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Objectives: To evaluate the dimensional reduction of the peri-implant hard tissues and esthetic outcome after immediate implant placement (IIP) in the esthetic zone.
Material And Methods: Patients who received IIP with bone grafts in the esthetic zone, with either immediate or delayed restoration, were included in this retrospective cohort study. The implants were categorized into three groups based on the labial bone thickness (LBT) before implantation: Group 1 (≤ 0.5 mm), Group 2 (0.5-1 mm), Group 3 (≥ 1 mm). The horizontal bone loss (HBL) at 0, 3, 5 mm apical to implant shoulder, peri-implant marginal bone loss (MBL), and Pink Esthetic Score (PES) were used to evaluate the hard and soft tissue after IIP.
Results: A total of 87 implants in 74 patients met the inclusion criteria. Compared to group 3, there was significant severe bone loss in the HBL-0 mm in groups 1 (p = 0.017); and the implant located in the central incisor position and female may led to increased bone resorption (p = 0.021, p = 0.061, respectively). For HBL-3 mm and HBL-5 mm, the non-immediate restoration may reduce bone resorption (p = 0.013, p = 0.022, respectively). The MBL during short-term follow-up and PES score showed no significant difference among three groups.
Conclusions: Despite limitations, our study found that LBT < 0.5 mm significantly affected horizontal bone loss. Meanwhile, immediate restoration, implant position of central incisors and female may also be considered as risk factors for HBL. However, the difference in the labial bone did not significantly affect MBL, or peri-implant soft tissue outcomes.
Trial Registration: This study was registered in a clinical trial registry (www.chictr.org.cn, No: ChiCTR2400087990).
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http://dx.doi.org/10.1111/cid.13439 | DOI Listing |
Introduction: The ADHEAR is a non-surgical Bone Conduction Device (BCD) that makes use of an adhesive adapter. While clinical trials have demonstrated its efficacy with regards to audiological performance, safety and compliance, data on real-world paediatric cohorts is scarce.
Methods: This retrospective cohort study analysed data from paediatric patients fitted with ADHEAR at a tertiary centre between January 2017 and September 2024.
FASEB J
September 2025
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials
The onset and progression of periodontitis are closely related to metabolic reprogramming in the periodontal microenvironment, with osteoclasts playing a critical role in tissue destruction. Single-cell RNA sequencing (scRNA-seq) of periodontal tissues from healthy individuals and patients with severe chronic periodontitis revealed a significant increase in the expression of mitochondrial-related genes during osteoclast differentiation, suggesting the critical role of mitochondrial function in this process. This study investigates the potential of the novel mitoribosome-targeting antibiotic radezolid in inhibiting osteoclast differentiation.
View Article and Find Full Text PDFJCI Insight
September 2025
Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute, and.
Steroid-refractory gut acute graft-versus-host disease (SR-Gut-aGVHD) is the major cause of nonrelapse death after allogeneic hematopoietic cell transplantation. High numbers of donor-type IL-22+ T cells, IL-22-dependent dysbiosis, and loss of antiinflammatory CX3CR1hi mononuclear phagocytes (MNPs) play critical roles in SR-Gut-aGVHD pathogenesis. CEACAM1 on intestinal epithelial cells (IECs) is proposed to regulate bacterial translocation and subsequent immune responses in the intestine.
View Article and Find Full Text PDFFASEB J
September 2025
Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, The University of Osaka, Osaka, Japan.
In bone marrow, cell numbers are balanced between production and loss. After chemotherapy, blood cell counts decrease initially but later recover as hematopoietic progenitor cells expand, although the mechanisms underlying this recovery are still unclear. We investigated the influence of red blood cells (RBCs) on hematopoietic stem cell (HSC) function during bone marrow recovery.
View Article and Find Full Text PDFOrthod Craniofac Res
September 2025
Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Objective(s): In this pilot study, exosomes from saliva were isolated and tested for the presence of metabolomic biomarkers for physiological external root resorption and/or pathological alveolar bone resorption.
Settings And Sample Population: Saliva samples of 20 individuals in the mixed dentition stage of dental development.
Materials And Methods: Saliva was obtained from healthy control children with resorbing primary teeth or children with localised aggressive periodontitis (LAP) showing alveolar bone loss but little root resorption.