Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000-May 2024). Trends, Collaborations, and Emerging Insights.

Purpose: Exosomes have emerged as promising therapeutic agents for spinal cord injury (SCI). The present study was conducted to provide a systematic bibliometric analysis of research trends related to SCI and exosomes.

Patients And Methods: Publications on exosomes in SCI were identified from the Web of Science Core Collection using specific search criteria.

E7 peptide and magnesium oxide-functionalized coaxial fibre membranes enhance the recruitment of bone marrow mesenchymal stem cells and promote bone regeneration.

Background: The repair of bone defects remains a significant clinical challenge. Although magnesium (Mg)-based biomimetic scaffolds are widely utilized for bone defect repair, the release of Mg²⁺ ions often leads to an alkaline microenvironment, thereby adversely affecting bone regeneration. Regenerative medicine strategies that leverage the recruitment of endogenous bone marrow mesenchymal stem cells (BMSCs) offer a novel approach to treating bone defects.

Investigation of nanotexture fabrication by magnetic field assisted ultra-precision diamond cutting.

Ultra-precision machining (UPM) is crucial for producing parts with functional surfaces featuring nano textures, yet it faces challenges in generating such textures. This paper explores the potential of magnetic field-assisted UPM to overcome these challenges by leveraging magnetophoresis to generate nanotextures and thoroughly investigating the importance of cutting velocity on magnetophoresis in diamond cutting. Experimental results from cutting force, surface profile, surface topography, and atomic force microscopy images demonstrate that magnetic fields enable nanotexture generation on aluminum alloys surfaces in diamond cutting.

Single-nucleus and spatial transcriptomics identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees.

Animal behavior is linked to the gene regulatory network (GRN) coordinating gene expression in the brain. Eusocial honeybees, with their natural behavioral plasticity, provide an excellent model for exploring the connection between brain activity and behavior. Using single-nucleus RNA sequencing and spatial transcriptomics, we analyze the expression patterns of brain cells associated with the behavioral maturation from nursing to foraging.

Marine Metagenome Mining Reveals Lanthipeptides Colwesin A-C, Exhibiting Novel Ring Topology and Anti-inflammatory Activity.

Marine natural products are promising sources for drug discovery due to their unique structures and diverse biological activities. The establishment of the Global Marine Microbiome Genome Catalogue (GOMC) has significantly expanded the repository of natural products derived from marine-associated bacteria. In this study, we identified the Class I lanthipeptide biosynthetic gene cluster from sp.

Traceability analysis and risk assessment of river antibiotics based on dissolved organic matter spectral features and the positive matrix factorization receptor model.

Identifying pollution sources is crucial for controlling antibiotic contamination and preventing risks to aquatic environments. This study quantified four categories of antibiotics (quinolones,macrolides, sulfonamides, and tetracyclines) in Dafeng River during the dry season using SPE-UHPLC-MS，analyzing their sources and risks. The source apportionment results for antibiotics using the Positive Matrix Factorization (PMF) model were validated against those identified based on Dissolved Organic Matter (DOM) fluorescence characteristics.

Hyaluronic acid methacryloyl hydrogel with sustained IL-10 release promotes macrophage M2 polarization and motor function after spinal cord injury.

(1)Background: Inflammation plays a key role in spinal cord injury (SCI), where excessive inflammatory responses exacerbate neural damage and hinder regeneration. Modulating macrophage polarization, particularly through the sustained release of IL-10 to promote the anti-inflammatory M2 phenotype, represents a promising strategy to mitigate inflammation. In this study we developed a Hyaluronic Acid Methacryloyl (HAMA) hydrogel capable of sustained IL-10 release to regulate macrophage polarization and explore its therapeutic potential.

Study on the Electrical and Mechanical Properties of TiC Particle-Reinforced Copper Matrix Composites Regulated by Different Rare Earth Elements.

Copper matrix composites (CMCs) synergistically reinforced with rare earth oxides (ReO) and TiC were prepared using a powder metallurgy process with vacuum hot-pressing and sintering technology, aiming to explore new ways to optimize the properties of composites. Through this innovative approach, we propose a new solution strategy and idea for the difficult problem of mutual constraints between electrical and mechanical properties faced by traditional dual-phase reinforced Cu-matrix composites. Meanwhile, the modulation mechanism of ReO in CMCs and the electrical and mechanical properties of the composites were investigated.

Comparative metagenomics highlights the habitat-related diversity in taxonomic composition and metabolic potential of deep-sea sediment microbiota.

Sediment plays a pivotal role in deep-sea ecosystems by providing habitats for a diverse range of microorganisms and facilitates the cycling processes of carbon, sulfur and nitrogen. Beyond the normal seafloor (NS), distinctive geographical features such as cold seeps (CS) and hydrothermal vent (HV) are recognized as life oases harboring highly diverse microbial communities. A global atlas of microorganisms can reveal the notable association between geological processes and microbial colonization.

