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Article Abstract
Chizhiaroterpenoids A-C (-), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 (), 6/6/6/6/7 (), and 6/6/6/5/6 () ring systems, were isolated from . Their biosynthetic pathways were proposed. and suppressed lipopolysaccharide-induced inflammation in BV2 cells, restored BDNF levels, and alleviated depression-like behaviors in mice. Additionally, and inhibited cancer-associated fibroblast-mediated extracellular matrix remodeling by modulating laminin, suggesting potential anti-breast cancer effects.
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| http://dx.doi.org/10.1021/acs.orglett.5c03142 | DOI Listing |
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