Investigation of Novel Therapeutic Targets for Rheumatoid Arthritis Through Human Plasma Proteome.

: Rheumatoid arthritis (RA) is an autoimmune disease that remains incurable. An increasing number of proteomic genome-wide association studies (GWASs) are emerging, offering immense potential for identifying novel therapeutic targets for diseases. This study aims to identify potential therapeutic targets for RA based on human plasma proteome.

Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration.

The immune system plays a pivotal role in bone regeneration, and biomaterials engineered to modulate immune responses present a promising strategy for the treatment of extensive bone defects and osteolytic conditions. This review critically evaluates recent advancements in immunomodulatory biomaterials for bone repair, integrating perspectives from both immunology and materials science. It offers a comprehensive analysis of key design strategies and the underlying principles guiding the development of these biomaterials, with a particular focus on their physical and chemical properties, bioactive molecule delivery systems, cell transplantation techniques, and responses to external stimuli.

Anterior bone loss after anterior cervical discectomy and fusion: influence factors and its impact on surgical outcomes.

Background: Anterior cervical discectomy and fusion (ACDF) has been regarded as a standard procedure to treat Cervical degenerative disc disease (CDDD). Anterior bone loss (ABL), observed at the anterior vertebral body of the operative segment, usually considered to occur only after cervical disc replacement. However, some research showed ABL appears to be similarly prevalent following ACDF.

Long-term results of cervical disc arthroplasty: a single-center retrospective study with a minimum 10-year follow-up.

Objective: This study aimed to retrospectively evaluate the long-term clinical and radiological outcomes following cervical disc arthroplasty (CDA).

Methods: This study included 74 patients who underwent single- or two-level CDA between November 2004 and December 2013, with a minimum 10-year follow-up (22 in the Bryan disc group and 52 in the Prestige LP disc group). Patient-reported outcomes and radiological parameters were collected for comparisons.

Anterior Cervical V-Shaped Osteotomy and Fusion (ACVF) for Retro-Corporeal Decompression Bypassing Anterior Corpus Vertebra: A Technical Note.

Objective: Anterior cervical discectomy and fusion (ACDF) is a trans-intervertebral space procedure with limited ability to treat compression at the back of the vertebral body. Anterior cervical corpectomy and fusion (ACCF) can be applied in this case, but the higher complication rates restrict its usage. This study aims to describe an ACDF-based procedure named anterior cervical V-shaped osteotomy and fusion (ACVF) with a long axial decompression range while preserving the intact anterior half of the vertebral body.

Paraspinal Muscle Parameters Predict Postoperative Sagittal Balance in Cervical Disc Arthroplasty: A Structural Equation Model Analysis.

Study Design: Retrospective analysis.

Objective: To identify the associations between preoperative paraspinal muscle parameters and postoperative outcomes following cervical disc arthroplasty (CDA), while screening for predictors.

Summary Of Background Data: Paraspinal muscles play a critical role in maintaining cervical alignment, significantly contributing to cervical mobility and stability.

Clinical and biomechanical effects of bone-implant interface gap after cervical disc replacement.

Purpose: Due to the irregularity of cervical inferior endplate morphology among individuals and segments, a bone-implant interface (BII) gap is usually unavoidable between the prosthesis and endplate after cervical disc replacement (CDR). This study aimed to investigate the clinical and biomechanical effects of the BII gap after CDR.

Methods: We retrospectively reviewed the clinical and radiological data of 180 patients who underwent 1-level or 2-level CDR.

Comparison of Two-Screw versus Four-Screw Internal Fixation on Fusion Speed in Anterior Cervical Discectomy and Fusion: A Prospective Randomized Controlled Trial.

Background Context: The insertion process of the new two-screw internal fixation is simpler than that of four-screw internal fixation for anterior cervical discectomy and fusion (ACDF). However, it is unclear whether there is a difference in fusion rate.

Purpose: This study aimed to compare the time required to achieve osseous fusion and the clinical efficacy of four-screw versus two-screw internal fixation.

Biomechanical Effects of Zero-P Height on Anterior Cervical Discectomy and Fusion: A Finite Element Study.

Objective: The principle of selecting a Zero-P implant of an appropriate height remains a topic of debate, particularly when similarly sized implants seem to appropriately fit the intervertebral space. Thus, this study compared the biomechanical performance of smaller and larger Zero-P implants within an appropriate height range with that of oversized Zero-P implants for anterior cervical discectomy and fusion (ACDF).

Methods: A three-dimensional finite element (FE) model of the C2-C7 cervical spine was constructed and validated.

Impact of titanium mesh cage slotting width on anterior cervical corpectomy and fusion for compression cervical spondylosis with MRI T2WI hyperintensity: a one-year follow-up study.

Background: Anterior cervical corpectomy and fusion (ACCF) is a standard surgical procedure for cervical spondylosis with spinal cord compression (CSWSCC), especially in patients with intensity on T2-weighted imaging high signal (T2WIHS). The titanium mesh cage (TMC) utilized in this procedure is essential in stabilizing the spine; however, the optimal slotting width of the TMC remains unclear.

Objective: This study aimed to investigate the impact of TMC slotting width on the clinical and radiological outcomes of ACCF in patients with spinal cord compression type cervical spondylosis with intensity on T2WIHS (CST2WIHS).

Does two-level hybrid surgery promote early fusion compared with two-level anterior cervical discectomy and fusion?

Background Context: Hybrid surgery (HS), which involves both anterior cervical discectomy and fusion (ACDF) and cervical disc replacement (ACDR), is increasingly used to treat multilevel cervical disc degenerative disease, yielding satisfactory clinical outcomes. Early fusion is critical after anterior cervical fusion surgeries, but there are no studies comparing the rate of early fusion of HS with that of ACDF.

