Population pharmacokinetics and pharmacodynamics of meropenem in critically ill patients with renal impairment or on continuous renal replacement therapy.

Purpose: This study aimed to characterize the pharmacokinetics (PK) of meropenem in patients with renal impairment or on continuous renal replacement therapy (CRRT), investigate the factors contributing to PK variability, and evaluate the performance of different dosing regimens to optimize the pharmacokinetics/pharmacodynamics PK/PD) targets.

Methods: This study enrolled patients with severe infections and renal impairment who received meropenem treatment at the Second Affiliated Hospital of Soochow University. Participants were grouped according to whether CRRT was used.

Heterogeneous strong asperities and tectonic complexity control irregular cascading ruptures.

Rupture characteristics and heterogeneity of large earthquakes are essential for seismic hazard assessments. We use relocated aftershocks, geodetic measurements, and seismic waveform data to distinguish contributions from closely separated fault structures of the 2024 7.5 Noto earthquake.

Effect of ecological restoration on carbon storage of damaged mountain slope in China's East Ussuri River Basin.

Ecological restoration techniques are extensively employed in the ecological restoration of damaged mountain ecosystems effectively restoring the plant community and improving soil functions. Aggregate spray seeding technology as an effective ecological restoration method, can quickly restore the damaged slopes to their previous status and keep the ecosystem functions. However, the lack of understanding of the characteristic of carbon storage as well as its influencing factors limits the scientific management of carbon sink function of the rehabilitated damaged mountain ecosystem.

Assessing and avoiding C isotopic contamination artefacts in mesocosm-scale CO/CO labelling systems: from biomass components to purified carbohydrates and dark respiration.

Background: Quantitative understanding of plant carbon (C) metabolism by CO/CO-labelling studies requires absence (or knowledge) of C-isotopic contamination artefacts during tracer application and sample processing. Surprisingly, this concern has not been addressed systematically and comprehensively yet is especially crucial in experiments at different atmospheric CO concentrations ([CO]), when experimental protocols require frequent access to the labelling chambers. Here, we used a plant growth chamber-based CO/CO gas exchange-facility to address this topic.

Prenatal stress and cortical morphometric similarity network in offspring: Transcriptional signatures of associated genes.

Background: Prenatal stress is known to disrupt neurodevelopment in offspring, heightening their risk of mental health disorders. However, its impact on the morphometric similarity network (MSN)-a framework that integrates multiple anatomical features to quantify structural similarity across brain regions in the developing offspring-remains poorly understood.

Methods: Using data from the Queensland Twin Adolescent Brain (QTAB) longitudinal study focusing on adolescent twins, we investigated the impact of prenatal stress on cortical MSN in 414 early adolescents (aged 9-14 years).

How natural light influences HSR drivers' visual behavior.

Existing studies have shown that the lighting environment is essential in influencing a driver's visual behavior. Due to the pivotal role of high-speed railway (HSR) in worldwide transit, it is necessary to examine how HSR drivers' visual behavior adjust under different lighting environments. However, the methods for evaluating and categorizing lighting conditions have not been fully explored.

Performance improvement of GaN-based laser diode by TMAH solution treatment on an m-plane-facet sidewall ridge structure.

GaN-based laser diodes have been developed rapidly in recent years, but the hexagonal crystal system is not involved in the design of a ridge waveguide structure for an edge-emitting laser diode. In this study, m-plane was set to be the facet of the ridge sidewall of the GaN-based laser diode, which was etched by tetramethylammonium hydroxide (TMAH) solution to remove dry-etching damage and improve the device performance, with the threshold current decreasing from 194 mA to 183 mA, and the slope efficiency increasing from 0.49 W/A to 0.

Enhancing the stability and catalytic efficiency of alkyl halide dehalogenase through poloxamer temperature-sensitive gel.

Dha A, a biocatalyst with pronounced efficacy in the degradation of mustard gas, is constrained by its inherent instability, which impedes its broader application. In this study, we encapsulated Dha A within a poloxamer-based thermosensitive hydrogel, a widely utilized protein carrier, to assess its physicochemical characteristics, catalytic performance, and stability enhancement. The Dha A-loaded thermosensitive gel (Dha A@TSG) exhibited interactions between Dha A and poloxamer molecules via hydrogen bonding, with an optimal gelation temperature of 25°C.

Outcomes of liver transplantation of hepatoblastoma: single-center data in mainland China.

Objective: HB is the most common liver malignancy in children. Giving the rarity of the research reporting outcomes of LT for HB in China, updated long-term data are needed. The primary objective was to evaluate the outcomes of liver transplantation in HB.

Effects of Qiamagu (Brassica rapa L.) polysaccharide on growth performance, immunity and gut health of yellow-feathered broilers.

This study aimed to investigate the effects of adding Qiamagu polysaccharides to feed on the growth performance, immunity and gut health of yellow-feathered broilers. A total of 240 healthy, day-old, male yellow-feathered broiler chickens with similar body weights were randomly divided into four groups, each with six replicates and 10 chickens per replicate. The groups consisted of a control group (CON) and three treatment groups: TP1 (250 mg/kg), TP2 (500 mg/kg), and TP3 (1000 mg/kg) of Qiamagu polysaccharide in the diet, with a feeding period of 64 days.

Management of Post-Stroke Cold Sensations: A Case Study on Sympathetic Nerve Ablation.

BACKGROUND Stroke is a leading cause of mortality worldwide and often results in complex sequelae. Peripheral circulation disorders in paralyzed limbs are particularly challenging, presenting as persistent cold sensations and cold-induced pain that severely impair patients' quality of life. This report presents an innovative approach to managing refractory post-stroke limb coldness and pain using computed tomography (CT)-guided sympathetic nerve radiofrequency ablation.

