A 20-year retrospective analysis of ocular and adnexal injuries resulting from animal attacks in Eastern China.

Background: This study aimed to assess the clinical characteristics, management strategies, and outcomes of ocular and adnexal injuries caused by animal attacks.

Methods: A retrospective analysis was conducted on patients hospitalized for animal-induced eye injuries at the Eye and ENT Hospital of Fudan University (2003-2023). This study was approved by the Ethics Committee of the Eye and ENT Hospital of Fudan University (Ref.

Beyond direct visualization: a comparative analysis of computed tomography dacryocystographic features in dacryolithiasis, lacrimal sac cysts, and primary acquired nasolacrimal duct obstruction.

Background: Dacryoliths occur in approximately 5.8-18% of patients undergoing dacryocystorhinostomy (DCR), but conventional diagnostic methods often fail to distinguish them from other causes of nasolacrimal duct obstruction (NLDO). This study aimed to analyze the characteristic features of dacryoliths on computed tomography dacryocystography (CT-DCG) and to establish imaging criteria for their differential diagnosis from lacrimal sac cysts and primary acquired nasolacrimal duct obstruction (PANDO).

Rare TGFBI Mutation c.1553T>G p.(L518R) in Lattice Corneal Dystrophy: Comprehensive Clinical and Genetic Analysis in a Chinese Family.

Purpose: To provide a comprehensive clinical and genetic characterization of a rare variant lattice corneal dystrophy (LCD) from TGFBI mutation c.1553T>G p.(L518R) in a Chinese family.

Highly Conductive Polymer Electrolyte Membranes with Polyoxometalate Hybrid Nanodomains for High-Temperature Fuel Cells.

Phosphoric acid (PA)-doped polymer electrolyte membranes represent the most widely used high-temperature proton exchange membranes (HT-PEMs) in fuel cells. However, these materials face a significant challenge in achieving high proton conductivity under low PA content. Here, we report the fabrication of highly conductive nanodomains in HT-PEMs to solve this issue.

Outcomes of flow diversion in intracranial aneurysms accompanied by parent artery stenosis.

Background: The impact of parent artery stenosis on the treatment of intracranial aneurysms by using flow diversion (FD) remains unknown. This multicenter retrospective study aimed to evaluate the clinical and radiological outcomes of patients with intracranial aneurysms accompanied by parent artery stenosis of different etiologies after FD implantation.

Methods: The study cohort included patients who received FD treatment at four comprehensive centers from March 2013 to June 2024.

Combined Detection of Serum Brain-Derived Neurotrophic Factor and Interleukin-6 for Evaluating Therapeutic Efficacy in Major Depressive Disorder.

The assessment of major depressive disorder (MDD) treatment efficacy typically relies on clinician-rated scales of depressive symptoms with a notable absence of predictive biomarkers. In this study, a concentration ratio of serum brain-derived neurotrophic factor (BDNF) to interleukin-6 (IL-6) was identified as a promising predictive biomarker. To overcome the significant disparity in blood levels between BDNF (ng·mL range) and IL-6 (pg·mL range), a dual-pathway signal amplification method involving small carbon dots (Fe-CDs and Pb-CDs) was employed.

Bioinformatics Analysis Reveals Microrchidia Family Genes as the Prognostic and Therapeutic Markers for Colorectal Cancer.

Aim: The aim of this study is to examine the role of the microrchidia (MORC) family, a group of chromatin remodeling proteins, as the therapeutic and prognostic markers for colorectal cancer (CRC).

Background: MORC protein family genes are a highly conserved nucleoprotein superfamily whose members share a common domain but have distinct biological functions. Previous studies have analyzed the roles of MORCs as epigenetic regulators and chromatin remodulators; however, the involvement of MORCs in the development and pathogenesis of CRC was less examined.

Exposure to particulate matter (PM) weakens corneal defense by downregulating thrombospondin-1 and tight junction proteins.

Background: Fine particulate matter (PM) induces ocular surface toxicity through pyroptosis, oxidative stress, autophagy, and inflammatory responses. However, the precise molecular pathways through which PM causes corneal damage remain unclear. This study aims to investigate the underlying mechanisms by exposing human corneal epithelial cells (HCECs) to PM.

