Synthesis, in vivo analgesic activity, molecular docking and density functional theory analysis of acyl hydrazide derivatives of mefenamic acid.

This study explores the synthesis of new acyl hydrazide derivatives of mefenamic acid as potent analgesics with enhanced safety profiles. Thirteen compounds were synthesized via hydrazide intermediate functionalization and characterized spectroscopically (H/C NMR, and HRESI-MS). In vivo evaluation (acetic acid writhing, formalin paw licking, and tail immersion tests) revealed significant peripheral and central analgesic activity, with compounds 5 (N'-(4-chlorobenzoyl)) and 11 (N'-(2,4-dichlorophenyl)) outperforming mefenamic acid (81.

Polymorphic and Expressional Analysis of Genes and in Cardiovascular Patients Using Conventional and qPCR Approach.

In the modern age, the problem of heart disease is increasing day by day which cause even more deaths than cancer. The study was designed to evaluate the polymorphism and expressional analysis of genes and in cardiovascular patients. Blood samples of 300 cardiovascular patients and 300 controls were collected from Gannan and other hospitals of Pakistan.

Synthesis and computational investigation of novel 2-mercaptoimidazolones as dual antimicrobial and anti-proliferative agents with potential multitargeting kinase inhibitory activity.

Anticancer drug therapy-induced immunosuppression increases the incidence of treatment-resistant infectious diseases in cancer patients. Combining antibacterial and anticancer capabilities into a single medication can potentially enhance the treatment outcomes. In this light, the current study focused on developing innovative 5-arylidene-3-phenyl-2-thioimidazolones 1a-e and evaluated them as antimicrobial candidates against a panel of Gram-positive and Gram-negative bacterial and fungal isolates.

Comparative efficacy and safety of intravascular lithotripsy versus rotational atherectomy in coronary artery calcification: An updated meta-analysis.

Background: The presence of coronary artery calcification during percutaneous coronary intervention is associated with an increased risk of complications and poor outcomes. Comparison of the efficacy and safety of intravascular lithotripsy and rotational atherectomy in coronary artery calcification has always been a topic of debate in the literature.

Aim: To present the most recent comparative analysis of these two calcium debulking techniques.

Bioaccumulation and Haematological Alterations Induced by Varying Concentrations of Cadmium in Selected Organs of Golden Misri Chickens () in Khyber Pakhtunkhwa, Pakistan.

The aim of the research was to evaluate the effects of Cadmium (Cd) toxicity on hematological parameters and its bioaccumulation in Golden Misri chickens ( domesticus), focusing on both dosage and exposure duration. The study was conducted from June to September 2021 at the Zoology Department of Islamia College Peshawar and included 60 sexually mature Golden Misri chickens, each weighing approximately 1 kg and aged 8 weeks. The chickens were systematically divided into two batches for short-term (3 and 5 days) and long-term exposure studies (14, 20, 40, and 60 days).

New precise solitary wave solutions for coupled Higgs field equations via two enhanced methods.

We utilized the enhanced Sardar sub-equation and generalized Riccati equation methods to explore precise solitary wave solutions for the coupled Higgs field equations. These equations characterize the behavior of conserved scalar nucleons interacting with a neutral scalar meson. Our findings revealed the formation of various types of solitons, including periodic, dark-bell, bright, and anti-bell solutions, which can be expressed using exponential, hyperbolic, rational and trigonometric functions.

The impact of adverse childhood experiences in the development of post-traumatic stress disorder in adults over 18 years of age: a systematic review.

Background: Post-traumatic stress disorder (PTSD) affects mental health in the long term and is often associated with past psychological trauma. This systematic review was conducted with a purpose to investigate the correlation between adverse childhood experiences (ACE), experiences of child maltreatment, and the occurrence of PTSD in adults over 18 years to optimize treatment guidelines accordingly.

Method: The review utilized articles searched on PubMed, Google Scholar, Scopus, and Cochrane.

Genetics, epidemiology and management of clubfoot and related disorders.

