Early hyperferritinemia in polytrauma: a biomarker of systemic inflammation and mortality risk in a multicenter cohort study.

Background: Severe polytrauma is one of the leading causes of death and disability worldwide. Hyperferritinemia is increasingly recognized as a biomarker of critical illness, yet its prognostic significance in polytrauma remains underexplored. This multicenter study investigates the temporal dynamics of serum ferritin in polytrauma patients and its association with systemic inflammation, organ dysfunction, and mortality.

Altered EEG Microstate Dynamics in First Unprovoked Seizure and Newly Diagnosed Epilepsy Patients.

Objective: To identify the Electroencephalogram (EEG) microstate characteristics that can distinguish between patients with first unprovoked seizure (FUS) and newly diagnosed epilepsy (NDE), providing insight into predicting the progress of FUS to NDE, and to find the predictive biomarkers for the responsiveness to initial antiseizure medication (ASM) therapy.

Methods: Fifty-six NDE patients in a drug naïve state, 26 FUS patients, and 31 healthy controls (HCs) were compared on microstates features of 21-channel resting-state EEG without artifact. Four classic EEG microstates (A, B, C and D) were derived.

Multifactorial Analysis of Trueness in Computer-Assisted Implant Surgery: A Retrospective Study.

Objectives: To investigate the clinically acceptable deviation threshold and the factors associated with trueness across three computer-assisted implant surgery (CAIS) approaches: static CAIS (s-CAIS), dynamic CAIS (d-CAIS), and robotic CAIS (r-CAIS).

Materials And Methods: A total of 314 implants in 194 patients were retrospectively included, with preoperative and postoperative CBCT scans collected. Outcome measures included platform, apex, and angular deviations, which were assessed by registering postoperative CBCT scans to preoperative implant plans using a jawbone matching technique.

Dynamic changes in comorbid conditions following vagus nerve stimulation for epilepsy.

Background: Vagus nerve stimulation (VNS) has been widely used in the clinical treatment of epilepsy, while its effects on comorbidities in epilepsy remain incompletely elucidated. This study aimed to evaluate the impact of VNS on comorbidities and quality of life in adult patients with epilepsy.

Methods: A longitudinal, multicenter cohort study was conducted from 2021 to 2024 among adult patients with epilepsy who underwent VNS implantation.

Isolation and Identification of a Novel sp.C8: Unleashing the Potential for Chitin Oligosaccharides Production.

Chitin oligosaccharides (CHOS) possess potential applications in food, medicine, and agriculture. Nevertheless, their low production efficiency and polymerization degree severely restrict their extensive utilization. In the present study, a Chitinase-producing bacterium was isolated and identified as sp.

Effectiveness of Restoration Strategies for Posterior Missing Teeth With Dental Implants: A Retrospective Study.

Aim: This study aimed to assess the effectiveness of a treatment strategy involving only implant restoration of the first molars (M1s) in cases where both M1s and second molars (M2s) lost.

Materials And Methods: A retrospective study design compared two groups: one underwent simultaneous implant restoration of both M1s and M2s (Group 1), while the other underwent restoration of only M1s (Group 2). Statistical models were used to evaluate implant survival, complication-free survival rates, cumulative treatment costs, peri-implant conditions, and patient-reported outcomes (PROMs).

A Visible-Light Photocatalysis/Hydrolysis Hydrogen-Generating Nanoplatform for Dynamic Inflammation Management via Immune Metabolism Orchestration during Wound Repair.

Effective management of inflammation is one of the promising strategies to prevent the formation of chronic wounds. Despite hydrogen being a prospective molecule for anti-inflammatory effects, the on-demand delivery of hydrogen that could synchronize with the dynamic inflammation stages has yet remained unaddressed. Moreover, its specific immunomodulatory mechanisms are still veiled.

Evaluation of the effect of cervical spine bone distribution on fixation in ankylosing spondylitis.

Purpose: The distribution of cervical bones in ankylosing spondylitis (AS) differs from that of the normal cervical spine. Traditional simulation methods often yield inaccurate results in finite element analysis. The current study aimed to construct ankylosing spondylitis cervical spine fracture (ASCF) models based on Hounsfield Unit (HU) values to analyze the effects of different fixation approaches.

Changes of potential shorty-chain fatty acids producing bacteria in the gut of patients with spinal cord injury: a systematic review and meta-analysis.

Gut bacteria that potential produce short-chain fatty acids (SCFAs) influences the recovery of motor function in the host in patients with spinal cord injury (SCI). We aimed to conduct a review and meta-analysis of the literature on gut microbiota in SCI patients. Following the Preferred Reporting Project for Systematic Review and Meta-Analysis (PRISMA), we searched Embase, PubMed, Cochrane Library, Web of Science (WOS) and ClinicalTrials.

Adaptation of Natural Killer Cells to Hypoxia: A Review of the Transcriptional, Translational, and Metabolic Processes.

As important innate immune cells, natural killer (NK) cells play an essential role in resisting pathogen invasion and eliminating transformed cells. However, the hypoxic microenvironment caused by disease conditions is an important physicochemical factor that impairs NK cell function. With the increasing prominence of NK cells in immunotherapy, there has been a surge of interest in developing biological means through which NK cells may overcome the inhibition caused by hypoxia in disease conditions.