Comprehensive analysis of mitochondrial-related gene signature for prognosis, tumor immune microenvironment evaluation, and candidate drug development in colon cancer.

Colon adenocarcinoma (COAD), a common digestive system malignancy, involves crucial alterations in mitochondria-related genes influencing tumor growth, metastasis, and immune evasion. Despite limited studies on prognostic models for these genes in COAD, we established a mitochondrial-related risk prognostic model, including nine genes based on available TCGA and MitoCarta 3.0 databases, and validated its predictive power.

Dynamic Changes in Functional Components of Dendrobium officinale and Their Applications in Food Science: A Review.

Dendrobium officinale is a medicinal and edible plant whose bioactive components, including polysaccharides, alkaloids, flavonoids, and phenolic compounds, exhibit antioxidant, anti-inflammatory, immune-regulating, and digestive-promoting effects. This review outlines the functional roles of Dendrobium's bioactive components, systematically exploring their accumulation patterns across different growth stages and environmental conditions, as well as their applications in the food industry. The literature review reveals that specific accumulation patterns occur of secondary metabolites, with these compounds accumulating most during the flowering and fruiting stages.

Use of failure mode and effect analysis to improve the monoclonal antibody drugs management process in pharmacy intravenous admixture services.

Monoclonal antibodies (mAbs) constitute a new form of immunotherapy that has shown great success in long-term tumour control. These injectable drugs are managed and compounded by the Pharmacy Intravenous Admixture Services (PIVAS) staff in a specified sterile environment. This study utilized failure mode and effect analysis (FMEA) as a risk management tool to manage mAb drugs within the PIVAS.

Perfluorooctane sulfonate induces hepatotoxicity through promoting inflammation, cell death and autophagy in a rat model.

Perfluorooctane sulfonate (PFOS) is reported to cause hepatotoxicity in animals and humans. However, the underlying mechanism by which it affects organelle toxicity in the liver are not well elucidated yet. This study aimed to investigate the mechanisms underlying PFOS-induced hepatic toxicity, focusing on inflammation, cell death, and autophagy.

Application and development of CRISPR technology in the secondary metabolic pathway of the active ingredients of phytopharmaceuticals.

As an efficient gene editing tool, the CRISPR/Cas9 system has been widely employed to investigate and regulate the biosynthetic pathways of active ingredients in medicinal plants. CRISPR technology holds significant potential for enhancing both the yield and quality of active ingredients in medicinal plants. By precisely regulating the expression of key enzymes and transcription factors, CRISPR technology not only deepens our understanding of secondary metabolic pathways in medicinal plants but also opens new avenues for drug development and the modernization of traditional Chinese medicine.

Preparation, structural property, and antioxidant activities of a novel pectin polysaccharide from the flowers of Linn.

Introduction: Oxidative stress, triggered by an imbalance between reactive oxygen species (ROS) production and cellular antioxidant defense mechanisms, is implicated in various pathological conditions. Plant-derived polysaccharides have gained significant attention as potential natural antioxidants due to their biocompatibility, biodegradability, and structural versatility.

Methods: This study focuses on the purification, structural characterization, and antioxidant activities of a novel pectin polysaccharide (HFPS) isolated from the flowers of Linn.

A Respiratory Signal Monitoring Method Based on Dual-Pathway Deep Learning Networks in Image-Guided Robotic-Assisted Intervention System.

Background: Percutaneous puncture procedures, guided by image-guided robotic-assisted intervention (IGRI) systems, are susceptible to disruptions in patients' respiratory rhythm due to factors such as pain and psychological distress.

Methods: We developed an IGRI system with a coded structured light camera and a binocular camera. Our system incorporates dual-pathway deep learning networks, combining convolutional long short-term memory (ConvLSTM) and point long short-term memory (PointLSTM) modules for real-time respiratory signal monitoring.

Constructing Dense CoRu-CoMoO Heterointerfaces with Electron Redistribution for Synergistically Boosted Alkaline Electrocatalytic Water Splitting.

Constructing metal alloys/metal oxides heterostructured electrocatalysts with abundant and strongly coupling interfaces is vital yet challenging for practical electrocatalytic water splitting. Herein, CoRu nanoalloys uniformly anchored on CoMoO nanosheet heterostructured electrocatalyst (CoRu-CoMoO/NF) are synthesized via a self-templated strategy by simply annealing of Ru-etched CoMoO/NF precursor in a reduction atmosphere. The dense and robustly coupled interface not only provides abundant active sites for water splitting but also strengthens the charge transfer efficiency.

Clinical outcomes of Omicron infection and vaccine acceptance among pediatric liver transplant recipients: insights from a cross-sectional survey.

Objectives: Our study aims to explore the clinical characteristics of Omicron infection in pediatric liver transplant recipients (PLTRs), after the national COVID-19 outbreak. Additionally, we will investigate changes in vaccine coverage and parental attitudes towards vaccinating their children after this current outbreak.

Methods: We conducted a web-based questionnaire survey to gather information on Omicron infection, vaccination status, and guardian attitude among PLTRs.

Construction and validation of transcription‑factor‑based prognostic signature for TACE non‑response and characterization of tumor microenvironment infiltration in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Despite continuous development of treatment methods, overall survival rate of liver cancer is low. Transcatheter arterial chemoembolization (TACE) is a first-choice treatment for advanced liver cancer.

Predictive value of qSOFA and hypothermia combined with PT for prognosis in patients with severe trauma: a single-center retrospective cohort study.

Background: Trauma represents a significant global health challenge.The development of an effective scoring tool capable of predicting mortality risk in trauma cases is essential. This study aimed to investigate the combined effects of quick sequential organ failure assessment (qSOFA) and hypothermia (H) along with prothrombin time (PT) in predicting the prognosis of patients with severe trauma.