Exploring causal links between autoimmune liver diseases, chronic hepatitis C, and thyroid disorders: Evidence from NHANES and GWAS studies.

Autoimmune liver diseases (AILDs), including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), often have complex interactions with thyroid diseases (TDs), such as hypothyroidism, hyperthyroidism, and Hashimoto thyroiditis (HT). These conditions frequently coexist and may share common autoimmune mechanisms, but their exact relationship remains poorly understood. Chronic hepatitis C (CHC), a viral liver disease, also affects thyroid function, but its interaction with TD is still under investigation.

A risk score model for post-endoscopic retrograde cholangiopancreatography complications in elderly patients with choledocholithiasis.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is the preferred treatment for choledocholithiasis. This study aimed to identify the independent risk factors for post-ERCP complications in elderly patients with choledocholithiasis and establish a risk score model.

Methods: This study enrolled patients over the age of 75 with choledocholithiasis, who underwent ERCP at two hospitals.

Red Meat Diet Exacerbates Colitis by Promoting the Accumulation of Myeloid Cells and Disrupting Gut Microbiota.

Inflammatory bowel disease (IBD) poses a significant threat to public health, yet its exact etiology remains unclear. Epidemiological studies reveal a strong correlation between red meat consumption and the development of IBD. In this study, we aimed to determine whether intake of different red meats increased colitis sensitivity and to explore the underlying mechanisms.

Dual-action mechanism of Tamarix polyphenols in inhibiting IQ and MeIQ: Synergistic scavenging of free radicals and trapping of reactive carbonyls.

Tamarix lamb skewers are highly favored for its distinctive flavor profile, with polyphenol-rich Tamarix branches demonstrating inhibitory effects on heterocyclic amine (HAs) formation during lamb roasting. Four major polyphenols were evaluated for suppressing 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethyl-imidazo[4,5-f]quinoline (MeIQ) in chemical models and lamb patties. Mechanistic investigations employed Electron Spin Resonance (ESR) to quantify radical scavenging capacity and UPLC-MS/MS to assess reactive carbonyl (acrolein/crotonaldehyde) trapping efficiency.

Efficient extracellular expression and rapid screening of human-like recombinant gelatin in Komagataella phaffii.

To obtain a strain that efficiently secretes and expresses hlrGEL (recombinant human-like gelatin), and to establish a rapid method for detecting this expression, this study began with the original strain GS115/pPICZα-gel6 (4# clone). High-copy transformants were obtained through Zeocin resistance screening, and positive expression strains were rapidly screened using single-cell laser Raman spectroscopy (SCLRS) technology. The results revealed that the Raman spectral features of positive expressing strains were located at 1447 cm, 1658 cm, and 2929 ~ 2943 cm, and their peak intensities were correlated with the expression level of hlrGEL while being consistent with SDS-PAGE, Western blotting and BCA methods analysis results.

Primary pulmonary spindle cell sarcoma with novel MBNL2::NUTM1 fusion and associated langerhans cell hyperplasia.

NUTM1-rearranged sarcomas are rare, genetically diverse tumors with variable histologic features and fusion partners. Their diagnosis remains challenging, especially in low-grade or unusual presentations. We describe the first reported case of a pulmonary spindle cell sarcoma with MBNL2::NUTM1 fusion in a 67-year-old man.

PuMYB12 regulates the accumulation of fruit acid the rich-flavor of 'Nanhong' pear is due to PuMYB12 affecting the expression of PuVHA-G1-LIKE and PuNADP-ME.

The elevated sugar and acid levels contribute to the rich flavor of fruits and enhance their commercial values. Our previous research demonstrated that the 'Nanhong' pear, a bud sport of the 'Nanguo' pear, exhibits a higher sugar content. In the present study, we examined the acid content in two cultivars of Ussurian pears (Pyrus ussuriensis) and discovered that the 'Nanhong' pear also possesses a higher acid content.

A functionally tunable magnetic nanochains platform for N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids.

Extracellular vesicles (EVs) carry complex glycoproteins critical mediators of disease progression and hold great potential for liquid biopsy applications. However, their low abundance presents significant analytical challenges. This study develop a versatile platform for EV N-glycoproteomic analysis (EVGpro), which enables tandem EV capture, EV protein digestion, and enrichment of N-glycopeptides.

