as the precursors.

Highly pre-organized fluorescent naphthotube for efficient detection of uranyl ions.

Supramolecular fluorescent sensors have garnered extensive research attention and found broad applications in biochemical sensing attributed to their high selectivity, rapid response, stimulus responsiveness, and ease of modification, which stem from their inherent molecular recognition and self-assembly capabilities. Herein, supramolecular fluorescent sensors based on anthracene-functionalized naphthotubes have been successfully developed and utilized for the efficient detection of uranyl ions. Owing to the highly pre-organized carboxyl groups on the naphthotubes, uranyl ions are effectively captured, forming a non-fluorescent or weakly fluorescent complex to quench the fluorescence of anthracene.

[Characterization and features of dampness-heat obstruction syndrome in rats with knee osteoarthritis based on "disease-syndrome-symptom" combination research strategy].

A combination of the "disease-syndrome-symptom" approach was used to study the syndrome characterization and features of dampness-heat obstruction syndrome in papain-induced knee osteoarthritis(KOA) model rats during the disease process. Forty-eight male SD rats were randomly divided into sham and model groups. The KOA model was established by injecting a mixture of papain and L-cysteine into the joint cavity on days 1, 3, and 5.

DSUP modified mesenchymal stem cells exert significant radiation protective effect by enhancing the hematopoietic niche.

Background: Radiation induced hematopoietic failure was the primary cause of death after exposure to a moderate or high dose of whole body irradiation, causing increased challenge for nuclear or radiological treatment, so it is an urgent need to develop radioprotectors for attenuating hematopoietic damage caused by acute radiation syndrome (ARS). Given the excellent therapeutic effects and special benefits of mesenchymal stem cells (MSCs) in radiation damaged hematopoietic stem/progenitor cells (HSPCs) recovery and hematopoietic niche reconstruction, enhancing the hematopoietic niche with the radiotolerance MSCs can be an alternative solution to prevent and attenuate hematopoietic radiation damage, which needs to be studied.

Methods: Here, we constructed MSCs modified with Damage Suppressor Protein (DSUP), a radiotolerance gene identified from tardigrade Ramazzotius varieornatus, and verify its radiation protection effect in HSPCs-MSCs co-culture model in vitro and radiation damaged mice model in vivo.

Knockdown of circRNA_0030042 Attenuates Heart Failure via miR-568/PRG4 Pathway.

Heart failure is a common heart disease and cause of death globally which is caused by structural and functional abnormalities. circRNA_0030042 is a newly discovered circRNA that derived from its host gene forkhead box O1 (FOXO1). However, the role of circRNA_0030042 in heart failure is not revealed.

Snail family transcriptional repressor 1 radiosensitizes esophageal cancer via epithelial-mesenchymal transition signaling: From bioinformatics to integrated study.

Background: Esophageal cancer (ESCA) poses a significant challenge in oncology because of the limited treatment options and poor prognosis. Therefore, enhancing the therapeutic effects of radiotherapy for ESCA and identifying relevant therapeutic targets are crucial for improving both the survival rate and quality of life of patients.

Aim: To define the role of the transcription factor Snail family transcriptional repressor 1 (SNAI1) in ESCA, particularly its regulation of radiosensitivity.

Spectral CT findings of bladder urothelial carcinoma with gastric metastasis: a case report.

Background: Bladder cancer is one of the most common cancers worldwide, and urothelial carcinoma is the most common form of bladder cancer. Gastric metastasis of urothelial carcinoma of the bladder is a rare condition. Cystoscopy plays an important role in the diagnosis of bladder cancer; however, it is an invasive procedure that may affect the patient's prognosis and does not allow for the observation of cancer infiltration and metastasis.

Molecular recognition and potentiometric determination of neostigmine and pyridostigmine by a methylene-bridged naphthotube.

A macrocyclic arene featuring rigid bis-naphthalene possesses a remarkable ability to strongly bind neostigmine ( = 2.7 × 10 M) and pyridostigmine ( = 2.2 × 10 M) within its deep cavity.

Screen time is a predictor of cognitive function in children with attention deficit hyperactivity disorder.

Background: Screen exposure may affect cognitive function in children with attention deficit hyperactivity disorder (ADHD). We aimed to investigate the relationship between screen time and cognitive function in children with ADHD and explore other risk factors for cognitive function.

