Repurposing fluoroquinolones as cancer chemosensitizers: a way to overcome cancer therapeutic bottleneck.

Drug repurposing (DR) is a strategy to develop novel drugs from pre-approved drugs. To overcome the limitations of conventional drug development pathways, DR is a novel method that is cost-effective, with minimal side effects, and less time-consuming. Contrary to de novo drug discovery, DR eliminates the need for FDA approval.

Retraction: Comparative Effectiveness of Endoscopic Versus Pharmacological Interventions for Variceal Rebleeding in Cirrhosis: A Systematic Review.

[This retracts the article DOI: 10.7759/cureus.72085.

Characterizing the molecular and spatial heterogeneity of midline gliomas in adults: a single institution analysis.

Purpose: Primary gliomas arising within midline structures of the central nervous system are associated with a worse prognosis compared with hemispheric gliomas. In adults, compared to their pediatric counterparts, adult midline gliomas are not as clearly characterized on the clinical behavior, prognostic factors, and treatment approaches for these diseases.

Methods: This retrospective cohort assessed all adult (≥ 18 years) patients from our institution with diffuse gliomas arising from midline structures at time of diagnosis (2014-2020).

Comparative Efficacy and Long-Term Outcomes of Beta-Blockers Alone or in Combination With Angiotensin-Converting Enzyme (ACE) Inhibitors in Chronic Heart Failure: A Systematic Review.

This systematic review provides a comprehensive comparison of beta-blockers and angiotensin-converting enzyme (ACE) inhibitors in the management of chronic heart failure (CHF), with a focus on their long-term efficacy and safety profiles. By synthesizing evidence from randomized controlled trials (RCTs) and clinical studies, the review highlights the significant benefits of both drug classes in reducing mortality and hospital readmissions, and improving patient outcomes. Beta-blockers, such as bisoprolol and carvedilol, demonstrated superior efficacy in reducing sudden cardiac death, particularly in patients with heart failure with reduced ejection fraction (HFrEF).

Family physician service quality and sustainability: a roadmap for Pakistan's healthcare sector.

Introduction: The number of family medicine consultants has increased during and after the COVID-19 pandemic. However, research on family medicine services specific to Pakistan remains limited. Therefore, this study aimed to explore family physician services in Pakistan.

Revolutionizing photocatalysis: Synthesis of innovative poly(N-tertiary-butylacrylamide)-graft-hydroxypropyl cellulose polymers for thermo-responsive applications via metal-free organic photoredox catalysis.

In this study, we present a groundbreaking approach utilizing metal-free, visible light-mediated organic photoredox catalyzed atom transfer radical polymerization (O-ATRP) to synthesize cellulose-based stimuli-responsive polymers. Our method resulted in the successful synthesis of innovative metal-free poly(N-tertiary-butylacrylamide)-graft-hydroxypropyl cellulose (PNTBAM-g-HPC) polymers with exceptional control over molecular weight and narrow dispersity index (Đ) and explored their applications in organo-photocatalytic reactions. This approach addresses the limitations of traditional atom transfer radical polymerization method, which suffer from metal contamination and toxicity related problems.

The Role of Omega-3 Fatty Acid Supplementation in Slowing Cognitive Decline Among Elderly Patients With Alzheimer's Disease: A Systematic Review of Randomized Controlled Trials.

This systematic review explores the impact of omega-3 fatty acid supplementation, particularly docosahexaenoic acid (DHA), on cognitive decline in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Omega-3 fatty acids are widely recognized for their neuroprotective properties, but the evidence regarding their efficacy in mitigating cognitive decline remains mixed. Through a comprehensive analysis of eleven randomized controlled trials, we aimed to assess the role of DHA in improving cognitive functions and slowing brain atrophy.

Postpartum Guillain-Barré Syndrome Presenting as Acute Motor Axonal Neuropathy in a Young Female: A Report of a Rare Case.

This case report presents a rare instance of acute motor axonal neuropathy (AMAN), a subtype of Guillain-Barré syndrome (GBS), in a 25-year-old postpartum female. The patient experienced a seven-day history of progressive, ascending motor weakness in all four limbs, beginning shortly before delivery and rapidly worsening postpartum. Notably, she exhibited no sensory deficits, a hallmark feature of AMAN, which was confirmed by nerve conduction studies revealing significant motor axonal involvement with preserved sensory function.

Global impact of COVID-19 on food safety and environmental sustainability: Pathways to face the pandemic crisis.

The COVID-19 pandemic poses ongoing challenges to the sustainability of various socioeconomic sectors, including agriculture, the food supply chain, the food business, and environmental sustainability. This study employs data obtained from the World Health Organization (WHO), and Food and Agriculture Organization (FAO), as well as scientific and technical research publications, to evaluate the impacts of COVID-19 on agriculture and food security. This article seeks to highlight the profound influence of the COVID-19 pandemic on agriculture, the supply and demand of food, and the overall safety of food.

Modulating alginate-polyurethane elastomer properties: Influence of NCO/OH ratio with aliphatic diisocyanate.