Clubfoot, medically termed congenital talipes equinovarus (CTEV), is a prevalent musculoskeletal birth defect, affecting approximately 0.3% of all live births. This serious congenital anomaly results from structural abnormalities in the foot and lower leg, leading to abnormal positioning of the ankle and foot joints.

Retraction: Comparative Effectiveness of Endoscopic Versus Pharmacological Interventions for Variceal Rebleeding in Cirrhosis: A Systematic Review.

[This retracts the article DOI: 10.7759/cureus.72085.

Green synthesis, , and assessments of hydrazone-Schiff bases as potential antileishmanial agents.

Aims: To synthesize and assess hydrazone Schiff bases using green chemistry principles for potential antileishmanial activity.

Materials & Methods: Sixteen hydrazone Schiff bases, including seven novel compounds (SSB2, SSB4, SSB5, RSB4, SSB14, SSB15, and SSB31), were synthesized under solvent-free conditions using grinding technique. The compounds were structurally confirmed via FT-IR, H NMR, and C NMR spectroscopy.

Recurrent Acrodermatitis Enteropathica in a Pediatric Patient: A Rare Case Report with Zinc Deficiency and Complications.

Introduction: Acrodermatitis enteropathica (AE) is a rare genetic disorder that results in impaired zinc absorption due to a mutation in the SLC39A4 gene, leading to systemic zinc deficiency with characteristic dermatologic, immunologic, and gastrointestinal manifestations.

Case Presentation: This case report presents a 6-year-old boy with recurrent AE, exhibiting widespread vesiculopustular lesions, alopecia, chronic diarrhea, and poor growth, symptoms typical of zinc deficiency syndromes. Initial diagnosis was supported by low serum zinc levels, elevated C-reactive protein, and IgE, indicating an inflammatory process.

Biomarker Potential of DNA Repair Genes and Polymorphisms in Ovarian Cancer Patients.

Ovarian cancer remains one of the most lethal gynecological malignancies, with a high mortality rate primarily due to late-stage diagnosis. Genetic predispositions play a significant role in its development, alongside environmental and lifestyle factors. The main objective of the study was to check the association of and gene polymorphism with ovarian cancer.

Enhancing concrete strength for sustainability using a machine learning approach to improve mechanical performance.

The construction industry faces growing pressure to adopt sustainable practices due to the environmental burden of concrete waste and the overuse of natural resources. One promising solution is the use of recycled concrete aggregate (RCA) as a partial or full replacement for natural aggregates. However, the inconsistent performance of RCA concrete due to differences in source material, composition, and mix design poses challenges for its widespread adoption.

Preparation, Characterization and Removal of Acid Blue 129 and Erioglaucine Dyes from Aqueous Solution by Corn Cob Based Activated Carbon.

Herein, corn cobs (maize) have been converted into an activated carbon by subjecting to carbonization which were then treated with 1:1 solution of HCl and HNO and finally passed through CH solution and finally activated at a high temperature of 400◦C. The obtained activated sample was subjected to XRD, EDX, and SEM analysis. The surface area was estimated as 913 m/g using a reported method in literature.

Synthesis of aceclofenac and L-Arginine salt, characterization and bioactivities.

Molecular salt synthesis is promising technique for increasing the bioavailability and solubility of the FDA-drugs. The present investigations focus on the synthesis of aceclofenac salt in a 1:1 molar ratio, employing the rapid solvent evaporation precipitation technique in conjunction with the coformor l-arginine. The salt was characterized through Fourier Transform Infrared (FTIR), Differential Scanning Calorimeter (DSC), Powder X-ray Diffraction (PXRD) and Thermo Gravimetric Analysis (TGA).

Impact of reducing carbohydrate type and concentration on the Maillard reaction-induced cross-linking and heat curing of egg albumen-based edible films.

This study explores the enhancement of egg albumen-based edible films through Maillard reaction-induced modification using various carbohydrates-glucose, maltose, and maltodextrin (DE 10 and 18)-at different ratios (1:2, 1:4, and 1:8). To further promote cross-linking, heat curing was applied to both the film-forming solution (at 40-60 °C for 10-30 min) and the dried films (at 40-60 °C for 24-72 h). The effects of these modifications were evaluated in terms of film color, hydrophobicity, solubility, mechanical strength, and moisture barrier properties.