Purpose: The purpose of this study was to compare the rate of early fusion (3-6 months postoperatively) of two-level HS with that of two-level ACDF surgery.

The Influence of Zero-Profile Implant Selection on the Outcomes of Anterior Cervical Discectomy and Fusion.

Objectives: Anterior cervical discectomy and fusion (ACDF) has been widely used in the treatment of cervical degenerative disc disease (CDDD). Previous studies have demonstrated that the size of implants in ACDF determines radiological and clinical outcomes. However, the principles of choosing an appropriate implant size in ACDF remain controversial.

Overloaded Vertebral Body Following Consecutive Three-Level Hybrid Surgery Comparing with Anterior Cervical Discectomy and Fusion.

Objective: Based on the varying number and relative positions of cervical disc replacement (CDR) and anterior cervical discectomy and fusion (ACDF) procedures, three-segment hybrid surgery (HS) presents a diverse structural approach. Currently, the potential differential effects of HS with different segment combinations and surgical procedures on overloaded vertebral body (OVB) occurrence remain unexplored. The purpose of this retrospective study is to compare the clinical and radiological outcomes of HS and ACDF in treating cervical degenerative disc disease (CDDD), aiming to provide further insights into OVB.

Does the Angulation of the Screws in the Zero-P Implant Affect the Clinical and Radiological Outcomes of Patients?

Objective: When implanting the Zero-P device, the screws of Zero-P form a bone wedge with a 40 ± 5° cranial and caudal angle (CCA). However, no study has been performed in the optimal CCA of the Zero-P implant. To investigate whether the cranial/caudal angles (CCA) of the screws affect the clinical and radiological outcomes in patients undergoing ACDF with the Zero-P implant.

Artificial intelligence in predicting postoperative heterotopic ossification following anterior cervical disc replacement.

Objective: This study aimed to develop and validate a machine learning (ML) model to predict high-grade heterotopic ossification (HO) following Anterior cervical disc replacement (ACDR).

Methods: Retrospective review of prospectively collected data of patients undergoing ACDR or hybrid surgery (HS) at a quaternary referral medical center was performed. Patients diagnosed as C3-7 single- or multi-level cervical disc degeneration disease with > 2 years of follow-up and complete pre- and postoperative radiological imaging were included.

The Effect of Thrombin-gelatin Matrix Compared With Absorbable Gelatin Sponge on Intraoperative Hemostasis in Unilateral Open-door Laminoplasty: A Randomized Controlled Trial.

Study Design: Prospective, randomized, parallel-controlled trial.

Objective: The primary aim of this study was to determine whether thrombin-gelatin matrix (TGM) combined with an absorbable gelatin sponge (AGS) could more greatly reduce intraoperative blood loss (IBL) in unilateral open-door laminoplasty than the sole use of an AGS could. The secondary aims were to evaluate the hemostatic efficiency, amount of postoperative bleeding, and safety of the application of TGM combined with an AGS.

Biomechanical Effects on the Prostheses and Vertebrae of Three-Level Hybrid Surgery: A Finite Element Study.

Purpose: Three-level hybrid surgery (HS) consisting of cervical disc arthroplasty (CDA) and anterior cervical discectomy and fusion (ACDF) has been partly used for the treatment of multi-level cervical degenerative disc disease (CDDD). The complications related to the implants and the collapse of the surgical vertebral bodies had been reported in multi-level anterior cervical spine surgery. Thus, this study aimed to explore the biomechanical effects on the prostheses and vertebrae in three-level HS.

More anterior bone loss in middle vertebra after contiguous two-segment cervical disc arthroplasty.

Background: Contiguous two-segment cervical disc arthroplasty (CDA) is safe and effective, while post-operative radiographic change is poorly understood. We aimed to clarify the morphological change of the three vertebral bodies operated on.

Methods: Patients admitted between 2015 and 2020 underwent contiguous two-level Prestige LP CDA were included.

Effects of nurses-led multidisciplinary-based psychological management in spinal surgery: a retrospective, propensity-score-matching comparative study.

Background: Patients in spine surgery often have emotional disorders which is caused by multi-factors. Therefore, a multidisciplinary and multimodal intervention program is required to improve emotional disorders during the perioperative period. However, related studies were rare.

The association of cervical sagittal alignment with anterior bone loss following single-level anterior cervical surgery.

Background: Anterior bone loss (ABL) is a common phenomenon after cervical disc replacement (CDR), which can also be observed after anterior cervical discectomy and fusion (ACDF). This study aimed to investigate the incidence and severity of ABL in single-level CDR and ACDF and explore the association of cervical sagittal alignment with ABL.

Methods: This is a single-center retrospective cohort study.

Predictive Value of Cervical Degenerative Quantitative Scoring System on Postoperative Disc Height Loss After Cervical Disc Replacement.

Study Design: A retrospective study.

Objective: In this study, a cervical degenerative quantitative scoring system was used to identify the risk factors for disc height loss after cervical disc replacement (CDR) and to verify their accuracy.

Background: Disc height loss after CDR is drawing much attention.

[Influence of preoperative symptom duration on effectiveness of cervical disc arthroplasty in cervical spondylotic radiculopathy patients].

Objective: To investigate the influence of preoperative symptom duration on effectiveness of cervical disc arthroplasty (CDA) in cervical spondylotic radiculopathy (CSR) patients.

Methods: The clinical data of 90 CSR patients who underwent single-segment CDA between January 2008 and March 2020 and met the selection criteria were retrospectively analyzed. Based on preoperative symptom duration, patients were divided into an early intervention group (preoperative symptom duration <24 months) and a late intervention group (preoperative symptom duration ≥24 months).