A predictive model for prognosis in infants with surgical necrotizing enterocolitis.

Background: Surgical intervention could improve the prognosis of infants with necrotizing enterocolitis (NEC), but it's also an independent risk factor for severe complications and death. This study aimed to establish a nomogram to predict the prognosis of infants with surgical NEC.

Methods: A total of 189 infants with surgical NEC were enrolled from January 2013 to May 2024.

Using integrated bioinformatics, network pharmacology and molecular docking to explore the mechanisms underlying the antidepressant effect of celastrol.

Celastrol, a natural compound derived from the root of Hook. F., has shown potential efficacy in alleviating depression in animal models, yet its specific target remains unelucidated.

Inverse opal anatase/rutile TiO multi-heterojunctions enable efficient photoelectrochemical water splitting.

TiO has garnered significant attention in the field of photoelectrochemical (PEC) water splitting due to its non-toxicity, cost-effectiveness, and exceptional photochemical stability. However, its practical efficiency in H production is greatly hindered by inherent limitations such as low electron mobility, a short carrier diffusion length, and a wide optical band gap. Herein, we present a strategy of combining a crystal phase heterojunction and crystal facet heterojunction to enhance electron-hole separation efficiency in TiO.

Mask use in Chinese children admitted to the outpatient department: a single-center cross-sectional study.

Background: Mask use is a critical precaution to prevent the transmission of SARS-CoV-2 in a crowded or densely populated indoor environment. There is still a lack of large-sample studies on mask use in children during the COVID-19 pandemic.

Methods: A questionnaire was distributed to individuals under 18 years of age from the pediatric outpatient department from November 2021 to May 2022.

Ruscogenin Exerts Anxiolytic-Like Effect via Microglial NF-κB/MAPKs/NLRP3 Signaling Pathways in Mouse Model of Chronic Inflammatory Pain.

Long-term inflammation can cause chronic pain and trigger patients' anxiety by sensitizing the central nervous system. However, effective drugs with few side effects for treating chronic pain-induced anxiety are still lacking. The anxiolytic and anti-inflammatory effects of ruscogenin (RUS), an important active compound in Ophiopogon japonicus, were evaluated in a mouse model of chronic inflammatory pain and N9 cells.

The Impact of Nursing Interventions on the Treatment Outcomes of Renal Cell Carcinoma with Postoperative Interleukin-2 and Recombinant Human Interferon.

Objective: This study investigates the impact of nursing interventions on treatment outcomes and adverse reaction rates in renal cell carcinoma (RCC) patients treated postoperatively with Interleukin-2 and recombinant human Interferon.

Methods: In a retrospective analysis of 90 RCC patients, 43 received standard care (control group), while 47 received additional nursing interventions (intervention group), including psychological care, vital signs monitoring, dietary care, adverse reaction management, and post-discharge care. Patients with concurrent major diseases or other malignancies were excluded.

Moxibustion ameliorates visceral hypersensitivity by regulating hypothalamus-spinal cord-colon axis in rats with irritable bowel syndrome with diarrhea.

Objectives: To observe the effect of moxibustion intervention on the hypothalamus-spinal cord-colon axis of rats with irritable bowel syndrome with diarrhea (IBS-D) and explore the mechanism of moxibustion in improving visceral hypersensitivity in rats with IBS-D.

Methods: A total of 36 SD rats were randomly divided into normal, model, and moxibustion groups, with 12 rats in each group. The IBS-D model was established by maternal separation + acetic acid stimulation + chronic restraint.

TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.

Aims: To assess the effect of the translocator protein 18 kDa (TSPO) on postpartum depression and explore its mechanism.

Methods: Postpartum depression (PPD) mouse model was established, and flow cytometry, immunofluorescence, Western blot analysis, real-time quantitative PCR, adeno-associated virus (AAV), co-immunoprecipitation-mass spectrometry and immunofluorescence co-staining were used to detect the effect of TSPO ligand ZBD-2 on PPD mice.

Results: ZBD-2 inhibits the overactivation of microglia in the hippocampus and amygdala of PPD model mice.

Schisandrin B, a dual positive allosteric modulator of GABA and glycine receptors, alleviates seizures in multiple mouse models.