Multiparametric MRI-based radiomics nomogram for the preoperative prediction of lymph node metastasis in rectal cancer: A two-center study.

Purpose: To develop a radiomic nomogram based on multiparametric magnetic resonance imaging for the preoperative prediction of lymph node metastasis (LNM) in rectal cancer.

Methods: This retrospective study included 318 patients with pathologically proven rectal adenocarcinoma from two hospitals. Radiomic features were extracted from T2-weighted imaging, diffusion-weighted imaging, and contrast-enhanced T1-weighted imaging scans of the training cohort, and the radsore model was then constructed.

In Situ Self-Growth of a ZnO Nanorod Array on Nonwoven Fabrics for Empowering Superhydrophobic and Antibacterial Features.

ZnO nanorod nonwoven fabrics (ZNRN) were developed through hydrothermal synthesis to facilitate the prevention of the transmission of respiratory pathogens. The superhydrophobicity and antibacterial properties of ZNRN were improved through the response surface methodology. The synthesized material exhibited significant water repellency, indicated by a water contact angle of 163.

Neural substrates of the interaction between effort-expenditure reward decision-making and outcome anticipation.

Objective: Reward anticipation is important for future decision-making, possibly due to re-evaluation of prior decisions. However, the exact relationship between reward anticipation and prior effort-expenditure decision-making, and its neural substrates are unknown.

Method: Thirty-three healthy participants underwent fMRI scanning while performing the Effort-based Pleasure Experience Task (E-pet).

Novel Fluorinated Anion Exchange Membranes Based on Poly(Pentafluorophenyl-Carbazole) with High Ionic Conductivity and Alkaline Stability for Fuel Cell Applications.

Constructing good microphase separation structures by designing different polymer backbones and ion-conducting groups is an effective strategy for improving the ionic conductivity and chemical stability of anion exchange membranes (AEMs). In this study, a series of AEMs based on the poly(pentafluorophenylcarbazole) backbone grafted with different cationic groups are designed and prepared to construct well-defined microphase separation morphology and improve the trade-off between the properties of AEMs. Highly hydrophobic fluorinated backbone and alkyl spaces enhance phase separation and construct interconnected hydrophilic channels for anion transport.

Ultra-broadband holography in visible and infrared regions with full-polarization nondispersive response.

Holography is promising to fully record and reconstruct the fundamental properties of light, while the limitations of working bandwidth, allowed polarization states, and dispersive response impede further advances in the integration level and functionality. Here, we propose an ultra-broadband holography based on twisted nematic liquid crystals (TNLCs), which can efficiently work in both the visible and infrared regions with a working spectrum of over 1000 nm. The underlying physics is that the electric field vector of light through TNLCs can be parallelly manipulated in the broad spectral range, thus enabling to build the ultra-broadband TNLC hologram by dynamic photopatterning.

Water-Soluble Metallo-Supramolecular Nanoreactors for Mediating Visible-Light-Promoted Cross-Dehydrogenative Coupling Reactions.

Water-soluble metallo-supramolecular cages with well-defined nanosized cavities have a wide range of functions and applications. Herein, we design and synthesize two series of metallo-supramolecular octahedral cages based on the self-assembly of two congeneric truxene-derived tripyridyl ligands modified with two polyethylene glycol (PEG) chains, i.e.

Programmable Jigsaw Puzzles of Soft Materials Enabled by Pixelated Holographic Surface Reliefs.

Manual intervention in the self-organization of soft matter to obtain a desired superstructure is a complex but significant project. Specifically, optical components made fully or partially from reconfigurable and stimuli-responsive soft materials, referred to as soft photonics, are poised to form versatile platforms in various areas; however, a limited scale, narrow spectral adaptability, and poor stability are still formidable challenges. Herein, a facile way is developed to program the optical jigsaw puzzle of nematic liquid crystals via pixelated holographic surface reliefs, leading to an era of manufacturing for programmable soft materials with tailored functions.

