Bioengineered urethral grafts for strictures: a perspective on advancements, functional restoration, and affordability.

Urethral stricture is a chronic urological condition that remains challenging to manage due to the limitations of traditional treatments like dilation and urethroplasty, which are prone to recurrence and complications. Tissue-engineered urethral grafts have emerged as a promising alternative, offering durable, functional restoration with reduced donor site morbidity. Innovations in scaffold fabrication, especially 3D bioprinting and hydrogel-based bio-inks, have led to the creation of structurally and biologically compatible constructs that can regenerate native urothelial layers.

Smart dosing: revolutionizing uveal melanoma treatment with AI.

Uveal melanoma, the most common primary intraocular malignancy in adults, presents a significant challenge due to its high metastatic potential and the need to preserve vision during treatment. While conventional therapies such as plaque brachytherapy and proton beam radiation aim to balance tumor control with ocular preservation, recent advances in artificial intelligence (AI) and machine learning (ML) offer transformative potential in personalizing radiation dosing. By integrating radiologic features with genomic markers such as BAP1 mutations, monosomy 3, and chromosome 8q gain, AI models can predict tumor radiosensitivity and guide dose modulation based on individual tumor biology.

Exploring the Mechanisms Linking Digital Leadership to Employee Creativity: A Moderated Mediation Model.

Employee creativity is essential for navigating digital disruption and maintaining organizational competitiveness; however, the mechanisms through which digital leadership fosters creativity remain underexplored. This study investigates the psychological and social processes through which digital leadership influences workplace creativity. Grounded in social cognitive and social exchange theories, the proposed model incorporates innovation self-efficacy and knowledge sharing as mediators and technology readiness as a moderator.

Reframing robotics in Mohs surgery for rare cutaneous sarcomas: conceptual promise and clinical realities in precision oncology.

Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive cutaneous sarcoma in which achieving histologically negative margins is paramount to minimizing recurrence. Mohs micrographic surgery (MMS) has transformed margin control in DFSP by enabling sequential, layer-by-layer excision with immediate histologic assessment, yet it remains technically challenging in anatomically complex sites and in cases with ambiguous deep or subclinical peripheral spread. Recent advances in robotic microsurgical platforms-characterized by tremor elimination, high-resolution imaging, and ergonomic interfaces-offer a conceptual framework for enhancing the precision and consistency of MMS.

Percutaneous nephrolithotomy versus retrograde intrarenal surgery: a systematic review and meta-analysis of stone-free rates and complication profiles.

Background: Nephrolithiasis is a highly prevalent urological condition, necessitating effective and minimally invasive treatment strategies. Percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS) are commonly employed for managing renal calculi, but their comparative efficacy and safety remain subjects of ongoing debate. This meta-analysis aims to synthesize current evidence, providing a comprehensive assessment of surgical outcomes between PCNL and RIRS for renal stones under 2 cm and greater than 2 cm, reported across different study designs, various surgical techniques, and different geographical distributions to guide clinical decision-making.

Menopausal Status-Dependent Alterations in Bone Mineral Density in Women Transitioning from Menopause to Postmenopause: An Observational Multicenter Study.

Introduction: Bone loss begins between 30 and 40 years of age in men and women, with women experiencing an accelerated decline in bone mass and density after menopause. Understanding the interplay of hormonal changes, inflammation, and other factors during this period is critical for addressing bone health. The objective was to investigate the impact of menopausal transition and postmenopausal status on bone mineral density (BMD) and its associations with biochemical, anthropometric, and lifestyle factors among Pakistani women.

Three-decade analysis of regional disparities in metabolic risk factor related ischemic heart disease mortality: Contrasting trends between South Asia and North America.

Background: The impact of metabolic risk factors on ischemic heart disease (IHD) exhibits substantial regional variability. This study aims to analyze three-decade mortality trends in two contrasting regions of North America (NA) and South Asia (SA), focusing on age- and gender-specific variations.