Epilepsy is a prevalent and severe neurological disorder and approximately 30% of patients are resistant to existing medications. It is of utmost importance to develop alternative therapies to treat epilepsy. Schisandrin B (SchB) is a major bioactive constituent of Schisandra chinensis (Turcz.

Carpets with visual cues can improve gait in Parkinson's disease patients: may be independent of executive function.

Background: Gait impairment is common in Parkinson's disease (PD) patients, which greatly reduces their quality of life. Executive dysfunction is associated with gait impairment. Compensatory strategies, including visual cues, have been shown to be effective in improving PD gait.

[Association of phthalate and polycyclic aromatic hydrocarbon exposure during early pregnancy with premature delivery: A cohort study].

Objective: To explore the relationship of the exposure to phthalate esters (PAE) and polycyclic aromatic hydrocarbons (PAH) with clinical premature delivery during early pregnancy.

Methods: We conducted a baseline questionnaire survey among 821 pregnant women undergoing prenatal examination in Hubei Provincial Maternal and Child Health Care Hospital, collected their morning urine samples and followed them up to the outcomes of pregnancy. We quantitatively analyzed 10 PAE and 10 PAH metabolites in the urine samples, followed by Mann-Whitney U test, chi-square test, and logistic regression analysis.

An Investigation of the Effects of Gene rs10754339 and Gene rs12976445 on Cancer Susceptibility.

Objective: To investigate the effects of the gene rs10754339 and gene rs12976445 on cancer susceptibility through a case-control study and meta-analysis.

Methods: A total of 1,490 cancer patients (lung/gastric/liver/: 550/460/480) and 800 controls were recruited in this case-control study. The meta-analysis was performed by pooling the data from previous related studies and the present study.

[Transmission and Growth Characteristics of Severe PM Pollution Events from 2013 to 2021 in Xingtai, Hebei].

The correlation between the growth rate of PM with transport source, atmospheric circulation, and wind field were analyzed, focusing on the severe and above pollution process (SAAP) in Xingtai, Hebei Province from 2013 to 2021. The results showed that from 2013 to 2021, a total of 164 pollution processes and 103 SAAP occurred in Xingtai. In the ground circulation, although the probability occurrence of the inverted trough was low, the probability of pollution was the highest (61.

[Moxibustion relieves colonic inflammation by up-regulating expression of miR-345-3p/miR-216a-5p and down-regulating NF-κB p65 in colonic tissue of rats with diarrhea-predominant irritable bowel syndrome].

Objective: To observe the effect of moxibustion on the expression of miR-345-3p, miR-216a-5p and nuclear factor-κB p65(NF-κB p65) in colonic tissue of rats with diarrhea-predominant irritable bowel syndrome (IBS-D), so as to explore its anti-inflammatory mechanism in relieving IBS-D.

Methods: SD rats were randomly divided into normal control (=12), model (=12), moxibustion (=12) and ammonium pyrrolidine dithiocarbamate (PDTC,=12) groups. The IBS-D model was established by neonatal mother-child separation combined with acetic acid enema stimulation and chronic binding methods.

Reduced platelet 5-HT content is associated with rest tremor in Parkinson's disease.

Introduction: Parkinson's disease (PD) is highly heterogeneous in manifestations and pathogenesis. Serotonergic neurotransmitter system dysfunction is frequently implicated in PD tremor. Serotonin (5-HT) content in platelets is highly correlated with that in cerebrospinal fluid.

Mechanism of Resveratrol Improving Ischemia-Reperfusion Injury by Regulating Microglial Function Through microRNA-450b-5p/KEAP1/Nrf2 Pathway.

Alterations in the M1/M2 polarization phenotype significantly affect disease progression. Antioxidant and anti-inflammatory protective effects of resveratrol (Res) have been demonstrated. This paper tested the hypothesis that Res could protect against cerebral ischemia-reperfusion injury (CI/RI) by modulating microglial polarization via the miR-450b-5p/KEAP1/Nrf2 pathway.

[Distributions of Antibiotic Resistance Genes and Microbial Communities in the Nearshore Area of the Yangtze River Estuary].