Perceptual confidence of visual stimulus features is associated with duration perception.

It has been shown that the perceived duration of an object in the subsecond range is closely associated with its nontemporal perceptual properties, the mechanism under which remains unclear. Previous studies have revealed a modulatory effect of early visual feature processing on the apparent duration. Here, we further examined the relationship between perceptual confidence and subjective time by asking participants to simultaneously perform temporal and nontemporal perceptual judgments.

Prognostic and Immunological Value of GNB4 in Gastric Cancer by Analyzing TCGA Database.

Background: Gastric cancer (GC) represents a universal malignant tumor of the digestive system. Stromal and immune cells belong to two main nontumor components exerting a vital function in the tumor microenvironment.

Methods: Based on TCGA database, this study downloaded clinical information and gene profiles of GC.

Dynamically actuated soft heliconical architecture via frequency of electric fields.

Dynamic electric field frequency actuated helical and spiral structures enable a plethora of attributes for advanced photonics and engineering in the contemporary era. Nevertheless, leveraging the frequency responsiveness of adaptive devices and systems within a broad dynamic range and maintaining restrained high-frequency induced heating remain challenging. Herein, we establish a frequency-actuated heliconical soft architecture that is quite distinct from that of common frequency-responsive soft materials.

A Quadri-Dimensional Manipulable Laser with an Intrinsic Chiral Photoswitch.

Dynamic and multi-dimensional manipulation of laser emission with light allows for optical coding, computing, and imaging photonic chips. However, the coupling balance between photonic resonance and transmission is a formidable challenge due to the uncontrollable chiral microcavity with photo-reversibility, which is limited to the multi-freedom of the laser with sustainable and repeatable output beams. Herein, a helical superstructure system with a unique intrinsic chiral photoswitch is developed for resolving the always pendent problems on organized defects in the microcavity.

Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis.

Skin aging is a physiological issue that is still relatively poorly understood. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging. However, the roles of the changes in ECM characteristics and the molecules that are secreted to the extracellular space and are involved in the formation of the dermal matrix from birth to old age remain unclear.

[Integration-based co-expression network analysis to investigate tumor-associated modules across three cancer types].

In case/control gene expression data, differential expression (DE) represents changes in gene expression levels across various biological conditions, whereas differential co-expression (DC) represents an alteration of correlation coefficients between gene pairs. Both DC and DE genes have been studied extensively in human diseases. However, effective approaches for integrating DC-DE analyses are lacking.

Construction of Proton Transport Highways Induced by Polarity-Driving in Proton Exchange Membranes to Enhance the Performance of Fuel Cells.

The approach to constructing proton transport channels via direct adjustments, including hydrophilia and analytical acid concentration in hydrophilic domains, has been proved to be circumscribed when encouraging the flatter hydrophilic-hydrophobic microphase separation structures and reducing conductivity activation energy. Here, we propose a constructive solution by regulating the polarity of hydrophobic domains, which indirectly varies the aggregation and connection of hydrophilic ion clusters during membrane formation, enabling orderly self-assembly and homogeneously distributed microphase structures. Accordingly, a series of comb-shaped polymers were synthesized with diversified optimization, and more uniformly distributed ion cluster lattices were subsequently observed using high-resolution transmission electron microscopy.

Correlation of microRNA-367 in the clinicopathologic features and prognosis of breast cancer patients.

Breast cancer (BC) is a malignant tumor originating from cells of the breast. Notably, microRNAs have been recognized as biomarkers of BC metastasis. The present study is designed to evaluate the association between microRNA (miR)-367 expression and BC with the variance of clinicopathologic features and prognosis.

The "Matrisome" reveals the characterization of skin keloid microenvironment.

Keloids are fibroproliferative dermal tumors of unknown origin that are characterized by the overabundant accumulation of extracellular matrix (ECM) components. The mechanism of keloid formation has remained unclear because of a poor understanding of its molecular basis. In this study, the dermal ECM components of keloids were identified and the pathological features of keloid formation were characterized using large-scale quantitative proteomic analyses of decellularized keloid biomatrix scaffolds.