Methods: The study included 184 patients with ADHD (aged 6-16 years).

Advances in imaging techniques for tumor microenvironment evaluation in hepatocellular carcinoma.

The tumor microenvironment (TME) plays a critical role in the development and treatment of liver cancer, which ranks sixth in incidence and third in mortality worldwide, according to the "Global Cancer Statistics 2022". Hepatocellular carcinoma (HCC), the most common form of liver cancer, is heavily influenced by the TME, which affects tumor growth, invasion, metastasis, and the response to various treatments. Despite advancements in surgery, liver transplantation, targeted therapies, and immunotherapy, the complexity of the TME often limits treatment efficacy, especially in advanced-stage HCC cases.

WTAP-mediated mA methylation of PHF19 facilitates cell cycle progression by remodeling the accessible chromatin landscape in t(8;21) AML.

Wilms' tumor 1-associated protein (WTAP) is a key N6-methyladenosine (mA) methyltransferase that is upregulated in t(8;21) acute myeloid leukemia (AML) under hypoxia inducible factor 1α-mediated transcriptional activation, promoting leukemogenesis through transcriptome-wide mA modifications. However, the specific substrates and intrinsic regulatory mechanisms of WTAP are not well understood. Here, we provide evidence that PHD finger protein 19 (PHF19) overexpression is regulated by WTAP-mediated mA modification and promotes cell cycle progression by altering chromatin accessibility.

[Effect of colostrum oral immune therapy on the the clinical outcomes in very low birth weight infants: a Meta analysis].

Objectives: To evaluate the effect of colostrum oral immune therapy (COIT) on clinical outcomes in very low birth weight (VLBW) infants.

Methods: A computer-based search was conducted in databases including China National Knowledge Infrastructure, Wanfang Data, Weipu Database, Chinese Biomedical Literature Service System, PubMed, Embase, Web of Science, the Cochrane Library, and CINAHL for randomized controlled trials regarding the application of COIT in VLBW infants published from the establishment of the database to February 2024. Meta analysis was performed using RevMan 5.

Association of Zona Pellucida Gene Variants With Female Infertility: A Retrospective Genetic Analysis.

Objective: We investigated the clinical characteristics and pregnancy outcomes of patients with zona pellucida (ZP) gene variants undergoing assisted reproductive technology (ART) treatment, to identify variants associated with female infertility.

Design: Retrospective study.

Setting: University-based reproductive medicine centre.

The role of third component in coumarin-based all-small-molecule ternary organic solar cells with non-fullerene acceptor based on molecular stacking.

The power conversion efficiency (PCE) of ternary all-small-molecule organic solar cells (T-ASM-OSCs) differs significantly from that of the polymer systems (2 %), and the role of third component remains unclear. The electron donor of coumarin derivatives with simple structure and strong and broad light absorption has high PCE for T-ASM-OSCs composed of non-fullerene acceptors (Y6 and DBTBT-IC). Here, we calculated the electronic structure and interfacial properties of the binary C1-CN:Y6 and ternary C1-CN:Y6:DBTBT-IC systems using molecular dynamic (MD) simulations and density functional theory (DFT) to explore the role of the third component (DBTBT-IC).

Tracheal reconstructive surgery under ECMO for the treatment of congenital tracheal stenosis in the premature infant: case report.

Background: Congenital tracheal stenosis (CTS) is a rare but life-threatening malformation of the trachea. Surgical reconstruction is the treatment of choice in symptomatic cases which is highly risky and is rarely performed in extremely premature infants. With this, reporting a case of CTS managed by tracheal reconstructive surgery under ECMO in a baby weighing 1.

Fusion Modes and Number of Fused Rings: Their Impact on Acceptor-Donor-Acceptor Nonfullerene Acceptors in Organic Solar Cells.

The power conversion efficiency (PCE) of organic solar cells (OSCs) devices has surpassed 19% owing to the blooming of fused-ring nonfullerene acceptors (NFAs), especially for acceptor-donor-acceptor (A-D-A) type NFAs. However, the structural effect of the angular/linear fusion mode and number of fused rings for A-D-A type NFAs on the photovoltaic performance in OSCs devices remains unclear. Herein, the A-D-A type NFAs (, , and ) have been selected to obtain the intrinsic role of structural design strategies including the angular/linear fusion mode and the number of fused rings.