Surface-Modified Graphite Anodes for High-Rate Long-Cycling in Sulfide All-Solid-State Batteries.

Graphite is a promising anode for realizing high power density in sulfide-based all-solid-state lithium batteries (ASSLIBs). However, their fast-charging capabilities are limited in practice. This paper demonstrates that the reactivity between lithiated graphite and sulfide electrolytes and undesirable side reactions at the amorphous carbon interface negatively affect the fast-charging capacities of ASSLIBs.

Association between blood heavy metal levels and COPD risk: a cross-sectional study based on NHANES data.

Objective: Heavy metals such as cadmium (Cd), lead (Pb), mercury (Hg), selenium (Se), and manganese (Mn) are commonly found in the environment and could increase the risk of COPD, potentially through key biological mechanisms such as oxidative stress and inflammation. Nonetheless, evidence on the association between exposure to these metals and COPD remains limited and inconclusive. This study aims to evaluate the potential association between blood levels of Cd, Pb, Hg, Se, and Mn and the likelihood of developing COPD.

Designing Nonplanar Electron Acceptors for High-Performance Organic Photodetectors: Mechanism Analysis and Application in Gesture Recognition.

Realizing low dark current density () while maintaining high photoresponse is crucial yet challenging for organic photodetectors (OPDs). In this work, two nonplanar small molecule electron acceptors, BTTPCN-F and BTTPCN-Cl, were developed. The OPDs based on them achieved ultralow down to 2.

Abnormal Anti-Kasha Emission and TADF in Anionic Cycloarylenes.

Incorporation of non-benzoid rings into cycloarylenes significantly alters their molecular geometry and optical behavior. Recently, we synthesized two ferrocene-doped cycloarylenes, (CpFe)-1 and (CpFe)-2. However, the {FeCp} moieties in these architectures limited their optical properties.

DEVELOPMENT AND VALIDATION OF A PREDICTION MODEL FOR SEPTIC SHOCK-ASSOCIATED ACUTE KIDNEY INJURY: A MULTICENTER STUDY USING NOMOGRAM MODELING.

Background: Septic shock-associated acute kidney injury (SS-AKI) is a severe complication with high mortality. This study aimed to investigate the risk factors associated with AKI in patients with septic shock and establish a nomogram to predict its occurrence. Methods: Patients with septic shock were categorized based on the development of AKI.

The toxicity comparison of metformin and its degradant guanylurea through multi-routes exposure experiments using algae and rotifer.

Metformin (MET) and its metabolite guanylurea (GUA) are prevalent in aquatic environments, raising concerns about their potential risks to aquatic organisms. However, the toxicity of these compounds through different exposure routes has not been reported. This study evaluated the effects of MET and GUA on the growth of the green algae Tetradesmus obliquus and on life table parameters of the freshwater rotifer Brachionus calyciflorus through various exposure routes, including waterborne, foodborne, and combined waterborne + foodborne.

Association of the time interval between first and last birth with obesity in middle-aged postmenopausal Chinese women: a cross-sectional study in southern China.

Background: Birth interval is acknowledged as a significant factor affecting the health of women and their children. This study aimed to investigate the relationship between the time interval from the first to the last birth and the prevalence of general obesity, abdominal obesity, or both, among middle-aged postmenopausal Chinese women.

Methods: This cross-sectional survey examined 4,799 Chinese postmenopausal women, aged 45-59 years, who had at least one live birth.

CARD9 deficiency alleviates septic pulmonary embolism.

Dysfunction of pulmonary microvascular endothelial cells (PMVECs) is an important feature of pulmonary embolism (PE) in sepsis. This study aimed to explore the impact of caspase recruitment domain-containing protein 9 (CARD9) on sepsis-induced PE. Proteomic analysis was performed on serum of sepsis patients with PE to identify differentially expressed proteins.

Thiophene-backbone arcuate graphene nanoribbons: shotgun synthesis and length dependent properties.

Efficient synthetic methods are urgently needed to produce graphene nanoribbons (GNRs) with diverse structures and functions. Precise control over the topological edges of GNRs is also crucial for achieving diverse molecular topologies and desirable electro-optical properties. This study demonstrates a highly efficient "shotgun" synthesis of thiophene-backbone arcuate GNRs, offering a significant advantage over tedious iterative synthesis.

A novel PCB surface defect detection method based on separated global context attention to guide residual context aggregation.

In the production and manufacturing of Printed Circuit Boards (PCBs), defects can arise negatively impact to both product performance and usability. To tackle the issue of false detections stemming from a high volume of small defects and complex backgrounds in PCBs, we propose SRN_Net, an innovative small object detection framework specifically designed for PCB defect identification scenarios. Firstly, an advanced Separated Global Context Attention (SGC) mechanism is introduced to enhance the model's attention to small targets and improve the detection accuracy of the model for small targets.

Protein design accelerates the development and application of optogenetic tools.

Optogenetics has substantially enhanced our understanding of biological processes by enabling high-precision tracking and manipulation of individual cells. It relies on photosensitive proteins to monitor and control cellular activities, thereby paving the way for significant advancements in complex system research. Photosensitive proteins play a vital role in the development of optogenetics, facilitating the establishment of cutting-edge methods.

The impact of a PERMA model-based positive psychology intervention on fear of stroke recurrence: a randomized controlled trial.

Introduction: This study aimed to examine the effects of a positive psychological intervention, grounded in the PERMA model, on fear levels, psychological capital, overall well-being, and quality of life among stroke patients.

