Oral Ingestion of Bean Sprouts Containing the HASPIN Inhibitor Coumestrol Increased Blood Testosterone Levels in Men.

Extending healthy lifespans is an important public health goal in societies with a long life expectancy. Late-onset hypogonadism (LOH), a condition associated with an age-related decrease in testosterone level, contributes to the onset of various diseases. Previously, we demonstrated that the oral ingestion of bean sprouts rich in the HASPIN inhibitor coumestrol increased blood testosterone levels in mice.

Prevalence and Factors Associated with Premature Ejaculation in Japan: First Nationwide Cross-Sectional Survey by the Japanese Society for Sexual Medicine.

Purpose: Premature ejaculation (PE) is a most common sexual complaint among men worldwide, but its prevalence and associated factors in Japan remain underexplored. This study aimed to determine the prevalence of self-reported PE, lifelong PE (LPE), and acquired PE (APE) among Japanese men, as well as to identify associated factors, distress levels, and healthcare-seeking behaviors through a nationwide cross-sectional survey.

Materials And Methods: This internet-based nationwide cross-sectional survey was conducted among Japanese men from 20 to 79 years old by the Clinical Research Promotion Committee of the Japanese Society for Sexual Medicine (JSSM).

Global Andrology Forum (GAF) Clinical Guidelines on the Management of Non-obstructive Azoospermia: Bridging the Gap between Controversy and Consensus.

Purpose: Non-obstructive azoospermia (NOA), defined as the absence of sperm in the ejaculate due to testicular failure, is observed in 5% to 15% of infertile men and accounts for two-thirds of azoospermia cases. The management of NOA is marked by significant controversy and global variation in diagnostic and therapeutic approaches, highlighting the crucial need for well-designed and standardized clinical practice guidelines. We present comprehensive graded clinical practice recommendations and statements for diagnosing and treating NOA, aiming to establish standardized strategies that can globally help guide practitioners in their practice.

How do fertility facilities in Japan perceive disclosing institutional success rates for IVF? A nationwide survey of registered assisted reproductive technology facilities.

To evaluate the current perspectives on reporting success rates for assisted reproductive technology, the authors conducted a nationwide survey. Of the 327 facilities that responded (response rate: 53.5%), over half recognized potential benefits of reporting in vitro fertilization (IVF) success rates, such as aiding patients in selecting a clinic (68.

Efficacy, Satisfaction, and Safety of Low-Intensity, Large-Area Shock Wave Therapy With Dual-Probe Energy Delivery for Erectile Dysfunction.

Objective: We evaluated the efficacy and safety of a new low-intensity extracorporeal shockwave therapy generator, the Morenova system (Direx Systems GmbH, Wiesbaden, Germany), that offers fewer treatments and shorter treatment times through dual-probe energy delivery for patients with erectile dysfunction (ED). We additionally examined whether aging affects treatment efficacy and whether there are independent factors that predict treatment efficacy. To evaluate efficacy from the viewpoint of patient satisfaction, free comments written by the patients were analyzed by artificial intelligence (AI) to clarify the percentage of responses judged to be "positive.

Summary of the Clinical Practice Guidelines for Male Infertility by the Japanese Urological Association With the Support of the Japan Society for Reproductive Medicine.

These 2024 guidelines address male infertility amid Japan's declining birth rate, following the recent provision of national health insurance coverage for infertility treatments. Male factors contribute to approximately 50% of infertility cases, with spermatogenic dysfunction being the most common cause (82.4%).

Is Testosterone Replacement Therapy Effective and Safe Even for Eugonadal Men With Symptoms of Late-Onset Hypogonadism?

Objective: To clarify the efficacy and safety of testosterone replacement treatment for eugonadal patients with symptoms of late-onset hypogonadism.

Materials And Methods: 565 eugonadal men with symptoms of late-onset hypogonadism who underwent testosterone replacement treatment were included in this study. Physical factors, laboratory and endocrinologic variables, and scores of several questionnaires were evaluated.

Possible Clinical Effects of Ketoconazole on Sorafenib-induced Hand-Foot Skin Reaction and Cytoprotection Mechanisms of Antifungal Agents against Multikinase Inhibitor-induced Keratinocyte Toxicity.