Two-parameter dynamics and multistability of a non-smooth railway wheelset system with dry friction damping.

A deep understanding of non-smooth dynamics of vehicle systems, particularly with dry friction damping offer valuable insights into the design and optimization of railway vehicle systems, ultimately enhancing the safety and reliability of railway operations. In this paper, the two-parameter dynamics of a non-smooth railway wheelset system incorporating dry friction damping are investigated. The effect of the crucial parameters on the complexity of the evolution process is comprehensively exposed by identifying different dynamic responses in the two-parameter plane.

Source apportionment and ecological risk assessment of antibiotics in Dafeng River Basin using PMF and Monte-Carlo simulation.

Antibiotics, prevalent in aquatic ecosystems, pose a grave threat to human health and the ecological well-being. This paper performed a case study on Dafeng River Basin in southern China. Specifically, techniques including positive matrix factorization (PFM) and Monte-Carlo simulation were employed to comprehensively investigate the spatial variations, possible sources, and ecological risks of antibiotics in four groups: sulfonamides (SAs), macrolides (MLs), quinolones (QNs), and tetracyclines (TCs).

Potential therapies for HCC involving targeting the ferroptosis pathway.

Liver cancer ranks as the third leading cause of cancer-related mortality worldwide, predominantly in the form of hepatocellular carcinoma (HCC). Conventional detection and treatment approaches have proven inadequate for addressing the elevated incidence and mortality rates associated with HCC. However, a significant body of research suggests that combating HCC through the induction of ferroptosis is possible.

Mechanical Properties of TiAlC/Cu Composites Reinforced by MAX Phase Chemical Copper Plating.

Among the various reinforcement phases available in Cu-based composites, the unique layered structure and easy diffusion of A-layer atoms make MAX phases more suitable for reinforcing a copper matrix than others. In this study, Cu-coated TiAlC particles (Cu@TiAlC) were prepared through electroless plating, and Cu@TiAlC/Cu composites were fabricated via vacuum hot-press sintering. The phase composition and microstructure of both Cu@TiAlC powder and composites were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).

Nonlinear optical response of heme solutions.

Heme is the prosthetic group for cytochrome that exists in nearly all living organisms and serves as a vital component of human red blood cells (RBCs). Tunable optical nonlinearity in suspensions of RBCs has been demonstrated previously, however, the nonlinear optical response of a pure heme (without membrane structure) solution has not been studied to our knowledge. In this work, we show optical nonlinearity in two common kinds of heme (i.

Fates of Terrigenous Dissolved Organic Carbon in the Gulf of Maine.

A significant amount of organic carbon is transported in dissolved form from soils to coastal oceans via inland water systems, bridging land and ocean carbon reservoirs. However, it has been discovered that the presence of terrigenous dissolved organic carbon (tDOC) in oceans is relatively limited. Therefore, understanding the fates of tDOC in coastal oceans is essential to account for carbon sequestration through land ecosystems and ensure accurate regional carbon budgeting.

community transcriptomics illuminates CO-fixation potentials and supporting roles of phagotrophy and proton pump in plankton in a subtropical marginal sea.

Lineage-wise physiological activities of plankton communities in the ocean are important but challenging to characterize. Here, we conducted whole-assemblage metatranscriptomic profiling at continental shelf and slope sites in the South China Sea to investigate carbon fixation potential in different lineages. expression, the proxy of Calvin carbon fixation (CCF) potential, was mainly contributed by Bacillariophyta, Chlorophyta, Cyanobacteria, and Haptophyta, which was differentially affected by environmental factors among lineages.

Stability and Bautin bifurcation of four-wheel-steering vehicle system with driver steering control.

In this paper, the stability and Bautin bifurcation of a four-wheel-steering (4WS) vehicle system, by considering driver steering control, are investigated. By using the central manifold theory and projection method, the first and second Lyapunov coefficients are calculated to predict the type of Hopf bifurcation of the vehicle system. The topological structure of Bautin bifurcation, a degenerate Hopf bifurcation of the 4WS vehicle system, is presented in parameter space, and it reveals the dynamics of the vehicle system of different choices of control parameters.

Use of differential stimulation of the nucleus accumbens and anterior limb of the internal capsule to improve outcomes of obsessive-compulsive disorder.

Objective: Personalized stimulation is key to optimizing the outcomes of deep brain stimulation (DBS) for refractory obsessive-compulsive disorder (OCD). However, the contacts in a single conventional electrode cannot be programmed independently, which may affect the therapeutic efficacy of DBS for OCD. Therefore, a novel designed electrode and implantable pulse generator (IPG) that could achieve differential stimulation parameters for different contacts was implanted into the nucleus accumbens (NAc) and anterior limb of the internal capsule (ALIC) of a cohort of patients with OCD.