This research addresses the need for enhanced biomaterials by investigating the influence of the NCO/OH ratio on sodium alginate-based polyurethane elastomers(Al-PUEs), offering novel insights into their structural, thermal, mechanical and swelling behavior. Al-PUEs were prepared by blending the chain extenders with key ingredients in a specific molar ratio using aliphatic HMDI and HTPB monomers. The chemical linkages, crystalline behavior, homogeneity, and surface morphology of PUEs were evaluated by FT-IR, XRD, SEM, and EDX analysis.

Repurposing FDA approved drugs against monkeypox virus DNA dependent RNA polymerase: virtual screening, normal mode analysis and molecular dynamics simulation studies.

Zoonotic monkeypox disease, caused by the double-stranded DNA monkeypox virus, has become a global concern. Due to the absence of a specific small molecule drug for the disease, this report aims to identify potential inhibitor drugs for monkeypox. This study explores a drug repurposing strategy using virtual screening to evaluate 1615 FDA approved drugs against the monkeypox virus DNA dependent RNA polymerase subunit A6R.

3D Melt-Extrusion Printing of Medium Chain Length Polyhydroxyalkanoates and Their Application as Antibiotic-Free Antibacterial Scaffolds for Bone Regeneration.

In this work, we investigated, for the first time, the possibility of developing scaffolds for bone tissue engineering through three-dimensional (3D) melt-extrusion printing of medium chain length polyhydroxyalkanoate (mcl-PHA) (i.e., poly(3-hydroxyoctanoate--hydroxydecanoate--hydroxydodecanoate), P(3HO--3HD--3HDD)).

Enhancing telehealth services development in Pakistani healthcare sectors through examining various medical service quality characteristics.

Introduction: The telehealth service increased attention both during and after the Covid-19 outbreak. Nevertheless, there is a dearth of research in developing countries, including Pakistan. Hence, the objective of this study was to examine telehealth service quality dimensions to promote the telehealth behavior intention and sustainable growth of telehealth in Pakistan.

An Efficient Propagation Approach to Forcing Softwood Shoots from Epicormic Buds and Subsequent Rooting of S. Y. Hu.

The current research describes the multiplication of S. Y. Hu, a timber plant, through the forcing of softwood shoots from epicormic buds under glasshouse conditions in spring and fall seasons.

CO-Free Ethylene Oxide Production via Liquid-Phase Epoxidation with FeO/MSM Catalyst.

In this study, we present an approach for ethylene oxide (EO) production that addresses environmental concerns by eliminating greenhouse gas emissions. Our catalyst, FeO/MSM, was synthesized using a hydrothermal method, incorporating FeO nanoparticles into a well-structured mesoporous silica matrix (MSM). We selected peracetic acid as the oxidant, enabling CO-free EO production while yielding valuable by-products such as acetic acid, monoethylene glycol, and diethylene glycol.

Theabrownin: a dietary nutraceutical with diverse anticancer mechanisms.

Cancer, a highly deadly disease, necessitates safe, cost-effective, and readily accessible treatments to mitigate its impact. Theabrownin (THBR), a polyphenolic pigment found in Pu-erh tea, has garnered attention for its potential benefits in memory, liver health, and inflammation control. By observing different biological activities of THBR, recently researchers have unveiled THBR's promising anticancer properties across various human cancer types.

Correction: Development of a chromium oxide loaded mesoporous silica as an efficient catalyst for carbon dioxide-free production of ethylene oxide.

[This corrects the article DOI: 10.1039/D3RA05858A.].

Development of a chromium oxide loaded mesoporous silica as an efficient catalyst for carbon dioxide-free production of ethylene oxide.

Ethylene oxide (EO) is a significant raw material used in many commodities for consumers, particularly ethoxylates, polymers, and certain other glycol derivatives. We synthesized a catalyst by incorporation of chromium oxide into a mesoporous silica material (Cr/MSM) the hydrothermal method, an effective catalyst for partial ethylene oxidation for producing carbon dioxide (CO) free EO. Subsequently, XRD, BET, XPS, and TEM were used to analyse the structural characteristics of the Cr/MSM catalyst.

Coronary artery complications with left bundle branch area pacing: A review of literature.

Left bundle branch area pacing (LBBAP) is an emerging technique in cardiac resynchronization therapy that shows promise in improving ventricular synchrony and clinical outcomes in patients with heart failure. However, the potential risk of coronary artery complications with LBBAP necessitates careful attention and management. This literature review explores the mechanisms, acute coronary events, and clinical implications associated with coronary artery complications in LBBAP.

Impact of COVID-19 pandemic on health care workers (HCWs) in Sindh Province of Pakistan.

Background: In Pakistan, the COVID-19 outbreak posed a significant challenge for healthcare workers in the country's public hospitals. The HCWs faced several problems in terms of the COVID-19 pandemic. Therefore this study investigated how the COVID-19 pandemic has affected the medical staff at the public hospital in Sindh Province, Pakistan.