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http://dx.doi.org/10.21037/hbsn-2025-392 | DOI Listing |
Hepatobiliary Surg Nutr
August 2025
Department of Hepatobiliary Surgery and Liver Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
PLoS Negl Trop Dis
September 2025
Joint Laboratory for Emerging Infectious Diseases in China (Guangxi)-ASEAN, Life Sciences Institute, Guangxi Medical University, Guangxi. China.
Background: Talaromyces marneffei (T. marneffei), a life-threatening opportunistic fungal pathogen, is endemic to Southeast Asia. Although elevated aspartate aminotransferase (AST) levels are commonly observed in infected individuals, the origin and mechanism of this phenomenon remain unclear.
View Article and Find Full Text PDFAm J Transplant
August 2025
Department of Digestive, Hepato-Biliary and Pancreatic Surgery and Liver Transplantation, AP-HP Pitié-Salpêtrière Hospital, Paris, France; Sorbonne Université, Paris, France; Centre de Recherche de Saint-Antoine (CRSA), INSERM, UMRS-938, Paris, France. Electronic address:
We report the case of a cirrhotic patient with significant portal hypertension (PHT) who underwent a RAPID procedure (Resection and Partial Liver Segment 2/3 Transplantation with Delayed Total Hepatectomy) using a hyper-small left liver graft with a graft-to-recipient weight ratio (GRWR) of 0.29. To reduce the risk of small-for-size syndrome (SFSS) and modulate portal inflow, a preoperative transjugular intrahepatic portosystemic shunt (TIPS) was placed, decreasing the portosystemic gradient from 15 to 8 mmHg.
View Article and Find Full Text PDFTransplantation
August 2025
Department of Hepatobiliary Surgery, Daping Hospital, Army Medical University, Chongqing, China.
The resection and partial liver segment 2/3 transplantation with delayed total hepatectomy (RAPID) represents an innovative fusion of 2 of the most challenging procedures of modern liver surgery: auxiliary partial orthotopic liver transplantation and associating liver partition and portal vein ligation for staged hepatectomy. By combining the principles of auxiliary partial orthotopic liver transplantation of partial graft implantation with staged parenchymal modulation of associating liver partition and portal vein ligation for staged hepatectomy, RAPID enables sequential hypertrophy of the transplanted graft followed by complete native liver removal, addressing critical limitations in donor-recipient size matching. Current evidence highlights its primary application in treating unresectable hepatic malignancies, demonstrating advantages over conventional strategies in preserving functional liver volume, minimizing the risk of small-for-size syndrome, and accelerating graft regeneration.
View Article and Find Full Text PDFZhonghua Gan Zang Bing Za Zhi
July 2025
Department of Liver Disease, the Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing 210029, China.
Autoimmune hepatitis (AIH) is a kind of chronic inflammatory liver disease mainly characterized by hepatocellular damage. There is no gold standard for its diagnosis, and it still relies on liver histological examination. Pathological examination is indispensable in the differential diagnosis and disease assessment of AIH.
View Article and Find Full Text PDF