BAY11-7082 Targets RNF25 to Reverse TRIP4 Ubiquitination-dependent NF-κB Activation and Apoptosis Resistance in Renal Cell Carcinoma.

NF-κB pathway dysregulation, a common driver of therapy resistance in cancer, promotes survival by suppressing apoptosis. While the anti-apoptotic role of NF-κB is recognized, the molecular mechanisms underlying this process remain poorly defined. Here, we identify the E3 ubiquitin ligase RNF25 as a key mediator of NF-κB-dependent apoptosis resistance in renal cell carcinoma cells, enabling evasion of multiple targeted therapies.

A Peptide-Based PROTAC Degrader of BRCA2 Sensitizes Metastatic Castration-Resistant Prostate Cancer to PARP Inhibition.

Defects in homologous recombination repair (HR) make cells highly susceptible to PARP inhibitors. However, the limited efficacy of PARP inhibitors in targeting HR wild-type tumors restricts their broad utility in cancer treatment. Clinical trials of PARP inhibitors have revealed greater efficacy in men with metastatic castration-resistant prostate cancer (mCRPC) harboring BRCA2 mutations compared to those with mutations in other HR genes.

Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment.

Nuclear size is crucial for cellular functions and often increases with malignancy. Irregular nuclei are linked to aggressive tumors, driven by genetic and epigenetic changes. However, the precise mechanisms controlling nuclear size are still not fully understood.

Small pre-trained model for background understanding in multi-round question answering.

Multi-round Q&A based on background text needs to infer the answer to the question through the current question, historical Q&A pairs, and background text. The pre-trained model has proved its effectiveness in this task; however, the existing model has many problems such as too many parameters and high resource consumption. We propose a knowledge transfer method that combines knowledge distillation, co-learning of similar datasets, and fine-tuning of similar tasks.

The Clinical and Neuroimaging Factors of Stroke Outcome of Unilateral Moyamoya Disease.

Rationale And Objectives: The clinical feature and long-term prognosis of unilateral moyamoya disease (MMD) have not been fully described and studied. The study aimed to investigate independent risk factors for stroke in unilateral MMD patients during a long-term follow-up.

Materials And Methods: A total of 393 unilateral MMD patients (median age, 40 years) were assessed at baseline and followed for an average time of 68.

PlantPan: A comprehensive multi-species plant pan-genome database.

The pan-genome represents the complete genomic diversity of specific species, serving as a valuable resource for studying species evolution, crop domestication, and guiding crop breeding and improvement. While there are several single-species-specific plant pan-genome databases, the availability of multi-species pan-genome databases is limited. Additionally, variations in methods and data types used for plant pan-genome analysis across different databases hinder the comparison and integration of pan-genome information from various projects at multi-species or single-species levels.

Effects of antiplatelet therapy on reducing stroke risk in patients with moyamoya disease: the role of postcontrast MR vessel wall imaging.

Objective: To evaluate the role of vessel wall enhancement in the efficacy of antiplatelet therapy (APT) on reducing the stroke risk in patients with Moyamoya disease (MMD) based on postcontrast MR vessel wall imaging.

Methods: Consecutive patients with MMD underwent postcontrast MR vessel wall imaging and were divided into APT and non-APT groups according to the prescribed antiplatelet agents. Kaplan-Meier survival and Cox regression analyses were performed to determine the association between APT and stroke risk of patients with MMD, and subgroup analysis was performed to determine the role of vessel wall enhancement in reducing stroke risk after APT.

The Effects of Polyphenols on Doxorubicin-Induced Nephrotoxicity by Modulating Inflammatory Cytokines, Apoptosis, Oxidative Stress, and Oxidative DNA Damage.

Doxorubicin (DOX) is an anthracyclic antibiotic with anti-neoplastic activity that has been found to be a highly effective and commonly used chemotherapeutic agent in the treatment of a variety of solid and hematologic malignancies. However, its effectiveness has been limited by the occurrence of dose-related renal, myocardial, and bone marrow toxicities. The clinical use of DOX is associated with nephrotic syndrome characterized by heavy proteinuria, hypoalbuminemia, and hyperlipidemia.

Global Hotspots and Research Frontiers of Moyamoya Disease and Radiological Features: A Bibliometric Analysis.

Background: Moyamoya disease (MMD) is a cerebrovascular disorder characterized by the progressive stenosis of the intracranial internal carotid artery and the development of a collateral network in the brain. As medical imaging technology and artificial intelligence have advanced, various imaging methods have been widely used in the clinical diagnosis of MMD. In this study, we conducted bibliometric visualization of research papers about MMD and radiological features between 2000 and 2024, intending to explore the development status quo, hotspots, and future developments and contributing to studies on imaging in diagnosis of cerebrovascular diseases.

Analysis of Risk Factors Associated with Organic Erectile Dysfunction in Patients with Type 2 Diabetes Mellitus and Erectile Dysfunction.

Background: Diabetes mellitus is a common metabolic disorder, and diabetic erectile dysfunction (DMED) is one of its common complications. The differentiation of the types of erectile dysfunction (ED) is fundamental to treatment, yet there is a lack of simple and efficacious tools for this purpose in clinical practice. In this study, we endeavor to predict ED types using commonly available clinical data from diabetic patients, aiming to develop and assess a risk prediction model for organic erectile dysfunction in individuals with type 2 diabetes.