Isoflavones extracted from Millettia pachyloba prevent the infection of the rice blast fungus by inhibiting its conidial germination and appressorium formation.

Background: The ascomycete Magnaporthe oryzae is a destructive phytopathogenic fungus that causes rice blast disease and can greatly reduce rice yields. Due to the widespread use of synthesized chemical fungicides and the frequent occurrence of fungicide resistance and environmental pollution as a result, it has become increasingly urgent to develop environmentally friendly biocontrol alternatives, including plant crude extracts.

Results: In this study, the crude extracts of the tropical plant Millettia pachyloba were screened out and exhibited excellent preventive effects against M.

Immediate Implant Placement in the Esthetic Zone: A Multi-Variate Analysis of Influencing Factors.

Objectives: To evaluate the dimensional reduction of the peri-implant hard tissues and esthetic outcome after immediate implant placement (IIP) in the esthetic zone.

Material And Methods: Patients who received IIP with bone grafts in the esthetic zone, with either immediate or delayed restoration, were included in this retrospective cohort study. The implants were categorized into three groups based on the labial bone thickness (LBT) before implantation: Group 1 (≤ 0.

The diagnostic and prognostic value of serum miR-199a-5p combined with echocardiography in acute myocardial infarction.

Background: Diagnosis and prognostic evaluation of acute myocardial infarction (AMI) are crucial for patients.

Objective: The clinical significance of serum miR-199a-5p combined with echocardiography in AMI was investigated to provide some reference for clinical treatment.

Methods: The study subjects were 90 AMI patients and 50 acute chest pain patients (control).

Uncertain significance and molecular insights of CPLANE1 variants in prenatal diagnosis of Joubert syndrome: a case report.

Background: Prenatal whole exome sequencing (WES) is becoming an increasingly used diagnostic tool for fetuses with structural anomalies. However, the identification of variants of uncertain significance (VUS) in clinically relevant genes can significantly complicate prenatal diagnosis and genetic counseling.

Case Presentation: A fetus conceived through in vitro fertilization at the third attempt presented with polydactyly and molar tooth sign at 24 + 6 weeks of gestation.

Development of a nomogram for individualized prediction of acute gastrointestinal injury in polytrauma patients.

Objective: Previous reports have indicated the occurrence of acute gastrointestinal injury (AGI) in critically ill individuals. Yet, there is limited information regarding the frequency and potential causes of AGI in individuals with polytrauma. The complicated diagnostic tools often mistaken and mislead the evaluation of AGI.

Risk Estimation of Deep Venous Thrombosis in Polytrauma Patients with Traumatic Brain Injury: A Nomogram Approach.

Background: Deep venous thrombosis (DVT), known to be a major factor in poor outcomes and death rates, is common after polytrauma with traumatic brain injury (TBI). In this study, a nomogram will be developed to predict the risk of DVT in polytrauma patients with TBI, since there is currently no specific and convenient diagnostic method.

Methods: A retrospective and observational trial was conducted between November 2021 and May 2023.

Tim-3 pathway dysregulation and targeting in sepsis-induced immunosuppression.

Sepsis is a major medical problem which causes millions of deaths worldwide every year. The host immune response in sepsis is characterized by acute inflammation and a simultaneous state of immunosuppression. In the later stage of sepsis, immunosuppression is a crucial factor that increases the susceptibility of septic patients to secondary infection and mortality.

From trauma to chronicity: Understanding the incidence and early immune changes of chronic complications in polytrauma patients.

Objective: Polytrauma is a complex condition associated with poor outcomes and high mortality rates resulting from severe damage and complicated complications. This study sought to ascertain the incidence of chronic complications in polytrauma patients, as well as the early immune changes and risk factors.

Methods: A multicenter, prospective and observational cohort study was conducted at the emergency surgery or traumatic intensive care unit (TICU) of the Advanced Trauma Center from August 2020 to July 2023.

Clinical application value of simultaneous plasma and bronchoalveolar lavage fluid metagenomic next generation sequencing in patients with pneumonia-derived sepsis.

Background: Despite the increasing use of metagenomic next-generation sequencing (mNGS) in sepsis, identifying clinically relevant pathogens remains challenging. This study was aimed to evaluate the clinical utility of simultaneous plasma and bronchoalveolar lavage fluid (BALF) detection using mNGS.

Methods: This retrospective study enrolled 95 patients with pneumonia-derived sepsis (PDS) admitted to the intensive care unit (ICU) between October 2021 and January 2023.

Everyone is searching for it and those who acquired it enjoy better mental health: a latent profile analysis of Chinese adolescents' meaning in life.

Objective: One factor associated with rising rates of depression and anxiety among youth is a lack of meaning in life (MIL). The importance of living a meaningful and purposeful life cannot be overstressed, especially for adolescents who are in a critical life stage and have recently experienced a 3-year-long global health crisis, namely the COVID-19 pandemic. Although previous studies have examined adolescents' MIL, the majority of them adopted a variable-centered approach.