Methods: A single-blind, two-arm randomized controlled trial with a repeated measures design was conducted at the Affiliated Hospital of Jiangnan University from January to December 2023. A total of 125 patients experiencing fear of stroke recurrence were randomly assigned to either the intervention group ( = 63), which received a positive psychological intervention based on the PERMA model, or the control group ( = 62), which received standard care.

Refining the Understanding of Autoimmune Liver Disease Mortality.

The comprehensive population-based cohort study of autoimmune liver disease (AILD) mortality by Lasyte et al. provides valuable epidemiological insights. Several methodological perspectives merit consideration, including public database limitations, temporal mortality trends and the role of chronic kidney disease as an unmeasured covariate in mortality risk assessment.

Toward Low Energetic Disorder in Organic Solar Cells: The Critical Role of Polymer Donors.

Compared with those of inorganic and perovskite solar cells, the power conversion efficiencies of organic solar cells (OSCs) are severely limited by a large energetic disorder. However, the origin of energetic disorder for OSCs remains poorly understood. Herein, we systematically investigate the energetic disorder in representative OSCs and the effect of both the acceptors and polymer donors by combining atomistic molecular dynamics simulations with density functional theory calculations.

Developing a ceRNA-based lncRNA-miRNA-mRNA regulatory network to uncover roles in skeletal muscle development.

The precise role of lncRNAs in skeletal muscle development and atrophy remain elusive. We conducted a bioinformatic analysis of 26 GEO datasets from mouse studies, encompassing embryonic development, postnatal growth, regeneration, cell proliferation, and differentiation, using R and relevant packages (limma et al.).

Biocomputing at the crossroad between emulating artificial intelligence and cellular supremacy.

Biocomputation aims to create sophisticated biological systems capable of addressing important problems in (bio)medicine with a machine-like precision. At present, computational gene networks engineered by single- or multi-layered assembly of DNA-, RNA- and protein-level gene switches have allowed bacterial or mammalian cells to perform various regulation logics of interest, including Boolean calculation or neural network-like computing. This review highlights the molecular building blocks, design principles, and computational tasks demonstrated by current biocomputers, before briefly discussing possible fields where biological computers may ultimately outcompete their electronic counterparts and achieve cellular supremacy.

Surface Modification of Polyvinylidene Fluoride Latex Nanoparticles through Chain Entanglement by Poly(meth)acrylate Monomer Swelling Seeded Emulsion Polymerization.

Polyvinylidene fluoride (PVDF) latex nanoparticles serve as a versatile platform for surface modification due to their role as precursors in PVDF manufacturing. However, the strong chemical stability and poor compatibility of PVDF present significant challenges for effective surface modification. To address this, we developed a method that facilitates surface modification through chain entanglement.

A trigger-inducible split-Csy4 architecture for programmable RNA modulation.

The CRISPR-derived endoribonuclease Csy4 is a popular tool for controlling transgene expression in various therapeutically relevant settings, but adverse effects potentially arising from non-specific RNA cleavage remains largely unexplored. Here, we report a split-Csy4 architecture that was carefully optimized for in vivo usage. First, we separated Csy4 into two independent protein moieties whose full catalytic activity can be restored via various constitutive or conditional protein dimerization systems.

Cationic Magnetically Active Nitrogen-Doped Polycyclic Aromatic Hydrocarbon with Record Low Band Gap.

Polycyclic aromatic hydrocarbons (PAHs) have attracted significant interest in material chemistry, particularly if they own extremely low band gaps and magnetic properties. However, challenges remain regarding the synthetic accessibility and energy saturation issues. In this study, we introduce NR-11, which consists of eleven aromatic rings in its main conjugation and is separately doped with two electron-rich nitrogen atoms.

Toxicity and intergenerational accumulation effect of tire wear particles and their leachate on Brachionus plicatilis.

Tire wear particles (TWP) are one of the main sources of microplastic (MP) pollution in the marine environment, causing adverse effects on marine life and attracting increasing attention. This study aimed to investigate the chemical composition of TWP (particles and leachate) and their toxic effects on Brachionus plicatilis. The results showed that Zn and acenaphthene were the most frequently detected compounds in the three TWP treatments.

PD-L2 act as an independent immune checkpoint in colorectal cancer beyond PD-L1.

Introduction: Immunotherapy, especially immune checkpoint blockade (ICB), holds promise as a therapeutic strategy in colorectal cancer (CRC) by harnessing the patient's immune system to target malignant cells. Particularly, the PD-1/PD-L1 axis is widely recognized for its critical role in tumor microenvironment immunosuppression. Antibodies targeting PD-1 or PD-L1 have shown sustained efficacy against various cancers, including CRC.

Effects of multicomponent exercise nursing intervention in elderly stroke patients with frailty: a randomized controlled trial.

This study examines how multicomponent exercise nursing interventions affect the state of frailty, daily activities, and quality of life in elderly stroke patients with frailty. A total of 125 elderly stroke patients with frailty were randomly assigned to either a control group ( = 62) or an intervention group ( = 63). The control group received standard nursing care, while the intervention group received a multicomponent exercise nursing intervention in addition to standard care.

Effects of home disease management strategies based on the dyadic illness management theory on elderly patients with chronic heart failure and informal caregivers' physical and psychological outcomes: protocol of a randomized controlled trial.

Background: Currently, most elderly chronic heart failure (CHF) patients go home for rehabilitation after certain treatment in hospitals. However, the results of their rehabilitation at home are not satisfactory. According to studies, dyadic treatments can increase the efficiency of home rehabilitation, enhance both partners' quality of life, lessen the caregiver's load of care, and alleviate the strain of medical resources.