Exploring causal pathways between hypertension, lipid levels, and gout: Insights from Mendelian randomization and NHANES observations.

Gout, a common form of inflammatory arthritis, is caused by the deposition of monosodium urate crystals in joints and soft tissues. While associations between hypertension, lipid levels, and gout have been explored, their causal relationships remain unclear. This study aimed to examine the causal effects of hypertension and lipid levels on gout using multivariable Mendelian randomization (MR) and observational data from the National Health and Nutrition Examination Survey.

The value of CD47 and CAP1 levels in early diagnosis and MACE prediction for patients with non-ST-segment elevation myocardial infarction.

Background: Cardiovascular diseases, particularly atherosclerosis, remain a leading cause of global mortality, presenting significant challenges with non-ST-segment elevation myocardial infarction (NSTEMI). Novel biomarkers such as cluster of differentiation 47 (CD47) and adenylate cyclase-associated protein 1(CAP1) have emerged as potential candidates for improving early diagnosis and risk stratification in NSTEMI patients.

Methods: This prospective cohort study was conducted at Tianjin Chest Hospital from November 2023 to June 2024, involving a total of 270 patients categorized into NSTEMI and unstable angina (UA) groups.

Clinical features and laboratory indicators of dengue infection in China: a retrospective study of adult patients in a hospital of traditional Chinese medicine.

Background: Dengue is an arboviral disease caused by the dengue virus, primarily transmitted by mosquitoes in tropical and subtropical regions. Despite preventive measures, the incidence and mortality of dengue remain significant. While the acute phase of infection often presents with mild, self-limiting symptoms and may mimic other undifferentiated febrile illnesses, the risk of mortality is particularly high during the acute phase of secondary infections, which are associated with more severe clinical manifestations.

Investigating the molecular mechanisms of the "Astragalus-Codonopsis" herb pair in treating diabetes: a network pharmacology and bioinformatics approach with molecular docking validation.

Astragalus membranaceus and Codonopsis pilosula are widely used in traditional chinese medicine for the treatment of diabetes because of their notable hypoglycemic pharmacological effects. Studies have indicatedthat the active compounds in the Astragalus-Codonopsis herb pair may exert their hypoglycemic effects through the modulation of the insulin receptor (IRSP) signaling pathway. In this study, the rhamnolitrin and folic acid were confirmed as the key active components in the Astragalus-Codonopsis herb pair that regulate the IRSP, with their synergistic mechanisms in Type 2 Diabetes Mellitus (T2DM) being further systematically explored by network pharmacology combined with DFT theoretical calculation, molecular docking, molecular dynamics simulation and alanine scanning mutation technology.

Introduction of Diverse Divalent Main-Group Metal Cations to Tune the Physical Properties of Rare-Earth Thiophosphates.

Metal chalcophosphates have extensive applications in numerous frontier scientific fields due to their rich structures. Herein, six novel quaternary thiophosphates (MEu)PS (M = Ca, Sr, Ba, and Pb), viz. (CaEu)PS (), (SrEu)PS (), (BaEu)PS (), (PbEu)PS (), (BaEu)PS (), and (BaEu)PS (), were synthesized by the flux-assisted boron-sulfur solid-state reactions.

Neural correlates differ between crystallized and fluid intelligence in adolescents.

Fluid and crystallized intelligence are acknowledged as distinct facets of cognitive ability during brain development, but the specific neural substrates and molecular mechanisms underlying them remain unclear. This study used a sample comprising 7471 young adolescents (mean age 9.87 ± 0.

DAFF-SNN: Dual Attention-driven and Feature Fusion-based Spiking Neural Network for Epilepsy Detection based on Electroencephalogram.

Electroencephalogram (EEG) signals provide rich spatiotemporal brain features crucial for epilepsy diagnosis. Though traditional deep neural networks combining attention mechanisms excel in feature extraction, these models do not fully emulate the neural processing efficiency of the brain and they fall short in fully harnessing the spatiotemporal dynamics of EEG data. This study introduces the dual attention-driven and feature fusion-based spiking neural network (DAFF-SNN), which synergizes the spatiotemporal attention mechanism with SNNs' inherent temporal processing prowess to enhance the precision and efficiency for epilepsy detection.

Single Sublayer Reconstruction in Substrate-Supported WS Twisted Bilayers.

