A novel perspective on dissemination: somatic metastasis of germ cell tumors from the central nervous system.

Purpose: Primary germ cell tumors (GCTs) of the central nervous system are rare malignancies, with somatic metastasis being even less common. This study aims to propose a novel classification framework for dissemination patterns in CNS GCTs.

Methods: A group of 4 patients with somatic metastasis were identified among 284 germ cell tumors.

Apatinib combined with temozolomide in diffuse midline glioma: a novel and effective therapy.

Purpose: Diffuse midline glioma (DMG), H3 K27M-mutant is a type of diffuse high-grade glioma that occurs in the brain midline carrying an extremely poor prognosis under the best efforts of surgery, radiation, and other therapies. For better therapy, we explored the efficacy and toxicity of a novel therapy that combines apatinib and temozolomide in DMG.

Methods: A retrospective analysis of 32 patients with DMG who underwent apatinib plus temozolomide treatment was performed.

Combining therapy with recombinant human endostatin and cytotoxic agents for recurrent disseminated glioblastoma: a retrospective study.

Background: The optimal chemotherapeutics of recurrent disseminated glioblastoma has yet to be determined. We analyzed the efficacy and safety of recombinant human endostatin (rh-ES) combined with temozolomide and irinotecan in patients with recurrent disseminated glioblastoma.

Methods: We retrospectively reviewed 30 adult patients with recurrent disseminated glioblastoma treated with this combination chemotherapy at Department of Neuro-Oncology, Sanbo Brain Hospital, Capital Medical University of China from November 2009 to August 2018.