Due to the extensive use of antibiotics, the resistance of microorganisms to antibiotics in the environment is increasing, and the problem of antibiotic resistance genes (ARGs) is becoming more and more severe, which seriously threatens ecological security and human health. In order to study the distribution characteristics of ARGs and the microbial community in different media in the coastal area of the Yangtze River Estuary, water and sediment samples from eight sites were collected through a field investigation. Two sulfonamide resistance genes (, ) and six tetracycline resistance genes (, , , , , and ), one integrase gene , 16S rRNA gene, and the microbial community were detected and analyzed.

Neck pain and absence of cranial nerve symptom are clues of cervical myelopathy mimicking stroke: Two case reports.

Background: Cervical myelopathy is a potential stroke imitator, for which intravenous thrombolysis would be catastrophic.

Case Summary: We herein present two cases of cervical myelopathy. The first patient presented with acute onset of right hemiparesis and urinary incontinence, and the second patient presented with sudden-onset right leg monoplegia.

14-3-3 proteins contribute to autophagy by modulating SINAT-mediated degradation of ATG13.

In multicellular eukaryotes, autophagy is a conserved process that delivers cellular components to the vacuole or lysosome for recycling during development and stress responses. Induction of autophagy activates AUTOPHAGY-RELATED PROTEIN 1 (ATG1) and ATG13 to form a protein kinase complex that initiates autophagosome formation. However, the detailed molecular mechanism underlying the regulation of this protein complex in plants remains unclear.

[Anti-inflammation effect of moxibustion for rats with diarrhea-predominant irritable bowel syndrome based on multiple miRNAs regulating NF-κB signal pathway].

Objective: To observe the effect of moxibustion on the regulation of nuclear factor-kappa B (NF-κB) and inflammatory factors by multiple microRNAs (miRNAs) in rats with diarrhea-predominant irritable bowel syndrome (IBS-D), and to explore the anti-inflammatory mechanism of moxibustion on IBS-D.

Methods: Twelve of 52 newborn rats were randomly selected into a normal group. The remaining rats were made into IBS-D model.

[Construction and Expression of Eukaryotic and Prokaryotic Recombinant Vectors of and 63 Dominant Epitopes of ].

Objective: To construct eukaryotic and prokaryotic recombinant vectors containing - 63 and to achieve protein expression by selecting the dominant epitope genes of and 63 of .

Methods: The secondary structure and HLA epitopes of phosphoenolpyruvate carboxylase (PEPCK) were predicted by in silico analysis, and the dominant epitopes were picked out. According to the analysis results of glycoprotein of 63×10 (GP63) epitopes identified by the same method in our laboratory, the dominant epitope genes of and 63 were used to construct pET32a- - 63 and pVAX1- - 63 by overlapping PCR and enzyme reaction.

Molecular Iodine-Promoted [3 + 2] Oxidative Cyclization for the Synthesis of Heteroarene-Fused [1,2,4] Thiadiazoles/Selenadiazoles.

Two new classes of heteroarene-fused [1,2,4]thiadiazole and [1,2,4]selenadiazole are synthesized through the iodine-mediated [3 + 2] oxidative cyclization of 2-aminoheteroarenes and isothiocyanates/isoselenocyanates. This oxidative [3 + 2] annulation strategy is highly regiospecific to proceed a selective C-N bond formation at the endo-nitrogen of 2-aminoheteroarenes followed by an intramolecular oxidative N-S/N-Se bond formation. It is the first example of an I-mediated oxidative nitrogen-selenium (N-Se) bond formation.

[Characteristics and Influencing Factors of Polycyclic Aromatic Hydrocarbons in Surface Soils from Typical Industrial Areas of Chengdu].

To improve the pollution signature database for polycyclic aromatic hydrocarbons (PAHs) in typical industrial areas in China, surface soil samples were collected from four typical petroleum-processing industrial areas of Chengdu. The concentration and composition of 16 PAHs listed for prior control by the United States Environmental Protection Agency (US EPA) were determined using high-performance liquid chromatography (HPLC). The result showed that the concentration of PAHs in surface soils of the four industrial areas ranged from 191.