Prognostic factors of lenvatinib plus pembrolizumab therapy for advanced or recurrent endometrial cancer: analysis of a multicenter cohort study in Japan.

Background: Lenvatinib plus pembrolizumab (LP) therapy has emerged as an effective treatment for patients with advanced or recurrent endometrial cancer. However, limited data are available regarding its outcomes in real-world settings. This study aimed to identify prognostic factors associated with the efficacy of LP therapy.

Cooling-induced brushite crystallization in urine as a predictive risk marker for calcium kidney stone recurrence.

Kidney stones have a high recurrence rate-10% within 5 years and 50% within 10. Crystalluria reflects the urinary physicochemical environment and may serve as a recurrence marker, but key crystals like brushite are rarely detected under ambient conditions. This study aimed to identify novel recurrence markers by inducing crystallization through urine cooling and analyzing crystal composition.

Preparation of Bifunctional Orthosilicophosphate MgO-CaO-ZnO-PO-SiO Glasses: in vitro Evaluation of Antibacterial Activity and Osteoblast Gene Expression Behavior.

Phosphate and phosphate invert glasses contain various elements, with a wide range of compositions. Recently, our group reported orthosilicophosphate glasses (SPGs) and the glass network structure composed of orthophosphates and orthosilicates crosslinked by cations. ZnO is an intermediate oxide that improves the chemical durability of glass.

Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models.

Stress-related disorders, such as depression and anxiety, have been one of the most important medical issues. Accumulating evidence suggests that the activation of the pituitary adenylate cyclase-activating polypeptide and its receptor PAC1 are involved in the stress axis and the development of stress-related disorders. We recently developed PA-915, a small-molecule, non-peptide, high-affinity PAC1 antagonist, and demonstrated that it significantly suppresses anxiety-like behavior in acute stress-induced mice.

A theoretical interpretation of diffusion weighted and intravoxel incoherent motion imaging for cerebrospinal fluid flow.

Purpose: Diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) imaging are well-established approaches for evaluating cerebrospinal fluid (CSF) flow in subarachnoid and perivascular spaces, and have recently been applied to study ventricular CSF flow. However, DWI does not directly measure flow velocity, and the physical implications of DWI measurements are unclear. This study aimed to provide a theoretical interpretation of the DWI and IVIM imaging of CSF flow velocity fields.

Testis expressed 50 is essential for maintaining sperm acrosome integrity during epididymal transit.

In mammals, sperm formation is completed in the seminiferous tubules within the testis, and sperm maturation occurs during the epididymal transit of the spermatozoa. Sperm morphology drastically changes when abnormal spermatozoa migrate from the testis to the epididymis. Detailed molecular mechanisms for sperm survival in the epididymis have not been determined yet.

Kinome analysis of Madurella mycetomatis identified kinases in the cell wall integrity pathway as novel potential therapeutic drug targets in eumycetoma caused by Madurella mycetomatis.

Eumycetoma is a neglected tropical subcutaneous disease most commonly caused by the fungus Madurella mycetomatis. Currently, eumycetoma is treated by a combination of antifungal therapy and surgery, with limited success rates. To identify novel drug targets we used an in silico approach to determine the kinases present in M.

Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn's disease.

Tissue-resident memory T cells (TRM) remain in nonlymphatic barrier tissues for extended periods and are deeply involved in immune memory at the site of inflammation. Here, we employed multilayered single-cell analytic approaches including chromatin, gene, and protein profiling to characterize a unique CD4+ TRM subset present in the inflamed gut mucosa of Crohn's disease patients. We identified two key transcription factors, RUNX2 and BHLHE40, as regulators of pathologically relevant CD4+ TRM.

Oral Ingestion of Bean Sprouts Containing the HASPIN Inhibitor Coumestrol Increased Blood Testosterone Levels in Men.

Extending healthy lifespans is an important public health goal in societies with a long life expectancy. Late-onset hypogonadism (LOH), a condition associated with an age-related decrease in testosterone level, contributes to the onset of various diseases. Previously, we demonstrated that the oral ingestion of bean sprouts rich in the HASPIN inhibitor coumestrol increased blood testosterone levels in mice.

Smartphone application-based interventions for cardiometabolic risk factor management: A systematic review and meta-analysis.

We previously conducted a systematic review and meta-analysis examining the effects of smartphone application-based interventions on blood pressure (BP). Building on that work, here we present a secondary analysis which explored the effects of these interventions on cardiometabolic risk factors. We searched MEDLINE, the Cochrane Library, and Ichushi for randomized controlled trials and observational studies comparing smartphone application-based interventions with usual care excluding digital technologies.

Recellularization of decellularized vascular grafts via aligned seeding of endothelial cells derived from human iPS cells.

The development of decellularized vascular tissues for tissue engineering and vascular implants presents a promising approach to creating functional blood vessels. However, effective endothelialization with human endothelial cells remains challenging. This study examined the endothelialization of decellularized porcine aortas using human induced pluripotent stem (hiPS) cell-derived endothelial cells.

Advances in malignant hyperthermia: novel insights into heat-induced Ca release as a thermal signaling.

Thermoregulation is essential for maintaining homeostasis in mammals under various environmental conditions. Impairment of this function can result in severe conditions, such as fever, heat stroke, and malignant hyperthermia (MH). In this review, we will focus on the role of the type 1 ryanodine receptor (RYR1), a Ca release channel that is crucial for excitation-contraction coupling in skeletal muscles.

