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Article Abstract
Background: Diagnosis and prognostic evaluation of acute myocardial infarction (AMI) are crucial for patients.
Objective: The clinical significance of serum miR-199a-5p combined with echocardiography in AMI was investigated to provide some reference for clinical treatment.
Methods: The study subjects were 90 AMI patients and 50 acute chest pain patients (control). All patients were examined by echocardiography and recorded LVEDV, LVESV, and LVEF. RT-qPCR was performed to detect the serum miR-199a-5p level. Pearson analysis was used to analyze the correlation of miR-199a-5p with LVEF and cTnI. The diagnostic value of miR-199a-5p combined with LVEDV, LVESV, and LVEF was assessed by the ROC curve. The occurrence of major adverse cardiovascular events (MACE) was recorded to analyze the prognostic value of miR-199a-5p by the Kaplan-Meier curve and Cox regression.
Results: Serum miR-199a-5p was elevated in AMI, positively correlated with cTnI and negatively correlated with LVEF. The combination of miR-199a-5p with LVEDV, LVESV, and LVEF enhanced the sensitivity and specificity for the diagnosis of AMI. Patients with high miR-199a-5p expression were more likely to develop MACE. The combination of miR-199a-5p with LVEF improved the prediction of MACE.
Conclusions: The combination of miR-199a-5p with echocardiography improved the diagnostic efficiency of AMI and provided prognostic information.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705689 | PMC |
| http://dx.doi.org/10.1186/s13019-024-03201-z | DOI Listing |
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