Antibiotic resistance in empyema thoracis: clinical outcomes and contributing factors in a tertiary care setting in Pakistan.

Objectives: This study aimed to determine the antibiotic resistance patterns, clinical outcomes, and factors influencing treatment outcomes in patients with empyema thoracis (ET).

Methods: A total of 294 patients with ET (65.9% males, 34.

Efficacy and Safety of Moderate-Intensity Statin and Ezetimibe Combination Therapy Versus High-Intensity Statin Monotherapy in Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Statins represent the first-line therapy for cholesterol management. However, for patients prone to statin side effects, unable to tolerate higher doses, or requiring additional low-density lipoprotein cholesterol (LDL-C) reduction, ezetimibe alone or in combination with statins is recommended. This meta-analysis aimed to evaluate the safety and efficacy of combining low- or moderate-intensity statins with ezetimibe compared to high-intensity statin monotherapy, yielding reliable evidence to guide clinical decision-making and personalize treatment strategies.

The Impact of Sleep Deprivation on Brain Fog, Cognitive Decline, and Cardiovascular Risk in Young Adults.

Introduction Sleep deprivation is an escalating public health concern among young adults, as it impairs cognitive function and increases the risk of cardiovascular disease (CVD). Existing studies have linked chronic sleep deficiencies to mental confusion, reduced cognitive performance, and early signs of cognitive decline. Research also indicates that inadequate sleep contributes to metabolic dysregulation and autonomic system instability, both of which elevate cardiovascular risk.

Mathematical modeling of sorption isotherms and the thermodynamic properties of vacuum-dried and freeze-dried Barhi dates.

Studying the moisture sorption behavior of Barhi dates is key to enhancing their drying efficiency, packaging strategies, and storage conditions to ensure long-term stability and shelf-life. This research analyzed the sorption isotherms of vacuum-dried (VDBD) and freeze-dried Barhi dates (FDBD) via a dynamic vapor sorption apparatus across different temperatures and a wide range of water activity levels. Various mathematical models were evaluated to determine their accuracy in predicting sorption behavior, and the thermodynamic properties of sorption were examined in relation to the equilibrium moisture content (X).

Active Immunization Against Inhibin Impaired Spermatogenesis, Plasma Luteinizing Hormone, Pituitary Prolactin mRNA, and Hypothalamic Vasoactive Intestinal Peptide mRNA Expressions in Yangzhou Ganders.

Inhibin (INH) plays a key role in the regulation of the reproductive performance of geese. It inhibits follicle-stimulating hormone (FSH) secretion from the anterior pituitary gland to regulate spermatogenesis. Immunization against INH in male geese leads to the production of antibodies to neutralize the INH activity that enhances testicular function and gonadotropin production.

Improving the techno-functional properties and glycemic index of Khai Mod Rin rice starch through autoclaving-chilling cycles.

Long-term food sustainability and security require the recognition and preservation of indigenous rice varieties and the exploration of their broader applications. Khai Mod Rin rice, a non-glutinous variety (Oryza sativa L.), is being conserved in the Nakhon Si Thammarat region of southern Thailand.

Longitudinal analysis of hsa-miR-3163, hsa-miR-124-3p, hsa-miR-548c-3p, and hsa-miR-27a-3p as prognostic biomarkers in HIV-infected patients.

Introduction: MicroRNAs (miRNAs), key regulators of cellular pathways, play crucial roles in the pathogenesis of various diseases, including Human Immunodeficiency Virus (HIV). This study aimed to evaluate the expression and diagnostic potential of -identified miRNAs (miR-124-3p, miR-27a-3p, miR-548ac-3p, miR-3163) before and during antiretroviral treatment (ART), together with their correlations with immunological markers (CD4 count, CD4/CD45 ratio) and virological parameters (HIV RNA load).

Methods: Blood samples and clinical data of 16 patients were collected at 4 different time points; before the initiation of ART (baseline), 1, 2 and 6 months following HIV diagnosis.