Timing of first pembrolizumab infusion and long-term outcomes in non-small cell lung cancer: A retrospective multicenter study.

Background: Circadian rhythms modulate immunity, and a preclinical study suggests that the timing of the first immune checkpoint inhibitor dose affects antitumor efficacy. However, clinical confirmation is scarce. We aimed to evaluate whether the timing of the first pembrolizumab infusion affects outcomes in unresectable non-small cell lung cancer (NSCLC).

Microbial Intervention in the Soaking Step during Tempeh Preparation to Modulate B Vitamin Contents: A Metabolomics Approach.

B vitamins are integral in maintaining human health. Owing to its high B vitamin contents, tempeh serves as an excellent plant-based option to achieve an adequate intake of these nutrients through diet. In order to investigate the metabolomic profile of tempeh and modulate the contents of vitamins B and B in it, we employed microbial interventions using two species of lactic acid bacteria (LAB) and various inoculum sizes in the soaking step during tempeh production.

Neural Basis of Anxiety in Dementia With Lewy Bodies.

Objective: The association between core clinical features and anxiety and the neural basis of anxiety in patients with dementia with Lewy bodies (DLB) are unknown. Therefore, this study examined the core clinical features associated with anxiety in DLB and identified the brain regions associated with anxiety using statistical imaging analysis.

Methods: This study was conducted using a part of the data from "The Japan multicenter study: Behavioral and psychological symptoms Integrated Research in Dementia-Retrospective Neuroimaging part".

Super-Enhancer-Mediated DLX5 Activation Defines Regulatory Mechanisms in Human Embryonic Stem Cell-Derived Osteoblasts.

Osteoblast differentiation is essential for skeletal development and homeostasis. Although bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) are commonly used to study osteoblast differentiation in the context of bone homeostasis, their relevance to osteoblast differentiation during human skeletal development remains unclear. To understand the regulatory mechanisms underlying osteoblast differentiation in a human developmental context, we performed Assay for Transposase-Accessible Chromatin sequencing (ATAC-seq) and RNA-seq analyses on osteoblasts isolated from an in vivo implantation system using induced sclerotome derived from Col2.

Evaluation of the Glucocorticoid-Sparing Effect of Adding Methotrexate in Polymyalgia Rheumatica: A Single-Center Retrospective Study.

Objective This study assessed whether the addition of methotrexate (MTX) to glucocorticoid therapy reduces overall glucocorticoid usage in patients with polymyalgia rheumatica (PMR), focusing particularly on those exhibiting glucocorticoid-resistant disease.  Methods This retrospective study included 82 patients with PMR treated with glucocorticoids. After applying matching weights, outcomes were compared between weighted populations of 18 patients receiving MTX and 18 receiving glucocorticoid monotherapy.

Polymorphism and Thermally Induced Structural Transformation in Semiconducting Cd(II) Coordination Polymers.

Three polymorphs of a semiconducting Cd(II)-thiolate coordination polymer with the formula [Cd(2-SNPh)] (2-HSNPh = 2-naphthalenethiol) have been reported. Single-crystal X-ray structural analysis revealed that adopts a one-dimensional (1D) structure composed of single-strand (-Cd-S-) ladder chains, whereas adopts a 1D architecture with double-strand (-Cd-S-) chains assembled through S···S interactions. In contrast, microcrystal electron diffraction analysis demonstrated that , obtained through thermal treatment of and , exhibits the formation of a 1D structure comprising triple-strand (-Cd-S-) chains, also formed via S···S interactions.

Enhancement of Emission Efficiency and Color Tuning by Mixing Platinum(II) and Palladium(II) Complexes in a One-dimensional Chain.

A series of mixed metal crystals comprising square-planar platinum(II) and palladium(II) complexes, K[M(CN)(dFppy)]·HO (M = Pt, Pd; dFppy = 2-(4,6-difluorophenyl)pyridinate), were prepared, and their unique luminescence properties-emerging upon mixing-were revealed. Seven mixed crystals with Pt/Pd ratios of 1:0.5, 1:1, 1:1.

Association between plasma mid-regional pro-adrenomedullin levels and muscle properties.

Aim: Adrenomedullin exerts a vasodilative effect and is thought to be associated with skeletal muscle properties by regulating microcirculation. This cross-sectional study aimed to clarify the possible association in older adults aged ≥65 years.

Methods: The study population included 978 community residents (mean age 71.

Correspondence of high dimensional emotion structures elicited from video clips between humans and multimodal LLMs.

Recent studies have revealed that human emotions exhibit a high-dimensional, complex structure. A full capturing of this complexity requires new approaches, as conventional models that disregard high dimensionality risk overlooking key nuances of human emotions. Here, we examined the extent to which the latest generation of rapidly evolving Multimodal Large Language Models (MLLMs) capture these high-dimensional, intricate emotion structures, including capabilities and limitations.

Epidermal growth factor receptor inhibitor-related skin toxicities: a review of management and possible preventive and therapeutic approaches for Asian patients by the Japanese Pharmacist-led Oncodermatology Study Team.

Epidermal growth factor receptor antibodies and tyrosine kinase inhibitors cause various skin toxicities. Acneiform rash, paronychia, and pruritus are the major side effects, and their incidence is high, especially in Asian patients. These skin disorders greatly reduce the patients' quality of life and can affect treatment intensity.