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Retinal fundus photographs are now widely used in developing artificial intelligence (AI) systems for the detection of various fundus diseases. However, the application of AI algorithms in intraocular tumors remains limited due to the scarcity of large, publicly available, and diverse multi-disease fundus image datasets. Ultra-wide-field (UWF) fundus images, with a broad imaging range, offer unique advantages for early detection of intraocular tumors. In this study, we developed a comprehensive dataset containing 2,031 UWF fundus images, encompassing five distinct types of intraocular tumors and normal images. These images were classified by three expert annotators to ensure accurate labeling. This dataset aims to provide a robust, multi-disease, real-world data source to facilitate the development and validation of AI models for the early diagnosis and classification of intraocular tumors.
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http://dx.doi.org/10.1038/s41597-025-05864-2 | DOI Listing |
Am J Ophthalmol
September 2025
Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital,
Int Ophthalmol
September 2025
Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technolog
Purpose: To analyze macular microvascular networks and investigate correlations between visual acuity and quantitative parameters in patients with Leber's hereditary optic neuropathy (LHON) using optical coherence tomography angiography (OCTA).
Methods: An observational, cross-sectional study was conducted, including 25 eyes from 25 genetically confirmed chronic LHON patients and 25 eyes from 25 age-matched healthy controls. Images were obtained using a spectral domain OCTA system.
Front Ophthalmol (Lausanne)
August 2025
Aier Eye Institute, Changsha, China.
High myopia is a global health concern, often leading to degenerative retinal changes known as myopic retinopathy. Although mechanical stress, hypoperfusion, extracellular matrix remodeling, and growth factor dysregulation have been implicated in the pathogenesis of myopic retinopathy, emerging evidence highlights the critical role of chronic low-grade inflammation. Both innate and adaptive immune systems participate in myopic retinopathy through systemic and local inflammation.
View Article and Find Full Text PDFJ Clin Neurosci
September 2025
Department of Radiology, Gumushane State Hospital, Gumushane, Turkey.
Ann Med Surg (Lond)
September 2025
The Maldives National University, Malé, Maldives.
Uveal melanoma, the most common primary intraocular malignancy in adults, presents a significant challenge due to its high metastatic potential and the need to preserve vision during treatment. While conventional therapies such as plaque brachytherapy and proton beam radiation aim to balance tumor control with ocular preservation, recent advances in artificial intelligence (AI) and machine learning (ML) offer transformative potential in personalizing radiation dosing. By integrating radiologic features with genomic markers such as BAP1 mutations, monosomy 3, and chromosome 8q gain, AI models can predict tumor radiosensitivity and guide dose modulation based on individual tumor biology.
View Article and Find Full Text PDF