In recent years, molecular target drugs have become integral in treating malignant tumours. Multikinase inhibitors (MKIs) have been associated with serious skin disorders, including hand-foot skin reaction (HFSR), which impair patient quality of life, often disrupting activities of daily living necessitating dose reduction or discontinuation. As the pathogenic mechanisms of these skin disorders are unknown, no effective treatments have been established.

Global Andrology Forum Clinical Guidelines on the Relevance of Sperm DNA Fragmentation in Reproductive Medicine.

Purpose: To evaluate the evidence on sperm DNA fragmentation (SDF) and its clinical applications in reproductive medicine, highlighting benefits, limitations, and guidelines for its use to assist clinicians in objective decision-making.

Materials And Methods: A multidisciplinary team of clinicians and reproductive experts from the Global Andrology Forum (GAF) reviewed the latest evidence on SDF, covering indications, testing methods, recurrent pregnancy loss, varicocele and its repair, assisted reproductive technologies (ART), treatment of associated conditions, antioxidant therapy, and sperm selection for ART. Expert statements and recommendations were developed and graded with the GRADE system using a modified Delphi process.

Comparative analysis of gut microbiota in hormone-sensitive and castration-resistant prostate cancer in Japanese men.

Gut microbiota plays a crucial role in the development and progression of prostate cancer, with previous studies indicating that certain bacterial taxa are more abundant in castration-resistant prostate cancer (CRPC) compared to hormone-sensitive prostate cancer (HSPC). Notably, the composition of gut microbiota can vary significantly by geographic region, and Japanese individuals have a distinct microbial profile. However, research exploring these differences within Japanese populations remains limited.

Erectile Function and Sexual Activity Are Declining in the Younger Generation: Results from a National Survey in Japan.

Purpose: Twenty five years have passed since the first national survey on erectile dysfunction (ED) in Japan. The Japanese Society for Sexual Medicine conducted a nationwide survey on the actual status of sexual function targeting men over 20 years old in Japan using validated questionnaires commonly used in clinical practice.

Materials And Methods: Japanese men aged 20 to 79 years participated in our online epidemiological study on sexual dysfunction.

Efficacy of a new vacuum erection device (Vigor 2020) for erectile dysfunction: A retrospective study in Japan.

Objectives: The vacuum erection device (VED) is a second-line treatment tool recommended in erectile dysfunction (ED) guidelines but has long been unavailable in Japan. A new VED, Vigor 2020 (A & HB Company Limited, Tokyo, Japan), has now been manufactured and received medical approval from the Pharmaceuticals and Medical Devices Agency in Japan. We conducted a retrospective observational study of ED patients who used Vigor 2020 in clinical practice.

Aggressive Prostate Cancer After a 14-Year Gonadotropin Therapy: A Case Report.

A 40-year-old man with a four-year history of infertility was referred to our department. The semen analysis revealed low motility, and the blood test showed low luteinizing hormone levels. Gonadotropin therapy was initiated upon the diagnosis of hypogonadotropic hypogonadism.

Circadian Rhythm of Voided Volume, Maximum Flow Rate, and Voiding Time Evaluated by Toilet Uroflowmetry in Hospitalized Women With Nocturia.

Objective: To clarify the circadian rhythm of urination in hospitalized women with nocturia measured by toilet uroflowmetry and its age-related change.

Methods: We evaluated 2602 urinations of 58 female patients (age, 68.4 ± 15.

Efficacy of testosterone replacement treatment for patients with symptoms of late-onset hypogonadism based on real-world patient satisfaction.

Late-onset hypogonadism is generally treated with testosterone replacement treatment. However, the efficacy rate of treatment for patients with low testosterone is not clear because patients without low testosterone are also treated in real-world clinical settings. This study comprised 110 men with low testosterone concentration of <3.

Bone scan index (BSI) scoring by using bone scintigraphy and circulating tumor cells (CTCs): predictive factors for enzalutamide effectiveness in patients with castration-resistant prostate cancer and bone metastases.

Reports of Bone Scan Index (BSI) calculations as imaging biomarkers to predict survival in patients with metastatic castration-resistant prostate cancer (mCRPC) have been mainly from retrospective studies. To evaluate the effectiveness of enzalutamide (ENZ) in Japanese patients with mCRPC and bone metastases using BSI (bone scintigraphy) and circulating tumor cell (CTC) analysis. Prospective, single-arm study at Juntendo University affiliated hospitals, Japan.