Methods: Data from the Global Burden of Disease (GBD) database [1990-2021] were employed in Joinpoint Regression Program to compute the Annual Percent Changes (APC) and Average Annual Percent Changes (AAPC).

Exploring evolutionary perspectives and antibiogram analysis of biofilm-forming Staphylococcus aureus in goat mastitis.

Biofilm formation plays a key role in developing antimicrobial resistance in Staphylococcus aureus (S. aureus) and is thus a major virulence factor responsible for persistent intramammary infections and subclinical mastitis in goats. The current study investigated the prevalence and molecular characterization of biofilm-forming S.

Beyond blood transfusions: exploring iron chelation therapies in transfusion-dependent beta-thalassemia.

Introduction: Abnormal hemoglobin, or hemoglobinopathy, affects about 7% of the global population. Major hemoglobinopathies like beta-thalassemia and sickle cell disease require regular blood transfusions, leading to chronic iron overload. This review examines the efficacy and safety of deferiprone, an oral iron chelator, in managing iron overload in pediatric patients with transfusion-dependent conditions.

The Impact of Novel Lipid-Lowering Agents on Cardiovascular Risk Reduction: A Systematic Review and Meta-Analysis.

Introduction: Reducing the risk of atherosclerotic cardiovascular disease is the aim of lipid-lowering therapy (ASCVD). It is commonly acknowledged that low-density lipoprotein (LDL) is a major cause of ASCVD. Several online databases and search engines, such as Pub- Med and the Cochrane Library, were used to conduct a thorough search.

Epidemiology of pediatric dengue virus infection, Scenario from a tertiary level hospital in Bangladesh.

Background: Dengue fever is the most rapidly spreading mosquito-borne disease and has grown to be a major public health issue, especially in tropical nations like Bangladesh. Globally, children, adolescents, and young adults bear the largest burden of Dengue; the infection rate is highest among infants. However, the epidemiology of pediatric dengue virus infection has been poorly explored in Bangladesh.

Soft computing paradigm for climate change adaptation and mitigation in Iran, Pakistan, and Turkey: A systematic review.

This systematic review examines the application of artificial intelligence (AI), including machine learning (ML) and deep learning (DL), for climate change adaptation and mitigation in Iran, Pakistan, and Turkey. These three nations-key Economic Cooperation Organization (ECO) members and a nexus between Europe and South Asia-are experiencing diverse environmental challenges due to varying climatic conditions. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a comprehensive search in the Scopus database, ultimately identifying 76 relevant articles out of an initial 492.

Enhancing Recovery in Gastrointestinal and Cardiovascular Surgeries Through Enhanced Recovery After Surgery (ERAS) Protocols.

Enhanced Recovery After Surgery (ERAS) protocols aim to improve perioperative outcomes and expedite recovery across various surgical specialties. While ERAS protocols have shown significant benefits in gastrointestinal and cardiovascular surgeries, their impact and effectiveness require further synthesis. This systematic review and meta-analysis evaluated the efficacy of ERAS protocols in enhancing recovery and reducing complications in gastrointestinal and cardiovascular surgeries.

Evolution of Treatment Modalities for Posttraumatic Stress Disorder: Top 100 Cited Articles From 1990 to 2020.

Posttraumatic stress disorder (PTSD) is seen in a substantial proportion of individuals experiencing trauma. The last few decades have been significant in terms of PTSD-related research; however, a quantitative charting of the evolution in evidence-based treatment modalities for PTSD is lacking. The objective of this study was to conduct a bibliometric analysis to bridge this gap in knowledge.

On the generalization of Hermite-Hadamard type inequalities for -convex function via fractional integrals.

The main motivation in this article is to prove new integral identities and related results. In this paper, we deal with -convex function, Hermite-Hadamard type inequalities, and Katugampola fractional integrals. Firstly, we established the Hermite-Hadamard type inequalities for -convex function via Katugampola fractional integrals operators.