Marginally twisted WS bilayers undergo lattice reconstructions, but it is unclear if the distortion is equally distributed or confined to specific sublayers. Here, we use combined noncontact atomic force microscopy with scanning tunneling spectroscopy to tune the probing depth to extract electronic and atomic lattice information for each sublayer separately. We find a lattice reconstruction unexpectedly confined to the WS layer in contact with graphite only, governed by transition metal dichalcogenide-substrate interactions, leading to a peculiar type of a ferroelectric domain wall.

Coherence in resonance fluorescence.

Resonance fluorescence of a two-level emitter displays persistently anti-bunching irrespective of the excitation intensity, but inherits the driving laser's linewidth under weak monochromatic excitation. These properties are commonly explained in terms of two disjoined pictures, i.e.

Microstructure of porous network CoFeO@CoO/CNT based on zeolitic imidazolate framework as electrode materials for supercapacitors application.

Transition metal oxides (TMOs), especially spinel-type iron oxides, are widely used as electrode materials for supercapacitors due to their high specific capacitance. However, as a kind of pseudocapacitive electrode material, transition metal oxide undergoes volume changes during the charge-discharge process, leading to a decrease in its cycling stability. Carbon nanotubes (CNTs), as a common carbon-based material, exhibit excellent cycling stability.

A Series of Pentanary Rare-Earth Oxysulfides Obtained by Heterovalent Cation and Anion Cosubstitution Exhibiting Nonlinear Optical Activity and Ultrawide Band Gaps.

Considering the shortcomings of commercial infrared nonlinear optical (NLO) crystals, it is necessary and urgent to explore new ones. Oxychalcogenides are regarded as potential candidates due to their abundant structures and possible balance between NLO indicators. Herein, isostructural REGaGeOS (RE = La (), Ce (), Pr (), and Nd ()) were derived from KNbGeO () via the heterovalent cation/anion cosubstitution strategy.

Triplet-Triplet Annihilation Upconversion with Large Anti-Stokes Shift.

Triplet-triplet annihilation (TTA) upconversion is a phenomenon that converts low-energy photons into high-energy ones. TTA upconversion with a large anti-Stokes shift is highly desired but less easily obtained because intersystem crossing (ISC), triplet energy transfer (TET), and the TTA process in upconversion are all accompanied by significant energy losses. This review, on the basis of the three above-mentioned energy loss channels, systematically summarized three roads to large anti-Stokes shift: (i) Reduce the energy loss of ISC process by utilizing photosensitizers based on small S/T energy gap due to charge transfer, small S/T energy gap due to multiresonance, direct excitation into S → T, minimal exchange splitting (S/T) of inorganic materials, etc.

SPARC promotes malignant progression and predicts poor prognosis in cervical squamous cell carcinoma.

Background: Cervical cancer continues to pose a significant global threat to women's health, with rising incidence and mortality rates in recent years. Pathologically, cervical cancer primarily comprises squamous cell carcinoma (CESC) and adenocarcinoma, where CESC represents more than 80 % of diagnosed cases. Most patients present with advanced-stage CESC at diagnosis, and nearly half eventually develop distant metastases, leading to markedly diminished cure rates and five-year survival below 30 %.

Burden of knee osteoarthritis in China and globally: 1990-2045.

Background: Knee osteoarthritis (KOA) is a major global health challenge, with rising prevalence, incidence, and disability-adjusted life years (DALYs). This disease increasingly burdens healthcare systems worldwide, particularly as populations age and obesity rates rise. In China, the rapid demographic shift towards an aging population, combined with rising obesity rates, makes KOA a pressing public health issue.

Multi-objective operation optimization method of microgrid considering the influence of electric vehicle.

In view of the negative impact on the stable operation of the system caused by the disorderly charging of large-scale electric vehicles connected to the microgrid, an optimization method for the operation of microgrid considering the impact of electric vehicles is proposed. Based on the traditional microgrid, a grid-connected microgrid system with electric vehicles is designed, and the system is studied. Based on Monte Carlo simulation method, the load model of disorderly charging and orderly charging and discharging of electric vehicles is constructed.

ALK-rearranged papillary thyroid carcinoma with a germline MEN1 mutation.

Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. The 5th edition of the World Health Organization (WHO) Classification of Thyroid Tumors divides PTC into 13 distinct morphological subtypes based on its morphological characteristics. According to molecular features, thyroid cancer is classified into RAS-like and BRAF-like tumors.