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The comprehensive population-based cohort study of autoimmune liver disease (AILD) mortality by Lasyte et al. provides valuable epidemiological insights. Several methodological perspectives merit consideration, including public database limitations, temporal mortality trends and the role of chronic kidney disease as an unmeasured covariate in mortality risk assessment. These methodological elements further enhance the interpretation of this robust AILD mortality analysis.
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http://dx.doi.org/10.1111/liv.70044 | DOI Listing |
United European Gastroenterol J
September 2025
Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital and Vita Salute San Raffaele University, Milan, Italy.
Background: Few data are available on the impact of primary sclerosing cholangitis (PSC) on inflammatory bowel disease (IBD).
Objective: We conducted a retrospective study using TriNetX to compare the outcomes of patients with IBD and those with concomitant IBD and PSC.
Methods: All patients with a confirmed diagnosis of Crohn's disease (CD), ulcerative colitis (UC), or indeterminate colitis with or without PSC were eligible.
J Viral Hepat
October 2025
Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Chronic liver disease (CLD) is a leading cause of global morbidity and mortality, necessitating effective preventive strategies. Growing evidence is linking coffee consumption with reduced risk of disease progression in various CLDs, including metabolic dysfunction associated steatotic liver disease (MASLD), alcoholic liver disease, hepatitis B and C, autoimmune hepatitis, and a reduction in the risk of hepatocellular carcinoma development. Coffee, a globally consumed beverage, contains bioactive compounds like caffeine, chlorogenic acids, diterpenes, and polyphenols, which may offer hepatoprotective benefits through anti-inflammatory, antioxidant, and metabolic regulatory effects.
View Article and Find Full Text PDFCureus
August 2025
Department of Nephrology, Texas Tech University Health Sciences Center, Odessa, USA.
Uremic polyserositis is a rare and often underdiagnosed manifestation of end-stage renal disease (ESRD), typically characterized by concurrent or sequential inflammation of multiple serosal membranes. We report a diagnostically challenging case of a 40-year-old woman with ESRD on intermittent hemodialysis who presented with dyspnea following a missed dialysis session. Imaging revealed bilateral pleural effusions, a moderate-to-large pericardial effusion, and ascites.
View Article and Find Full Text PDFClin J Gastroenterol
September 2025
Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Hepatic reactive lymphoid hyperplasia (RLH), also known as hepatic pseudolymphoma, is a rare benign condition that predominantly affects middle-aged-to-elderly women and is often associated with autoimmune disorders. The imaging features of hepatic RLH frequently mimic those of malignant hepatic tumors, such as hepatocellular carcinoma (HCC), cholangiocarcinoma, or metastatic liver tumors, making its diagnosis based solely on imaging modalities challenging, often leading to unnecessary surgical resection. However, the optimal diagnostic strategy for hepatic RLH remains controversial.
View Article and Find Full Text PDFJ Hepatol
September 2025
Department of Pathology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Greece; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, UK; European Reference Network on Hepatological Diseases (ERN RARE-LIVER).