Ultrathin MWCNT/TiCT Hybrid Films for Electromagnetic Interference Shielding.

The disordered assembly and low conductivity of carbon nanotubes are the main problems that limit the application of electromagnetic interference (EMI) shielding. In this work, an ordered lamellar assembly structure of multiwalled carbon nanotube/TiCT (MWCNT/TiCT) hybrid films was achieved by vacuum-assisted filtration through the hybridization of TiCT nanosheets and carbon nanotubes, where carbon nanotubes were tightly sticking on the surface of TiCT nanosheets via physical adsorption and hydrogen bonding. Compared with the pure carbon nanotubes films, the hybrid MWCNT/TiCT films achieved a significant improvement in conductivity of 452.

Predicting thermodynamic stability of inorganic compounds using ensemble machine learning based on electron configuration.

Machine learning offers a promising avenue for expediting the discovery of new compounds by accurately predicting their thermodynamic stability. This approach provides significant advantages in terms of time and resource efficiency compared to traditional experimental and modeling methods. However, most existing models are constructed based on specific domain knowledge, potentially introducing biases that impact their performance.

Deep learning model for automated diagnosis of moyamoya disease based on magnetic resonance angiography.

Background: This study explores the potential of the deep learning-based convolutional neural network (CNN) to automatically recognize MMD using MRA images from atherosclerotic disease (ASD) and normal control (NC).

Methods: In this retrospective study in China, 600 participants (200 MMD, 200 ASD and 200 NC) were collected from one institution as an internal dataset for training and 60 from another institution were collected as external testing set for validation. All participants were divided into training (N = 450) and validation sets (N = 90), internal testing set (N = 60), and external testing set (N = 60).

Identifying Prostatic Utricle Translucent Membrane in Hematospermia Patients Using a Novel Nomogram.

Hematospermia, characterized by blood in the ejaculate, is a common and distressing condition in urology. Identifying the underlying causes, including translucent membranes in the prostatic utricle, is crucial for effective management. Despite advancements in diagnostic techniques, reliable predictive tools are needed to enhance preoperative planning and patient outcomes.

Real-world evidence of a novel tetravalent immunoglobulin Y effectiveness and safety in patients with the refractory Helicobacter pylori infection.

Background: Refractory Helicobacter pylori (H. pylori) infection inevitably increase the difficulty of drug selection. Here, we described our experience with the use of a novel tetravalent IgY against H.

The catalytic hydro-dechlorination of 2, 4, 4' trichlorobiphenyl at mild temperatures and atmospheric pressure.

Polychlorinated biphenyls (PCBs), including all 209 congeners, are designated as persistent organic pollutants (POPs) due to their high toxicity and bioaccumulation in human bodies and the ecosystem. The need for PCB remediation still remains long after their production ban. In this study, a catalytic hydro-dechlorination (HDC) method was employed to dechlorinate 2,4,4'-trichlorobiphenyl (PCB 28), a congener found ubiquitously in multiple environmental media.

Chemodivergent mechanosynthesis of cyclopentenyl and pyrrolinyl spirobarbiturates from unsaturated barbiturates and enamino esters.

A novel and interesting controllable spirocyclization of unsaturated barbiturates with enamino esters for the assembly of cyclopentenyl and pyrrolinyl spirobarbiturates has been developed under ball-milling conditions. The present protocol features high chemoselectivity and efficiency, excellent functional group tolerance and mild reaction conditions.

Risk Factors for Massive Cerebral Infarction in Pediatric Patients With Moyamoya Disease.

Background: To explore the risk factors for preoperative massive cerebral infarction (MCI) in pediatric patients with moyamoya disease (MMD).

Methods: Pediatric patients with MMD treated between 2017 and 2022 were enrolled. Logistic regression analysis was performed to identify risk factors for MCI among the patients, and a nomogram was constructed to identify potential predictors of MCI.

Minimally invasive transurethral holmium laser surgery for the management of an IUD with bladder migration.

Case: Intrauterine device (IUD) is used worldwide as an effective contraceptive method, but the migration of IUD is a serious complication. We report the case of IUD migration leading to bladder calculus formation and a minimally invasive transurethral surgical approach was performed for treatment. Holmium laser was used to break up the bladder calculus and cut through the bladder mucosa where the IUD was attached, finally the IUD was removed through the urethra.

Gb3-Coated Bovine Milk Exosomes as a Practical Neutralizer for Shiga Toxin.

Shiga toxin (Stx) is associated with foodborne infections of some spp. and Shiga toxin-producing (STEC), leading to life-threatening hemolytic uremic syndrome (HUS). Target-specific therapeutics against HUS are currently unavailable in clinical practice.

Safety, tolerability and pharmacokinetics of forsythin in healthy subjects: a double-blinded, placebo-controlled single-dose and multiple-dose escalation and food effect study.

Background: Forsythin, an active compound from Forsythiae Fructus, has the potential to treat the common cold and influenza through its antipyretic-analgesic, anti-inflammatory and antiviral effects. The safety, tolerability and pharmacokinetic (PK) profile of forsythin were evaluated in healthy Chinese subjects.

Methods: This phase 1a study included three parts: double-blind, randomized, placebo-controlled single-ascending-dose (SAD) (50, 100, 200, 400, 600 or 800 mg), food effect investigation (100 mg) and multiple-ascending-dose (MAD) (50, 100 or 200 mg TID for 5 days).